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  1. Article: Nasal Dorsum Rotation-Transposition Flap Associated with Guitar-String Sutures: One-Stage Reconstruction of Large Defects on the Nose.

    Antoñanzas, Javier / Tomás-Velázquez, Alejandra / Salido-Vallejo, Rafael / Redondo, Pedro

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: 1) ...

    Abstract (1)
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051404
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  2. Article: Variation in responses to incretin therapy: Modifiable and non-modifiable factors.

    Austin, Gregory O / Tomas, Alejandra

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1170181

    Abstract: Type 2 diabetes (T2D) and obesity have reached epidemic proportions. Incretin therapy is the second line of treatment for T2D, improving both blood glucose regulation and weight loss. Glucagon-like peptide-1 (GLP-1) and glucose-stimulated insulinotropic ... ...

    Abstract Type 2 diabetes (T2D) and obesity have reached epidemic proportions. Incretin therapy is the second line of treatment for T2D, improving both blood glucose regulation and weight loss. Glucagon-like peptide-1 (GLP-1) and glucose-stimulated insulinotropic polypeptide (GIP) are the incretin hormones that provide the foundations for these drugs. While these therapies have been highly effective for some, the results are variable. Incretin therapies target the class B G protein-coupled receptors GLP-1R and GIPR, expressed mainly in the pancreas and the hypothalamus, while some therapeutical approaches include additional targeting of the related glucagon receptor (GCGR) in the liver. The proper functioning of these receptors is crucial for incretin therapy success and here we review several mechanisms at the cellular and molecular level that influence an individual's response to incretin therapy.
    Language English
    Publishing date 2023-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1170181
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Variation in responses to incretin therapy

    Gregory O. Austin / Alejandra Tomas

    Frontiers in Molecular Biosciences, Vol

    Modifiable and non-modifiable factors

    2023  Volume 10

    Abstract: Type 2 diabetes (T2D) and obesity have reached epidemic proportions. Incretin therapy is the second line of treatment for T2D, improving both blood glucose regulation and weight loss. Glucagon-like peptide-1 (GLP-1) and glucose-stimulated insulinotropic ... ...

    Abstract Type 2 diabetes (T2D) and obesity have reached epidemic proportions. Incretin therapy is the second line of treatment for T2D, improving both blood glucose regulation and weight loss. Glucagon-like peptide-1 (GLP-1) and glucose-stimulated insulinotropic polypeptide (GIP) are the incretin hormones that provide the foundations for these drugs. While these therapies have been highly effective for some, the results are variable. Incretin therapies target the class B G protein-coupled receptors GLP-1R and GIPR, expressed mainly in the pancreas and the hypothalamus, while some therapeutical approaches include additional targeting of the related glucagon receptor (GCGR) in the liver. The proper functioning of these receptors is crucial for incretin therapy success and here we review several mechanisms at the cellular and molecular level that influence an individual’s response to incretin therapy.
    Keywords incretin—based therapy ; GLP-1 (glucagon-like peptide-1) ; GIP (glucose-dependent insulinotropic polypeptide) ; T2D (type 2 diabetes) ; obesity ; incretin receptors ; Biology (General) ; QH301-705.5
    Subject code 612
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Multiple Firm Papules on the Face of a Young Man.

    Marcillo-Alvarez, Johanna / Tomás-Velázquez, Alejandra / Antoñanzas, Javier / Salido-Vallejo, Rafael

    Indian journal of dermatology

    2023  Volume 67, Issue 6, Page(s) 832–833

    Language English
    Publishing date 2023-03-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
    ISSN (online) 1998-3611
    ISSN 0019-5154
    DOI 10.4103/ijd.ijd_388_21
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  5. Article ; Online: [No title information]

    Tomás-Velázquez, Alejandra / Redondo, Pedro

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2020  Volume 18, Issue 5, Page(s) 512–515

    Title translation Streben nach Symmetrie bei der Rekonstruktion des apikalen Oberlippendreiecks mit einem Hatchet flap.
    Language German
    Publishing date 2020-05-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14085_g
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  6. Article ; Online: Appreciating the potential for GPCR crosstalk with ion channels.

    Davies, Amy / Tomas, Alejandra

    Progress in molecular biology and translational science

    2022  Volume 195, Page(s) 101–120

    Abstract: G protein-coupled receptors (GPCRs) are expressed by most tissues in the body and are exploited pharmacologically in a variety of pathological conditions including diabetes, cardiovascular disease, neurological diseases, and cancers. Numerous cell ... ...

    Abstract G protein-coupled receptors (GPCRs) are expressed by most tissues in the body and are exploited pharmacologically in a variety of pathological conditions including diabetes, cardiovascular disease, neurological diseases, and cancers. Numerous cell signaling pathways can be regulated by GPCR activation, depending on the specific GPCR, ligand and cell type. Ion channels are among the many effector proteins downstream of these signaling pathways. Saliently, ion channels are also recognized as druggable targets, and there is evidence that their activity may regulate GPCR function via membrane potential and cytoplasmic ion concentration. Overall, there appears to be a large potential for crosstalk between ion channels and GPCRs. This might have implications not only for targeting GPCRs for drug development, but also opens the possibility of co-targeting them with ion channels to achieve improved therapeutic outcomes. In this review, we highlight the large variety of possible GPCR-ion channel crosstalk modes.
    MeSH term(s) Humans ; Cardiovascular Diseases/metabolism ; Ion Channels/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction ; Receptor Cross-Talk/physiology
    Chemical Substances Ion Channels ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2022-07-25
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 2471995-X
    ISSN 1878-0814 ; 0079-6603 ; 1877-1173
    ISSN (online) 1878-0814
    ISSN 0079-6603 ; 1877-1173
    DOI 10.1016/bs.pmbts.2022.06.013
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  7. Article: Enhancing Lower Extremity Defect Coverage: High Viability Ultra-Thin Split-Thickness Skin Grafts Obtained from the Scalp.

    Tomás-Velázquez, Alejandra / Antoñanzas, Javier / Salido-Vallejo, Rafael / Redondo, Pedro

    Journal of clinical medicine

    2023  Volume 12, Issue 19

    Abstract: Background: Repairing lower extremity defects presents challenges due to the scarcity of available local tissue. Skin grafting is a widely employed technique for addressing non-healing ulcers, improving the quality of life of patients and minimizing ... ...

    Abstract Background: Repairing lower extremity defects presents challenges due to the scarcity of available local tissue. Skin grafting is a widely employed technique for addressing non-healing ulcers, improving the quality of life of patients and minimizing discomfort. However, using traditional donor sites, such as the thigh, can hinder mobility and result in noticeable scarring and pigmentation changes.
    Objectives: This study aims to assess the effectiveness of a novel approach utilizing autologous ultra-thin split-thickness skin grafts (STSGs) harvested from the scalp using a disposable, commercially available razor blade named DermaBlade.
    Methods: Fifteen patients (median age: 72 years, eight males and seven females) with diverse lower limb lesions, including carcinomas and ulcers of varying etiologies, were prospectively enrolled. Donor sites included the sideburn extending to the hairy temporal skin (nine cases) and hairy occipital skin (six cases). Ultra-thin skin strips (<0.2 mm thick) were obtained from the scalp through the use of the disposable flexible blade DermaBlade. The strips were positioned over the receptor area with no sutures in most cases and secured using dressings. A substantial majority of patients (90%) achieved successful graft take with no complications. Swift re-epithelialization occurred within a median of 12 days for the donor site and 24 days for the receptor site. No hair transfer or alopecic scars were noted.
    Conclusions: In contrast to traditional grafting methods, DermaBlade-assisted scalp grafting yields highly viable STSGs that adhere to wound beds without the need for sutures. Notable advantages of this technique encompass rapid wound healing, minimal complications, and superior cosmetic outcomes. Furthermore, it avoids scarring and alopecia, making it a promising approach for addressing lower extremity defects.
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12196109
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  8. Article ; Online: Pursuing symmetry in reconstruction of the upper lip apical triangle with a hatchet flap.

    Tomás-Velázquez, Alejandra / Redondo, Pedro

    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG

    2020  Volume 18, Issue 5, Page(s) 512–515

    MeSH term(s) Carcinoma, Basal Cell/surgery ; Humans ; Lip/surgery ; Lip Neoplasms/surgery ; Male ; Mohs Surgery ; Reconstructive Surgical Procedures/methods ; Surgical Flaps ; Treatment Outcome
    Language English
    Publishing date 2020-05-15
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 2093479-8
    ISSN 1610-0387 ; 1610-0379
    ISSN (online) 1610-0387
    ISSN 1610-0379
    DOI 10.1111/ddg.14085
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  9. Article ; Online: First winter record of Latrodectus mirabilis (Araneae: Theridiidae) in arid Patagonia: A consequence of climate change and urbanization?

    Zaffaroni, Facundo Tomas / Sandoval, Alejandra Esther / Marti, Gerardo Aníbal / Cheli, Germán Horacio

    Acta tropica

    2024  Volume 252, Page(s) 107147

    Abstract: Cases of araneism reported in the province of Chubut (Argentina) have tripled in the last two decades, and almost 80 % of them involve Latrodectus mirabilis (Holmberg) (Araneae: Theridiidae). According to descriptions of the life cycle of this species in ...

    Abstract Cases of araneism reported in the province of Chubut (Argentina) have tripled in the last two decades, and almost 80 % of them involve Latrodectus mirabilis (Holmberg) (Araneae: Theridiidae). According to descriptions of the life cycle of this species in Argentina, the low temperatures typical of autumn-winter cause the death of all adult spiders, so that no adult specimens of L. mirabilis are observed in winter. Field samplings, observations by the Grupo de Entomología Patagónica (GENTPAT, IPEEC CCT CENPAT CONICET), and citizen reports for more than 15 years suggested a similar cycle in northeastern Patagonia. However, for the last three consecutive years, we have recorded adult females in the field throughout the Patagonian winter. Some of these individuals even survived the winter and were alive the following spring. The purpose of this note is to report the field presence of adult female specimens of L. mirabilis in the outskirts of the city of Puerto Madryn (Chubut, Argentina) during the last three consecutive winters corresponding to the years 2021, 2022 and 2023; and to note that at least two of them survived the winter, arriving alive (and in good condition) the following spring. Given the medical importance of this spider, the publication of this information, the context of the findings, and their ecological implications will help to prevent its spread and reduce the likelihood of accidents.
    MeSH term(s) Humans ; Animals ; Adult ; Female ; Mirabilis ; Urbanization ; Climate Change ; Spiders ; Seasons
    Language English
    Publishing date 2024-02-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 210415-5
    ISSN 1873-6254 ; 0001-706X
    ISSN (online) 1873-6254
    ISSN 0001-706X
    DOI 10.1016/j.actatropica.2024.107147
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  10. Article ; Online: Lipid regulation of the glucagon receptor family.

    Oqua, Affiong Ika / Manchanda, Yusman / McGlone, Emma Rose / Jones, Ben / Rouse, Sarah / Tomas, Alejandra

    The Journal of endocrinology

    2024  

    Abstract: The glucagon receptor family are typical class B1 G protein-coupled receptors (GPCRs) with important roles in metabolism, including the control of pancreas, brain, and liver function. As proteins with 7 transmembrane domains, GPCRs are intimately in ... ...

    Abstract The glucagon receptor family are typical class B1 G protein-coupled receptors (GPCRs) with important roles in metabolism, including the control of pancreas, brain, and liver function. As proteins with 7 transmembrane domains, GPCRs are intimately in contact with lipid bilayers and therefore can be putatively regulated by interactions with their lipidic components, including cholesterol, sphingolipids, and other lipid species. Additionally, these receptors, as well as the agonists they bind to, can undergo lipid modifications, which can influence their binding capacity and/or elicit modified or biased signalling profiles. While the effect of lipids, and in particular cholesterol, has been widely studied for other GPCR classes, information about their role in regulating the glucagon receptor family is only beginning to emerge. Here we summarise our current knowledge on the effects of cholesterol modulation of glucagon receptor family signalling and trafficking profiles, as well as existing evidence for specific lipid-receptor binding and indirect effects of lipids via lipid modification of cognate agonists. Finally, we discuss the different methodologies that can be employed to study lipid-receptor interactions and summarise the importance of this area of investigation to increase our understanding of the biology of this family of metabolically relevant receptors.
    Language English
    Publishing date 2024-04-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 3028-4
    ISSN 1479-6805 ; 0022-0795
    ISSN (online) 1479-6805
    ISSN 0022-0795
    DOI 10.1530/JOE-23-0335
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