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  1. Article ; Online: Taking a genetic scalpel to the Streptomyces colony.

    Chater, Keith F

    Microbiology (Reading, England)

    2021  Volume 144, Issue 6, Page(s) 1465–1478

    Abstract: 1997 Fred Griffith Review Lecture(Delivered at the 138th Meeting of the Society for General Microbiology, 2 September 1977). ...

    Abstract 1997 Fred Griffith Review Lecture(Delivered at the 138th Meeting of the Society for General Microbiology, 2 September 1977).
    Language English
    Publishing date 2021-01-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/00221287-144-6-1465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Recent advances in understanding

    Chater, Keith F

    F1000Research

    2016  Volume 5, Page(s) 2795

    Abstract: About 2,500 papers dated 2014-2016 were recovered by searching the PubMed database ... ...

    Abstract About 2,500 papers dated 2014-2016 were recovered by searching the PubMed database for
    Language English
    Publishing date 2016
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.9534.1
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  3. Article ; Online: Curing baldness activates antibiotic production.

    Chater, Keith F

    Chemistry & biology

    2013  Volume 20, Issue 10, Page(s) 1199–1200

    Abstract: Kalan and colleagues describe an unusual way of activating a "silent" gene cluster for the biosynthesis of a new antibiotic by analyzing and curing the aerial growth defect of an old Streptomyces isolate, Streptomyces calvus. This commentary addresses ... ...

    Abstract Kalan and colleagues describe an unusual way of activating a "silent" gene cluster for the biosynthesis of a new antibiotic by analyzing and curing the aerial growth defect of an old Streptomyces isolate, Streptomyces calvus. This commentary addresses the broad scientific and historical context and practical and biological significance of this finding.
    MeSH term(s) Gene Expression Regulation, Bacterial ; Genes, Bacterial/genetics ; Genetic Complementation Test ; Multigene Family ; Polyenes/metabolism ; Streptomyces/genetics ; Streptomyces/metabolism
    Chemical Substances Polyenes
    Language English
    Publishing date 2013-10-24
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 917827-2
    ISSN 1879-1301 ; 1074-5521
    ISSN (online) 1879-1301
    ISSN 1074-5521
    DOI 10.1016/j.chembiol.2013.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4429: Show issues Location:
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  4. Article ; Online: Recent advances in understanding Streptomyces [version 1; referees

    Keith F. Chater

    F1000Research, Vol

    4 approved]

    2016  Volume 5

    Abstract: About 2,500 papers dated 2014–2016 were recovered by searching the PubMed database for Streptomyces, which are the richest known source of antibiotics. This review integrates around 100 of these papers in sections dealing with evolution, ecology, ... ...

    Abstract About 2,500 papers dated 2014–2016 were recovered by searching the PubMed database for Streptomyces, which are the richest known source of antibiotics. This review integrates around 100 of these papers in sections dealing with evolution, ecology, pathogenicity, growth and development, stress responses and secondary metabolism, gene expression, and technical advances. Genomic approaches have greatly accelerated progress. For example, it has been definitively shown that interspecies recombination of conserved genes has occurred during evolution, in addition to exchanges of some of the tens of thousands of non-conserved accessory genes. The closeness of the association of Streptomyces with plants, fungi, and insects has become clear and is reflected in the importance of regulators of cellulose and chitin utilisation in overall Streptomyces biology. Interestingly, endogenous cellulose-like glycans are also proving important in hyphal growth and in the clumping that affects industrial fermentations. Nucleotide secondary messengers, including cyclic di-GMP, have been shown to provide key input into developmental processes such as germination and reproductive growth, while late morphological changes during sporulation involve control by phosphorylation. The discovery that nitric oxide is produced endogenously puts a new face on speculative models in which regulatory Wbl proteins (peculiar to actinobacteria) respond to nitric oxide produced in stressful physiological transitions. Some dramatic insights have come from a new model system for Streptomyces developmental biology, Streptomyces venezuelae, including molecular evidence of very close interplay in each of two pairs of regulatory proteins. An extra dimension has been added to the many complexities of the regulation of secondary metabolism by findings of regulatory crosstalk within and between pathways, and even between species, mediated by end products. Among many outcomes from the application of chromosome immunoprecipitation sequencing (ChIP-seq) analysis and ...
    Keywords Cellular Microbiology & Pathogenesis ; Environmental Microbiology ; Evolutionary/Comparative Genetics ; Microbial Evolution & Genomics ; Microbial Growth & Development ; Microbial Physiology & Metabolism ; Medicine ; R ; Science ; Q
    Subject code 580
    Language English
    Publishing date 2016-11-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Book ; Conference proceedings: Protein targeting

    Chater, Keith F.

    proceedings of the Eighth John Innes Symposium, Norwich [6th to 9th September] 1988

    (Journal of cell science : Supplement ; 11)

    1989  

    Event/congress John Innes Symposium (8, 1988, Norwich)
    Author's details ed. by K. F. Chater
    Series title Journal of cell science : Supplement ; 11
    Journal of cell science
    Journal of cell science ; Supplement
    Collection Journal of cell science
    Journal of cell science ; Supplement
    Keywords Biological Transport / congresses ; Proteins / congresses ; Proteine ; Targeted drug delivery ; Zielerkennung
    Subject Eiweiss ; Protein ; Drug targeting ; Gezielte Pharmakotherapie ; Zielgerichtete Pharmakotherapie ; Zielerfassung
    Language English
    Size 253 S. : Ill., graph. Darst.
    Publisher Company of Biologists
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT003376100
    ISBN 0-948601-21-3 ; 978-0-948601-21-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 1200 -Suppl.11- verfügbar in Königswinter Königswinter

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  6. Article ; Online: Bacterial extracellular biology.

    Chater, Keith F

    FEMS microbiology reviews

    2010  Volume 34, Issue 2, Page(s) 87–88

    MeSH term(s) Antibiosis ; Bacteria/metabolism ; Bacterial Physiological Phenomena ; Bacterial Proteins/metabolism ; Bacterial Proteins/secretion ; Enzymes/metabolism ; Enzymes/secretion ; Inorganic Chemicals/metabolism ; Organic Chemicals/metabolism ; Signal Transduction
    Chemical Substances Bacterial Proteins ; Enzymes ; Inorganic Chemicals ; Organic Chemicals
    Language English
    Publishing date 2010-03
    Publishing country England
    Document type Editorial
    ZDB-ID 283740-7
    ISSN 1574-6976 ; 0168-6445
    ISSN (online) 1574-6976
    ISSN 0168-6445
    DOI 10.1111/j.1574-6976.2009.00203.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Conference proceedings: Genetic rearrangement

    Chater, Keith F.

    proceedings of the fifth John Innes Symposium, Biological Consequences of DNA Structure and Genome Arrangement

    1983  

    Event/congress John Innes Symposium (5, 1982, Norwich)
    Author's details ed. by K. F. Chater
    Keywords RECOMBINATION, GENETIC / CONGRESSES ; Rekombination ; Genetik
    Subject Allgemeine Genetik ; Erbbiologie ; Erbforschung ; Erblehre ; Vererbungslehre ; Vererbungswissenschaft ; Erblichkeitslehre ; Ladungsrekombination ; Ladungsneutralisation
    Size 296 S. : Ill., graph. Darst.
    Publisher Croom Helm
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT002565362
    ISBN 0-7099-0779-6 ; 978-0-7099-0779-4
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1984 A 2613 order for loan Magazin

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  8. Article: Bacterial extracellular biology

    Chater, Keith F

    FEMS microbiology reviews. 2010 Mar., v. 34, no. 2

    2010  

    Language English
    Dates of publication 2010-03
    Size p. 87-88.
    Publisher Blackwell Publishing Ltd
    Publishing place Oxford, UK
    Document type Article
    ZDB-ID 283740-7
    ISSN 1574-6976 ; 0168-6445
    ISSN (online) 1574-6976
    ISSN 0168-6445
    DOI 10.1111/j.1574-6976.2009.00203.x
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences.

    Chandra, Govind / Chater, Keith F

    FEMS microbiology reviews

    2013  Volume 38, Issue 3, Page(s) 345–379

    Abstract: To illuminate the evolution and mechanisms of actinobacterial complexity, we evaluate the distribution and origins of known Streptomyces developmental genes and the developmental significance of actinobacteria-specific genes. As an aid, we developed the ... ...

    Abstract To illuminate the evolution and mechanisms of actinobacterial complexity, we evaluate the distribution and origins of known Streptomyces developmental genes and the developmental significance of actinobacteria-specific genes. As an aid, we developed the Actinoblast database of reciprocal blastp best hits between the Streptomyces coelicolor genome and more than 100 other actinobacterial genomes (http://streptomyces.org.uk/actinoblast/). We suggest that the emergence of morphological complexity was underpinned by special features of early actinobacteria, such as polar growth and the coupled participation of regulatory Wbl proteins and the redox-protecting thiol mycothiol in transducing a transient nitric oxide signal generated during physiologically stressful growth transitions. It seems that some cell growth and division proteins of early actinobacteria have acquired greater importance for sporulation of complex actinobacteria than for mycelial growth, in which septa are infrequent and not associated with complete cell separation. The acquisition of extracellular proteins with structural roles, a highly regulated extracellular protease cascade, and additional regulatory genes allowed early actinobacterial stationary phase processes to be redeployed in the emergence of aerial hyphae from mycelial mats and in the formation of spore chains. These extracellular proteins may have contributed to speciation. Simpler members of morphologically diverse clades have lost some developmental genes.
    MeSH term(s) Actinobacteria/classification ; Actinobacteria/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Classification ; Evolution, Molecular ; Genome, Bacterial ; Phylogeny ; Streptomyces/cytology ; Streptomyces/genetics
    Chemical Substances Bacterial Proteins
    Language English
    Publishing date 2013-11-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 283740-7
    ISSN 1574-6976 ; 0168-6445
    ISSN (online) 1574-6976
    ISSN 0168-6445
    DOI 10.1111/1574-6976.12047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: Extracellular biology

    Chater, Keith F

    (FEMS microbiology reviews : Thematic issue ; 34.2010,2)

    2010  

    Author's details issue ed.: Keith F. Chater
    Series title FEMS microbiology reviews : Thematic issue ; 34.2010,2
    Language English
    Size S. 87 - 230
    Publisher Blackwell
    Publishing place Oxford
    Document type Book
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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