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Article ; Online: Evaluation of the efficacy and safety of an integrated telerehabilitation platform for home-based cardiac REHABilitation in patients with heart failure (E-REHAB): protocol for a randomised controlled trial.

2023 Volume 13, Issue 8, Page(s) e073846

Abstract: ... analysis: The E-REHAB trial aims to evaluate the efficacy and safety of RH-01 for home-based CR compared ...

Abstract	Introduction: Cardiac rehabilitation (CR) is strongly recommended as a medical treatment to improve the prognosis and quality of life of patients with heart failure (HF); however, participation rates in CR are low compared with other evidence-based treatments. One reason for this is the geographical distance between patients' homes and hospitals. To address this issue, we developed an integrated telerehabilitation platform, RH-01, for home-based CR. We hypothesised that using the RH-01 platform for home-based CR would demonstrate non-inferiority compared with traditional centre-based CR. Methods and analysis: The E-REHAB trial aims to evaluate the efficacy and safety of RH-01 for home-based CR compared with traditional centre-based CR for patients with HF. This clinical trial will be conducted under a prospective, randomised, controlled and non-inferiority design with a primary focus on HF patients. Further, to assess the generalisability of the results in HF to other cardiovascular disease (CVD), the study will also include patients with other CVDs. The trial will enrol 108 patients with HF and 20 patients with other CVD. Eligible HF patients will be randomly assigned to either traditional centre-based CR or home-based CR in a 1:1 fashion. Patients with other CVDs will not be randomised, as safety assessment will be the primary focus. The intervention group will receive a 12-week programme conducted two or three times per week consisting of a remotely supervised home-based CR programme using RH-01, while the control group will receive a traditional centre-based CR programme. The primary endpoint of this trial is change in 6 min walk distance. Ethics and dissemination: The conduct of the study has been approved by an institutional review board at each participating site, and all patients will provide written informed consent before entry. The report of the study will be disseminated via scientific fora, including peer-reviewed publications and presentations at conferences. Trial registration number: jRCT:2052200064.
MeSH term(s)	Humans ; Cardiac Rehabilitation ; Telerehabilitation ; Prospective Studies ; Quality of Life ; Heart Failure ; Cardiovascular Diseases ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-08-24
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-073846
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Article ; Online: An Ionizable Lipid Material with a Vitamin E Scaffold as an mRNA Vaccine Platform for Efficient Cytotoxic T Cell Responses.

Oyama, Ryotaro / Ishigame, Harumichi / Tanaka, Hiroki / Tateshita, Naho / Itazawa, Moeko / Imai, Ryosuke / Nishiumi, Naomasa / Kishikawa, Jun-Ichi / Kato, Takayuki / Anindita, Jessica / Nishikawa, Yoshifumi / Maeki, Masatoshi / Tokeshi, Manabu / Tange, Kota / Nakai, Yuta / Sakurai, Yu / Okada, Takaharu / Akita, Hidetaka

ACS nano

2023 Volume 17, Issue 19, Page(s) 18758–18774

Abstract: RNA vaccines based on lipid nanoparticles (LNPs) ... ...

Abstract	RNA vaccines based on lipid nanoparticles (LNPs) with
MeSH term(s)	Animals ; Mice ; T-Lymphocytes, Cytotoxic ; CD8-Positive T-Lymphocytes ; Vitamin E/pharmacology ; Vaccines, Synthetic ; mRNA Vaccines ; Antigens ; Ovalbumin ; Nanoparticles ; RNA, Messenger/genetics ; Lipids/pharmacology ; Mice, Inbred C57BL ; Dendritic Cells
Chemical Substances	Vitamin E (1406-18-4) ; Vaccines, Synthetic ; mRNA Vaccines ; Antigens ; Ovalbumin (9006-59-1) ; RNA, Messenger ; Lipids
Language	English
Publishing date	2023-09-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c02251
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Article ; Online: Comparison of the efficacy and tolerability of elobixibat plus sodium picosulfate with magnesium citrate and split-dose 2-L polyethylene glycol with ascorbic acid for bowel preparation before outpatient colonoscopy: a study protocol for the multicentre, randomised, controlled E-PLUS trial.

Hotta, Kinichi / Otake, Yosuke / Yamaguchi, Daisuke / Shimodate, Yuichi / Hanabata, Norihiro / Ikematsu, Hiroaki / Yabuuchi, Yohei / Sano, Yasushi / Shimoda, Ryo / Sugimoto, Shinya / Oba, Mari / Takamaru, Hiroyuki / Kimura, Kouichiro / Kishida, Yoshihiro / Takada, Kazunori / Ito, Sayo / Imai, Kenichiro / Hosotani, Kazuya / Murano, Tatsuro /

Yamada, Masayoshi / Shinmura, Kensuke / Takezawa, Rio / Tomonaga, Michito / Saito, Yutaka

BMC gastroenterology

2024 Volume 24, Issue 1, Page(s) 61

Abstract: Background: Sodium picosulfate (SP)/magnesium citrate (MC) and polyethylene glycol (PEG) plus ascorbic acid are recommended by Western guidelines as laxative solutions for bowel preparation. Clinically, SP/MC has a slower post-dose defaecation response ... ...

Abstract	Background: Sodium picosulfate (SP)/magnesium citrate (MC) and polyethylene glycol (PEG) plus ascorbic acid are recommended by Western guidelines as laxative solutions for bowel preparation. Clinically, SP/MC has a slower post-dose defaecation response than PEG and is perceived as less cleansing; therefore, it is not currently used for major bowel cancer screening preparation. The standard formulation for bowel preparation is PEG; however, a large dose is required, and it has a distinctive flavour that is considered unpleasant. SP/MC requires a small dose and ensures fluid intake because it is administered in another beverage. Therefore, clinical trials have shown that SP/MC is superior to PEG in terms of acceptability. We aim to compare the novel bowel cleansing method (test group) comprising SP/MC with elobixibat hydrate and the standard bowel cleansing method comprising PEG plus ascorbic acid (standard group) for patients preparing for outpatient colonoscopy. Methods: This phase III, multicentre, single-blind, noninferiority, randomised, controlled, trial has not yet been completed. Patients aged 40-69 years will be included as participants. Patients with a history of abdominal or pelvic surgery, constipation, inflammatory bowel disease, or severe organ dysfunction will be excluded. The target number of research participants is 540 (standard group, 270 cases; test group, 270 cases). The primary endpoint is the degree of bowel cleansing (Boston Bowel Preparation Scale [BBPS] score ≥ 6). The secondary endpoints are patient acceptability, adverse events, polyp/adenoma detection rate, number of polyps/adenomas detected, degree of bowel cleansing according to the BBPS (BBPS score ≥ 8), degree of bowel cleansing according to the Aronchik scale, and bowel cleansing time. Discussion: This trial aims to develop a "patient-first" colon cleansing regimen without the risk of inadequate bowel preparation by using both elobixibat hydrate and SP/MC. Trial registration: Japan Registry of Clinical Trials (jRCT; no. s041210067; 9 September 2021; https://jrct.niph.go.jp/ ), protocol version 1.5 (May 1, 2023).
MeSH term(s)	Humans ; Polyethylene Glycols ; Cathartics ; Outpatients ; Ascorbic Acid/adverse effects ; Single-Blind Method ; Colonoscopy/methods ; Polyps ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic ; Clinical Trials, Phase III as Topic ; Dipeptides ; Citrates ; Thiazepines ; Organometallic Compounds ; Citric Acid ; Picolines
Chemical Substances	picosulfate sodium (LR57574HN8) ; magnesium citrate (RHO26O1T9V) ; Polyethylene Glycols (3WJQ0SDW1A) ; elobixibat (865UEK4EJC) ; Cathartics ; Ascorbic Acid (PQ6CK8PD0R) ; Dipeptides ; Citrates ; Thiazepines ; Organometallic Compounds ; Citric Acid (2968PHW8QP) ; Picolines
Language	English
Publishing date	2024-02-03
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-024-03146-6
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Article ; Online: [The impairment of excitation-contraction (E-C) coupling in myasthenia gravis].

Imai, Tomihiro

Rinsho shinkeigaku = Clinical neurology

2012 Volume 52, Issue 11, Page(s) 1309–1311

Abstract: We have developed a new novel method to assess the function of excitation-contraction (E-C ... stimulating the trigeminal motor nerve with a needle electrode. The E-C coupling time (ECCT) was calculated ... Our serial studies demonstrate that masseteric E-C coupling is impaired in some MG patients, and ...

Abstract	We have developed a new novel method to assess the function of excitation-contraction (E-C) coupling in patients with myasthenia gravis (MG). In our procedure, masseteric compound muscle action potential (CMAP) and mandibular movement-related potentials (MRP) were recorded simultaneously after stimulating the trigeminal motor nerve with a needle electrode. The E-C coupling time (ECCT) was calculated by the latency difference between CMAP and MRP. Bite force was measured using a pressure-sensitive sheet. Our serial studies demonstrate that masseteric E-C coupling is impaired in some MG patients, and functional recovery of E-C coupling contributes at least in part to the increase in bite force after treatment. We also reveal that presence of anti-RyR antibodies is associated with significantly prolonged masseteric ECCT compared to absence of the antibodies in MG, and tacrolimus (FK506) induces ECCT shortening accompanying clinical improvement within 2 weeks. These results indicate the contribution of anti-ryanodine receptor (RyR) antibody to E-C coupling impairment, and the early effect of tacrolimus as a pharmacological enhancement of RyR function to improve E-C coupling in MG. In further studies, the present method may be applied to assess the post-tetanic potentiation of E-C coupling in human skeletal muscles.
MeSH term(s)	Autoantibodies/immunology ; Excitation Contraction Coupling/physiology ; Humans ; Masseter Muscle/physiopathology ; Myasthenia Gravis/physiopathology ; Ryanodine Receptor Calcium Release Channel/immunology
Chemical Substances	Autoantibodies ; Ryanodine Receptor Calcium Release Channel
Language	Japanese
Publishing date	2012-11-08
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.52.1309
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Article ; Online: Differential Cross Section and Photon-Beam Asymmetry for the γ[over →]p → π^{-}Δ^{++}(1232) Reaction at Forward π^{-} Angles for E_{γ}=1.5-2.95 GeV.

Kohri, H / Shiu, S H / Chang, W C / Yanai, Y / Ahn, D S / Ahn, J K / Chen, J Y / Daté, S / Ejiri, H / Fujimura, H / Fujiwara, M / Fukui, S / Gohn, W / Hicks, K / Hosaka, A / Hotta, T / Hwang, S H / Imai, K / Ishikawa, T /

Joo, K / Kato, Y / Kon, Y / Lee, H S / Maeda, Y / Mibe, T / Miyabe, M / Morino, Y / Muramatsu, N / Nakano, T / Nakatsugawa, Y / Nam, S I / Niiyama, M / Noumi, H / Ohashi, Y / Ohta, T / Oka, M / Parker, J D / Rangacharyulu, C / Ryu, S Y / Sawada, T / Shimizu, H / Strokovsky, E A / Sugaya, Y / Sumihama, M / Tsunemi, T / Uchida, M / Ungaro, M / Wang, S Y / Yosoi, M

Physical review letters

2018 Volume 120, Issue 20, Page(s) 202004

Abstract: ... reaction have been measured for 0.7E_{γ}=1.5-2.95 GeV at SPring-8/LEPS. The first ... for 1.5<E_{γ}(GeV)<2.8 are obtained for the first time. This reaction has a unique feature for studying ... predictions is observed at E_{γ}=1.5-1.8 GeV. The asymmetries are found to be negative in most of the present ...

Abstract	Differential cross sections and photon-beam asymmetries for the γ[over →]p→π^{-}Δ^{++}(1232) reaction have been measured for 0.7<cosθ_{π}^{c.m.}<1 and <mark>E_{γ}=1.5-2.95 GeV at SPring-8/LEPS. The first-ever high statistics cross-section data are obtained in this kinematical region, and the asymmetry data for 1.5<E_{γ}(GeV)<2.8 are obtained for the first time. This reaction has a unique feature for studying the production mechanisms of a pure uu[over ¯] quark pair in the final state from the proton. Although there is no distinct peak structure in the cross sections, a non-negligible excess over the theoretical predictions is observed at E_{γ}=1.5-1.8 GeV. The asymmetries are found to be negative in most of the present kinematical regions, suggesting the dominance of π exchange in the t channel. The negative asymmetries at forward meson production angles are different from the asymmetries previously measured for the photoproduction reactions producing a dd[over ¯] or an ss[over ¯] quark pair in the final state. Advanced theoretical models introducing nucleon resonances and additional unnatural-parity exchanges are needed to reproduce the present data.
Language	English
Publishing date	2018-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.120.202004
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Article ; Online: Synthesis and circularly polarized luminescence properties of BINOL-derived bisbenzofuro[2,3-b:3’,2’-e]pyridines (BBZFPys)

Ryo Takishima / Yuji Nishii / Tomoaki Hinoue / Yoshitane Imai / Masahiro Miura

Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 325-

2020 Volume 336

Abstract: A series of optically active bisbenzofuro[2,3-b:3’,2’-e]pyridine (BBZFPy) derivatives was ...

Abstract	A series of optically active bisbenzofuro[2,3-b:3’,2’-e]pyridine (BBZFPy) derivatives was synthesized starting with the readily available (S)- and (R)-1,1’-bi-2-naphthols through a palladium-catalyzed multiple intramolecular C–H/C–H coupling as the key ring-closure step. The effect of terminal tert-butyl substituents on the BBZFPy skeleton was systematically investigated to uncover a unique aggregation-induced enhancement of CPL characteristics in the solid state. The crystal structures of the coupling products were also evaluated by single crystal X-ray analysis and the well-ordered intermolecular stacking arrangements appeared to be responsible for the enhanced CPL.
Keywords	binol ; c–h activation ; circularly polarized luminescence ; palladium ; Science ; Q ; Organic chemistry ; QD241-441
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	Beilstein-Institut
Document type	Article ; Online
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Article ; Online: AN E-HEALTHCARE SYSTEM FOR UBIQUITOUS AND LIFE-LONG HEALTH MANAGEMENT

Eiichi Miyazaki / Hiroshi Kamano / Kazuaki Ando / Yoshiro Imai

International Journal of Digital Information and Wireless Communications, Vol 6, Iss 3, Pp 163-

2016 Volume 172

Abstract: An e-Healthcare system with IC card authentication, automatic health screening sub-system and Web ... presents an organization of the above e-Healthcare system, demonstrates its real usages in university ...

Abstract	An e-Healthcare system with IC card authentication, automatic health screening sub-system and Web-based health information monitoring, has been designed and implemented for university health education. It looks like a prototype of private Cloud service of eHealthcare for university students which can obtain their health records from physical measuring devices with their IC card-based authentication, manage their health data in suitable database, investigate the relevant data according to requests from doctors/nurses, and provide such data as necessary information for selfhealthcare through Web-DB service. This paper presents an organization of the above e-Healthcare system, demonstrates its real usages in university health education and describes its trial quantitative evaluation, and describes expanding plan through practical applications.
Keywords	e-Healthcare ; IC card authentication ; health information monitoring and retrieving ; System evaluation ; Science ; Q ; Mathematics ; QA1-939 ; Instruments and machines ; QA71-90 ; Electronic computers. Computer science ; QA75.5-76.95
Subject code	360
Publishing date	2016-07-01T00:00:00Z
Publisher	Society of Digital Information and Wireless Communications
Document type	Article ; Online
DOI	10.17781/P002069
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Article ; Online: Refractory cholestasis presenting as cholangiolitis in an Rh (E)-incompatible neonate.

Taba, Ryusuke / Yamakawa, Masaru / Miyakoshi, Chisato / Imai, Yukihiro

Journal of paediatrics and child health

2012 Volume 48, Issue 3, Page(s) E126–31

Abstract: ... case of refractory cholestasis presenting with cholangiolitis in a newborn with anti-E isoimmunisation ...

Abstract	Cholestasis in neonates is infrequently associated with Rh isoimmunization, and usually resolves within a month. The suggested pathophysiology is inspissated bile and hepatocellular damage. We report a rare case of refractory cholestasis presenting with cholangiolitis in a newborn with anti-E isoimmunisation. The cholangiolitis was disclosed by immunohistochemical investigation of conjugated hyperbilirubinaemia and by liver biopsy, which showed a number of CD8(+) lymphocytes within the portal tract damaging the interlobular bile duct. Bilirubin levels dramatically decreased after 14-day corticosteroid therapy (prednisolone, 2 mg/kg/day) implying that the cause of cholestasis could be immune-mediated cholangiolitis.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Bile Duct Diseases/complications ; Cholestasis/diagnosis ; Cholestasis/drug therapy ; Cholestasis/etiology ; Diagnosis, Differential ; Erythroblastosis, Fetal ; Female ; Humans ; Infant, Newborn ; Male ; Pregnancy ; Pregnancy Complications ; Rh Isoimmunization ; Treatment Outcome
Chemical Substances	Adrenal Cortex Hormones
Language	English
Publishing date	2012-03
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	1024476-1
ISSN	1440-1754 ; 1034-4810
ISSN (online)	1440-1754
ISSN	1034-4810
DOI	10.1111/j.1440-1754.2010.01874.x
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Article: Long-term follow up of peginterferon-α-2a treatment of hepatitis B e-antigen (HBeAg) positive and HBeAg negative chronic hepatitis B patients in phase II and III studies.

Hepatology research : the official journal of the Japan Society of Hepatology

2016 Volume 46, Issue 10, Page(s) 992–1001

Abstract: ... in hepatitis B e-antigen (HBeAg) positive and negative chronic hepatitis B patients.: Methods: One hundred ...

Abstract	Aim: We analyzed the 5-year post-treatment response to peginterferon α-2a (PEG IFN-α-2a) in hepatitis B e-antigen (HBeAg) positive and negative chronic hepatitis B patients. Methods: One hundred and thirty-seven chronic hepatitis B (CHB) patients receiving 90 μg or 180 μg of PEG IFN-α-2a for 24 or 48 weeks in phase II or III studies were enrolled in the study, including 100 HBeAg positive patients and 37 HBeAg negative patients; 121 patients (88.4%) had genotype C. Results: Of the 137 patients, 94 received additional antiviral therapy because of viral reactivation and 43 did not receive any additional antiviral treatment during follow up. Five years upon PEG IFN-α-2a treatment, 32 patients (23.4%) who did not receive any additional antiviral agent after PEG IFN-α-2a therapy achieved a good response (normal serum alanine aminotransferase, low-level hepatitis B virus [HBV] DNA, and HBeAg negativity). Female sex and low HBV DNA levels by the end of treatment were independently associated with favorable 5-year post-treatment responses. Forty-eight-week administration of PEG IFN-α-2a showed a better response (26.4%) than 24-week administration (18.0%). Six patients (4.3%), four males and two females, cleared hepatitis B surface antigen (HBsAg) during the 5-year follow-up period. Conclusion: The 48-week administration of PEG IFN-α-2a achieved better biochemical and virological responses than the 24-week administration, particularly in younger females. The 5-year post-treatment response rate was 23.4%; however, more than two-thirds of the patients received additional antiviral therapy because of viral reactivation after PEG IFN-α-2a treatment. HBsAg clearance was noted in six patients (4.3%). PEG IFN-α-2a is effective in young female patients.
Language	English
Publishing date	2016-01-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1387041-5
ISSN	1386-6346 ; 0928-4346
ISSN	1386-6346 ; 0928-4346
DOI	10.1111/hepr.12638
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Article ; Online: Distribution of vitamin E intake among Japanese dietary supplement and fortified food users: a secondary analysis from the National Health and Nutrition Survey, 2003-2009.

Tsubota-Utsugi, Megumi / Nakade, Makiko / Imai, Eri / Tsuboyama-Kasaoka, Nobuyo / Nozue, Miho / Umegaki, Keizo / Yoshizawa, Takeshi / Okuda, Nagako / Nishi, Nobuo / Takimoto, Hidemi

Journal of nutritional science and vitaminology

2013 Volume 59, Issue 6, Page(s) 576–583

Abstract: ... 2) examine the differences in vitamin E intake with and without dietary supplementation and/or ... fortified food use, and (3) determine whether some individuals consume vitamin E above the tolerable upper intake ... Both dietary supplement and fortified food use accounted for maximum vitamin E intake; however, the use ...

Abstract	This study was performed to: (1) assess the prevalence of dietary supplement and fortified food use, (2) examine the differences in vitamin E intake with and without dietary supplementation and/or fortified food use, and (3) determine whether some individuals consume vitamin E above the tolerable upper intake level (UL). Data were obtained from 64,624 individuals (age, ≥1 y; 47.4% males) who completed a 1-d household dietary assessment that was part of the National Health and Nutrition Survey conducted in Japan, 2003-2009. The survey also obtained information on the brand or generic name of each dietary supplement or fortified food reported, including their ingredients, through dietary assessment. The prevalence of a potential risk of excess was estimated by the proportion of persons above the age-/sex-specific ULs provided by the Dietary Reference Intakes for Japanese 2010. Supplement use was reported by 5.8% of men and 7.7% of women, whereas fortified food consumption was reported by only 2.9% of men and 3.6% of women. Use of dietary supplements was most common among older women, whereas use of fortified foods was most common among younger women. Both dietary supplement and fortified food use accounted for maximum vitamin E intake; however, the use of dietary supplements and fortified foods had little effect on the median and 95th percentile intake values. None of the subjects consumed nutrients above the UL. The collected data confirm that the use of both dietary supplements and fortified foods contributes a small amount to nutrient intake in Japanese subjects.
MeSH term(s)	Adolescent ; Adult ; Age Distribution ; Aged ; Child ; Child, Preschool ; Diet/methods ; Diet/statistics & numerical data ; Diet Surveys ; Dietary Supplements/statistics & numerical data ; Female ; Food, Fortified/statistics & numerical data ; Humans ; Infant ; Japan ; Male ; Middle Aged ; Nutrition Surveys/methods ; Nutrition Surveys/statistics & numerical data ; Sex Distribution ; Vitamin E/administration & dosage ; Young Adult
Chemical Substances	Vitamin E (1406-18-4)
Language	English
Publishing date	2013-12-27
Publishing country	Japan
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	191366-9
ISSN	1881-7742 ; 0301-4800
ISSN (online)	1881-7742
ISSN	0301-4800
DOI	10.3177/jnsv.59.576
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