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  1. Article ; Online: Reply to Viel.

    Recknor, Christopher / Hansen, Scott G / Gaylis, Norman B / Tiwary, Meenakshi / Sacha, Jonah B / Yang, Otto O

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 75, Issue 8, Page(s) 1486–1487

    Language English
    Publishing date 2022-07-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac390
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    Zs.A 1505: Show issues Location:
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  2. Article ; Online: Timothy Ray Brown: The Serendipitous Hero of HIV Cure Research.

    Hope, Thomas J / Klatt, Nichole R / Sacha, Jonah B / Cannon, Paula M

    AIDS research and human retroviruses

    2020  Volume 36, Issue 11, Page(s) 883–885

    Language English
    Publishing date 2020-10-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2020.0253
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  3. Article ; Online: Vector-Mediated Delivery of Human Major Histocompatibility Complex-I into Hepatocytes Enables Investigation of T Cell Receptor-Redirected Hepatitis B Virus-Specific T Cells in Mice, and in Macaque Cell Cultures.

    Festag, Julia / Festag, Marvin M / Asen, Theresa / Wettengel, Jochen M / Mück-Häusl, Martin A / Abdulhaqq, Shaheed / Stahl-Hennig, Christiane / Sacha, Jonah B / Burwitz, Benjamin J / Protzer, Ulrike / Wisskirchen, Karin

    Human gene therapy

    2023  Volume 34, Issue 23-24, Page(s) 1204–1218

    Abstract: Adoptive T cell therapy using natural T cell receptor (TCR) redirection is a promising approach to fight solid cancers and viral infections in liver and other organs. However, clinical efficacy of such ... ...

    Abstract Adoptive T cell therapy using natural T cell receptor (TCR) redirection is a promising approach to fight solid cancers and viral infections in liver and other organs. However, clinical efficacy of such TCR
    MeSH term(s) Humans ; Mice ; Animals ; Hepatitis B virus/genetics ; Hepatocytes ; Receptors, Antigen, T-Cell/genetics ; T-Lymphocytes ; Cell Culture Techniques ; HLA-A Antigens
    Chemical Substances Receptors, Antigen, T-Cell ; HLA-A Antigens
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1028152-6
    ISSN 1557-7422 ; 1043-0342
    ISSN (online) 1557-7422
    ISSN 1043-0342
    DOI 10.1089/hum.2023.035
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  4. Article ; Online: Strategies to target non-T-cell HIV reservoirs.

    Sacha, Jonah B / Ndhlovu, Lishomwa C

    Current opinion in HIV and AIDS

    2016  Volume 11, Issue 4, Page(s) 376–382

    Abstract: Purpose of review: A central question for the HIV cure field is to determine new ways to target clinically relevant, latently and actively replicating HIV-infected cells beyond resting memory CD4 T cells, particularly in anatomical areas of low drug ... ...

    Abstract Purpose of review: A central question for the HIV cure field is to determine new ways to target clinically relevant, latently and actively replicating HIV-infected cells beyond resting memory CD4 T cells, particularly in anatomical areas of low drug penetrability.
    Recent findings: HIV eradication strategies being positioned for targeting HIV for extinction in the CD4 T-cell compartment may also show promise in non-CD4 T-cells reservoirs. Furthermore, several exciting novel therapeutic approaches specifically focused on HIV clearance from non-CD4 T-cell populations are being developed.
    Summary: Although reservoir validity in these non-CD4 T cells continues to remain debated, this review will highlight recent advances and make an argument as to their clinical relevancy as we progress towards an HIV cure.
    MeSH term(s) Biomedical Research/trends ; Drug Therapy/methods ; HIV/physiology ; HIV Infections/therapy ; HIV Infections/virology ; Humans ; Immunotherapy/methods ; Virus Latency ; Virus Replication
    Language English
    Publishing date 2016-03-29
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000283
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  5. Article ; Online: Reduced Cell Surface Levels of C-C Chemokine Receptor 5 and Immunosuppression in Long Coronavirus Disease 2019 Syndrome.

    Gaylis, Norman B / Ritter, Angela / Kelly, Scott A / Pourhassan, Nader Z / Tiwary, Meenakshi / Sacha, Jonah B / Hansen, Scott G / Recknor, Christopher / Yang, Otto O

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2022  Volume 75, Issue 7, Page(s) 1232–1234

    Abstract: In an exploratory trial treating "long COVID" with the CCR5-binding antibody leronlimab, we observed significantly increased blood cell surface CCR5 in treated symptomatic responders but not in nonresponders or placebo-treated participants. These ... ...

    Abstract In an exploratory trial treating "long COVID" with the CCR5-binding antibody leronlimab, we observed significantly increased blood cell surface CCR5 in treated symptomatic responders but not in nonresponders or placebo-treated participants. These findings suggest an unexpected mechanism of abnormal immune downmodulation in some persons that is normalized by leronlimab. Clinical Trials Registration. NCT04678830.
    MeSH term(s) COVID-19 ; Chemokines, CC ; Humans ; Immunosuppression Therapy ; Receptors, CCR5
    Chemical Substances Chemokines, CC ; Receptors, CCR5
    Language English
    Publishing date 2022-04-22
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciac226
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  6. Article ; Online: Rhesus Cytomegalovirus-Specific CD8

    Rosen, Brandon C / Pedreño-Lopez, Nuria / Ricciardi, Michael J / Reed, Jason S / Sacha, Jonah B / Rakasz, Eva G / Watkins, David I

    Frontiers in immunology

    2020  Volume 11, Page(s) 1960

    Abstract: ... ...

    Abstract CD8
    MeSH term(s) Animals ; Antigens, Viral/immunology ; Cell Degranulation ; Chronic Disease ; Cytomegalovirus/immunology ; Cytomegalovirus/pathogenicity ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/metabolism ; Cytomegalovirus Infections/virology ; Cytotoxicity, Immunologic ; Disease Models, Animal ; Granzymes/metabolism ; Host-Pathogen Interactions ; Immunodominant Epitopes/immunology ; Immunologic Memory ; Macaca mulatta ; Phenotype ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/metabolism ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus/immunology ; Simian Immunodeficiency Virus/pathogenicity ; T-Lymphocytes, Cytotoxic/immunology ; T-Lymphocytes, Cytotoxic/metabolism ; T-Lymphocytes, Cytotoxic/virology ; Time Factors ; Viral Load
    Chemical Substances Antigens, Viral ; Immunodominant Epitopes ; Granzymes (EC 3.4.21.-)
    Language English
    Publishing date 2020-08-12
    Publishing country Switzerland
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01960
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  7. Article ; Online: Improving rigor and reproducibility in nonhuman primate research.

    Bliss-Moreau, Eliza / Amara, Rama R / Buffalo, Elizabeth A / Colman, Ricki J / Embers, Monica E / Morrison, John H / Quillen, Ellen E / Sacha, Jonah B / Roberts, Charles T

    American journal of primatology

    2021  Volume 83, Issue 12, Page(s) e23331

    Abstract: Nonhuman primates (NHPs) are a critical component of translational/preclinical biomedical research due to the strong similarities between NHP and human physiology and disease pathology. In some cases, NHPs represent the most appropriate, or even the only, ...

    Abstract Nonhuman primates (NHPs) are a critical component of translational/preclinical biomedical research due to the strong similarities between NHP and human physiology and disease pathology. In some cases, NHPs represent the most appropriate, or even the only, animal model for complex metabolic, neurological, and infectious diseases. The increased demand for and limited availability of these valuable research subjects requires that rigor and reproducibility be a prime consideration to ensure the maximal utility of this scarce resource. Here, we discuss a number of approaches that collectively can contribute to enhanced rigor and reproducibility in NHP research.
    MeSH term(s) Animals ; Biomedical Research ; Disease Models, Animal ; Primates ; Reproducibility of Results
    Language English
    Publishing date 2021-09-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1495834-X
    ISSN 1098-2345 ; 0275-2565
    ISSN (online) 1098-2345
    ISSN 0275-2565
    DOI 10.1002/ajp.23331
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  8. Article ; Online: Improved delivery of broadly neutralizing antibodies by nanocapsules suppresses SHIV infection in the CNS of infant rhesus macaques.

    Wen, Jing / Cheever, Tracy / Wang, Lan / Wu, Di / Reed, Jason / Mascola, John / Chen, Xuejun / Liu, Cuiping / Pegu, Amarendra / Sacha, Jonah B / Lu, Yunfeng / Haigwood, Nancy L / Chen, Irvin S Y

    PLoS pathogens

    2021  Volume 17, Issue 7, Page(s) e1009738

    Abstract: Broadly neutralizing antibodies (bNAbs) directed to HIV-1 have shown promise at suppressing viremia in animal models. However, the use of bNAbs for the central nervous system (CNS) infection is confounded by poor penetration of the blood brain barrier ( ... ...

    Abstract Broadly neutralizing antibodies (bNAbs) directed to HIV-1 have shown promise at suppressing viremia in animal models. However, the use of bNAbs for the central nervous system (CNS) infection is confounded by poor penetration of the blood brain barrier (BBB). Typically, antibody concentrations in the CNS are extremely low; with levels in cerebrospinal fluid (CSF) only 0.1% of blood concentrations. Using a novel nanotechnology platform, which we term nanocapsules, we show effective transportation of the human bNAb PGT121 across the BBB in infant rhesus macaques upon systemic administration up to 1.6% of plasma concentration. We demonstrate that a single dose of PGT121 encased in nanocapsules when delivered at 48h post-infection delays early acute infection with SHIVSF162P3 in infants, with one of four animals demonstrating viral clearance. Importantly, the nanocapsule delivery of PGT121 improves suppression of SHIV infection in the CNS relative to controls.
    MeSH term(s) Animals ; Animals, Newborn ; Antibodies, Viral/administration & dosage ; Blood-Brain Barrier ; Brain/drug effects ; Brain/virology ; Broadly Neutralizing Antibodies/administration & dosage ; Humans ; Macaca mulatta ; Nanocapsules ; Simian Acquired Immunodeficiency Syndrome/virology ; Simian Immunodeficiency Virus ; Viral Load/drug effects
    Chemical Substances Antibodies, Viral ; Broadly Neutralizing Antibodies ; Nanocapsules
    Language English
    Publishing date 2021-07-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2205412-1
    ISSN 1553-7374 ; 1553-7366
    ISSN (online) 1553-7374
    ISSN 1553-7366
    DOI 10.1371/journal.ppat.1009738
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  9. Article ; Online: Long-term hepatitis B virus infection of rhesus macaques requires suppression of host immunity

    Sreya Biswas / Lauren N. Rust / Jochen M. Wettengel / Sofiya Yusova / Miranda Fischer / Julien N. Carson / Josie Johnson / Lei Wei / Trason Thode / Mohan R. Kaadige / Sunil Sharma / Majd Agbaria / Benjamin N. Bimber / Thomas Tu / Ulrike Protzer / Alexander Ploss / Jeremy V. Smedley / Gershon Golomb / Jonah B. Sacha /
    Benjamin J. Burwitz

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 12

    Abstract: Here, Biswas et al. present and characterize a second-generation model of HBV infection in rhesus macaques, showing that extended infection requires suppression of host immunity. ...

    Abstract Here, Biswas et al. present and characterize a second-generation model of HBV infection in rhesus macaques, showing that extended infection requires suppression of host immunity.
    Keywords Science ; Q
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Identification and Characterization of Antigen-Specific CD8

    Abdulhaqq, Shaheed / Ventura, Abigail B / Reed, Jason S / Bashirova, Arman A / Bateman, Katherine B / McDonald, Eric / Wu, Helen L / Greene, Justin M / Schell, John B / Morrow, David / Wisskirchen, Karin / Martin, Jeffrey N / Deeks, Steven G / Carrington, Mary / Protzer, Ulrike / Früh, Klaus / Hansen, Scott G / Picker, Louis J / Sacha, Jonah B /
    Bimber, Benjamin N

    Journal of immunology (Baltimore, Md. : 1950)

    2021  Volume 207, Issue 12, Page(s) 2913–2921

    Abstract: ... ...

    Abstract CD8
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes ; Epitopes ; Epitopes, T-Lymphocyte ; HIV Infections ; Macaca mulatta ; Receptors, Antigen, T-Cell ; Tumor Necrosis Factor-alpha
    Chemical Substances Epitopes ; Epitopes, T-Lymphocyte ; Receptors, Antigen, T-Cell ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2021-11-22
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2100535
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