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Article ; Online: Strategies for cell membrane functionalization.

Armstrong, James Pk / Perriman, Adam W

Experimental biology and medicine (Maywood, N.J.)

2016 Volume 241, Issue 10, Page(s) 1098–1106

Abstract: The ability to rationally manipulate and augment the cytoplasmic membrane can be used to overcome many of the challenges faced by conventional cellular therapies and provide innovative opportunities when combined with new biotechnologies. The focus of ... ...

Abstract	The ability to rationally manipulate and augment the cytoplasmic membrane can be used to overcome many of the challenges faced by conventional cellular therapies and provide innovative opportunities when combined with new biotechnologies. The focus of this review is on emerging strategies used in cell functionalization, highlighting both pioneering approaches and recent developments. These will be discussed within the context of future directions in this rapidly evolving field.
MeSH term(s)	Animals ; Biocompatible Materials/metabolism ; Cell Membrane/chemistry ; Cell Membrane/physiology ; Cell- and Tissue-Based Therapy/methods ; Humans
Chemical Substances	Biocompatible Materials
Language	English
Publishing date	2016-05-27
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	4015-0
ISSN	1535-3699 ; 1525-1373 ; 0037-9727
ISSN (online)	1535-3699 ; 1525-1373
ISSN	0037-9727
DOI	10.1177/1535370216650291
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Article: Using Remote Fields for Complex Tissue Engineering

Armstrong, James P.K / Stevens, Molly M

Trends in biotechnology. 2020 Mar., v. 38, no. 3

2020

Abstract: Great strides have been taken towards the in vitro engineering of clinically relevant tissue constructs using the classic triad of cells, materials, and biochemical factors. In this perspective, we highlight ways in which these elements can be ... ...

Abstract	Great strides have been taken towards the in vitro engineering of clinically relevant tissue constructs using the classic triad of cells, materials, and biochemical factors. In this perspective, we highlight ways in which these elements can be manipulated or stimulated using a fourth component: the application of remote fields. This arena has gained great momentum over the last few years, with a recent surge of interest in using magnetic, optical, and acoustic fields to guide the organization of cells, materials, and biochemical factors. We summarize recent developments and trends in this arena and then lay out a series of challenges that we believe, if met, could enable the widespread adoption of remote fields in mainstream tissue engineering.
Keywords	acoustics ; magnetism ; tissue engineering
Language	English
Dates of publication	2020-03
Size	p. 254-263.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	47474-5
ISSN	1879-3096 ; 0167-7799
ISSN (online)	1879-3096
ISSN	0167-7799
DOI	10.1016/j.tibtech.2019.07.005
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Article ; Online: Glycosylated superparamagnetic nanoparticle gradients for osteochondral tissue engineering.

Li, Chunching / Armstrong, James Pk / Pence, Isaac J / Kit-Anan, Worrapong / Puetzer, Jennifer L / Correia Carreira, Sara / Moore, Axel C / Stevens, Molly M

Biomaterials

2018 Volume 176, Page(s) 24–33

Abstract: In developmental biology, gradients of bioactive signals direct the formation of structural transitions in tissue that are key to physiological function. Failure to reproduce these native features in an in vitro setting can severely limit the success of ... ...

Abstract	In developmental biology, gradients of bioactive signals direct the formation of structural transitions in tissue that are key to physiological function. Failure to reproduce these native features in an in vitro setting can severely limit the success of bioengineered tissue constructs. In this report, we introduce a facile and rapid platform that uses magnetic field alignment of glycosylated superparamagnetic iron oxide nanoparticles, pre-loaded with growth factors, to pattern biochemical gradients into a range of biomaterial systems. Gradients of bone morphogenetic protein 2 in agarose hydrogels were used to spatially direct the osteogenesis of human mesenchymal stem cells and generate robust osteochondral tissue constructs exhibiting a clear mineral transition from bone to cartilage. Interestingly, the smooth gradients in growth factor concentration gave rise to biologically-relevant, emergent structural features, including a tidemark transition demarcating mineralized and non-mineralized tissue and an osteochondral interface rich in hypertrophic chondrocytes. This platform technology offers great versatility and provides an exciting new opportunity for overcoming a range of interfacial tissue engineering challenges.
MeSH term(s)	Biocompatible Materials/chemistry ; Bone Morphogenetic Protein 2/metabolism ; Cartilage/cytology ; Cell Differentiation ; Cell Survival ; Cells, Cultured ; Drug Carriers ; Drug Liberation ; Electromagnetic Fields ; Glycosylation ; Humans ; Hydrogels/chemistry ; Magnetite Nanoparticles/chemistry ; Mesenchymal Stem Cells/cytology ; Osteogenesis ; Sepharose/chemistry ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry
Chemical Substances	Biocompatible Materials ; Bone Morphogenetic Protein 2 ; Drug Carriers ; Hydrogels ; Magnetite Nanoparticles ; Sepharose (9012-36-6)
Language	English
Publishing date	2018-05-21
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603079-8
ISSN	1878-5905 ; 0142-9612
ISSN (online)	1878-5905
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2018.05.029
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Article: Glycosylated superparamagnetic nanoparticle gradients for osteochondral tissue engineering

Li, Chunching / Armstrong, James PK / Pence, Isaac J / Kit-Anan, Worrapong / Puetzer, Jennifer L / Correia Carreira, Sara / Moore, Axel C / Stevens, Molly M

Biomaterials. 2018 Sept., v. 176

2018

Abstract	In developmental biology, gradients of bioactive signals direct the formation of structural transitions in tissue that are key to physiological function. Failure to reproduce these native features in an in vitro setting can severely limit the success of bioengineered tissue constructs. In this report, we introduce a facile and rapid platform that uses magnetic field alignment of glycosylated superparamagnetic iron oxide nanoparticles, pre-loaded with growth factors, to pattern biochemical gradients into a range of biomaterial systems. Gradients of bone morphogenetic protein 2 in agarose hydrogels were used to spatially direct the osteogenesis of human mesenchymal stem cells and generate robust osteochondral tissue constructs exhibiting a clear mineral transition from bone to cartilage. Interestingly, the smooth gradients in growth factor concentration gave rise to biologically-relevant, emergent structural features, including a tidemark transition demarcating mineralized and non-mineralized tissue and an osteochondral interface rich in hypertrophic chondrocytes. This platform technology offers great versatility and provides an exciting new opportunity for overcoming a range of interfacial tissue engineering challenges.
Keywords	agarose ; biobased products ; bone formation ; bone morphogenetic proteins ; cartilage ; chondrocytes ; glycosylation ; growth factors ; humans ; hydrogels ; magnetic fields ; nanoparticles ; stem cells ; tissue engineering
Language	English
Dates of publication	2018-09
Size	p. 24-33.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	603079-8
ISSN	0142-9612
ISSN	0142-9612
DOI	10.1016/j.biomaterials.2018.05.029
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Article: Advances in the Fabrication of Biomaterials for Gradient Tissue Engineering

Li, Chunching / Ouyang, Liliang / Armstrong, James P.K / Stevens, Molly M

Trends in biotechnology. 2021 Feb., v. 39, no. 2

2021

Abstract: Natural tissues and organs exhibit an array of spatial gradients, from the polarized neural tube during embryonic development to the osteochondral interface present at articulating joints. The strong structure–function relationships in these ... ...

Abstract	Natural tissues and organs exhibit an array of spatial gradients, from the polarized neural tube during embryonic development to the osteochondral interface present at articulating joints. The strong structure–function relationships in these heterogeneous tissues have sparked intensive research into the development of methods that can replicate physiological gradients in engineered tissues. In this Review, we consider different gradients present in natural tissues and discuss their critical importance in functional tissue engineering. Using this basis, we consolidate the existing fabrication methods into four categories: additive manufacturing, component redistribution, controlled phase changes, and postmodification. We have illustrated this with recent examples, highlighted prominent trends in the field, and outlined a set of criteria and perspectives for gradient fabrication.
Keywords	biocompatible materials ; biotechnology ; embryogenesis
Language	English
Dates of publication	2021-02
Size	p. 150-164.
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	47474-5
ISSN	1879-3096 ; 0167-7799
ISSN (online)	1879-3096
ISSN	0167-7799
DOI	10.1016/j.tibtech.2020.06.005
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Violation of Bell's Inequality Using Continuous Variable Measurements.

Thearle, Oliver / Janousek, Jiri / Armstrong, Seiji / Hosseini, Sara / Schünemann Mraz, Melanie / Assad, Syed / Symul, Thomas / James, Matthew R / Huntington, Elanor / Ralph, Timothy C / Lam, Ping Koy

Physical review letters

2018 Volume 120, Issue 4, Page(s) 40406

Abstract: A Bell inequality is a fundamental test to rule out local hidden variable model descriptions of correlations between two physically separated systems. There have been a number of experiments in which a Bell inequality has been violated using discrete- ... ...

Abstract	A Bell inequality is a fundamental test to rule out local hidden variable model descriptions of correlations between two physically separated systems. There have been a number of experiments in which a Bell inequality has been violated using discrete-variable systems. We demonstrate a violation of Bell's inequality using continuous variable quadrature measurements. By creating a four-mode entangled state with homodyne detection, we recorded a clear violation with a Bell value of B=2.31±0.02. This opens new possibilities for using continuous variable states for device independent quantum protocols.
Language	English
Publishing date	2018-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.120.040406
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Article: Synthesis of cationized magnetoferritin for ultra-fast magnetization of cells

Correia Carreira, Sara / Armstrong, James P.K / Okuda, Mitsuhiro / Seddon, Annela M / Perriman, Adam W / Schwarzacher, Walther

Journal of visualized experiments. 2016 Dec. 13, , no. 118

2016

Abstract: Many important biomedical applications, such as cell imaging and remote manipulation, can be achieved by labeling cells with superparamagnetic iron oxide nanoparticles (SPIONs). Achieving sufficient cellular uptake of SPIONs is a challenge that has ... ...

Abstract	Many important biomedical applications, such as cell imaging and remote manipulation, can be achieved by labeling cells with superparamagnetic iron oxide nanoparticles (SPIONs). Achieving sufficient cellular uptake of SPIONs is a challenge that has traditionally been met by exposing cells to elevated concentrations of SPIONs or by prolonging exposure times (up to 72 hr). However, these strategies are likely to mediate toxicity. Here, we present the synthesis of the protein-based SPION magnetoferritin as well as a facile surface functionalization protocol that enables rapid cell magnetization using low exposure concentrations. The SPION core of magnetoferritin consists of cobalt-doped iron oxide with an average particle diameter of 8.2 nm mineralized inside the cavity of horse spleen apo-ferritin. Chemical cationization of magnetoferritin produced a novel, highly membrane-active SPION that magnetized human mesenchymal stem cells (hMSCs) using incubation times as short as one minute and iron concentrations as lows as 0.2 mM.
Keywords	cationization ; exposure duration ; horses ; humans ; image analysis ; iron ; mesenchymal stromal cells ; nanoparticles ; particle size ; spleen ; toxicity
Language	English
Dates of publication	2016-1213
Size	p. e54785.
Publishing place	Journal of Visualized Experiments
Document type	Article
ZDB-ID	2259946-0
ISSN	1940-087X
ISSN	1940-087X
DOI	10.3791/54785
Database	NAL-Catalogue (AGRICOLA)

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Article: Pandemic influenza preparedness.

Fizzell, Jane / Armstrong, Paul K / Branley, James M

New South Wales public health bulletin

2006 Volume 17, Issue 9-10, Page(s) 151

MeSH term(s)	Animals ; Birds ; Communicable Diseases, Emerging/epidemiology ; Communicable Diseases, Emerging/virology ; Disease Outbreaks/prevention & control ; Humans ; Influenza A Virus, H5N1 Subtype/genetics ; Influenza A Virus, H5N1 Subtype/isolation & purification ; Influenza in Birds/epidemiology ; Influenza in Birds/virology ; Influenza, Human/epidemiology ; Influenza, Human/virology ; New South Wales/epidemiology ; Planning Techniques ; Public Health Administration ; Zoonoses
Language	English
Publishing date	2006-09
Publishing country	Australia
Document type	Journal Article
ISSN	1034-7674
ISSN	1034-7674
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Article ; Online: Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection.

Williamson, Lauren E / Gilliland, Theron / Yadav, Pramod K / Binshtein, Elad / Bombardi, Robin / Kose, Nurgun / Nargi, Rachel S / Sutton, Rachel E / Durie, Clarissa L / Armstrong, Erica / Carnahan, Robert H / Walker, Lauren M / Kim, Arthur S / Fox, Julie M / Diamond, Michael S / Ohi, Melanie D / Klimstra, William B / Crowe, James E

Cell

2020 Volume 183, Issue 7, Page(s) 1884–1900.e23

Abstract: Eastern equine encephalitis virus (EEEV) is one of the most virulent viruses endemic to North America. No licensed vaccines or antiviral therapeutics are available to combat this infection, which has recently shown an increase in human cases. Here, we ... ...

Abstract	Eastern equine encephalitis virus (EEEV) is one of the most virulent viruses endemic to North America. No licensed vaccines or antiviral therapeutics are available to combat this infection, which has recently shown an increase in human cases. Here, we characterize human monoclonal antibodies (mAbs) isolated from a survivor of natural EEEV infection with potent (<20 pM) inhibitory activity of EEEV. Cryo-electron microscopy reconstructions of two highly neutralizing mAbs, EEEV-33 and EEEV-143, were solved in complex with chimeric Sindbis/EEEV virions to 7.2 Å and 8.3 Å, respectively. The mAbs recognize two distinct antigenic sites that are critical for inhibiting viral entry into cells. EEEV-33 and EEEV-143 protect against disease following stringent lethal aerosol challenge of mice with highly pathogenic EEEV. These studies provide insight into the molecular basis for the neutralizing human antibody response against EEEV and can facilitate development of vaccines and candidate antibody therapeutics.
MeSH term(s)	Adult ; Aerosols/administration & dosage ; Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Antigens, Viral/immunology ; Cryoelectron Microscopy ; Disease Models, Animal ; Encephalitis Virus, Eastern Equine/immunology ; Encephalitis Virus, Eastern Equine/ultrastructure ; Encephalomyelitis, Equine/immunology ; Encephalomyelitis, Equine/prevention & control ; Encephalomyelitis, Equine/virology ; Epitopes/chemistry ; Female ; Glycoproteins/immunology ; Humans ; Mice ; Models, Molecular ; Mutagenesis/genetics ; Neutralization Tests ; Protein Binding ; Protein Domains ; Recombinant Proteins/immunology ; Sindbis Virus/immunology ; Virion/immunology ; Virion/ultrastructure ; Virus Internalization
Chemical Substances	Aerosols ; Antibodies, Monoclonal ; Antibodies, Neutralizing ; Antibodies, Viral ; Antigens, Viral ; Epitopes ; Glycoproteins ; Recombinant Proteins
Language	English
Publishing date	2020-12-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2020.11.011
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Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

Shrine, Nick / Guyatt, Anna L / Erzurumluoglu, A Mesut / Jackson, Victoria E / Hobbs, Brian D / Melbourne, Carl A / Batini, Chiara / Fawcett, Katherine A / Song, Kijoung / Sakornsakolpat, Phuwanat / Li, Xingnan / Boxall, Ruth / Reeve, Nicola F / Obeidat, Ma'en / Zhao, Jing Hua / Wielscher, Matthias / Weiss, Stefan / Kentistou, Katherine A / Cook, James P /

Sun, Benjamin B / Zhou, Jian / Hui, Jennie / Karrasch, Stefan / Imboden, Medea / Harris, Sarah E / Marten, Jonathan / Enroth, Stefan / Kerr, Shona M / Surakka, Ida / Vitart, Veronique / Lehtimäki, Terho / Allen, Richard J / Bakke, Per S / Beaty, Terri H / Bleecker, Eugene R / Bossé, Yohan / Brandsma, Corry-Anke / Chen, Zhengming / Crapo, James D / Danesh, John / DeMeo, Dawn L / Dudbridge, Frank / Ewert, Ralf / Gieger, Christian / Gulsvik, Amund / Hansell, Anna L / Hao, Ke / Hoffman, Joshua D / Hokanson, John E / Homuth, Georg / Joshi, Peter K / Joubert, Philippe / Langenberg, Claudia / Li, Xuan / Li, Liming / Lin, Kuang / Lind, Lars / Locantore, Nicholas / Luan, Jian'an / Mahajan, Anubha / Maranville, Joseph C / Murray, Alison / Nickle, David C / Packer, Richard / Parker, Margaret M / Paynton, Megan L / Porteous, David J / Prokopenko, Dmitry / Qiao, Dandi / Rawal, Rajesh / Runz, Heiko / Sayers, Ian / Sin, Don D / Smith, Blair H / Artigas, María Soler / Sparrow, David / Tal-Singer, Ruth / Timmers, Paul R H J / Van den Berge, Maarten / Whittaker, John C / Woodruff, Prescott G / Yerges-Armstrong, Laura M / Troyanskaya, Olga G / Raitakari, Olli T / Kähönen, Mika / Polašek, Ozren / Gyllensten, Ulf / Rudan, Igor / Deary, Ian J / Probst-Hensch, Nicole M / Schulz, Holger / James, Alan L / Wilson, James F / Stubbe, Beate / Zeggini, Eleftheria / Jarvelin, Marjo-Riitta / Wareham, Nick / Silverman, Edwin K / Hayward, Caroline / Morris, Andrew P / Butterworth, Adam S / Scott, Robert A / Walters, Robin G / Meyers, Deborah A / Cho, Michael H / Strachan, David P / Hall, Ian P / Tobin, Martin D / Wain, Louise V

Nature genetics

2024

Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1108734-1
ISSN	1546-1718 ; 1061-4036
ISSN (online)	1546-1718
ISSN	1061-4036
DOI	10.1038/s41588-024-01752-4
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