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Article ; Online: Inflammatory and deleterious role of gut microbiota-derived trimethylamine on colon cells.

Jalandra, Rekha / Makharia, Govind K / Sharma, Minakshi / Kumar, Anil

2023 Volume 13, Page(s) 1101429

Abstract: Trimethylamine (TMA) is produced by the intestinal microbiota as a by-product of metabolism of dietary precursors. TMA has been implicated in various chronic health conditions. However, the effect of TMA in the colon and the underlying mechanism was not ... ...

Abstract	Trimethylamine (TMA) is produced by the intestinal microbiota as a by-product of metabolism of dietary precursors. TMA has been implicated in various chronic health conditions. However, the effect of TMA in the colon and the underlying mechanism was not clear. In this study, TMA exhibited toxic effects
MeSH term(s)	Mice ; Animals ; Gastrointestinal Microbiome ; Methylamines/metabolism ; Intestinal Mucosa/metabolism ; Colon/metabolism
Chemical Substances	trimethylamine (LHH7G8O305) ; Methylamines
Language	English
Publishing date	2023-01-16
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1101429
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A novel method for enrichment of Morganella morganii in fecal samples using designed culture medium.

Jalandra, Rekha / Dalal, Nishu / Mohan, Anand / Solanki, Pratima Rathi / Kumar, Anil

Cell biochemistry and function

2024 Volume 42, Issue 3, Page(s) e4004

Abstract: Morganella morganii is a gram negative, facultative anaerobic rod-shaped bacterium, commonly found in environment and in the intestine of human, mammals, and reptiles as a part of their gut microbiome. M. morganii can cause Gram-negative folliculitis, ... ...

Abstract	Morganella morganii is a gram negative, facultative anaerobic rod-shaped bacterium, commonly found in environment and in the intestine of human, mammals, and reptiles as a part of their gut microbiome. M. morganii can cause Gram-negative folliculitis, black nail infection, acute retiform purpura, fetal demise, and subdural empyema. The increasing frequency of M. morganii infections generate the need for efficient methods to enrich the presence of M. morganii in clinical samples to make its detection easier. Culturomics aims to grow and maximize the number of culturable bacteria. Different methods are followed to maximize the growth of minority population of bacteria by disrupting the growth of bacteria which are present in higher concentration. This article presents a method for selective enriching the M. morganii in human fecal samples. This method includes prior incubation of fecal microbiota in an anaerobic environment, adding supplement like fecal water to give dormant bacteria a break to become active to grow to threshold concentration, and an enrichment stage which provides the additional opportunity of growing to M. morganii on the selective medium. This method also provides an ingenuous way for augmenting the growth of fecal M. morganii species.
MeSH term(s)	Animals ; Humans ; Morganella morganii ; Mammals
Language	English
Publishing date	2024-04-07
Publishing country	England
Document type	Journal Article
ZDB-ID	283643-9
ISSN	1099-0844 ; 0263-6484
ISSN (online)	1099-0844
ISSN	0263-6484
DOI	10.1002/cbf.4004
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Article ; Online: Gut microbiota derived trimethylamine N-oxide (TMAO) detection through molecularly imprinted polymer based sensor.

Lakshmi, G B V S / Yadav, Amit K / Mehlawat, Neha / Jalandra, Rekha / Solanki, Pratima R / Kumar, Anil

Scientific reports

2021 Volume 11, Issue 1, Page(s) 1338

Abstract: Trimethylamine N-oxide (TMAO), a microbiota-derived metabolite has been implicated in human health and disease. Its early detection in body fluids has been presumed to be significant in understanding the pathogenesis and treatment of many diseases. Hence, ...

Abstract	Trimethylamine N-oxide (TMAO), a microbiota-derived metabolite has been implicated in human health and disease. Its early detection in body fluids has been presumed to be significant in understanding the pathogenesis and treatment of many diseases. Hence, the development of reliable and rapid technologies for TMAO detection may augment our understanding of pathogenesis and diagnosis of diseases that TMAO has implicated. The present work is the first report on the development of a molecularly imprinted polymer (MIP) based electrochemical sensor for sensitive and selective detection of TMAO in body fluids. The MIP developed was based on the polypyrrole (PPy), which was synthesized via chemical oxidation polymerization method, with and without the presence of TMAO. The MIP, NIP and the non-sonicated polymer (PPy-TMAO) were separately deposited electrophoretically onto the hydrolyzed indium tin oxide (ITO) coated glasses. The chemical, morphological, and electrochemical behavior of MIP, non-imprinted polymer (NIP), and PPy-TMAO were characterized using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and electrochemical techniques. The detection response was recorded using differential pulse voltammetry (DPV), which revealed a decrease in the peak current with the increase in concentration of TMAO. The MIP sensor showed a dynamic detection range of 1-15 ppm with a sensitivity of 2.47 µA mL ppm
MeSH term(s)	Gastrointestinal Microbiome ; Humans ; Limit of Detection ; Methylamines/analysis ; Molecularly Imprinted Polymers/chemistry ; Polymers/chemistry
Chemical Substances	Methylamines ; Molecularly Imprinted Polymers ; Polymers ; trimethyloxamine (FLD0K1SJ1A)
Language	English
Publishing date	2021-01-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-80122-6
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Article ; Online: Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer.

Jalandra, Rekha / Dalal, Nishu / Yadav, Amit K / Verma, Damini / Sharma, Minakshi / Singh, Rajeev / Khosla, Ajit / Kumar, Anil / Solanki, Pratima R

Applied microbiology and biotechnology

2021 Volume 105, Issue 20, Page(s) 7651–7660

Abstract: Among gut microbiota-derived metabolites, trimethylamine-N-oxide (TMAO) is receiving increased attention due to its possible role in the carcinogenesis of colorectal cancer (CRC). In spite of numerous reports implicating TMAO with CRC, there is a lack of ...

Abstract	Among gut microbiota-derived metabolites, trimethylamine-N-oxide (TMAO) is receiving increased attention due to its possible role in the carcinogenesis of colorectal cancer (CRC). In spite of numerous reports implicating TMAO with CRC, there is a lack of empirical mechanistic evidences to concretize the involvement of TMAO in the carcinogenesis of CRC. Possible mechanisms such as inflammation, oxidative stress, DNA damage, and protein misfolding by TMAO have been discussed in this review in the light of the latest advancements in the field. This review is an attempt to discuss the probable correlation between TMAO and CRC but this linkage can be concretized only once we get sufficient empirical evidences from the mechanistic studies. We believe, this review will augment the understanding of linking TMAO with CRC and will motivate researchers to move towards mechanistic study for reinforcing the idea of implicating TMAO with CRC causation. KEY POINTS: • TMAO is a gut bacterial metabolite which has been implicated in CRC in recent years. • The valid mechanistic approach of CRC causation by TMAO is unknown. • The article summarizes the possible mechanisms which need to be explored for validation.
MeSH term(s)	Colorectal Neoplasms ; Humans ; Methylamines ; Oxides
Chemical Substances	Methylamines ; Oxides ; trimethyloxamine (FLD0K1SJ1A) ; trimethylamine (LHH7G8O305)
Language	English
Publishing date	2021-09-27
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-021-11582-7
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Article: Emerging role of trimethylamine-N-oxide (TMAO) in colorectal cancer

Jalandra, Rekha / Dalal, Nishu / Yadav, Amit K. / Verma, Damini / Sharma, Minakshi / Singh, Rajeev / Khosla, Ajit / Kumar, Anil / Solanki, Pratima R.

Applied microbiology and biotechnology. 2021 Oct., v. 105, no. 20

2021

Abstract	Among gut microbiota-derived metabolites, trimethylamine-N-oxide (TMAO) is receiving increased attention due to its possible role in the carcinogenesis of colorectal cancer (CRC). In spite of numerous reports implicating TMAO with CRC, there is a lack of empirical mechanistic evidences to concretize the involvement of TMAO in the carcinogenesis of CRC. Possible mechanisms such as inflammation, oxidative stress, DNA damage, and protein misfolding by TMAO have been discussed in this review in the light of the latest advancements in the field. This review is an attempt to discuss the probable correlation between TMAO and CRC but this linkage can be concretized only once we get sufficient empirical evidences from the mechanistic studies. We believe, this review will augment the understanding of linking TMAO with CRC and will motivate researchers to move towards mechanistic study for reinforcing the idea of implicating TMAO with CRC causation. KEY POINTS: • TMAO is a gut bacterial metabolite which has been implicated in CRC in recent years. • The valid mechanistic approach of CRC causation by TMAO is unknown. • The article summarizes the possible mechanisms which need to be explored for validation.
Keywords	DNA damage ; biotechnology ; carcinogenesis ; colorectal neoplasms ; digestive system ; inflammation ; metabolites ; microbiology ; oxidative stress ; protein folding
Language	English
Dates of publication	2021-10
Size	p. 7651-7660.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	Review
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-021-11582-7
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Article ; Online: Gut microbiota derived trimethylamine N-oxide (TMAO) detection through molecularly imprinted polymer based sensor

G. B. V. S. Lakshmi / Amit K. Yadav / Neha Mehlawat / Rekha Jalandra / Pratima R. Solanki / Anil Kumar

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 14

Abstract: Abstract Trimethylamine N-oxide (TMAO), a microbiota-derived metabolite has been implicated in human health and disease. Its early detection in body fluids has been presumed to be significant in understanding the pathogenesis and treatment of many ... ...

Abstract	Abstract Trimethylamine N-oxide (TMAO), a microbiota-derived metabolite has been implicated in human health and disease. Its early detection in body fluids has been presumed to be significant in understanding the pathogenesis and treatment of many diseases. Hence, the development of reliable and rapid technologies for TMAO detection may augment our understanding of pathogenesis and diagnosis of diseases that TMAO has implicated. The present work is the first report on the development of a molecularly imprinted polymer (MIP) based electrochemical sensor for sensitive and selective detection of TMAO in body fluids. The MIP developed was based on the polypyrrole (PPy), which was synthesized via chemical oxidation polymerization method, with and without the presence of TMAO. The MIP, NIP and the non-sonicated polymer (PPy-TMAO) were separately deposited electrophoretically onto the hydrolyzed indium tin oxide (ITO) coated glasses. The chemical, morphological, and electrochemical behavior of MIP, non-imprinted polymer (NIP), and PPy-TMAO were characterized using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and electrochemical techniques. The detection response was recorded using differential pulse voltammetry (DPV), which revealed a decrease in the peak current with the increase in concentration of TMAO. The MIP sensor showed a dynamic detection range of 1–15 ppm with a sensitivity of 2.47 µA mL ppm−1 cm−2. The developed sensor is easy to construct and operate and is also highly selective to detect TMAO in body fluids such as urine. The present research provides a basis for innovative strategies to develop sensors based on MIP to detect other metabolites derived from gut microbiota that are implicated in human health and diseases.
Keywords	Medicine ; R ; Science ; Q
Subject code	620
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Omics technologies for improved diagnosis and treatment of colorectal cancer: Technical advancement and major perspectives.

Dalal, Nishu / Jalandra, Rekha / Sharma, Minakshi / Prakash, Hridayesh / Makharia, Govind K / Solanki, Pratima R / Singh, Rajeev / Kumar, Anil

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2020 Volume 131, Page(s) 110648

Abstract: Colorectal cancer (CRC) ranks third among the most commonly occurring cancers worldwide, and it causes half a million deaths annually. Alongside mechanistic study for CRC detection and treatment by conventional techniques, new technologies have been ... ...

Abstract	Colorectal cancer (CRC) ranks third among the most commonly occurring cancers worldwide, and it causes half a million deaths annually. Alongside mechanistic study for CRC detection and treatment by conventional techniques, new technologies have been developed to study CRC. These technologies include genomics, transcriptomics, proteomics, and metabolomics which elucidate DNA markers, RNA transcripts, protein and, metabolites produced inside the colon and rectum part of the gut. All these approaches form the omics arena, which presents a remarkable opportunity for the discovery of novel prognostic, diagnostic and therapeutic biomarkers and also delineate the underlying mechanism of CRC causation, which may further help in devising treatment strategies. This review also mentions the latest developments in metagenomics and culturomics as emerging evidence suggests that metagenomics of gut microbiota has profound implications in the causation, prognosis, and treatment of CRC. A majority of bacteria cannot be studied as they remain unculturable, so culturomics has also been strengthened to develop culture conditions suitable for the growth of unculturable bacteria and identify unknown bacteria. The overall purpose of this review is to succinctly evaluate the application of omics technologies in colorectal cancer research for improving the diagnosis and treatment strategies.
MeSH term(s)	Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/therapy ; Gastrointestinal Microbiome ; Humans ; Metabolomics ; Metagenomics ; Proteomics ; Transcriptome
Language	English
Publishing date	2020-10-19
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2020.110648
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Article ; Online: Strategies and perspectives to develop SARS-CoV-2 detection methods and diagnostics.

Jalandra, Rekha / Yadav, Amit K / Verma, Damini / Dalal, Nishu / Sharma, Minakshi / Singh, Rajeev / Kumar, Anil / Solanki, Pratima R

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2020 Volume 129, Page(s) 110446

Abstract: To develop diagnostics and detection methods, current research is focussed on targeting the detection of coronavirus based on its RNA. Besides the RNA target, research reports are coming to develop diagnostics by targeting structure and other parts of ... ...

Abstract	To develop diagnostics and detection methods, current research is focussed on targeting the detection of coronavirus based on its RNA. Besides the RNA target, research reports are coming to develop diagnostics by targeting structure and other parts of coronavirus. PCR based detection system is widely used and various improvements in the PCR based detection system can be seen in the recent research reports. This review will discuss multiple detection methods for coronavirus for developing appropriate, reliable, and fast alternative techniques. Considering the current scenario of COVID-19 diagnostics around the world and an urgent need for the development of reliable and cheap diagnostic, various techniques based on CRISPR technology, antibody, MIP, LAMP, microarray, etc. should be discussed and tried.
MeSH term(s)	Animals ; Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/virology ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/virology ; Polymerase Chain Reaction ; RNA, Viral/isolation & purification ; SARS-CoV-2 ; Sensitivity and Specificity
Chemical Substances	RNA, Viral
Keywords	covid19
Language	English
Publishing date	2020-06-19
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2020.110446
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Article ; Online: Gut microbiota-derived metabolites in CRC progression and causation.

Dalal, Nishu / Jalandra, Rekha / Bayal, Nitin / Yadav, Amit K / Harshulika / Sharma, Minakshi / Makharia, Govind K / Kumar, Pramod / Singh, Rajeev / Solanki, Pratima R / Kumar, Anil

Journal of cancer research and clinical oncology

2021 Volume 147, Issue 11, Page(s) 3141–3155

Abstract: Background: Based on recent research reports, dysbiosis and improper concentrations of microbial metabolites in the gut may result into the carcinogenesis of colorectal cancer. Recent advancement also highlights the involvement of bacteria and their ... ...

Abstract	Background: Based on recent research reports, dysbiosis and improper concentrations of microbial metabolites in the gut may result into the carcinogenesis of colorectal cancer. Recent advancement also highlights the involvement of bacteria and their secreted metabolites in the cancer causation. Gut microbial metabolites are functional output of the host-microbiota interactions and produced by anaerobic fermentation of food components in the diet. They contribute to influence variety of biological mechanisms including inflammation, cell signaling, cell-cycle disruption which are majorly disrupted in carcinogenic activities. Purpose: In this review, we intend to discuss recent updates and possible molecular mechanisms to provide the role of bacterial metabolites, gut bacteria and diet in the colorectal carcinogenesis. Recent evidences have proposed the role of bacteria, such as Fusobacterium nucleaturm, Streptococcus bovis, Helicobacter pylori, Bacteroides fragilis and Clostridium septicum, in the carcinogenesis of CRC. Metagenomic study confirmed that these bacteria are in increased abundance in CRC patient as compared to healthy individuals and can cause inflammation and DNA damage which can lead to development of cancer. These bacteria produce metabolites, such as secondary bile salts from primary bile salts, hydrogen sulfide, trimethylamine-N-oxide (TMAO), which are likely to promote inflammation and subsequently cancer development. Conclusion: Recent studies suggest that gut microbiota-derived metabolites have a role in CRC progression and causation and hence, could be implicated in CRC diagnosis, prognosis and therapy.
MeSH term(s)	Animals ; Colorectal Neoplasms/microbiology ; Colorectal Neoplasms/pathology ; Disease Progression ; Gastrointestinal Microbiome/physiology ; Gram-Negative Bacteria/metabolism ; Gram-Positive Bacteria/metabolism ; Humans ; Metagenomics
Language	English
Publishing date	2021-07-17
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-021-03729-w
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Article ; Online: Strategies and perspectives to develop SARS-CoV-2 detection methods and diagnostics

Jalandra, Rekha / Yadav, Amit K. / Verma, Damini / Dalal, Nishu / Sharma, Minakshi / Singh, Rajeev / Kumar, Anil / Solanki, Pratima R.

Biomedicine & Pharmacotherapy

2020 Volume 129, Page(s) 110446

Keywords	Pharmacology ; General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2020.110446
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