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  1. Article ; Online: Troponin Embedded in Clinical Decision Protocols: The Devil is in the Details.

    Saenger, Amy K

    Clinical chemistry

    2023  Volume 69, Issue 5, Page(s) 435–437

    MeSH term(s) Humans ; Troponin I ; Myocardial Infarction/diagnosis
    Chemical Substances Troponin I
    Language English
    Publishing date 2023-03-19
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvad026
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  2. Article ; Online: 2023 AACC Annual Scientific Meeting Abstracts: Elevating and Disseminating Science to the Next Level.

    Zhao, Zhen / Mears, Elia / Saenger, Amy K

    Clinical chemistry

    2023  , Page(s) 1206–1207

    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvad118
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  3. Article: Pick a Number, Any Number…Choosing Your Troponin Cutoff Wisely.

    Saenger, Amy K

    The journal of applied laboratory medicine

    2018  Volume 3, Issue 5, Page(s) 753–755

    MeSH term(s) Biological Assay ; Point-of-Care Systems ; Troponin I
    Chemical Substances Troponin I
    Language English
    Publishing date 2018-11-30
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2868926-4
    ISSN 2475-7241
    ISSN 2475-7241
    DOI 10.1373/jalm.2018.027714
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  4. Article ; Online: A Setback to Universal Pediatric Lipid Screening and a Call for More Research.

    Karger, Amy B / Saenger, Amy K

    Clinical chemistry

    2017  Volume 63, Issue 2, Page(s) 620–621

    MeSH term(s) Child ; Humans ; Lipids/analysis ; Research
    Chemical Substances Lipids
    Language English
    Publishing date 2017-02-17
    Publishing country England
    Document type News
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2016.267989
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  5. Article ; Online: Laboratory findings in a child with SARS-CoV-2 (COVID-19) multisystem inflammatory syndrome.

    Smith, Stephen W / Strobel, Ashley M / Saenger, Amy K / Apple, Fred S

    Clinical chemistry and laboratory medicine

    2021  Volume 59, Issue 6, Page(s) e259–e261

    MeSH term(s) Biomarkers/blood ; COVID-19/blood ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/epidemiology ; Child, Preschool ; Humans ; Male ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/blood ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/epidemiology ; Troponin I/blood
    Chemical Substances Biomarkers ; Peptide Fragments ; Troponin I ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2021-01-08
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2020-1699
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    Zs.A 121: Show issues Location:
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  6. Article ; Online: Analytical performance comparing siemens whole blood point of care Atellica VTLi to the central laboratory plasma Atellica IM high-sensitivity cardiac troponin I assays.

    Xiong-Hang, Kang / Schulz, Karen / Sandoval, Yader / Smith, Stephen W / Saenger, Amy K / Apple, Fred S

    Clinical biochemistry

    2023  Volume 114, Page(s) 79–85

    Abstract: Introduction: This study examined the analytical performance of a whole blood (WB) point of care (POC) hs-cTnI assay compared to a plasma central laboratory hs-cTnI assay in patients presenting with ischemic symptoms to a US emergency department.: ... ...

    Abstract Introduction: This study examined the analytical performance of a whole blood (WB) point of care (POC) hs-cTnI assay compared to a plasma central laboratory hs-cTnI assay in patients presenting with ischemic symptoms to a US emergency department.
    Methods: Fresh WB specimens collected at 0 and 2 h from 1089 consecutive patients (2152 total from 1076 matched specimens) were analyzed for hs-cTnI using WB on POC Siemens Atellica VTLi assay and plasma on central laboratory Siemens Atellica IM assay. Concordances were determined based on concentrations ranging from < limit of detection (LoD), LoD to overall and sex specific 99th percentiles from both the IFCC manufacturer package inserts and Universal Sample Bank (USB) data, and > 99th percentiles. Method comparisons were calculated using Passing Bablok regression and Bland Altmann plots, and linear regression determined by Pearson correlation coefficient.
    Results: Baseline concentration comparisons showed: POC VTLi < LoD 4-5 %, ≥ LoD 95 %; Atellica IM < LoD 5-7 %, and ≥ LoD 94-95 %. From the 2152 paired 0 and 2-hour samples, based on 99th percentiles, overall concordance was 91-92 % (kappa 0.72-0.77) and discordance 8 %. Passing Bablok regression analysis using 1924 specimens between LoD to 500 ng/L showed: slopes 0.469-0.490; y-intercepts 1.753-2.028; r values 0.631-0.817. Pearson correlation coefficient showed moderate to strong correlation strength, even with up to 53 % cTnI concentrations variance (Passing Bablok slopes) vs 27.0-40.1 % (Bland-Altmann plots).
    Conclusions: Up to 95 % of measured samples were > LoD for both the POC (Atellica VTLi) and central laboratory (Atellica IM) hs-cTnI assays. Moderate to strong concordance and correlation were observed between assays, despite up to 53 % variances in cTnI concentration.
    MeSH term(s) Male ; Female ; Humans ; Troponin I ; Point-of-Care Systems ; Limit of Detection ; Biological Assay/methods ; Laboratories
    Chemical Substances Troponin I
    Language English
    Publishing date 2023-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390372-2
    ISSN 1873-2933 ; 0009-9120
    ISSN (online) 1873-2933
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2023.02.004
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  7. Article ; Online: High-Sensitivity Cardiac Troponin-T and N-Terminal Prohormone of B-Type Natriuretic Peptide in Relation to Cardiovascular Outcomes in Type 1 Diabetes.

    Costacou, Tina / Saenger, Amy K / Orchard, Trevor J

    Diabetes care

    2020  Volume 43, Issue 9, Page(s) 2199–2207

    Abstract: Objective: High-sensitivity cardiac troponin-T (hs-cTnT) and N-terminal prohormone of B-type natriuretic peptide (NT-proBNP), biomarkers of cardiovascular disease (CVD) and heart failure, respectively, have not been widely studied in type 1 diabetes ( ... ...

    Abstract Objective: High-sensitivity cardiac troponin-T (hs-cTnT) and N-terminal prohormone of B-type natriuretic peptide (NT-proBNP), biomarkers of cardiovascular disease (CVD) and heart failure, respectively, have not been widely studied in type 1 diabetes (T1D). We evaluated whether their assessment in T1D enhances the prediction of CVD and major adverse cardiovascular events (MACE).
    Research design and methods: hs-cTnT and NT-proBNP were analyzed on the Roche Cobas E601 using the first available stored specimen (
    Results: Median hs-cTnT (5.0 ng/L; interquartile range <3.0, 10.0) was higher among men (
    Conclusions: Sex differences were observed in the concentration and predictive ability of hs-cTnT and NT-proBNP in T1D. Overall, their addition to traditional risk factor models increased the area under the curve for neither CVD nor MACE.
    MeSH term(s) Adult ; Biomarkers/analysis ; Biomarkers/blood ; Cohort Studies ; Diabetes Mellitus, Type 1/blood ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnosis ; Diabetic Angiopathies/blood ; Diabetic Angiopathies/diagnosis ; Female ; Heart Failure/blood ; Heart Failure/diagnosis ; Heart Failure/etiology ; Humans ; Male ; Myocardial Infarction/blood ; Myocardial Infarction/diagnosis ; Myocardial Infarction/etiology ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Prognosis ; Sex Characteristics ; Stroke/blood ; Stroke/diagnosis ; Stroke/etiology ; Troponin T/blood ; United States ; Young Adult
    Chemical Substances Biomarkers ; Peptide Fragments ; Troponin T ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2020-07-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc20-0359
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  8. Article ; Online: Universal lipid screening in children and adolescents: a baby step toward primordial prevention?

    Saenger, Amy K

    Clinical chemistry

    2012  Volume 58, Issue 8, Page(s) 1179–1181

    MeSH term(s) Adolescent ; Child ; Coronary Artery Disease/etiology ; Coronary Artery Disease/prevention & control ; Dyslipidemias/complications ; Dyslipidemias/diagnosis ; Dyslipidemias/drug therapy ; Humans ; Lipids/blood ; Mass Screening ; National Heart, Lung, and Blood Institute (U.S.) ; Practice Guidelines as Topic ; Risk Factors ; United States ; Young Adult
    Chemical Substances Lipids
    Language English
    Publishing date 2012-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2012.182287
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  9. Article ; Online: An investigation of enzymatic creatinine interference in a patient receiving dopamine and dobutamine.

    Seegmiller, Jesse C / Larson, Kathy A / Saenger, Amy K

    Clinical biochemistry

    2019  Volume 73, Page(s) 115–117

    Abstract: Background: A laboratory investigation was initiated after a renal failure patient had a 2.18 mg/dL decrease in serum creatinine, which was not explained through medical intervention. The investigation revealed specimens providing questionably low ... ...

    Abstract Background: A laboratory investigation was initiated after a renal failure patient had a 2.18 mg/dL decrease in serum creatinine, which was not explained through medical intervention. The investigation revealed specimens providing questionably low results had been collected from a peripherally inserted central catheter (PICC) line.
    Methods: Patient specimens and serum pools were analyzed by the Siemens Vista enzymatic creatinine measurement procedure. A simulation of the patient's infusion protocol examined potential PICC line carryover and specimen collection technique.
    Results: A simultaneously collected specimen set, arterial line and PICC line, yielded a difference of 1.86 mg/dL. Infusion and collection simulation studies suggested the most likely scenario was the infusion pump was not shut off while the specimen collection occurred and contaminated the specimen.
    Conclusion: Providers should be aware of erroneously low creatinine results when administering catecholamine drugs and collecting specimens through the same catheter. The mechanism of specimen contamination is consistent with a siphoning effect from one lumen to the other during collection with the infusion pumps still running.
    MeSH term(s) Blood Chemical Analysis ; Catheterization, Peripheral ; Creatinine/blood ; Dobutamine/administration & dosage ; Dopamine/administration & dosage ; Female ; Humans ; Male ; Middle Aged
    Chemical Substances Dobutamine (3S12J47372) ; Creatinine (AYI8EX34EU) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2019-08-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390372-2
    ISSN 1873-2933 ; 0009-9120
    ISSN (online) 1873-2933
    ISSN 0009-9120
    DOI 10.1016/j.clinbiochem.2019.08.001
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  10. Article: A tale of two biomarkers: the use of troponin and CK-MB in contemporary practice.

    Saenger, Amy K

    Clinical laboratory science : journal of the American Society for Medical Technology

    2010  Volume 23, Issue 3, Page(s) 134–140

    MeSH term(s) Biomarkers/blood ; Creatine Kinase, MB Form/blood ; Humans ; Immunoassay ; Myocardial Infarction/blood ; Myocardial Infarction/diagnosis ; Troponin/blood ; Troponin/chemistry
    Chemical Substances Biomarkers ; Troponin ; Creatine Kinase, MB Form (EC 2.7.3.2)
    Language English
    Publishing date 2010
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639386-x
    ISSN 0894-959X
    ISSN 0894-959X
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