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Article: Evolution of Antibiotic Resistance in

Mączyńska, Beata / Frej-Mądrzak, Magdalena / Sarowska, Jolanta / Woronowicz, Krystyna / Choroszy-Król, Irena / Jama-Kmiecik, Agnieszka

Journal of clinical medicine

2023 Volume 12, Issue 6

Abstract: In recent years, we have witnessed a growing drug resistance among bacteria, which is associated with the use and availability of an increasing number of broad-spectrum antimicrobial agents, as well as with their irrational and excessive use. The present ...

Abstract	In recent years, we have witnessed a growing drug resistance among bacteria, which is associated with the use and availability of an increasing number of broad-spectrum antimicrobial agents, as well as with their irrational and excessive use. The present study aims to analyze changes in the drug resistance of Gram-negative
Language	English
Publishing date	2023-03-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12062414
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Changes in Antibiotic Resistance of

Mączyńska, Beata / Jama-Kmiecik, Agnieszka / Sarowska, Jolanta / Woronowicz, Krystyna / Choroszy-Król, Irena / Piątek, Daniel / Frej-Mądrzak, Magdalena

Journal of clinical medicine

2023 Volume 12, Issue 15

Abstract: In recent years, we have witnessed increasing drug resistance among bacteria, which is associated with the use and availability of an increasing number of broad-spectrum antimicrobials, as well as with their irrational and excessive use. The present ... ...

Abstract	In recent years, we have witnessed increasing drug resistance among bacteria, which is associated with the use and availability of an increasing number of broad-spectrum antimicrobials, as well as with their irrational and excessive use. The present study aims to analyze changes in the drug resistance of Gram-negative
Language	English
Publishing date	2023-07-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12155020
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The influence of diet on gastrointestinal Candida spp. colonization and the susceptibility of Candida spp. to antifungal drugs

Jeziorek, Małgorzata / Frej-Mądrzak, Magdalena / Choroszy-Król, Irena

Roczniki Panstwowego Zakladu Higieny

2019 Volume 70, Issue 2, Page(s) 195–200

Abstract: Background: Candida spp. has been identified as the most common member of human gut microbiota. This yeast-like fungus is recognized as an opportunistic organism due to its potential to cause diseases in all parts of the gastrointestinal tract.: ... ...

Abstract	Background: Candida spp. has been identified as the most common member of human gut microbiota. This yeast-like fungus is recognized as an opportunistic organism due to its potential to cause diseases in all parts of the gastrointestinal tract. Objective: The aim of the study was to investigate the relationship between diet and health of the study participants and the presence of gastrointestinal Candida spp. Susceptibility of Candida to antifungal drugs was determined. Material and methods: Material comprised of oral swabs and fecal samples self-collected by the study participants. The participants filled in a nutritional questionnaire. A total of 30 people took part in the study, including 28 women and 2 men. The study was conducted in Wroclaw, Poland. Susceptibility of Candida to antifungal drugs was determined using Bio-Rad’s FUNGITEST™ Kit designed for the susceptibility testing of yeasts to six antifungal drugs. Results: In the group with negative Candida spp. cultures, healthier wheat flour substitutes were consumed significantly more frequently than in the group with positive Candida spp. cultures. Yellow cheeses and quark were eaten significantly more frequently in the group with negative Candida spp. cultures. No antifungal resistance was detected in the study group. Conclusions: The increased consumption of purified wheat flour products was linked to the presence of gastrointestinal Candida spp. A higher consumption of cheese was observed in the group with negative Candida spp. cultures, which may indicate the inhibitory effect of saturated fatty acids on the growth of human Candida spp. Sensitivity of C. albicans to antifungal drugs may increase effectiveness of candidiasis treatment.
MeSH term(s)	Adult ; Antifungal Agents/administration & dosage ; Colony Count, Microbial ; Diet/statistics & numerical data ; Drug Resistance, Fungal ; Drug Resistance, Microbial ; Female ; Gastrointestinal Tract/microbiology ; Humans ; Male ; Poland
Chemical Substances	Antifungal Agents
Language	English
Publishing date	2019-06-19
Publishing country	Poland
Document type	Journal Article
ZDB-ID	421739-1
ISSN	0035-7715
ISSN	0035-7715
DOI	10.32394/rpzh.2019.0070
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Susceptibility to Clotrimazole of

Frej-Mądrzak, Magdalena / Golec, Sabina / Włodarczyk, Katarzyna / Choroszy-Król, Irena / Nawrot, Urszula

Pathogens (Basel, Switzerland)

2021 Volume 10, Issue 9

Abstract: The aim of this study was to determine the susceptibility to clotrimazole of 125 isolates ... ...

Abstract	The aim of this study was to determine the susceptibility to clotrimazole of 125 isolates of
Language	English
Publishing date	2021-09-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens10091142
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Article: Susceptibility to Clotrimazole of Candida spp. Isolated from the Genitourinary System—A Single Center Study

Frej-Mądrzak, Magdalena / Golec, Sabina / Włodarczyk, Katarzyna / Choroszy-Król, Irena / Nawrot, Urszula

Pathogens. 2021 Sept. 04, v. 10, no. 9

2021

Abstract: The aim of this study was to determine the susceptibility to clotrimazole of 125 isolates of Candida spp. originated from the genitourinary system of hospitalized patients as well as outpatients, tested in the mycological laboratory of Wroclaw Medical ... ...

Abstract	The aim of this study was to determine the susceptibility to clotrimazole of 125 isolates of Candida spp. originated from the genitourinary system of hospitalized patients as well as outpatients, tested in the mycological laboratory of Wroclaw Medical University in the years 1999–2018. The minimal inhibitory concentrations of clotrimazole and fluconazole were determined with the use of the microdilution method according to EUCAST, and the MFC was determined by subsequent subculture on Sabouraud agar. For the tested population of Candida yeasts, the MIC values of clotrimazole ranged from 0.008 to 8 mg/L, and MIC90 was 1 mg/L, whereas MIC50 was 0.008 mg/L. The minimal fungicidal concentration ranged between 1 and >8 mg/L. The great majority of the isolates (88%; 110/125) displayed MIC < 1 mg/L and were classified as WT (wild-type), whereas MIC ≥ 1 mg/L was determined for 2/61 (3.2%) isolates of C. albicans, 9/38 (23.6%) of C. glabrata, 1/2 of C. tropicalis, and 3/3 of C. guilliermondii. Six isolates (four of C. glabrata and two of C. albicans), defined as non-WT for clotrimazole, were classified as resistant to fluconazole, according to CBP from EUCAST. The isolates with elevated MIC to clotrimazole originated mostly from patients of the pediatric hematology unit, and their proportion in this population amounted to 17.8% (13 out of 73 isolates). In contrast, among strains from ambulatory patients, the highest observed MIC value was 1 mg/L (1 out of 37 isolates; 2.7%). The data obtained correlate well with those of most published studies on the in vitro susceptibility of Candida spp. to clotrimazole, which is usually very high. However, the existence of reports regarding the growing prevalence of resistant isolates has also to be noted. These results support the need for routinely checking the susceptibility of Candida clinical isolates to this imidazole derivative.
Keywords	agar ; clotrimazole ; fluconazole ; hematology ; imidazole
Language	English
Dates of publication	2021-0904
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens10091142
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Antiviral Potential of Plants against Noroviruses.

Sarowska, Jolanta / Wojnicz, Dorota / Jama-Kmiecik, Agnieszka / Frej-Mądrzak, Magdalena / Choroszy-Król, Irena

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 15

Abstract: Human noroviruses, which belong to the enterovirus family, are one of the most common etiological agents of food-borne diseases. In recent years, intensive research has been carried out regarding the antiviral activity of plant metabolites that could be ... ...

Abstract	Human noroviruses, which belong to the enterovirus family, are one of the most common etiological agents of food-borne diseases. In recent years, intensive research has been carried out regarding the antiviral activity of plant metabolites that could be used for the preservation of fresh food, because they are safer for consumption when compared to synthetic chemicals. Plant preparations with proven antimicrobial activity differ in their chemical compositions, which significantly affects their biological activity. Our review aimed to present the results of research related to the characteristics, applicability, and mechanisms of the action of various plant-based preparations and metabolites against norovirus. New strategies to combat intestinal viruses are necessary, not only to ensure food safety and reduce infections in humans but also to lower the direct health costs associated with them.
MeSH term(s)	Animals ; Antiviral Agents/pharmacology ; Caliciviridae Infections/drug therapy ; Caliciviridae Infections/virology ; Humans ; Norovirus/drug effects ; Plant Extracts/pharmacology
Chemical Substances	Antiviral Agents ; Plant Extracts
Language	English
Publishing date	2021-08-02
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26154669
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Natural Products and Their Potential Anti-HAV Activity.

Jama-Kmiecik, Agnieszka / Sarowska, Jolanta / Wojnicz, Dorota / Choroszy-Król, Irena / Frej-Mądrzak, Magdalena

Pathogens (Basel, Switzerland)

2021 Volume 10, Issue 9

Abstract: The role of purified natural products in the prevention and treatment of countless diseases of bacterial, fungal, and viral origin cannot be overestimated. New antiviral drugs have been obtained from natural sources and transformed into preparations for ... ...

Abstract	The role of purified natural products in the prevention and treatment of countless diseases of bacterial, fungal, and viral origin cannot be overestimated. New antiviral drugs have been obtained from natural sources and transformed into preparations for prophylactic and therapeutic purposes. Flavonoids, polyphenols, saponins, proanthocyanins, polysaccharides, organic acids, proteins, polypeptides, and essential oils derived from plants, animals, or microorganisms can control and combat foodborne viral infections, including hepatitis A. The components of essential oils are characterized by numerous therapeutic and antioxidant properties and exhibit a broad spectrum of antimicrobial and antiviral activity. Due to these properties, they can be used to preserve meat, fruit, vegetables, and their products. Over the past two decades, much effort has been made to identify natural products, mostly of plant origin, to combat foodborne viruses. Natural plant extracts have several potential uses, not limited to increasing the safety of food products and improving their quality, but also as natural antiviral agents.
Language	English
Publishing date	2021-08-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens10091095
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Article ; Online: Exposing

Choroszy-Król, Irena / Futoma-Kołoch, Bożena / Kuźnik, Klaudia / Wojnicz, Dorota / Tichaczek-Goska, Dorota / Frej-Mądrzak, Magdalena / Jama-Kmiecik, Agnieszka / Sarowska, Jolanta

International journal of molecular sciences

2023 Volume 24, Issue 19

Abstract: European Union (EU) countries strive to improve the quality and safety of food of animal origin. Food production depends on a good microbiological quality of fodder. However, feed can be a reservoir or vector of pathogenic microorganisms, ... ...

Abstract	European Union (EU) countries strive to improve the quality and safety of food of animal origin. Food production depends on a good microbiological quality of fodder. However, feed can be a reservoir or vector of pathogenic microorganisms, including
MeSH term(s)	Animals ; Escherichia coli ; Vaccinium vitis-idaea ; Poultry ; Farms ; Salmonella ; Biofilms ; Formaldehyde/pharmacology ; Plant Extracts/pharmacology
Chemical Substances	Formaldehyde (1HG84L3525) ; Plant Extracts
Language	English
Publishing date	2023-09-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241914579
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Evolution of Antibiotic Resistance in Escherichia coli and Klebsiella pneumoniae Clinical Isolates in a Multi-Profile Hospital over 5 Years (2017–2021)

Beata Mączyńska / Magdalena Frej-Mądrzak / Jolanta Sarowska / Krystyna Woronowicz / Irena Choroszy-Król / Agnieszka Jama-Kmiecik

Journal of Clinical Medicine, Vol 12, Iss 2414, p

2023 Volume 2414

Abstract	In recent years, we have witnessed a growing drug resistance among bacteria, which is associated with the use and availability of an increasing number of broad-spectrum antimicrobial agents, as well as with their irrational and excessive use. The present study aims to analyze changes in the drug resistance of Gram-negative Enterobacterales : Escherichia coli and Klebsiella pneumoniae , isolated from infections in a multi-profile hospital over five years (from 2017 to 2021). Among the practical outcomes of the evaluation of these data will be the possibility of determining changes in susceptibility to the antibiotics used in the hospital. In turn, this will help propose new therapeutic options, especially for empirical therapy that is necessary in severe infections. The analysis of the use of individual groups of antibiotics allowed for identification of the causes of the increasing resistance of Gram-negative bacilli. The highest number of infections whose etiological agent was K. pneumoniae ESBL(+) and E. coli ESBL(+) was observed in 2018. In the analyzed five-year period, the number of multi-resistant (MDR) K. pneumoniae strains increased successively, which seems to be related to the growing use, especially in the pandemic period, of broad-spectrum antibiotics, mainly penicillins with inhibitors, third-generation cephalosporins, and carbapenems.
Keywords	multi-drug resistant strains ; Enterobacteriaceae ; ESBL ; Medicine ; R
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The influence of diet on gastrointestinal Candida spp. colonization and the susceptibility of Candida spp. to antifungal drugs

Małgorzata Jeziorek / Magdalena Frej-Mądrzak / Irena Choroszy-Król

Roczniki Panstwowego Zakladu Higieny, Vol 70, Iss 2, Pp 195-

2019 Volume 200

Abstract: Background. Candida spp. has been identified as the most common member of human gut microbiota. This yeast-like fungus is recognized as an opportunistic organism due to its potential to cause diseases in all parts of the gastrointestinal tract. Objective. ...

Abstract	Background. Candida spp. has been identified as the most common member of human gut microbiota. This yeast-like fungus is recognized as an opportunistic organism due to its potential to cause diseases in all parts of the gastrointestinal tract. Objective. The aim of the study was to investigate the relationship between diet and health of the study participants and the presence of gastrointestinal Candida spp. Susceptibility of Candida to antifungal drugs was determined. Material and methods. Material comprised of oral swabs and fecal samples self-collected by the study participants. The participants filled in a nutritional questionnaire. A total of 30 people took part in the study, including 28 women and 2 men. The study was conducted in Wroclaw, Poland. Susceptibility of Candida to antifungal drugs was determined using Bio-Rad’s FUNGITEST™ Kit designed for the susceptibility testing of yeasts to six antifungal drugs. Results. In the group with negative Candida spp. cultures, healthier wheat flour substitutes were consumed significantly more frequently than in the group with positive Candida spp. cultures. Yellow cheeses and quark were eaten significantly more frequently in the group with negative Candida spp. cultures. No antifungal resistance was detected in the study group. Conclusions. The increased consumption of purified wheat flour products was linked to the presence of gastrointestinal Candida spp. A higher consumption of cheese was observed in the group with negative Candida spp. cultures, which may indicate the inhibitory effect of saturated fatty acids on the growth of human Candida spp. Sensitivity of C. albicans to antifungal drugs may increase effectiveness of candidiasis treatment.
Keywords	Candida spp ; diet ; fecal samples ; antibiotics ; drug resistance ; Nutrition. Foods and food supply ; TX341-641 ; Industrial medicine. Industrial hygiene ; RC963-969 ; Public aspects of medicine ; RA1-1270
Subject code	630
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	National Institute of Public Health - National Institute of Hygiene
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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