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  1. Article ; Online: Dual-Capped Helical Interface Mimics.

    Mi, Tianxiong / Gao, Zhe / Mituta, Zeynep / Burgess, Kevin

    Journal of the American Chemical Society

    2024  Volume 146, Issue 15, Page(s) 10331–10341

    Abstract: Disruption of protein-protein interactions is medicinally important. Interface helices may be mimicked in helical probes featuring enhanced rigidities, binding to protein targets, stabilities in serum, and cell uptake. This form of mimicry is dominated ... ...

    Abstract Disruption of protein-protein interactions is medicinally important. Interface helices may be mimicked in helical probes featuring enhanced rigidities, binding to protein targets, stabilities in serum, and cell uptake. This form of mimicry is dominated by stapling between side chains of helical residues: there has been less progress on helical
    MeSH term(s) Peptides/chemistry ; Protein Structure, Secondary ; Proteolysis
    Chemical Substances Peptides
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c11717
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Bicyclic Schellman Loop Mimics (BSMs): Rigid Synthetic

    Mi, Tianxiong / Nguyen, Duyen / Burgess, Kevin

    ACS central science

    2023  Volume 9, Issue 2, Page(s) 300–306

    Abstract: Macrocyclic peptides are the prevalent way to mimic interface helices for disruption of protein interactions, but current strategies to do this via ... ...

    Abstract Macrocyclic peptides are the prevalent way to mimic interface helices for disruption of protein interactions, but current strategies to do this via synthetic
    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article
    ISSN 2374-7943
    ISSN 2374-7943
    DOI 10.1021/acscentsci.2c01265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Streamlined Protein-Protein Interface Loop Mimicry.

    Mi, Tianxiong / Siriwibool, Siriwalee / Burgess, Kevin

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 49, Page(s) e202307092

    Abstract: Cyclic peptides comprising endocyclic organic fragments, "cyclo-organopeptides", can be probes for perturbing protein-protein interactions (PPIs). Finding loop mimics is difficult because of high conformational variability amongst targets. Backbone ... ...

    Abstract Cyclic peptides comprising endocyclic organic fragments, "cyclo-organopeptides", can be probes for perturbing protein-protein interactions (PPIs). Finding loop mimics is difficult because of high conformational variability amongst targets. Backbone Matching (BM), introduced here, helps solve this problem in the illustrative cases by facilitating efficient evaluation of virtual cyclo-organopeptide core-structure libraries. Thus, 86 rigid organic fragments were selected to build a library of 602 cyclo-organopeptides comprising Ala and organic parts: "cyclo-{-(Ala)
    MeSH term(s) Proteins/chemistry ; Peptides, Cyclic/chemistry ; Molecular Conformation ; Protein Conformation
    Chemical Substances Proteins ; Peptides, Cyclic
    Language English
    Publishing date 2023-11-03
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202307092
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19.

    Mi, Tianxiong / Burgess, Kevin

    ACS medicinal chemistry letters

    2020  Volume 11, Issue 9, Page(s) 1663–1666

    Abstract: Four of five different monoclonal antibodies (mAbs) that have been crystallized in complex with the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S) have remarkably similar primary and secondary loop structures at the heavy chain ... ...

    Abstract Four of five different monoclonal antibodies (mAbs) that have been crystallized in complex with the receptor binding domain (RBD) of the SARS-CoV-2 spike protein (S) have remarkably similar primary and secondary loop structures at the heavy chain complementarity-determining regions (HCDR) 1 and 2. All these reports give a structural basis for the deceptively difficult problem of accurate peptidomimetic loop mimic design.
    Keywords covid19
    Language English
    Publishing date 2020-08-10
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.0c00409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Striking Similarities between CDRs in Some mAbs That Neutralize COVID-19

    Mi, Tianxiong / Burgess, Kevin

    ACS Medicinal Chemistry Letters

    2020  Volume 11, Issue 9, Page(s) 1663–1666

    Keywords covid19
    Language English
    Publisher American Chemical Society (ACS)
    Publishing country us
    Document type Article ; Online
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.0c00409
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: New, potent, small molecule agonists of tyrosine kinase receptors attenuate dry eye disease.

    Yu, Zhiyuan / Joy, Shaon / Mi, Tianxiong / Yazdanpanah, Ghasem / Burgess, Kevin / de Paiva, Cintia S

    Frontiers in medicine

    2022  Volume 9, Page(s) 937142

    Abstract: Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin3 (NT-3) bind to tyrosine kinase (Trk) receptors, TrkA, TrkB, and TrkC, respectively. This study investigated the efficacy of novel molecule agonists of Trk receptors in ...

    Abstract Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin3 (NT-3) bind to tyrosine kinase (Trk) receptors, TrkA, TrkB, and TrkC, respectively. This study investigated the efficacy of novel molecule agonists of Trk receptors in an
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.937142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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