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  1. Article ; Online: Mechanical Transduction and the Dark Energy of Biology.

    Sachs, Frederick

    Biophysical journal

    2018  Volume 114, Issue 1, Page(s) 3–9

    MeSH term(s) Humans ; Ion Channels/metabolism ; Mechanotransduction, Cellular/drug effects
    Chemical Substances Ion Channels
    Language English
    Publishing date 2018-01-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2017.10.035
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  2. Book: Cardiac mechano-electric coupling and arrhythmias

    Kohl, Peter / Sachs, Frederick / Franz, Michael R.

    2011  

    Author's details Peter Kohl ; Frederick Sachs and Michael R. Franz
    Language English
    Size XXX, 477 S., [14] Bl. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    Old title 1. Aufl. u.d.T. Cardiac mechano-electric feedback and arrhythmias
    HBZ-ID HT016955455
    ISBN 978-0-19-957016-4 ; 0-19-957016-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2011 A 3529 order for loan Magazin

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  3. Article ; Online: Prospective exploration of the role of combined internalizing symptoms in self-reported memory among older adults during the COVID-19 pandemic.

    Carr, Dawn C / Schmidt, Brad / Schubert, Frederick T / Sachs-Ericsson, Natalie

    Aging & mental health

    2024  , Page(s) 1–9

    Abstract: Objectives: A growing literature suggests depression and anxiety increase risk of cognitive decline. However, few studies have examined their combined effects on cognition, among older adults, especially during periods of high stress.: Method: Based ... ...

    Abstract Objectives: A growing literature suggests depression and anxiety increase risk of cognitive decline. However, few studies have examined their combined effects on cognition, among older adults, especially during periods of high stress.
    Method: Based on a sample of community dwelling older adults (
    Results: In separate models, we found participants with depression scores at least 1-SD above the mean and participants with anxiety scores at least 2-SD above the mean to report a significant decline in SRM. Moderation analyses revealed those with high depressive symptoms (at or above the mean) showed a decrease in SRM regardless of anxiety. The extent to which high pre-pandemic anxiety symptoms influenced SRM is dependent on whether pre-pandemic depression was at or above the mean.
    Conclusions: Pre-pandemic depression predicted a decline in SRM regardless of anxiety. Moderation analyses revealed that the extent to which anxiety symptoms influenced SRM was dependent on depression being at or above the mean. Those with high anxiety and depression are at highest risk of experiencing cognitive consequences related to stressful exposures like COVID-19.
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1474804-6
    ISSN 1364-6915 ; 1360-7863
    ISSN (online) 1364-6915
    ISSN 1360-7863
    DOI 10.1080/13607863.2023.2297049
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  4. Article: Membrane tension.

    Chao, Pei-Chuan / Sachs, Frederick

    Current topics in membranes

    2021  Volume 88, Page(s) 189–203

    Abstract: The cell membrane serves as a barrier that restricts the rate of exchange of diffusible molecules. Tension in the membrane regulates many crucial cell functions involving shape changes and motility, cell signaling, endocytosis, and mechanosensation. ... ...

    Abstract The cell membrane serves as a barrier that restricts the rate of exchange of diffusible molecules. Tension in the membrane regulates many crucial cell functions involving shape changes and motility, cell signaling, endocytosis, and mechanosensation. Tension reflects the forces contributed by the lipid bilayer, the cytoskeleton, and the extracellular matrix. With a fluid-like bilayer model, membrane tension is presumed uniform and hence propagated instantaneously. In this review, we discuss techniques to measure the mean membrane tension and how to resolve the stresses in different components and consider the role of bilayer heterogeneity.
    MeSH term(s) Cell Membrane ; Cytoskeleton ; Endocytosis ; Lipid Bilayers ; Membranes
    Chemical Substances Lipid Bilayers
    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1063-5823
    ISSN 1063-5823
    DOI 10.1016/bs.ctm.2021.09.002
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  5. Article: Mechanical transduction by ion channels: A cautionary tale.

    Sachs, Frederick

    World journal of neurology

    2016  Volume 5, Issue 3, Page(s) 74–87

    Abstract: Mechanical transduction by ion channels occurs in all cells. The physiological functions of these channels have just begun to be elaborated, but if we focus on the upper animal kingdom, these channels serve the common sensory services such as hearing and ...

    Abstract Mechanical transduction by ion channels occurs in all cells. The physiological functions of these channels have just begun to be elaborated, but if we focus on the upper animal kingdom, these channels serve the common sensory services such as hearing and touch, provide the central nervous system with information on the force and position of muscles and joints, and they provide the autonomic system with information about the filling of hollow organs such as blood vessels. However, all cells of the body have mechanosensitive channels (MSCs), including red cells. Most of these channels are cation selective and are activated by bilayer tension. There are also K
    Language English
    Publishing date 2016-12-22
    Publishing country United States
    Document type Journal Article
    ISSN 2218-6212
    ISSN 2218-6212
    DOI 10.5316/wjn.v5.i3.74
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  6. Article ; Online: Physical memory of astrocytes.

    Shireen, Tasnim / Sachs, Frederick / Hua, Susan Z

    Brain research

    2022  Volume 1796, Page(s) 148076

    Abstract: Traumatic brain injury (TBI) is a major risk factor for development of neurodegenerative disorders later in life. Short, repetitive, mechanical impacts can lead to pathology that appears days or months later. The cells have a physical "memory" of ... ...

    Abstract Traumatic brain injury (TBI) is a major risk factor for development of neurodegenerative disorders later in life. Short, repetitive, mechanical impacts can lead to pathology that appears days or months later. The cells have a physical "memory" of mechanical events. The origin of this memory is not known. To examine the properties of this memory, we used a microfluidic chip to apply programmed fluid shear pulses to adherent adult rat astrocytes. These caused a transient rise in intracellular Ca
    MeSH term(s) Animals ; Astrocytes/pathology ; Brain Injuries, Traumatic/pathology ; Cytoskeleton ; Neurodegenerative Diseases/pathology ; Plastics ; Rats
    Chemical Substances Plastics
    Language English
    Publishing date 2022-09-07
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2022.148076
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  7. Book: Cardiac mechano-electric feedback and arrhythmias

    Kohl, Peter / Sachs, Frederick / Franz, Michael R.

    from pipette to patients

    2005  

    Author's details Peter Kohl ; Frederick Sachs ; Michael R. Franz
    Keywords Heart Conduction System / physiology ; Heart Conduction System / physiopathology ; Myocardium ; Feedback ; Arrhythmia
    Language English
    Size XXI, 423 S., [6] Bl. : zahlr. Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    New title 2. Aufl. u.d.T. Cardiac mechano-electric feedback and arrhythmias
    HBZ-ID HT014313425
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2005 A 3250 order for loan Magazin

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  8. Article ; Online: Effects of membrane viscoelasticity on the red blood cell dynamics in a microcapillary.

    Gürbüz, Ali / Pak, On Shun / Taylor, Michael / Sivaselvan, Mettupalayam V / Sachs, Frederick

    Biophysical journal

    2023  Volume 122, Issue 11, Page(s) 2230–2241

    Abstract: The mechanical properties of red blood cells (RBCs) play key roles in their biological functions in microcirculation. In particular, RBCs must deform significantly to travel through microcapillaries with sizes comparable with or even smaller than their ... ...

    Abstract The mechanical properties of red blood cells (RBCs) play key roles in their biological functions in microcirculation. In particular, RBCs must deform significantly to travel through microcapillaries with sizes comparable with or even smaller than their own. Although the dynamics of RBCs in microcapillaries have received considerable attention, the effect of membrane viscoelasticity has been largely overlooked. In this work, we present a computational study based on the boundary integral method and thin-shell mechanics to examine how membrane viscoelasticity influences the dynamics of RBCs flowing through straight and constricted microcapillaries. Our results reveal that the cell with a viscoelastic membrane undergoes substantially different motion and deformation compared with results based on a purely elastic membrane model. Comparisons with experimental data also suggest the importance of accounting for membrane viscoelasticity to properly capture the transient dynamics of an RBC flowing through a microcapillary. Taken together, these findings demonstrate the significant effects of membrane viscoelasticity on RBC dynamics in different microcapillary environments. The computational framework also lays the groundwork for more accurate quantitative modeling of the mechanical response of RBCs in their mechanotransduction process in subsequent investigations.
    MeSH term(s) Erythrocyte Deformability/physiology ; Mechanotransduction, Cellular ; Erythrocytes/metabolism ; Viscosity ; Motion
    Language English
    Publishing date 2023-01-13
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 218078-9
    ISSN 1542-0086 ; 0006-3495
    ISSN (online) 1542-0086
    ISSN 0006-3495
    DOI 10.1016/j.bpj.2023.01.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Heterogeneous Cytoskeletal Force Distribution Delineates the Onset Ca

    Maneshi, Mohammad M / Sachs, Frederick / Hua, Susan Z

    Frontiers in cellular neuroscience

    2018  Volume 12, Page(s) 69

    Abstract: Mechanical perturbations increase intracellular ... ...

    Abstract Mechanical perturbations increase intracellular Ca
    Language English
    Publishing date 2018-03-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2018.00069
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  10. Article ; Online: Stretch-activated ion channels: what are they?

    Sachs, Frederick

    Physiology (Bethesda, Md.)

    2010  Volume 25, Issue 1, Page(s) 50–56

    Abstract: Mechanosensitive ion channels (MSCs) exist in all cells, but mechanosensitivity is a phenotype not a genotype. Specialized mechanoreceptors such as the hair cells of the cochlea require elaborate mechanical impedance matching to couple the channels to ... ...

    Abstract Mechanosensitive ion channels (MSCs) exist in all cells, but mechanosensitivity is a phenotype not a genotype. Specialized mechanoreceptors such as the hair cells of the cochlea require elaborate mechanical impedance matching to couple the channels to the external stress. In contrast, MSCs in nonspecialized cells appear activated by stress in the bilayer local to the channel--within about three lipids. Local mechanical stress can be produced by far-field tension, amphipaths, phase separations, the cytoskeleton, the extracellular matrix, and the adhesion energy between the membrane and a patch pipette. Understanding MSC function requires under standing the stimulus.
    MeSH term(s) Animals ; Cytoskeleton/metabolism ; Extracellular Matrix/metabolism ; Humans ; Ion Channels/drug effects ; Ion Channels/metabolism ; Lipid Bilayers/metabolism ; Mechanoreceptors/drug effects ; Mechanoreceptors/metabolism ; Mechanotransduction, Cellular/drug effects ; Models, Biological ; Stress, Mechanical
    Chemical Substances Ion Channels ; Lipid Bilayers
    Language English
    Publishing date 2010-02-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2158667-6
    ISSN 1548-9221 ; 1548-9213
    ISSN (online) 1548-9221
    ISSN 1548-9213
    DOI 10.1152/physiol.00042.2009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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