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  1. Article: Synthesis and biological evaluation of small molecule modulators of CDK8/Cyclin C complex with phenylaminoquinoline scaffold.

    Al-Sanea, Mohammad M

    PeerJ

    2020  Volume 8, Page(s) e8649

    Abstract: Background: CDK8/CycC complex has kinase activity towards the carboxyterminal domain of RNA polymerase II, and contributes to the regulation of transcription via association with the mediator complex. Different human malignancies, mainly colorectal and ... ...

    Abstract Background: CDK8/CycC complex has kinase activity towards the carboxyterminal domain of RNA polymerase II, and contributes to the regulation of transcription via association with the mediator complex. Different human malignancies, mainly colorectal and gastric cancers, were produced as a result of overexpression of CDK8/CycC in the mediator complex. Therefore, CDK8/CycC complex represents as a cancer oncogene and it has become a potential target for developing CDK8/CycC modulators.
    Methods: A series of nine 4-phenylaminoquinoline scaffold-based compounds
    Results: The scaffold substituent effects on the intrinsic inhibitory activity toward CDK8/CycC complex are addressed trying to present a novel outlook of CDK8/CycC Complex inhibitors with 4-phenylaminoquinoline scaffold in cancer therapy. The secondary benzenesulfonamide analogues proved to be the most potent compounds in suppressing CDK8/CycC enzyme, whereas, their primary benzenesulfonamide analogues showed inferior activity. Moreover, the benzene reversed sulfonamide analogues were totally inactive.
    Discussion: The titled scaffold showed promising inhibitory activity data and there is a crucial role of un/substituted sulfonamido group for CDK8/CycC complex inhibitory activity. Compound
    Language English
    Publishing date 2020-03-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.8649
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Nanostructured lipid carriers (NLCs) as drug delivery platform: Advances in formulation and delivery strategies.

    Elmowafy, Mohammed / Al-Sanea, Mohammad M

    Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

    2021  Volume 29, Issue 9, Page(s) 999–1012

    Abstract: NLCs have provoked the incessant impulsion for the development of safe and valuable drug delivery systems owing to their exceptional physicochemical and then biocompatible characteristics. Throughout the earlier period, a lot of studies recounting NLCs ... ...

    Abstract NLCs have provoked the incessant impulsion for the development of safe and valuable drug delivery systems owing to their exceptional physicochemical and then biocompatible characteristics. Throughout the earlier period, a lot of studies recounting NLCs based formulations have been noticeably increased. They are binary system which contains both solid and liquid lipids aiming to produce less ordered lipidic core. Their constituents particularly influence the physicochemical properties and effectiveness of the final product. NLCs can be fabricated by different techniques which are classified according to consumed energy. More utilization NLCs is essential due to overcome barriers surrounded by the technological procedure of lipid-based nanocarriers' formulation and increased information of the core mechanisms of their transport via various routes of administration. They can be used in different applications and by different routes such as oral, cutaneous, ocular and pulmonary. This review article seeks to present an overview on the existing situation of the art of NLCs for future clinics through exposition of their applications which shall foster their lucid use. The reported records evidently demonstrate the promise of NLCs for innovate therapeutic applications in the future.
    Language English
    Publishing date 2021-07-21
    Publishing country Saudi Arabia
    Document type Journal Article ; Review
    ZDB-ID 1378024-4
    ISSN 1319-0164
    ISSN 1319-0164
    DOI 10.1016/j.jsps.2021.07.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4758: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Synthesis and biological evaluation of small molecule modulators of CDK8/Cyclin C complex with phenylaminoquinoline scaffold

    Mohammad M. Al-Sanea

    PeerJ, Vol 8, p e

    2020  Volume 8649

    Abstract: ... showed submicromolar potency against CDK8/CycC (IC50 = 0.639 µM) and it can be used for further ...

    Abstract Background CDK8/CycC complex has kinase activity towards the carboxyterminal domain of RNA polymerase II, and contributes to the regulation of transcription via association with the mediator complex. Different human malignancies, mainly colorectal and gastric cancers, were produced as a result of overexpression of CDK8/CycC in the mediator complex. Therefore, CDK8/CycC complex represents as a cancer oncogene and it has become a potential target for developing CDK8/CycC modulators. Methods A series of nine 4-phenylaminoquinoline scaffold-based compounds 5a-i was synthesized, and biologically evaluated as potential CDK8/CycC complex inhibitors. Results The scaffold substituent effects on the intrinsic inhibitory activity toward CDK8/CycC complex are addressed trying to present a novel outlook of CDK8/CycC Complex inhibitors with 4-phenylaminoquinoline scaffold in cancer therapy. The secondary benzenesulfonamide analogues proved to be the most potent compounds in suppressing CDK8/CycC enzyme, whereas, their primary benzenesulfonamide analogues showed inferior activity. Moreover, the benzene reversed sulfonamide analogues were totally inactive. Discussion The titled scaffold showed promising inhibitory activity data and there is a crucial role of un/substituted sulfonamido group for CDK8/CycC complex inhibitory activity. Compound 5d showed submicromolar potency against CDK8/CycC (IC50 = 0.639 µM) and it can be used for further investigations and to design another larger library of phenylaminoquinoline scaffold-based analogues in order to establish detailed SARs.
    Keywords CDK8/CycC ; Cancer ; Sulfonamide ; Kinase inhibition ; Synthesis ; Quinoline ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 540
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Revealing the Underlying Mechanism of

    Alnusaire, Taghreed S / Qasim, Sumera / Al-Sanea, Mohammad M / Hendawy, Omnia / Uttra, Ambreen Malik / Ahmed, Shaimaa R

    Life (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: ... Acacia ... ...

    Abstract Acacia Nilotica
    Language English
    Publishing date 2023-02-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13020411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Design, synthesis and cytotoxic evaluation of novel bis-thiazole derivatives as preferential Pim1 kinase inhibitors with

    Al-Sanea, Mohammad M / Nasr, Tamer M / Bondock, Samir / Gawish, Aya Y / Mohamed, Nada M

    Journal of enzyme inhibition and medicinal chemistry

    2022  Volume 38, Issue 1, Page(s) 2166936

    Abstract: Bis-thiazole derivatives were synthesised conforming to the Pim1 pharmacophore model following Hantzsch condensation. Pim1 has a major role in regulating the G1/S phase which upon inhibition the cell cycle stops at its early stages. ... ...

    Abstract Bis-thiazole derivatives were synthesised conforming to the Pim1 pharmacophore model following Hantzsch condensation. Pim1 has a major role in regulating the G1/S phase which upon inhibition the cell cycle stops at its early stages. Derivatives
    MeSH term(s) Thiazoles/pharmacology ; Antineoplastic Agents/pharmacology ; Cell Cycle ; Staurosporine/pharmacology ; Up-Regulation ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Structure-Activity Relationship
    Chemical Substances Thiazoles ; Antineoplastic Agents ; Staurosporine (H88EPA0A3N)
    Language English
    Publishing date 2022-12-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2082578-X
    ISSN 1475-6374 ; 1475-6366
    ISSN (online) 1475-6374
    ISSN 1475-6366
    DOI 10.1080/14756366.2023.2166936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3004: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Integrating Chemical Profiling, In Vivo Study, and Network Pharmacology to Explore the Anti-inflammatory Effect of

    Alnusaire, Taghreed S / Sabouni, Ibrahim Lahbib / Khojah, Hanan / Qasim, Sumera / Al-Sanea, Mohammad M / Siddique, Sadaf / Mokhtar, Fatma Alzahraa / Ahmed, Shaimaa R

    ACS omega

    2023  Volume 8, Issue 36, Page(s) 32544–32554

    Abstract: The purpose of this study is to explore the anti-inflammatory activity ... ...

    Abstract The purpose of this study is to explore the anti-inflammatory activity of
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c02940
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  7. Article ; Online: Improving plant adaptation to soil antimony contamination: the synergistic contribution of arbuscular mycorrhizal fungus and olive mill waste.

    Albqmi, Mha / Selim, Samy / Bouqellah, Nahla Alsayd / Alnusaire, Taghreed S / Almuhayawi, Mohammed S / Al Jaouni, Soad K / Hussein, Shaimaa / Warrad, Mona / Al-Sanea, Mohammad M / Abdelgawad, Mohamed A / Mostafa, Ehab M / Aldilami, Mohammad / Ahmed, Enas S / AbdElgawad, Hamada

    BMC plant biology

    2024  Volume 24, Issue 1, Page(s) 364

    Abstract: Background: This study aimed to investigate the alterations in biochemical and physiological responses of oat plants exposed to antimony (Sb) contamination in soil. Specifically, we evaluated the effectiveness of an arbuscular mycorrhizal fungus (AMF) ... ...

    Abstract Background: This study aimed to investigate the alterations in biochemical and physiological responses of oat plants exposed to antimony (Sb) contamination in soil. Specifically, we evaluated the effectiveness of an arbuscular mycorrhizal fungus (AMF) and olive mill waste (OMW) in mitigating the effects of Sb contamination. The soil was treated with a commercial strain of AMF (Rhizophagus irregularis) and OMW (4% w/w) under two different levels of Sb (0 and 1500 mg kg
    Results: The combined treatment (OMW + AMF) enhanced the photosynthetic rate (+ 40%) and chlorophyll a (+ 91%) and chlorophyll b (+ 50%) content under Sb condition, which in turn induced more biomass production (+ 67-78%) compared to the contaminated control plants. More photosynthesis in OMW + AMF-treated plants gives a route for phenylalanine amino acid synthesis (+ 69%), which is used as a precursor for the biosynthesis of secondary metabolites, including flavonoids (+ 110%), polyphenols (+ 26%), and anthocyanins (+ 63%) compared to control plants. More activation of phenylalanine ammonia-lyase (+ 38%) and chalcone synthase (+ 26%) enzymes in OMW + AMF-treated plants under Sb stress indicated the activation of phenylpropanoid pathways in antioxidant metabolites biosynthesis. There was also improved shifting of antioxidant enzyme activities in the ASC/GSH and catalytic pathways in plants in response to OMW + AMF and Sb contamination, remarkably reducing oxidative damage markers.
    Conclusions: While individual applications of OMW and AMF also demonstrated some degree of plant tolerance induction, the combined presence of AMF with OMW supplementation significantly enhanced plant biomass production and adaptability to oxidative stress induced by soil Sb contamination.
    MeSH term(s) Mycorrhizae/physiology ; Olea/microbiology ; Soil Pollutants/metabolism ; Antimony/metabolism ; Adaptation, Physiological ; Industrial Waste ; Photosynthesis/drug effects ; Biodegradation, Environmental ; Biomass
    Chemical Substances Soil Pollutants ; Antimony (9IT35J3UV3) ; Industrial Waste
    Language English
    Publishing date 2024-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059868-3
    ISSN 1471-2229 ; 1471-2229
    ISSN (online) 1471-2229
    ISSN 1471-2229
    DOI 10.1186/s12870-024-05044-1
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  8. Article ; Online: Chromium(VI) Toxicity and Active Tolerance Mechanisms of Wheat Plant Treated with Plant Growth-Promoting Actinobacteria and Olive Solid Waste.

    Albqmi, Mha / Selim, Samy / Yaghoubi Khanghahi, Mohammad / Crecchio, Carmine / Al-Sanea, Mohammad M / Alnusaire, Taghreed S / Almuhayawi, Mohammed S / Al Jaouni, Soad K / Hussein, Shaimaa / Warrad, Mona / AbdElgawad, Hamada

    ACS omega

    2023  Volume 8, Issue 36, Page(s) 32458–32467

    Abstract: The present study aimed to assess the potential of plant growth-promoting Actinobacteria and olive solid waste (OSW) in ameliorating some biochemical and molecular parameters of wheat ( ...

    Abstract The present study aimed to assess the potential of plant growth-promoting Actinobacteria and olive solid waste (OSW) in ameliorating some biochemical and molecular parameters of wheat (
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c02447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Network Pharmacology Analysis of Cytotoxic Triterpenes Isolated from

    Ahmed, Shaimaa R / Al-Sanea, Mohammad M / Mostafa, Ehab M / Qasim, Sumera / Abelyan, Narek / Mokhtar, Fatma Alzahraa

    ACS omega

    2022  Volume 7, Issue 21, Page(s) 17713–17722

    Abstract: ... ...

    Abstract Euphorbia
    Language English
    Publishing date 2022-05-16
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c00750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Detailed Experimental and In Silico Investigation of Indomethacin Binding with Human Serum Albumin Considering Primary and Secondary Binding Sites.

    Ali, Mohd Sajid / Muthukumaran, Jayaraman / Jain, Monika / Tariq, Mohammad / Al-Lohedan, Hamad A / Al-Sanea, Abdullah Saad S

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 7

    Abstract: The interaction of indomethacin with human serum albumin (HSA) has been studied here considering the primary and secondary binding sites. The Stern-Volmer plots were linear in the lower concentration range of indomethacin while a downward curvature was ... ...

    Abstract The interaction of indomethacin with human serum albumin (HSA) has been studied here considering the primary and secondary binding sites. The Stern-Volmer plots were linear in the lower concentration range of indomethacin while a downward curvature was observed in the higher concentration range, suggesting the presence of more than one binding site for indomethacin inside HSA due to which the microenvironment of the fluorophore changed slightly and some of its fraction was not accessible to the quencher. The Stern-Volmer quenching constants (K
    MeSH term(s) Humans ; Serum Albumin, Human/chemistry ; Molecular Docking Simulation ; Protein Binding ; Indomethacin ; Ibuprofen ; Warfarin ; Hemin/metabolism ; Binding Sites ; Thermodynamics ; Spectrometry, Fluorescence ; Circular Dichroism
    Chemical Substances Serum Albumin, Human (ZIF514RVZR) ; Indomethacin (XXE1CET956) ; Ibuprofen (WK2XYI10QM) ; Warfarin (5Q7ZVV76EI) ; Hemin (743LRP9S7N)
    Language English
    Publishing date 2023-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28072979
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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