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  1. Article ; Online: Legends of allergology and immunology: Alex Straumann.

    Simon, Hans-Uwe

    Allergy

    2022  Volume 78, Issue 2, Page(s) 596–598

    MeSH term(s) Humans ; Hypersensitivity ; Allergy and Immunology
    Language English
    Publishing date 2022-09-26
    Publishing country Denmark
    Document type News
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15520
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.150: Show issues Location:
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  2. Article ; Online: The eosinophil and its role in physiology and disease: news and views.

    Simon, Hans-Uwe

    Seminars in immunopathology

    2021  Volume 43, Issue 3, Page(s) 291–293

    MeSH term(s) Eosinophils ; Humans
    Language English
    Publishing date 2021-06-25
    Publishing country Germany
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2316828-6
    ISSN 1863-2300 ; 1863-2297
    ISSN (online) 1863-2300
    ISSN 1863-2297
    DOI 10.1007/s00281-021-00866-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1425: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: A novel role for mitochondrial fission in macrophages: trained innate immunity induced by beta-glucan.

    Brichkina, Anna / Simon, Hans-Uwe

    Cellular & molecular immunology

    2023  Volume 20, Issue 8, Page(s) 864–866

    MeSH term(s) Trained Immunity ; beta-Glucans/pharmacology ; Mitochondrial Dynamics ; Macrophages ; Immunity, Innate
    Chemical Substances beta-Glucans
    Language English
    Publishing date 2023-04-17
    Publishing country China
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2435097-7
    ISSN 2042-0226 ; 1672-7681
    ISSN (online) 2042-0226
    ISSN 1672-7681
    DOI 10.1038/s41423-023-01017-w
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  4. Article ; Online: NETs: Important players in asthma?

    Stojkov, Darko / Yousefi, Shida / Simon, Hans-Uwe

    The Journal of allergy and clinical immunology

    2023  Volume 153, Issue 1, Page(s) 100–102

    MeSH term(s) Humans ; Extracellular Traps ; Asthma ; Receptor Protein-Tyrosine Kinases ; Neutrophils
    Chemical Substances Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.09.031
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  5. Article ; Online: Pharmacological Induction of Granulocyte Cell Death as Therapeutic Strategy.

    Kaufmann, Thomas / Simon, Hans-Uwe

    Annual review of pharmacology and toxicology

    2022  Volume 63, Page(s) 231–247

    Abstract: Apoptosis is central for the maintenance of health. In the immune system, apoptosis guarantees proper development of immune cells and shutdown of immune reactions by the coordinated elimination of activated immune cells. Limitation of the life span of ... ...

    Abstract Apoptosis is central for the maintenance of health. In the immune system, apoptosis guarantees proper development of immune cells and shutdown of immune reactions by the coordinated elimination of activated immune cells. Limitation of the life span of granulocytes is important, as overactivation of these cells is associated with chronic inflammation and collateral tissue damage. Consequently, targeted induction of granulocyte apoptosis may be beneficial in the course of respective immune disorders. Anti-inflammatory drugs such as glucocorticoids and monoclonal antibodies against IL-5Rα exert their function in part by triggering eosinophil apoptosis. Agonistic antibodies targeting Siglec-8 or death receptors are tested (pre)clinically. Moreover, a new class of inhibitors targeting antiapoptotic BCL-2 proteins shows great promise for anticancer treatments. Because of their specificity and tolerable side effects, these so-called BH3 mimetics may be worthwhile to evaluate in inflammatory disorders. Here, we review past and recent data on pharmacological apoptosis induction of granulocytes and highlight respective therapeutic potential.
    MeSH term(s) Humans ; Cell Death ; Eosinophils ; Apoptosis ; Inflammation/drug therapy
    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 196587-6
    ISSN 1545-4304 ; 0362-1642
    ISSN (online) 1545-4304
    ISSN 0362-1642
    DOI 10.1146/annurev-pharmtox-051921-115130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The birth of death, 30 years ago.

    Melino, Gerry / Knight, Richard A / Mak, Tak Wah / Piacentini, Mauro / Simon, Hans-Uwe / Shi, Yufang

    Cell death and differentiation

    2024  Volume 31, Issue 4, Page(s) 379–386

    MeSH term(s) Humans ; History, 20th Century ; Animals
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Historical Article ; Journal Article ; Editorial
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/s41418-024-01276-8
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    Zs.MG 80: Show issues

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  7. Article ; Online: In Reply.

    Mucke, Johanna / Simon, Hans-Uwe / Burmester, Gerd Rüdiger

    Deutsches Arzteblatt international

    2022  Volume 119, Issue 33-34, Page(s) 567

    Language English
    Publishing date 2022-11-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2022.0186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: International Archives of Allergy and Immunology: A Commitment to Serving the Community Worldwide.

    Simon, Hans-Uwe

    International archives of allergy and immunology

    2018  Volume 175, Issue 1-2, Page(s) 3–4

    Language English
    Publishing date 2018
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000485942
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  9. Book ; Conference proceedings: Eosinophilic esophagitis

    Straumann, Alex / Schoepfer, Alain / Simon, Hans-Uwe

    a novel chronic-inflammatory disease of the GI tract ; Falk Symposium 189, Graz, September 6 - 7, 2013

    (Digestive diseases ; 32,1/2)

    2014  

    Title variant GERD: Gastroesophageal reflux disease
    Event/congress Falk Symposium (189, 2013, Graz) ; Falk Workshop (2013, Graz)
    Author's details ed. A. Straumann ; A. Schoepfer ; H.-U. Simon
    Series title Digestive diseases ; 32,1/2
    Collection
    Keywords Speiseröhrenentzündung ; Refluxösophagitis
    Subject Refluxkrankheit ; Sodbrennen ; Ösophagitis ; Speiseröhre
    Language English
    Size 179 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book ; Conference proceedings
    HBZ-ID HT018196071
    ISBN 978-3-318-02592-7 ; 9783318025934 ; 3-318-02592-5 ; 3318025933
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 1853 -32- not available for loan Zeitschriften-Lesesaal

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  10. Article ; Online: The Safety of Antirheumatic Drugs.

    Mucke, Johanna / Simon, Hans-Uwe / Burmester, Gerd Rüdiger

    Deutsches Arzteblatt international

    2022  , Issue Forthcoming

    Abstract: Background: Drug therapy for rheumatic diseases has changed fundamentally in recent decades with the introduction of many new agents. As these drugs may have to be taken for many years, and many of them are of similar efficacy, their safety profiles ... ...

    Abstract Background: Drug therapy for rheumatic diseases has changed fundamentally in recent decades with the introduction of many new agents. As these drugs may have to be taken for many years, and many of them are of similar efficacy, their safety profiles play an important role in therapeutic decisionmaking.
    Methods: This review is based on pertinent literature retrieved by a selective search on the safety profiles of selected antirheumatic drugs.
    Results: Non-steroidal antirheumatic drugs, glucocorticoids, conventional disease-modifying drugs such as methotrexate, biological agents, and janus kinase (JAK) inhibitors are all used to treat rheumatic diseases. Register and trial data show that antirheumatic treatments are relatively safe. Infections, in particular, are much less common than initially expected. Cortisone administration is an exception because of its severe long-term sequelae. Biological agents are associated with severe infectious events at a rate of 4-5 events per 100 patient years. Screening before treatment with biological agents has been shown to lower the rate of tuberculosis from 564 to 95 cases per 100 000 patient years. JAK inhibitors have a good safety profile, with respect to infections as well, but there is evidence of their association with cardiovascular problems, malignancies, and thrombosis.
    Conclusion: A suitable, safe antirheumatic drug can be chosen for each patient in consideration of individual risk profiles. Regular monitoring enables the early detection of adverse effects. The risk profile of JAK inhibitors, in particular, will be studied in further trials.
    Language English
    Publishing date 2022-11-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.m2021.0389
    Database MEDical Literature Analysis and Retrieval System OnLINE

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