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Article ; Online: Editorial for "A New OATP-Mediated Hepatobiliary-Specific Mn(II)-Based MRI Contrast Agent for Hepatocellular Carcinoma in Mice: A Comparison With Gd-EOB-DTPA".

Caravan, Peter

Journal of magnetic resonance imaging : JMRI

2023 Volume 58, Issue 3, Page(s) 934–935

MeSH term(s)	Mice ; Animals ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/pathology ; Contrast Media ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/pathology ; Gadolinium DTPA ; Magnetic Resonance Imaging ; Organic Anion Transporters
Chemical Substances	Contrast Media ; gadolinium ethoxybenzyl DTPA ; Gadolinium DTPA (K2I13DR72L) ; Organic Anion Transporters
Language	English
Publishing date	2023-01-18
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	1146614-5
ISSN	1522-2586 ; 1053-1807
ISSN (online)	1522-2586
ISSN	1053-1807
DOI	10.1002/jmri.28601
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Zs.A 3648: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 236: Show issues

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Article ; Online: Divalent Manganese Complexes as Potential Replacements for Gadolinium-Based Contrast Agents.

Caravan, Peter

Investigative radiology

2023 Volume 59, Issue 2, Page(s) 187–196

Abstract: Abstract: Recent safety concerns surrounding the use of gadolinium-based contrast agents (GBCAs) have spurred research into identifying alternatives to GBCAs for use with magnetic resonance imaging. This review summarizes the molecular and ... ...

Abstract	Abstract: Recent safety concerns surrounding the use of gadolinium-based contrast agents (GBCAs) have spurred research into identifying alternatives to GBCAs for use with magnetic resonance imaging. This review summarizes the molecular and pharmaceutical properties of a GBCA replacement and how these may be achieved. Complexes based on high-spin, divalent manganese (Mn 2+ ) have shown promise as general purpose and liver-specific contrast agents. A detailed description of the complex Mn-PyC3A is provided, describing its physicochemical properties, its behavior in different animal models, and how it compares with GBCAs. The review points out that, although there are parallels with GBCAs in how the chemical properties of Mn 2+ complexes can predict in vivo behavior, there are also marked differences between Mn 2+ complexes and GBCAs.
MeSH term(s)	Animals ; Contrast Media/chemistry ; Manganese ; Gadolinium ; Organometallic Compounds ; Magnetic Resonance Imaging/methods
Chemical Substances	Contrast Media ; Manganese (42Z2K6ZL8P) ; Gadolinium (AU0V1LM3JT) ; Organometallic Compounds
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	80345-5
ISSN	1536-0210 ; 0020-9996
ISSN (online)	1536-0210
ISSN	0020-9996
DOI	10.1097/RLI.0000000000001053
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Zs.A 734: Show issues

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Article ; Online: 86

Le Fur, Mariane / Caravan, Peter

Methods in enzymology

2021 Volume 651, Page(s) 313–342

Abstract: Yttrium-86 is a non-standard positron emitter that can provide dosimetry information prior to therapy with yttrium-90 radiopharmaceuticals and be used to follow biochemical processes. In this chapter, we discuss the production, purification and ... ...

Abstract	Yttrium-86 is a non-standard positron emitter that can provide dosimetry information prior to therapy with yttrium-90 radiopharmaceuticals and be used to follow biochemical processes. In this chapter, we discuss the production, purification and applications of
MeSH term(s)	Positron-Emission Tomography ; Radiometry ; Radiopharmaceuticals
Chemical Substances	Radiopharmaceuticals
Language	English
Publishing date	2021-01-06
Publishing country	United States
Document type	Journal Article
ISSN	1557-7988
ISSN (online)	1557-7988
DOI	10.1016/bs.mie.2020.12.013
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Article ; Online: Novel Imaging Approaches in Systemic Sclerosis-Associated Interstitial Lung Disease.

Montesi, Sydney B / Caravan, Peter

Current rheumatology reports

2019 Volume 21, Issue 6, Page(s) 25

Abstract: Purpose of the review: Novel imaging approaches, such as quantitative computed tomography (CT), magnetic resonance imaging (MRI), and molecular imaging, are being applied to interstitial lung diseases to provide prognostic, functional, and molecular ... ...

Abstract	Purpose of the review: Novel imaging approaches, such as quantitative computed tomography (CT), magnetic resonance imaging (MRI), and molecular imaging, are being applied to interstitial lung diseases to provide prognostic, functional, and molecular information. Here, we review such imaging approaches and their applicability to systemic sclerosis-associated interstitial lung disease (SSc-ILD). Recent findings: Quantitative CT can be used to quantify the radiographic response to SSc-ILD therapy. Due to advances in MRI sequence development, MRI can detect the presence of SSc-ILD with high accuracy. MRI can also be utilized to provide functional information as to SSc-ILD and paired with molecular probes to provide non-invasive molecular information. MRI and ultrasound have promising test characteristics for diagnosing ILD in SSc without the use of ionizing radiation. Novel imaging approaches can detect SSc-ILD without the use of ionizing radiation, provide non-invasive functional and molecular information, and quantify treatment response in SSc-ILD. These techniques hold promise for translation into clinical care and clinical trials.
MeSH term(s)	Humans ; Lung/diagnostic imaging ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/etiology ; Magnetic Resonance Imaging ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/diagnostic imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2019-04-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2057357-1
ISSN	1534-6307 ; 1523-3774
ISSN (online)	1534-6307
ISSN	1523-3774
DOI	10.1007/s11926-019-0826-9
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Zs.A 5531: Show issues

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Article ; Online: Optimization of an Allysine-Targeted PET Probe for Quantifying Fibrogenesis in a Mouse Model of Pulmonary Fibrosis.

Shuvaev, Sergey / Knipe, Rachel S / Drummond, Matt / Rotile, Nicholas J / Ay, Ilknur / Weigand-Whittier, Jonah P / Ma, Hua / Zhou, Iris Yuwen / Roberts, Jesse D / Black, Katherine / Hariri, Lida P / Ning, Yingying / Caravan, Peter

Molecular imaging and biology

2023 Volume 25, Issue 5, Page(s) 944–953

Abstract: ... to guide clinicians making treatment decisions. The aim of this study was to develop a PET probe ... designed, synthesized, and radiolabeled with gallium-68 or copper-64. PET probe performance was assessed ... in C57BL/6J male mice 2 weeks after intratracheal bleomycin challenge and in naïve mice by dynamic PET/MR ...

Abstract	Purpose: Idiopathic pulmonary fibrosis (IPF) is a destructive lung disease with a poor prognosis, an unpredictable clinical course, and inadequate therapies. There are currently no measures of disease activity to guide clinicians making treatment decisions. The aim of this study was to develop a PET probe to identify lung fibrogenesis using a pre-clinical model of pulmonary fibrosis, with potential for translation into clinical use to predict disease progression and inform treatment decisions. Methods: Eight novel allysine-targeting chelators, PIF-1, PIF-2, …, PIF-8, with different aldehyde-reactive moieties were designed, synthesized, and radiolabeled with gallium-68 or copper-64. PET probe performance was assessed in C57BL/6J male mice 2 weeks after intratracheal bleomycin challenge and in naïve mice by dynamic PET/MR imaging and with biodistribution at 90 min post injection. Lung hydroxyproline and allysine were quantified ex vivo and histological staining for fibrosis and aldehyde was performed. Results: In vivo screening of probes identified Conclusion: A series of allysine-reactive PET probes with variations in the aldehyde-reactive moiety were evaluated in a pre-clinical model of lung fibrosis. The hydrazine-bearing probe,
Language	English
Publishing date	2023-08-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2079160-4
ISSN	1860-2002 ; 1536-1632
ISSN (online)	1860-2002
ISSN	1536-1632
DOI	10.1007/s11307-023-01845-2
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Zs.A 6468: Show issues

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Article ; Online: Gadolinium-Free Contrast Agents for Magnetic Resonance Imaging of the Central Nervous System.

Gale, Eric M / Caravan, Peter

ACS chemical neuroscience

2018 Volume 9, Issue 3, Page(s) 395–397

Abstract: We discuss how the recent revelation that gadolinium (Gd) from commercially available MRI contrast agents is irreversibly and cumulatively deposited in the central nervous system is driving innovation toward Gd-free contrast agents for neuroradiology. ...

Abstract	We discuss how the recent revelation that gadolinium (Gd) from commercially available MRI contrast agents is irreversibly and cumulatively deposited in the central nervous system is driving innovation toward Gd-free contrast agents for neuroradiology.
MeSH term(s)	Central Nervous System/pathology ; Contrast Media ; Gadolinium ; Gadolinium DTPA ; Humans ; Image Processing, Computer-Assisted/methods ; Magnetic Resonance Imaging/methods
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT) ; Gadolinium DTPA (K2I13DR72L)
Language	English
Publishing date	2018-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1948-7193
ISSN (online)	1948-7193
DOI	10.1021/acschemneuro.8b00044
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Article ; Online: The biological fate of gadolinium-based MRI contrast agents: a call to action for bioinorganic chemists.

Le Fur, Mariane / Caravan, Peter

Metallomics : integrated biometal science

2018 Volume 11, Issue 2, Page(s) 240–254

Abstract: Gadolinium-based contrast agents (GBCAs) are widely used with clinical magnetic resonance imaging (MRI), and 10 s of millions of doses of GBCAs are administered annually worldwide. GBCAs are hydrophilic, thermodynamically stable and kinetically inert ... ...

Abstract	Gadolinium-based contrast agents (GBCAs) are widely used with clinical magnetic resonance imaging (MRI), and 10 s of millions of doses of GBCAs are administered annually worldwide. GBCAs are hydrophilic, thermodynamically stable and kinetically inert gadolinium chelates. In clinical MRI, 5-10 millimoles of Gd ion is administered intravenously and the GBCA is rapidly eliminated intact primarily through the kidneys into the urine. It is now well-established that the Gd3+ ion, in some form(s), is partially retained in vivo. In patients with advanced kidney disease, there is an association of Gd retention with nephrogenic systemic fibrosis (NSF) disease. However Gd is also retained in the brain, bone, skin, and other tissues in patients with normal renal function, and the presence of Gd can persist months to years after the last administration of a GBCA. Regulatory agencies are restricting the use of specific GBCAs and inviting health care professionals to evaluate the risk/benefit ratio prior to using GBCAs. Despite the growing number of studies investigating this issue both in animals and humans, the biological distribution and the chemical speciation of the residual gadolinium are not fully understood. Is the GBCA retained in its intact form? Is the Gd3+ ion dissociated from its chelator, and if so, what is its chemical form? Here we discuss the current state of knowledge regarding the issue of Gd retention and describe the analytical and spectroscopic methods that can be used to investigate the Gd speciation. Many of the physical methods that could be brought to bear on this problem are in the domain of bioinorganic chemistry and we hope that this review will serve to inspire this community to take up this important problem.
MeSH term(s)	Contrast Media/chemistry ; Gadolinium/chemistry ; Magnetic Resonance Imaging/methods ; Molecular Structure
Chemical Substances	Contrast Media ; Gadolinium (AU0V1LM3JT)
Language	English
Publishing date	2018-12-20
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2474317-3
ISSN	1756-591X ; 1756-5901
ISSN (online)	1756-591X
ISSN	1756-5901
DOI	10.1039/c8mt00302e
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Article ; Online: Molecular MR Contrast Agents.

Shuvaev, Sergey / Akam, Eman / Caravan, Peter

Investigative radiology

2020 Volume 56, Issue 1, Page(s) 20–34

Abstract: Molecular magnetic resonance (MR) imaging utilizes molecular probes to provide added biochemical or cellular information to what can already be achieved with anatomical and functional MR imaging. This review provides an overview of molecular MR and ... ...

Abstract	Molecular magnetic resonance (MR) imaging utilizes molecular probes to provide added biochemical or cellular information to what can already be achieved with anatomical and functional MR imaging. This review provides an overview of molecular MR and focuses specifically on molecular MR contrast agents that provide contrast by shortening the T1 time. We describe the requirements for a successful molecular MR contrast agent and the challenges for clinical translation. The review highlights work from the last 5 years and places an emphasis on new contrast agents that have been validated in multiple preclinical models. Applications of molecular MR include imaging of inflammation, fibrosis, fibrogenesis, thromboembolic disease, and cancers. Molecular MR is positioned to move beyond detection of disease to the quantitative staging of disease and measurement of treatment response.
MeSH term(s)	Contrast Media ; Humans ; Magnetic Resonance Imaging
Chemical Substances	Contrast Media
Language	English
Publishing date	2020-10-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	80345-5
ISSN	1536-0210 ; 0020-9996
ISSN (online)	1536-0210
ISSN	0020-9996
DOI	10.1097/RLI.0000000000000731
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Zs.A 734: Show issues

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Article ; Online: Advances in functional and molecular MRI technologies in chronic liver diseases.

Zhou, Iris Y / Catalano, Onofrio A / Caravan, Peter

Journal of hepatology

2020 Volume 73, Issue 5, Page(s) 1241–1254

Abstract: MRI has emerged as the most comprehensive non-invasive diagnostic tool for liver diseases. In recent years, the value of MRI in hepatology has been significantly enhanced by a wide range of contrast agents, both clinically available and under development, ...

Abstract	MRI has emerged as the most comprehensive non-invasive diagnostic tool for liver diseases. In recent years, the value of MRI in hepatology has been significantly enhanced by a wide range of contrast agents, both clinically available and under development, that add functional information to anatomically detailed morphological images, or increase the distinction between normal and pathological tissues by targeting molecular and cellular events. Several classes of contrast agents are available for contrast-enhanced hepatic MRI, including i) conventional non-specific extracellular fluid contrast agents for assessing tissue perfusion; ii) hepatobiliary-specific contrast agents that are taken up by functioning hepatocytes and excreted through the biliary system for evaluating hepatobiliary function; iii) superparamagnetic iron oxide particles that accumulate in Kupffer cells; and iv) novel molecular contrast agents that are biochemically targeted to specific molecular/cellular processes for staging liver diseases or detecting treatment responses. The use of different functional and molecular MRI methods enables the non-invasive assessment of disease burden, progression, and treatment response in a variety of liver diseases. A high diagnostic performance can be achieved with MRI by combining imaging biomarkers.
MeSH term(s)	Chronic Disease ; Gastroenterology/methods ; Gastroenterology/trends ; Humans ; Liver/diagnostic imaging ; Liver/pathology ; Liver Diseases/diagnosis ; Magnetic Resonance Imaging/methods ; Molecular Imaging/methods
Language	English
Publishing date	2020-06-22
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2020.06.020
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Zs.A 2027: Show issues

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Article ; Online: Dynamic Contrast-enhanced MRI Demonstrates Pulmonary Microvascular Abnormalities Months After SARS-CoV-2 Infection.

Zhou, Iris Y / Mascia, Molly / Alba, George A / Magaletta, Michael / Ginns, Leo C / Caravan, Peter / Montesi, Sydney B

American journal of respiratory and critical care medicine

2023 Volume 207, Issue 12, Page(s) 1636–1639

MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Magnetic Resonance Imaging
Language	English
Publishing date	2023-04-23
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202210-1884LE
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