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  1. Article ; Online: Stressing the giant: a new approach to understanding dilated cardiomyopathy.

    Greaser, Marion Lewis

    Journal of molecular and cellular cardiology

    2009  Volume 47, Issue 3, Page(s) 347–349

    MeSH term(s) Alleles ; Cardiomyopathy, Dilated/diagnosis ; Cardiomyopathy, Dilated/genetics ; Connectin ; DNA Mutational Analysis ; DNA, Complementary/metabolism ; Exons ; Heterozygote ; Homozygote ; Humans ; Models, Biological ; Models, Genetic ; Muscle Proteins/genetics ; Mutation ; Myocardium/pathology ; Phenotype ; Protein Kinases/genetics ; Up-Regulation
    Chemical Substances Connectin ; DNA, Complementary ; Muscle Proteins ; TTN protein, human ; Protein Kinases (EC 2.7.-)
    Language English
    Publishing date 2009-06-22
    Publishing country England
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1016/j.yjmcc.2009.06.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Titin Isoform Size is Not Correlated with Thin Filament Length in Rat Skeletal Muscle

    MarionLewisGreaser

    Frontiers in Physiology, Vol

    2014  Volume 5

    Abstract: The mechanisms controlling thin filament length in muscle remain controversial. It was recently reported that thin filament length was related to titin size, and that the latter might be involved in thin filament length determination. Titin plays several ...

    Abstract The mechanisms controlling thin filament length in muscle remain controversial. It was recently reported that thin filament length was related to titin size, and that the latter might be involved in thin filament length determination. Titin plays several crucial roles in the sarcomere, but its function as it pertains to the thin filament has not been explored. We tested this relationship using several muscles from wild type rats and from a mutant rat model which results in increased titin size. Myofibrils were isolated from skeletal muscles (extensor digitorum longus, external oblique, gastrocnemius, longissimus dorsi, psoas major, and tibialis anterior) using both adult wild type (WT) and homozygous mutant (HM) rats. Phalloidin and antibodies against tropomodulin-4 and nebulin’s N-terminus were used to determine thin filament length. The WT rats studied express skeletal muscle titin sizes ranging from 3.2 to 3.7 MDa, while the HM rats express a giant titin isoform sized at 3.7 MDa. No differences in phalloidin-based thin filament length, nebulin N terminus distances from the Z line, or tropomodulin distances from the Z line were observed across genotypes. The data indicates that, although titin performs many sarcomeric functions, its correlation with thin filament length and structure could not be demonstrated in the rat. Current models of thin filament assembly are inadequate to explain the phalloidin, nebulin N terminus, and tropomodulin staining patterns in the myofibril.
    Keywords Tropomodulin ; Actin ; Titin ; phalloidin ; thin filament length ; Physiology ; QP1-981 ; Science ; Q
    Subject code 612
    Language English
    Publishing date 2014-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: The genome sequence of taurine cattle: a window to ruminant biology and evolution.

    Elsik, Christine G / Tellam, Ross L / Worley, Kim C / Gibbs, Richard A / Muzny, Donna M / Weinstock, George M / Adelson, David L / Eichler, Evan E / Elnitski, Laura / Guigó, Roderic / Hamernik, Debora L / Kappes, Steve M / Lewin, Harris A / Lynn, David J / Nicholas, Frank W / Reymond, Alexandre / Rijnkels, Monique / Skow, Loren C / Zdobnov, Evgeny M /
    Schook, Lawrence / Womack, James / Alioto, Tyler / Antonarakis, Stylianos E / Astashyn, Alex / Chapple, Charles E / Chen, Hsiu-Chuan / Chrast, Jacqueline / Câmara, Francisco / Ermolaeva, Olga / Henrichsen, Charlotte N / Hlavina, Wratko / Kapustin, Yuri / Kiryutin, Boris / Kitts, Paul / Kokocinski, Felix / Landrum, Melissa / Maglott, Donna / Pruitt, Kim / Sapojnikov, Victor / Searle, Stephen M / Solovyev, Victor / Souvorov, Alexandre / Ucla, Catherine / Wyss, Carine / Anzola, Juan M / Gerlach, Daniel / Elhaik, Eran / Graur, Dan / Reese, Justin T / Edgar, Robert C / McEwan, John C / Payne, Gemma M / Raison, Joy M / Junier, Thomas / Kriventseva, Evgenia V / Eyras, Eduardo / Plass, Mireya / Donthu, Ravikiran / Larkin, Denis M / Reecy, James / Yang, Mary Q / Chen, Lin / Cheng, Ze / Chitko-McKown, Carol G / Liu, George E / Matukumalli, Lakshmi K / Song, Jiuzhou / Zhu, Bin / Bradley, Daniel G / Brinkman, Fiona S L / Lau, Lilian P L / Whiteside, Matthew D / Walker, Angela / Wheeler, Thomas T / Casey, Theresa / German, J Bruce / Lemay, Danielle G / Maqbool, Nauman J / Molenaar, Adrian J / Seo, Seongwon / Stothard, Paul / Baldwin, Cynthia L / Baxter, Rebecca / Brinkmeyer-Langford, Candice L / Brown, Wendy C / Childers, Christopher P / Connelley, Timothy / Ellis, Shirley A / Fritz, Krista / Glass, Elizabeth J / Herzig, Carolyn T A / Iivanainen, Antti / Lahmers, Kevin K / Bennett, Anna K / Dickens, C Michael / Gilbert, James G R / Hagen, Darren E / Salih, Hanni / Aerts, Jan / Caetano, Alexandre R / Dalrymple, Brian / Garcia, Jose Fernando / Gill, Clare A / Hiendleder, Stefan G / Memili, Erdogan / Spurlock, Diane / Williams, John L / Alexander, Lee / Brownstein, Michael J / Guan, Leluo / Holt, Robert A / Jones, Steven J M / Marra, Marco A / Moore, Richard / Moore, Stephen S / Roberts, Andy / Taniguchi, Masaaki / Waterman, Richard C / Chacko, Joseph / Chandrabose, Mimi M / Cree, Andy / Dao, Marvin Diep / Dinh, Huyen H / Gabisi, Ramatu Ayiesha / Hines, Sandra / Hume, Jennifer / Jhangiani, Shalini N / Joshi, Vandita / Kovar, Christie L / Lewis, Lora R / Liu, Yih-Shin / Lopez, John / Morgan, Margaret B / Nguyen, Ngoc Bich / Okwuonu, Geoffrey O / Ruiz, San Juana / Santibanez, Jireh / Wright, Rita A / Buhay, Christian / Ding, Yan / Dugan-Rocha, Shannon / Herdandez, Judith / Holder, Michael / Sabo, Aniko / Egan, Amy / Goodell, Jason / Wilczek-Boney, Katarzyna / Fowler, Gerald R / Hitchens, Matthew Edward / Lozado, Ryan J / Moen, Charles / Steffen, David / Warren, James T / Zhang, Jingkun / Chiu, Readman / Schein, Jacqueline E / Durbin, K James / Havlak, Paul / Jiang, Huaiyang / Liu, Yue / Qin, Xiang / Ren, Yanru / Shen, Yufeng / Song, Henry / Bell, Stephanie Nicole / Davis, Clay / Johnson, Angela Jolivet / Lee, Sandra / Nazareth, Lynne V / Patel, Bella Mayurkumar / Pu, Ling-Ling / Vattathil, Selina / Williams, Rex Lee / Curry, Stacey / Hamilton, Cerissa / Sodergren, Erica / Wheeler, David A / Barris, Wes / Bennett, Gary L / Eggen, André / Green, Ronnie D / Harhay, Gregory P / Hobbs, Matthew / Jann, Oliver / Keele, John W / Kent, Matthew P / Lien, Sigbjørn / McKay, Stephanie D / McWilliam, Sean / Ratnakumar, Abhirami / Schnabel, Robert D / Smith, Timothy / Snelling, Warren M / Sonstegard, Tad S / Stone, Roger T / Sugimoto, Yoshikazu / Takasuga, Akiko / Taylor, Jeremy F / Van Tassell, Curtis P / Macneil, Michael D / Abatepaulo, Antonio R R / Abbey, Colette A / Ahola, Virpi / Almeida, Iassudara G / Amadio, Ariel F / Anatriello, Elen / Bahadue, Suria M / Biase, Fernando H / Boldt, Clayton R / Carroll, Jeffery A / Carvalho, Wanessa A / Cervelatti, Eliane P / Chacko, Elsa / Chapin, Jennifer E / Cheng, Ye / Choi, Jungwoo / Colley, Adam J / de Campos, Tatiana A / De Donato, Marcos / Santos, Isabel K F de Miranda / de Oliveira, Carlo J F / Deobald, Heather / Devinoy, Eve / Donohue, Kaitlin E / Dovc, Peter / Eberlein, Annett / Fitzsimmons, Carolyn J / Franzin, Alessandra M / Garcia, Gustavo R / Genini, Sem / Gladney, Cody J / Grant, Jason R / Greaser, Marion L / Green, Jonathan A / Hadsell, Darryl L / Hakimov, Hatam A / Halgren, Rob / Harrow, Jennifer L / Hart, Elizabeth A / Hastings, Nicola / Hernandez, Marta / Hu, Zhi-Liang / Ingham, Aaron / Iso-Touru, Terhi / Jamis, Catherine / Jensen, Kirsty / Kapetis, Dimos / Kerr, Tovah / Khalil, Sari S / Khatib, Hasan / Kolbehdari, Davood / Kumar, Charu G / Kumar, Dinesh / Leach, Richard / Lee, Justin C-M / Li, Changxi / Logan, Krystin M / Malinverni, Roberto / Marques, Elisa / Martin, William F / Martins, Natalia F / Maruyama, Sandra R / Mazza, Raffaele / McLean, Kim L / Medrano, Juan F / Moreno, Barbara T / Moré, Daniela D / Muntean, Carl T / Nandakumar, Hari P / Nogueira, Marcelo F G / Olsaker, Ingrid / Pant, Sameer D / Panzitta, Francesca / Pastor, Rosemeire C P / Poli, Mario A / Poslusny, Nathan / Rachagani, Satyanarayana / Ranganathan, Shoba / Razpet, Andrej / Riggs, Penny K / Rincon, Gonzalo / Rodriguez-Osorio, Nelida / Rodriguez-Zas, Sandra L / Romero, Natasha E / Rosenwald, Anne / Sando, Lillian / Schmutz, Sheila M / Shen, Libing / Sherman, Laura / Southey, Bruce R / Lutzow, Ylva Strandberg / Sweedler, Jonathan V / Tammen, Imke / Telugu, Bhanu Prakash V L / Urbanski, Jennifer M / Utsunomiya, Yuri T / Verschoor, Chris P / Waardenberg, Ashley J / Wang, Zhiquan / Ward, Robert / Weikard, Rosemarie / Welsh, Thomas H / White, Stephen N / Wilming, Laurens G / Wunderlich, Kris R / Yang, Jianqi / Zhao, Feng-Qi

    Science (New York, N.Y.)

    2009  Volume 324, Issue 5926, Page(s) 522–528

    Abstract: To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which ... ...

    Abstract To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.
    MeSH term(s) Alternative Splicing ; Animals ; Animals, Domestic ; Biological Evolution ; Cattle ; Evolution, Molecular ; Female ; Genetic Variation ; Genome ; Humans ; Male ; MicroRNAs/genetics ; Molecular Sequence Data ; Proteins/genetics ; Sequence Analysis, DNA ; Species Specificity ; Synteny
    Chemical Substances MicroRNAs ; Proteins
    Language English
    Publishing date 2009-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.1169588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 77: Show issues

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