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  1. Article ; Online: Masatoshi Koshiba (1926-2020).

    Nakahata, Masayuki / Suzuki, Atsuto

    Science (New York, N.Y.)

    2021  Volume 371, Issue 6527, Page(s) 349

    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abg1561
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  2. Article ; Online: Resuming automated peritoneal dialysis after laparoscopic peritoneal wall anchoring for peritoneal dialysis catheter fixation.

    Matsunami, Masatoshi / Suzuki, Tomo / Suzuki, Koichiro / Kuji, Hiroshi

    Journal of nephrology

    2024  

    Language English
    Publishing date 2024-03-21
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-024-01917-8
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  3. Article ; Online: Sphere-Based Expansion of Myogenic Progenitors from Human Pluripotent Stem Cells.

    Reilly, Megan / Robertson, Samantha / Suzuki, Masatoshi

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2640, Page(s) 159–174

    Abstract: The protocol presented here is to derive, maintain, and differentiate human pluripotent stem cells into skeletal muscle progenitor/stem cells (myogenic progenitors) using a sphere-based culture approach. This sphere-based culture is an attractive method ... ...

    Abstract The protocol presented here is to derive, maintain, and differentiate human pluripotent stem cells into skeletal muscle progenitor/stem cells (myogenic progenitors) using a sphere-based culture approach. This sphere-based culture is an attractive method for maintaining progenitor cells due to their longevity and the presence of cell-cell interactions and molecules. Large numbers of cells can be expanded in culture using this method, which represents a valuable source for cell-based tissue modeling and regenerative medicine.
    MeSH term(s) Humans ; Induced Pluripotent Stem Cells ; Cell Differentiation ; Pluripotent Stem Cells ; Muscle Fibers, Skeletal ; Satellite Cells, Skeletal Muscle ; Muscle, Skeletal ; Muscle Development
    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3036-5_12
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  4. Article: Comparison of mol-ecular structures of

    Mori, Masatoshi / Suzuki, Takayoshi

    Acta crystallographica. Section E, Crystallographic communications

    2020  Volume 76, Issue Pt 12, Page(s) 1813–1817

    Abstract: The crystal structures of the complexes ( ...

    Abstract The crystal structures of the complexes (
    Language English
    Publishing date 2020-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 2056-9890 ; 1600-5368
    ISSN 2056-9890 ; 1600-5368
    DOI 10.1107/S2056989020014437
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  5. Article ; Online: Growth rate estimation by 210Pb chronology in precious corals collected off the southern coast of Japan

    Masatoshi Yamada / Atsushi Suzuki / Nozomu Iwasaki

    Frontiers in Marine Science, Vol

    2023  Volume 10

    Abstract: The Lead 210 (210Pb) concentrations were determined to estimate the skeletal growth rates in the four species of precious corals including Japanese red coral (Corallium japonicum), pink coral (Pleurocorallium elatius), white coral (P. konojoi), and a ... ...

    Abstract The Lead 210 (210Pb) concentrations were determined to estimate the skeletal growth rates in the four species of precious corals including Japanese red coral (Corallium japonicum), pink coral (Pleurocorallium elatius), white coral (P. konojoi), and a deep-sea coral (Coralliidae sp.), and in a bamboo coral (Keratoisis sp.). Colonies were collected from the southern coast of Japan, western North Pacific margin. The 210Pb concentrations typically showed the exponential decrease with distance from the edge to the center of the skeleton axis in a cross section of main stem of colonies. The mean radial growth rates for colonies were estimated from the slopes of the best fit curves for exponential decrease in 210Pb concentration along the multiple transects. The obtained mean and standard deviation of radial growth rates in the diameter (the number of transects, n) for three colonies of C. japonicum were 0.31 mm/y (n = 1), 0.21 ± 0.05 mm/y (n = 2), and 0.36 ± 0.13 mm/y (n = 2), respectively, which were broadly comparable to the previously reported growth rates obtained by growth ring counting. Those obtained for three white coral colonies were 0.52 mm/y (n = 1), 0.60 mm/y (n = 1), and 0.36 ± 0.25 mm/y (n = 2). The radial growth rate for the bamboo coral colony was 0.13 mm/y in radius. The linear growth of the main steam of some colonies was analyzed from several cross sections. The linear growth rates of colonies could be estimated from the slope of the best fit curve (1) for increasing mean 210Pb concentration along the cross transects of the axis and (2) for increasing center 210Pb concentration of the skeleton axis. The linear growth rates calculated from the mean and center concentrations for two C. japonicum colonies were 8.5 and 6.1 mm/y, and 1.8 and 1.4 mm/y, respectively. Those for a P. elatius colony were 4.7 and 3.4 mm/y. The difference between the two estimates may reflect the morphological structure of the skeleton. The growth rates measured for the radial increase and linear extension of the main stem of ...
    Keywords Japanese red coral ; white coral ; pink coral ; deep-sea coral ; bamboo coral ; radial growth rate ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
    Subject code 590
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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  6. Article ; Online: Humoral response after a fourth "booster" dose of coronavirus disease 2019 vaccination and outcome of Japan's seventh wave of coronavirus disease 2019 infections in hemodialysis patients: A single-center experience.

    Matsunami, Masatoshi / Suzuki, Tomo / Kuji, Hiroshi

    Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy

    2022  Volume 27, Issue 3, Page(s) 597–598

    MeSH term(s) Humans ; Japan ; COVID-19 ; Vaccination ; Renal Dialysis
    Language English
    Publishing date 2022-12-01
    Publishing country Australia
    Document type Letter
    ZDB-ID 2119809-3
    ISSN 1744-9987 ; 1091-6660 ; 1744-9979
    ISSN (online) 1744-9987
    ISSN 1091-6660 ; 1744-9979
    DOI 10.1111/1744-9987.13953
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  7. Article ; Online: Assessment of oral methotrexate intolerance in Japanese adult patients with rheumatoid arthritis.

    Kanda, Masatoshi / Sato, Mayumi / Nagahata, Ken / Naishiro, Yasuyoshi / Murakami, Rieko / Honda, Saho / Suzuki, Chisako

    International journal of rheumatic diseases

    2024  Volume 27, Issue 1, Page(s) e15029

    Abstract: Aim: The objective of this study was to assess the gastrointestinal side (GI) effects of oral methotrexate (MTX) in Japanese adult patients with rheumatoid arthritis (RA).: Methods: In this single-center retrospective study, 112 Japanese adult ... ...

    Abstract Aim: The objective of this study was to assess the gastrointestinal side (GI) effects of oral methotrexate (MTX) in Japanese adult patients with rheumatoid arthritis (RA).
    Methods: In this single-center retrospective study, 112 Japanese adult patients (over 18 years old) with RA were examined by Methotrexate Intolerance and Severity assessment in Adults (MISA) questionnaire.
    Results: Forty-five (40.2%) of patients were MTX intolerant (MISA score ≥1). Twelve patients (11.2%) were moderate-to-severe MTX intolerant (MISA cross-product score ≥4). The most common GI side effects of MTX were gastric discomfort (26.8%), followed by loss of appetite or dysgeusia (14.3%), fatigue and lethargy (12.5%), and nausea (10.7%).
    Conclusions: Japanese adult patients with RA showed a high prevalence of MTX intolerance even in low-dose oral MTX. The MISA questionnaire was practical for finding patients with MTX intolerance.
    MeSH term(s) Adult ; Humans ; Adolescent ; Methotrexate/therapeutic use ; Antirheumatic Agents/therapeutic use ; Retrospective Studies ; Japan ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/chemically induced ; Treatment Outcome
    Chemical Substances Methotrexate (YL5FZ2Y5U1) ; Antirheumatic Agents
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.15029
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    Zs.A 6098: Show issues Location:
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  8. Article ; Online: An engineered in vitro model of the human myotendinous junction.

    Josvai, Mitchell / Polyak, Erzsebet / Kalluri, Meghana / Robertson, Samantha / Crone, Wendy C / Suzuki, Masatoshi

    Acta biomaterialia

    2024  

    Abstract: The myotendinous junction (MTJ) is a vulnerable region at the interface of skeletal muscle and tendon that forms an integrated mechanical unit. This study presents a technique for the spatially restrictive co-culture of human embryonic stem cell (hESC)- ... ...

    Abstract The myotendinous junction (MTJ) is a vulnerable region at the interface of skeletal muscle and tendon that forms an integrated mechanical unit. This study presents a technique for the spatially restrictive co-culture of human embryonic stem cell (hESC)-derived skeletal myocytes and primary tenocytes for two-dimensional modeling of the MTJ. Micropatterned lanes of extracellular matrix and a 2-well culture chamber define the initial regions of occupation. On day 1, both lines occupy less than 20 % of the initially vacant interstitial zone, referred to henceforth as the junction. Myocyte-tenocyte interdigitations are observed by day 7. Immunocytochemistry reveals enhanced organization and alignment of patterned myocyte and tenocyte features, as well as differential expression of multiple MTJ markers. On day 24, electrically stimulated junction myocytes demonstrate negative contractile strains, while positive tensile strains are exhibited by mechanically passive tenocytes at the junction. Unpatterned tenocytes distal to the junction experience significantly decreased strains in comparison to cells at the interface. Unpatterned myocytes have impaired organization and uncoordinated contractile behavior. These findings suggest that this platform is capable of inducing myocyte-tenocyte junction formation and mechanical coupling similar to the native MTJ, showing transduction of force across the cell-cell interface. STATEMENT OF SIGNIFICANCE: The myotendinous junction (MTJ) is an integrated structure that transduces force across the muscle-tendon boundary, making the region vulnerable to strain injury. Despite the clinical relevance, previous in vitro models of the MTJ lack the structure and mechanical accuracy of the native tissue and have difficulty transmitting force across the cell-cell interface. This study demonstrates an in vitro model of the MTJ, using spatially restrictive cues to inform human myocyte-tenocyte interactions and architecture. The model expressed MTJ markers and developed anisotropic myocyte-tenocyte integrations that resemble the native tissue and allow for force transduction from contracting myocytes to passive tenocyte regions. As such, this study presents a system capable of investigating development, injury, and pathology in the human MTJ.
    Language English
    Publishing date 2024-04-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2024.04.007
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  9. Article ; Online: Delayed kinetics of SARS-CoV-2 IgG antibody production in kidney transplant recipients following the third dose of COVID-19 vaccination.

    Matsunami, Masatoshi / Suzuki, Tomo / Yashima, Jun / Kuji, Hiroshi / Matsue, Kosei

    Clinical and experimental nephrology

    2022  

    Language English
    Publishing date 2022-08-05
    Publishing country Japan
    Document type Letter
    ZDB-ID 1338768-6
    ISSN 1437-7799 ; 1342-1751
    ISSN (online) 1437-7799
    ISSN 1342-1751
    DOI 10.1007/s10157-022-02261-6
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  10. Article: Relapsing Peritoneal Dialysis-Associated Peritonitis due to

    Nakata, Mayumi / Kuji, Hiroshi / Toishi, Takumi / Inoue, Tomohiko / Kawaji, Atsuro / Matsunami, Masatoshi / Fukuda, Junko / Ohara, Mamiko / Suzuki, Tomo

    Case reports in nephrology and dialysis

    2024  Volume 14, Issue 1, Page(s) 10–14

    Abstract: Introduction: The : Case presentation: The patient, a 78-year-old male, presented with turbid effluent PD fluid, accompanied by an elevated white blood cell count of 253 cells/μL, of which 59% were neutrophils. A diagnosis of PD-associated ... ...

    Abstract Introduction: The
    Case presentation: The patient, a 78-year-old male, presented with turbid effluent PD fluid, accompanied by an elevated white blood cell count of 253 cells/μL, of which 59% were neutrophils. A diagnosis of PD-associated peritonitis was established, leading to the initiation of intraperitoneal administration of ceftazidime and vancomycin. Subsequently,
    Conclusion: PD-associated peritonitis attributed to
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2809879-1
    ISSN 2296-9705
    ISSN 2296-9705
    DOI 10.1159/000534765
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