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Book: The complete guide to ECGs

O'Keefe, James H. / Hammill, Stephen C. / Freed, Mark S.

a comprehensive study guide to improve ECG interpretation skills

2017

Author's details	James H. O'Keefe, MD FACC, Stephen C. Hammill, MD, FACC, Mark S. Freed, MD, FACC
Keywords	Electrocardiography
Language	English
Size	ix, 615 Seiten, Illustrationen
Edition	Fourth edition
Publisher	Jones & Bartlett Learning
Publishing place	Burlington, Mass
Publishing country	United States
Document type	Book
HBZ-ID	HT019460216
ISBN	978-1-284-06634-0 ; 1-284-06634-7
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2017 A 1757	available for loan (reading room)	Lesesaal EG

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Article ; Online: Brave New World: Improving Obesity and Preventing Cardiovascular Disease.

O'Keefe, James H / O'Keefe, Evan L / Nassif, Michael E / Lavie, Carl J

Mayo Clinic proceedings

2023 Volume 98, Issue 1, Page(s) 11–14

MeSH term(s)	Humans ; Cardiovascular Diseases/prevention & control ; Obesity/prevention & control ; Literature, Modern
Language	English
Publishing date	2023-01-05
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2022.11.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Omega-3: The Overlooked Evidence-Based Therapy for Heart Failure.

O'Keefe, James H / O'Keefe, Evan L / Lavie, Carl J

JACC. Heart failure

2022 Volume 10, Issue 4, Page(s) 235–237

MeSH term(s)	Fatty Acids, Omega-3/therapeutic use ; Heart Failure/therapy ; Humans
Chemical Substances	Fatty Acids, Omega-3
Language	English
Publishing date	2022-03-09
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	2705621-1
ISSN	2213-1787 ; 2213-1779
ISSN (online)	2213-1787
ISSN	2213-1779
DOI	10.1016/j.jchf.2022.02.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Circulating Docosahexaenoic Acid and Risk of All-Cause and Cause-Specific Mortality.

O'Keefe, Evan L / O'Keefe, James H / Tintle, Nathan L / Westra, Jason / Albuisson, Luc / Harris, William S

Mayo Clinic proceedings

2024 Volume 99, Issue 4, Page(s) 534–541

Abstract: Objective: To assess the associations of docosahexaenoic acid (DHA), a marine omega-3 fatty acid, with long-term all-cause mortality, cardiovascular (CV) mortality, and cancer mortality.: Patients and methods: We analyzed data from UK Biobank, which ... ...

Abstract	Objective: To assess the associations of docosahexaenoic acid (DHA), a marine omega-3 fatty acid, with long-term all-cause mortality, cardiovascular (CV) mortality, and cancer mortality. Patients and methods: We analyzed data from UK Biobank, which included 117,702 subjects with baseline plasma DHA levels and 12.7 years of follow-up between April 2007 and December 2021. Associations with risk for mortality endpoints were analyzed categorically by quintile of DHA plasma levels. Results: Comparing the lowest to highest quintiles of circulating levels of DHA, there was 21% lower risk of all-cause mortality (HR, 0.79; 95% CI, 0.74 to 0.85; P<.0001). In a secondary analysis, we merged the UK Biobank findings with those from a recent FORCE (Fatty Acid and Outcome Research Consortium) meta-analysis that included 17 prospective cohort studies and 42,702 individuals examining DHA and mortality associations. The cumulative sample population included 160,404 individuals and 24,342 deaths during a median of 14 years of follow-up. After multivariable adjustment for relevant risk factors comparing the lowest to the highest quintiles of DHA, there was 17% lower risk of all-cause mortality (95% CI, 0.79 to 0.87; P<.0001), 21% lower risk for CV disease mortality (95% CI, 0.73 to 0.87; P<.001), 17% lower risk for cancer mortality (95% CI, 0.77 to 0.89; P<.0001), and 15% lower risk for all other mortality (95% CI, 0.79 to 0.91; P<.001). Conclusion: Higher DHA levels were associated with significant risk reductions in all-cause mortality, as well as reduced risks for deaths due to CV disease, cancer, and all other causes. The findings strengthen the hypothesis that DHA, a marine-sourced omega-3, may support CV health and lifespan.
MeSH term(s)	Humans ; Docosahexaenoic Acids ; Cause of Death ; Eicosapentaenoic Acid ; Prospective Studies ; Fatty Acids, Omega-3 ; Cardiovascular Diseases ; Risk Factors ; Neoplasms
Chemical Substances	Docosahexaenoic Acids (25167-62-8) ; Eicosapentaenoic Acid (AAN7QOV9EA) ; Fatty Acids, Omega-3
Language	English
Publishing date	2024-03-20
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	124027-4
ISSN	1942-5546 ; 0025-6196
ISSN (online)	1942-5546
ISSN	0025-6196
DOI	10.1016/j.mayocp.2023.11.026
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Article ; Online: SGLT inhibitors for improving Healthspan and lifespan.

O'Keefe, James H / Weidling, Robert / O'Keefe, Evan L / Franco, W Grant

Progress in cardiovascular diseases

2023 Volume 81, Page(s) 2–9

Abstract: Sodium-glucose cotransporter inhibitor/inhibition (SGLTi), initially approved as a glucose-lowering therapy for type 2 diabetes, is associated with decreased risks for many of the most common conditions of aging, including heart failure, chronic kidney ... ...

Abstract	Sodium-glucose cotransporter inhibitor/inhibition (SGLTi), initially approved as a glucose-lowering therapy for type 2 diabetes, is associated with decreased risks for many of the most common conditions of aging, including heart failure, chronic kidney disease, all-cause hospitalization, atrial fibrillation, cancer, gout, emphysema, neurodegenerative disease/dementia, emphysema, non-alcoholic fatty liver disease, atherosclerotic disease, and infections. Studies also show that SGLTi improves overall life expectancy and reduces risks of cardiovascular death and cancer death. These wide-ranging health benefits are largely unexplained by the SGLTi's modest improvements in standard risk factors. SGLTi produces upregulation of nutrient deprivation signaling and downregulation of nutrient surplus signaling. This in turn promotes autophagy, which helps to optimize cellular integrity and prevent apoptotic cell death. SGLTi decreases oxidative stress and endoplasmic reticulum stress, restores of mitochondrial health, stimulates mitochondrial biogenesis, and diminishes proinflammatory and profibrotic pathways. These actions help to revitalize senescent cells, tissues, and organs. In summary, SGLTi appears to slow aging, prevent disease, and improve life expectancy, and its mechanisms of action lend strong biological plausibility to this hypothesis. Further randomized trials are warranted to test whether SGLTi, a safe and well-tolerated, once-daily pill, might improve healthspan and lifespan.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2 ; Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors ; Longevity ; Neurodegenerative Diseases ; Glucose ; Emphysema ; Neoplasms
Chemical Substances	Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	209312-1
ISSN	1873-1740 ; 1532-8643 ; 0033-0620
ISSN (online)	1873-1740 ; 1532-8643
ISSN	0033-0620
DOI	10.1016/j.pcad.2023.10.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Training Strategies to Optimize Cardiovascular Durability and Life Expectancy.

O'Keefe, James H / O'Keefe, Evan L / Eckert, Ryan / Lavie, Carl J

Missouri medicine

2023 Volume 120, Issue 2, Page(s) 155–162

Abstract: The optimal dose of physical activity and best types of exercise for improving cardiovascular (CV) durability and optimizing longevity are unknown. The purpose of this article is to review the recent literature on the effects of duration and intensity of ...

Abstract	The optimal dose of physical activity and best types of exercise for improving cardiovascular (CV) durability and optimizing longevity are unknown. The purpose of this article is to review the recent literature on the effects of duration and intensity of exercise, physical fitness, and specific types of training/sports on long-term CV health and life expectancy. A systematic review of recent studies (2011 to 2022) was conducted using PubMed. Studies were included if they addressed the topic of fitness and/or exercise dose/type and CV health and/or life expectancy. Epidemiological studies show that cardiorespiratory fitness (is inversely related to risk of all-cause mortality, with no increased mortality risk in the most fit cohort. Being unfit is among most potent risk factors for all-cause mortality. Moderate PA (MPA) and vigorous PA (VPA) were associated with reduced CV and all-cause mortality in a recent definitive study. Paradoxically, high doses of MPA reduced both CV and all-cause mortality better than did high doses of VPA. A large meta-analysis showed that strength training was independently associated with lower rates of all-cause mortality and CV disease, though the best outcomes were associated with a cumulative dose of about 60 minutes/week. Physical interactive play is strongly associated with improved life expectancy. Physical fitness is a key determinant of CV health and life expectancy. Moderate to vigorous exercise, strength training and interactive sports are associated with improved life expectancy. Very large volumes of strenuous exercise and/or weightlifting may not be the ideal for optimizing longevity.
MeSH term(s)	Humans ; Physical Fitness ; Exercise ; Cardiorespiratory Fitness ; Sports ; Life Expectancy
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Systematic Review ; Meta-Analysis ; Journal Article
ZDB-ID	427362-x
ISSN	0026-6620
ISSN	0026-6620
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: PCSK9 inhibitor, ezetimibe, and bempedoic acid: Evidence-based therapies for statin-intolerant patients.

Gunta, Satya Preetham / O'Keefe, James H / O'Keefe, Evan L / Lavie, Carl J

Progress in cardiovascular diseases

2023 Volume 79, Page(s) 12–18

Abstract: Statins are first-line therapy for treating dyslipidemia because of their low-density lipoprotein cholesterol (LDL-C) lowering efficacy, superior event-reduction data and unrivaled cost-effectiveness. Yet, many people are intolerant of statins, whether ... ...

Abstract	Statins are first-line therapy for treating dyslipidemia because of their low-density lipoprotein cholesterol (LDL-C) lowering efficacy, superior event-reduction data and unrivaled cost-effectiveness. Yet, many people are intolerant of statins, whether due to true adverse events or the nocebo effect, so within one year about two-thirds of primary prevention patients and one-third of secondary prevention patients are no longer taking their prescription. Statins still dominate this landscape, but other agents, often used in combination, potently reduce LDL-C levels, regress atherosclerosis and lower risk of major adverse cardiovascular events (MACE). Ezetimibe lowers LDL-C by reducing intestinal absorption of cholesterol. Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) lower LDL-C by increasing the number and durability of hepatic LDL receptors. Bempedoic acid reduces hepatic cholesterol synthesis. Ezetimibe, PCSK9i and bempedoic are evidence-based, non-statin therapies that synergistically lower LDL-C and reduce risk of MACE; they also have benign side-effect profiles and are generally well tolerated.
MeSH term(s)	Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects ; Ezetimibe/adverse effects ; PCSK9 Inhibitors ; Cholesterol, LDL ; Proprotein Convertase 9 ; Anticholesteremic Agents/adverse effects ; Cholesterol
Chemical Substances	Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Ezetimibe (EOR26LQQ24) ; PCSK9 Inhibitors ; Cholesterol, LDL ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-) ; 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid (1EJ6Z6Q368) ; Anticholesteremic Agents ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2023-03-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	209312-1
ISSN	1873-1740 ; 1532-8643 ; 0033-0620
ISSN (online)	1873-1740 ; 1532-8643
ISSN	0033-0620
DOI	10.1016/j.pcad.2023.02.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Myo-inositol for insulin resistance, metabolic syndrome, polycystic ovary syndrome and gestational diabetes.

DiNicolantonio, James J / H O'Keefe, James

Open heart

2022 Volume 9, Issue 1

MeSH term(s)	Diabetes, Gestational/diagnosis ; Diabetes, Gestational/metabolism ; Female ; Humans ; Inositol/metabolism ; Inositol/therapeutic use ; Insulin ; Insulin Resistance ; Polycystic Ovary Syndrome/diagnosis ; Polycystic Ovary Syndrome/metabolism ; Pregnancy
Chemical Substances	Insulin ; Inositol (4L6452S749)
Language	English
Publishing date	2022-03-02
Publishing country	England
Document type	Editorial
ZDB-ID	2747269-3
ISSN	2053-3624
ISSN	2053-3624
DOI	10.1136/openhrt-2022-001989
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sodium restriction and insulin resistance

James J. DiNicolantonio / James H. O'Keefe

Journal of Insulin Resistance, Vol 6, Iss 1, Pp e1-e

A review of 23 clinical trials

2023 Volume 9

Abstract: Background: Many clinicians recommend low-salt diets for lowering blood pressure but there may be unintended consequences such as worsening insulin resistance. Aim: This paper aimed to find human clinical studies looking at low-salt diets on markers of ... ...

Abstract	Background: Many clinicians recommend low-salt diets for lowering blood pressure but there may be unintended consequences such as worsening insulin resistance. Aim: This paper aimed to find human clinical studies looking at low-salt diets on markers of glucose and insulin. Methods: We reviewed PubMed using the search terms ‘sodium’, ‘insulin’ and ‘insulin resistance’ and found 23 human clinical studies testing low-salt diets showing negative harms on insulin or glucose. Results: Twenty-three human clinical trials have shown that low-salt diets lead to systemic or vascular insulin resistance, glucose intolerance, elevated fasting insulin and/or elevations in glucose and/or insulin levels after an oral glucose tolerance test. Conclusion: We discovered 23 human clinical studies showing that low-salt diets worsen markers of insulin and glucose. Caution is advised when recommending salt restriction for blood pressure control as this may lead to worsening insulin resistance. Contribution: This review has revealed that low salt diets can induce insulin resistance.
Keywords	salt ; sodium ; insulin resistance ; insulin ; hyperinsulinaemia ; glucose ; Internal medicine ; RC31-1245 ; Diseases of the endocrine glands. Clinical endocrinology ; RC648-665
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	AOSIS
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Monounsaturated Fat vs Saturated Fat: Effects on Cardio-Metabolic Health and Obesity.

DiNicolantonio, James J / O'Keefe, James H

Missouri medicine

2022 Volume 119, Issue 1, Page(s) 69–73

Abstract: For over 40 years saturated fat, the fat found primarily in animal foods, was thought to be the main culprit for increasing cholesterol levels and causing heart disease. During this same time vegetable oils were promoted as being heart healthy because ... ...

Abstract	For over 40 years saturated fat, the fat found primarily in animal foods, was thought to be the main culprit for increasing cholesterol levels and causing heart disease. During this same time vegetable oils were promoted as being heart healthy because they could lower cholesterol. However, recently the evidence implicating saturated fat as being harmful to heart health has been challenged and more studies are beginning to show the harms from consuming industrially produced vegetable oils. Furthermore, monounsaturated fats, found in olives, olive oil, certain nuts and avocadoes have been promoted as being part of a healthy Mediterranean diet. This paper will provide a brief review comparing the effects of saturated fat to monounsaturated fat.
MeSH term(s)	Cholesterol ; Dietary Fats ; Fatty Acids ; Humans ; Obesity ; Plant Oils
Chemical Substances	Dietary Fats ; Fatty Acids ; Plant Oils ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2022-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	427362-x
ISSN	0026-6620
ISSN	0026-6620
Database	MEDical Literature Analysis and Retrieval System OnLINE

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