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Article ; Online: Pathogenesis underlying hexanucleotide repeat expansions in

Chong, Zhao Zhong / Menkes, Daniel L / Souayah, Nizar

2023 Volume 35, Issue 1, Page(s) 85–97

Abstract: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder. Mutations ... ...

Abstract	Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder. Mutations in
MeSH term(s)	Humans ; Amyotrophic Lateral Sclerosis/pathology ; C9orf72 Protein/genetics ; C9orf72 Protein/metabolism ; Proteins/genetics ; Proteins/metabolism ; Dipeptides/genetics ; Dipeptides/metabolism ; RNA ; Arginine ; Alanine ; Glycine ; Proline
Chemical Substances	C9orf72 Protein ; Proteins ; Dipeptides ; RNA (63231-63-0) ; Arginine (94ZLA3W45F) ; Alanine (OF5P57N2ZX) ; Glycine (TE7660XO1C) ; Proline (9DLQ4CIU6V) ; C9orf72 protein, human
Language	English
Publishing date	2023-08-02
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	639035-3
ISSN	2191-0200 ; 0334-1763
ISSN (online)	2191-0200
ISSN	0334-1763
DOI	10.1515/revneuro-2023-0060
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Article ; Online: Monoamine oxidase B activatable red fluorescence probe for bioimaging in cells and zebrafish.

Yang, Zhengmin / Zhong, Tiantian / Mo, Qingyuan / He, Jiman / Chong, Jia / Hu, Xianyun / Zhao, Shulin / Qin, Jiangke

Bioorganic chemistry

2024 Volume 145, Page(s) 107156

Abstract: A real-time and specific for the detection of Monoamine Oxidase B (MAO-B) to investigate the MAO-B-relevant disease development and treatment process is urgently desirable. Here, we utilized MAO-B to catalyze the conversion of propylamino groups to ... ...

Abstract	A real-time and specific for the detection of Monoamine Oxidase B (MAO-B) to investigate the MAO-B-relevant disease development and treatment process is urgently desirable. Here, we utilized MAO-B to catalyze the conversion of propylamino groups to aldehyde groups, which was then quickly followed by a β-elimination process to produce fluorescent probes (FNJP) that may be used to detect MAO-B in vitro and in vivo. The FNJP probe possesses unique properties, including favorable reactivity (K
MeSH term(s)	Animals ; Humans ; Monoamine Oxidase/metabolism ; Zebrafish/metabolism ; Fluorescence ; Neuroblastoma ; Hep G2 Cells ; Fluorescent Dyes ; Monoamine Oxidase Inhibitors
Chemical Substances	Monoamine Oxidase (EC 1.4.3.4) ; Fluorescent Dyes ; Monoamine Oxidase Inhibitors
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	120080-x
ISSN	1090-2120 ; 0045-2068
ISSN (online)	1090-2120
ISSN	0045-2068
DOI	10.1016/j.bioorg.2024.107156
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Zs.A 4207: Show issues

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Article ; Online: SARS-CoV-2 Induced Neurological Manifestations Entangles Cytokine Storm that Implicates for Therapeutic Strategies.

Chong, Zhao-Zhong / Souayah, Nizar

Current medicinal chemistry

2021 Volume 29, Issue 12, Page(s) 2051–2074

Abstract: The new coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can present neurological symptoms and induce neurological complications. The involvement in both the central and peripheral nervous ... ...

Abstract	The new coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can present neurological symptoms and induce neurological complications. The involvement in both the central and peripheral nervous systems in COVID-19 patients has been associated with direct invasion of the virus and the induction of cytokine storm. This review discussed the pathways for the virus invasion into the nervous system and characterized the SARS-CoV-2 induced cytokine storm. In addition, the mechanisms underlying the immune responses and cytokine storm induction after SARS-CoV-2 infection were also discussed. Although some neurological symptoms are mild and disappear after recovery from infection, some severe neurological complications contribute to the mortality of COVID-19 patients. Therefore, the insight into the cause of SARS-CoV-2 induced cytokine storm in context with neurological complications will formulate the novel management of the disease and also further identify new therapeutic targets for COVID-19.
MeSH term(s)	COVID-19/complications ; Cytokine Release Syndrome/drug therapy ; Humans ; Nervous System Diseases/drug therapy ; SARS-CoV-2
Language	English
Publishing date	2021-05-10
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867328666210506161543
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Article: Serum cytokines profile changes in amyotrophic lateral sclerosis.

Xu, Chun-Zuan / Huan, Xiao / Luo, Su-Shan / Zhong, Hua-Hua / Zhao, Chong-Bo / Chen, Yan / Zou, Zhang-Yu / Chen, Sheng

Heliyon

2024 Volume 10, Issue 7, Page(s) e28553

Abstract: Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder, characterized by progressive limb weakness, dysphagia, dysphonia, and respiratory failure due to degeneration of upper and lower motor neurons. The pathogenesis ...

Abstract	Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder, characterized by progressive limb weakness, dysphagia, dysphonia, and respiratory failure due to degeneration of upper and lower motor neurons. The pathogenesis of ALS is still unclear. Neuroinflammation has been found to be involved in its development and progression. Cytokines play a significant role in the inflammatory process. This study aims to identify novel biomarkers that may assist in the diagnosis of ALS. Methods: In Fujian Medical University Union Hospital and Huashan Hospital Fudan University, two independent centers, we prospectively recruited 50 ALS patients, and 41 healthy controls (25 ALS and 26 controls in the first stage and 25 ALS and 15 controls in the validation stage). An 18-plex Luminex kit was used to screen the serum cytokines levels in the first stage. Commercial ELISA kits were used to measure the levels of target cytokines in the validation stage. A single-molecule array HD-X platform was applied to assess the levels of serum neurofilament light chain (NFL). Results: The levels of serum IL-18 were markedly increased in patients with ALS in the first stage ( Conclusion: In this study, we identified systemic cytokine profile changes in the serum of ALS patients, especially the elevated IL-18, as well as the decreased IL-21 in elder patients. These changes in serum cytokine profiles may shed new light on an in-depth understanding of the immunopathogenic characteristics of ALS.
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28553
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Article ; Online: Evaluation of stability and antitumor activity of two-dimensional black phosphorus modified with positively charged protein.

Zhao, Chong / Lin, Jiamin / Cai, Yin / Zhong, Yuming / Li, Yinghua / Zhou, Benqing

Nanotechnology

2023 Volume 34, Issue 33

Abstract: Two-dimensional black phosphorus (2D BP), a novel 2D photoelectric material with excellent near-infrared optical absorption, biocompatibility, and degradability, has shown enormous potential in biomedical field. However, under the action of light, oxygen ...

Abstract	Two-dimensional black phosphorus (2D BP), a novel 2D photoelectric material with excellent near-infrared optical absorption, biocompatibility, and degradability, has shown enormous potential in biomedical field. However, under the action of light, oxygen and water, 2D BP is easily degraded to phosphate and phosphonate. In this work, trastuzumab (Tmab) as a positively charged protein was used to modify 2D BP through electrostatic interaction to form BP-Tmab. The Tmab layer on the surface of 2D BP can effectively protect BP from water, which significantly enhanced the water stability of BP. PEGylated 2D BP (BP-PEG) as a control was also prepared. After 7 days in air-exposed water, the attenuation value of BP-Tmab was only 6.62 ± 2.72% at room temperature, which was much lower than that of naked 2D BP (52.47 ± 2.26%) and BP-PEG (25.84 ± 2.80%) under the same conditions. The result was further confirmed by the temperature changes at different time points under laser irradiation, suggesting that the degradation of BP was effectively reduced by Tmab modification. In addition, BP-Tmab displayed satisfactory biocompatibility and can effectively destroy cancer cells under laser irradiation, showing an excellent photothermal therapy effect.
MeSH term(s)	Phosphorus/chemistry ; Proteins/chemistry ; Antineoplastic Agents/chemistry ; Humans ; Cell Line, Tumor ; Photochemotherapy
Chemical Substances	Phosphorus (27YLU75U4W) ; Proteins ; Antineoplastic Agents
Language	English
Publishing date	2023-06-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/acd647
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Article ; Online: Peripheral immune landscape for hypercytokinemia in myasthenic crisis utilizing single-cell transcriptomics.

Zhong, Huahua / Huan, Xiao / Zhao, Rui / Su, Manqiqige / Yan, Chong / Song, Jie / Xi, Jianying / Zhao, Chongbo / Luo, Feifei / Luo, Sushan

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 564

Abstract: Background: Myasthenia gravis (MG) is the most prevalent autoimmune disorder affecting the neuromuscular junction. A rapid deterioration in respiratory muscle can lead to a myasthenic crisis (MC), which represents a life-threatening condition with high ... ...

Abstract	Background: Myasthenia gravis (MG) is the most prevalent autoimmune disorder affecting the neuromuscular junction. A rapid deterioration in respiratory muscle can lead to a myasthenic crisis (MC), which represents a life-threatening condition with high mortality in MG. Multiple CD4 Methods: We conducted single-cell transcriptomic and immune repertoire sequencing on 33,577 peripheral blood mononuclear cells (PBMCs) from two acetylcholine receptor antibody-positive (AChR +) MG patients during MC and again three months post-MC. We followed the Scanpy workflow for quality control, dimension reduction, and clustering of the single-cell data. Subsequently, we annotated high-resolution cell types utilizing transfer-learning models derived from publicly available single-cell immune datasets. RNA velocity calculations from unspliced and spliced mRNAs were applied to infer cellular state progression. We analyzed cell communication and MG-relevant cytokines and chemokines to identify potential inflammation initiators. Results: We identified a unique subset of monocytes, termed monocytes 3 (FCGR3B Conclusions: In summary, our integrated analysis of single-cell transcriptomics and TCR/BCR sequencing has underscored the role of innate immune activation which is associated with hypercytokinemia in MC. The identification of a specific monocyte cluster that dominates the peripheral immune profile may provide some hints into the etiology and pathology of MC. However, future functional studies are required to explore causality.
MeSH term(s)	Humans ; Cytokine Release Syndrome ; Transcriptome/genetics ; CD8-Positive T-Lymphocytes ; Leukocytes, Mononuclear ; Myasthenia Gravis/genetics
Language	English
Publishing date	2023-08-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-04421-y
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Article ; Online: Targeting PRAS40 for multiple diseases.

Chong, Zhao Zhong

Drug discovery today

2016 Volume 21, Issue 8, Page(s) 1222–1231

Abstract: Proline-rich Akt substrate 40kDa (PRAS40) bridges cell signaling between protein kinase B (Akt) and the mammalian target of rapamycin complex 1 (mTORC1). Both Akt and mTORC1 can phosphorylate PRAS40. As a negative regulator of mTORC1, PRAS40 prevents the ...

Abstract	Proline-rich Akt substrate 40kDa (PRAS40) bridges cell signaling between protein kinase B (Akt) and the mammalian target of rapamycin complex 1 (mTORC1). Both Akt and mTORC1 can phosphorylate PRAS40. As a negative regulator of mTORC1, PRAS40 prevents the binding of mTOR to its substrates. The phosphorylation of PRAS40 results in its dissociation from mTORC1 and enhanced mTOR activation. PRAS40 in conjunction with mTORC1 has been closely associated with programmed cell death and is implicated in diabetes mellitus (DM), cardiovascular diseases, cancer, and neurological diseases. Thus, targeting PRAS40 might hold great promise for innovative therapeutic strategies for these diseases.
Language	English
Publishing date	2016-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2016.04.005
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Article: S100B raises the alert in subarachnoid hemorrhage.

Chong, Zhao Zhong

Reviews in the neurosciences

2016 Volume 27, Issue 7, Page(s) 745–759

Abstract: Subarachnoid hemorrhage (SAH) is a devastating disease with high mortality and mobility, the novel therapeutic strategies of which are essentially required. The calcium binding protein S100B has emerged as a brain injury biomarker that is implicated in ... ...

Abstract	Subarachnoid hemorrhage (SAH) is a devastating disease with high mortality and mobility, the novel therapeutic strategies of which are essentially required. The calcium binding protein S100B has emerged as a brain injury biomarker that is implicated in pathogenic process of SAH. S100B is mainly expressed in astrocytes of the central nervous system and functions through initiating intracellular signaling or via interacting with cell surface receptor, such as the receptor of advanced glycation end products. The biological roles of S100B in neurons have been closely associated with its concentrations, resulting in either neuroprotection or neurotoxicity. The levels of S100B in the blood have been suggested as a biomarker to predict the progress or the prognosis of SAH. The role of S100B in the development of cerebral vasospasm and brain damage may result from the induction of oxidative stress and neuroinflammation after SAH. To get further insight into mechanisms underlying the role of S100B in SAH based on this review might help us to find novel therapeutic targets for SAH.
Language	English
Publishing date	2016-10-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639035-3
ISSN	2191-0200 ; 0334-1763
ISSN (online)	2191-0200
ISSN	0334-1763
DOI	10.1515/revneuro-2016-0021
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Article ; Online: Fuzzy sliding mode control of piezo-driven stage.

Fang, Jiwen / Zhao, Jiuchun / Zhang, Lufan / Li, Chong / Zhong, Wei / Zhang, Lianren

The Review of scientific instruments

2022 Volume 93, Issue 1, Page(s) 15011

Abstract: The motion stage with flexible hinges as a guiding mechanism can realize nanometer-level precision positioning. This stage uses a piezoelectric (PZT) actuator as the driving unit. In order to describe the mechanical characteristics of this piezo-driven ... ...

Abstract	The motion stage with flexible hinges as a guiding mechanism can realize nanometer-level precision positioning. This stage uses a piezoelectric (PZT) actuator as the driving unit. In order to describe the mechanical characteristics of this piezo-driven stage, a double-parallel four-bar mechanism based on eight flexible hinges is analyzed. The natural frequency and modal of this stage are analyzed with the finite element method. In order to reduce the hysteresis influence of the PZT actuator, the model parameters based on the Bouc-Wen hysteresis model are identified by using the particle swarm optimization algorithm, and the boundedness of the hysteresis phenomenon is determined by this model. On this basis, the PZT hysteresis is regarded as a disturbance, and a proportional-integral-differential (PID)-type fuzzy sliding mode control (FSMC) is designed. Taking errors and the derivation in the errors as input and the parameters of the PID sliding surface as the output, the fuzzy sliding mode function is constructed. In addition, taking the absolute value of the sliding mode function as the input and the adjustment factor of the switching control as the output, the fuzzy switching control is constructed. Finally, the effectiveness of the FSMC is verified through several experiments.
Language	English
Publishing date	2022-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0075029
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Article ; Online: Autoantibodies in COVID-19: frequency and function.

Gao, Zhao-Wei / Zhang, Hui-Zhong / Liu, Chong / Dong, Ke

Autoimmunity reviews

2021 Volume 20, Issue 3, Page(s) 102754

MeSH term(s)	Autoantibodies ; COVID-19 ; Humans ; SARS-CoV-2
Chemical Substances	Autoantibodies
Language	English
Publishing date	2021-01-18
Publishing country	Netherlands
Document type	Letter
ZDB-ID	2144145-5
ISSN	1873-0183 ; 1568-9972
ISSN (online)	1873-0183
ISSN	1568-9972
DOI	10.1016/j.autrev.2021.102754
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