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  1. Article ; Online: One more step in the renal denervation trek.

    Townsend, Raymond R

    American journal of nephrology

    2023  

    Abstract: Is This REALLY Required? ...

    Abstract Is This REALLY Required?
    Language English
    Publishing date 2023-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 604540-6
    ISSN 1421-9670 ; 0250-8095
    ISSN (online) 1421-9670
    ISSN 0250-8095
    DOI 10.1159/000533885
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    Zs.A 1635: Show issues Location:
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  2. Article ; Online: Blocking Aldosterone Synthesis: Whose BrigHTN Idea Was That?

    Townsend, Raymond R

    Clinical journal of the American Society of Nephrology : CJASN

    2023  Volume 18, Issue 12, Page(s) 1631–1633

    MeSH term(s) Humans ; Aldosterone ; Sodium
    Chemical Substances Aldosterone (4964P6T9RB) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.0000000000000265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Is There

    Townsend, Raymond R

    Kidney360

    2020  Volume 1, Issue 1, Page(s) 6–8

    MeSH term(s) Humans ; Hypertension/therapy ; Sympathectomy
    Language English
    Publishing date 2020-01-02
    Publishing country United States
    Document type Journal Article
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000582019
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  4. Article ; Online: Time in therapeutic range: timely in hypertension therapeutics?

    Nagarajan, Nitin / Townsend, Raymond R

    Journal of human hypertension

    2023  Volume 37, Issue 3, Page(s) 244–247

    Abstract: Elevated blood pressure ranks among the most important modifiable risk factors for premature death, and disability from hypertension mediated organ damage in the world. Many studies attest to the value of lifestyle adjustments and pharmacologic therapy ... ...

    Abstract Elevated blood pressure ranks among the most important modifiable risk factors for premature death, and disability from hypertension mediated organ damage in the world. Many studies attest to the value of lifestyle adjustments and pharmacologic therapy in improving outcomes in patients with hypertension. Since blood pressure is a dynamic vitals sign, variability in visit-to-visit measurements is expected. While guidelines recommend a goal blood pressure, increasing attention is centered on how often a patient's blood pressure is found to be not only below the recommended goal value, but also how much of the time the blood pressure is below what is considered a safe lower goal threshold for blood pressure. In this Perspective we review a relatively new technique in addressing adequacy of blood pressure treatment, the time in therapeutic range, and provide examples supporting the clinical relevance of this novel metric.
    MeSH term(s) Humans ; Hypertension/diagnosis ; Hypertension/drug therapy ; Blood Pressure/physiology ; Blood Pressure Determination/methods ; Blood Pressure Monitoring, Ambulatory ; Risk Factors ; Antihypertensive Agents/therapeutic use
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2023-01-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-022-00800-y
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    Zs.A 2380: Show issues Location:
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  5. Article ; Online: Out-of-Office Blood Pressure Monitoring: A Comparison of Ambulatory Blood Pressure Monitoring and Home (Self) Monitoring Of Blood Pressure.

    Townsend, Raymond R

    Hypertension (Dallas, Tex. : 1979)

    2020  Volume 76, Issue 6, Page(s) 1667–1673

    MeSH term(s) Blood Pressure/physiology ; Blood Pressure Determination/methods ; Blood Pressure Monitoring, Ambulatory/methods ; Humans ; Hypertension/diagnosis ; Hypertension/physiopathology ; Office Visits ; Practice Guidelines as Topic ; Reproducibility of Results ; Self Care/methods ; Sensitivity and Specificity
    Language English
    Publishing date 2020-10-05
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.120.14650
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    Zs.A 1488: Show issues Location:
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  6. Article ; Online: Revisiting Renal Denervation.

    Townsend, Raymond R

    Mayo Clinic proceedings

    2019  Volume 94, Issue 9, Page(s) 1665–1667

    MeSH term(s) Denervation ; Humans ; Hypertension ; Kidney
    Language English
    Publishing date 2019-08-08
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2019.07.006
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  7. Article ; Online: How New Developments in Pharmacology Receptor Theory Are Changing (Our Understanding of) Hypertension Therapy.

    Watts, Stephanie W / Townsend, Raymond R / Neubig, Richard R

    American journal of hypertension

    2023  Volume 37, Issue 4, Page(s) 248–260

    Abstract: Background: Many hypertension therapeutics were developed prior to major advances in drug receptor theory. Moreover, newer drugs may take advantage of some of the newly understood modalities of receptor function.: Goal: The goal of this review is to ... ...

    Abstract Background: Many hypertension therapeutics were developed prior to major advances in drug receptor theory. Moreover, newer drugs may take advantage of some of the newly understood modalities of receptor function.
    Goal: The goal of this review is to provide an up-to-date summary of drug receptor theory. This is followed by a discussion of the drug classes recognized for treating hypertension to which new concepts in receptor theory apply.
    Results: We raise ideas for mechanisms of potential new antihypertensive drugs and whether they may take advantage of new theories in drug-receptor interaction.
    MeSH term(s) Humans ; Hypertension/drug therapy ; Antihypertensive Agents/therapeutic use ; Drug Interactions ; Receptors, Drug/therapeutic use
    Chemical Substances Antihypertensive Agents ; Receptors, Drug
    Language English
    Publishing date 2023-12-27
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 639383-4
    ISSN 1941-7225 ; 1879-1905 ; 0895-7061
    ISSN (online) 1941-7225 ; 1879-1905
    ISSN 0895-7061
    DOI 10.1093/ajh/hpad121
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    Zs.A 2329: Show issues Location:
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  8. Article ; Online: Treating Hypertension Using Renal Artery Denervation: Problems and Progress.

    Townsend, Raymond R

    Advances in chronic kidney disease

    2019  Volume 26, Issue 2, Page(s) 117–121

    Abstract: Early reports of renal denervation as a therapy for hypertension generated intense interest in this approach to management of elevated blood pressures despite ongoing treatment. The publication of the large, sham-controlled randomized clinical trial of ... ...

    Abstract Early reports of renal denervation as a therapy for hypertension generated intense interest in this approach to management of elevated blood pressures despite ongoing treatment. The publication of the large, sham-controlled randomized clinical trial of renal denervation, Symplicity HTN-3, failed to show superiority of renal denervation by radiofrequency energy ablation compared with a sham procedure similar to the procedure used for denervation but without the application of energy to the renal artery. This prompted consideration of confounding factors and rethinking about the protocol and the procedure itself. This review describes these confounders and the progress made to improve trial design in the field of renal artery denervation.
    MeSH term(s) Blood Pressure Monitoring, Ambulatory ; Confounding Factors, Epidemiologic ; Denervation/methods ; Humans ; Hypertension/surgery ; Placebos ; Radiofrequency Ablation/methods ; Randomized Controlled Trials as Topic ; Renal Artery/innervation ; Renal Artery/surgery ; Research Design ; Treatment Outcome
    Chemical Substances Placebos
    Language English
    Publishing date 2019-04-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1548-5609 ; 1548-5595
    ISSN (online) 1548-5609
    ISSN 1548-5595
    DOI 10.1053/j.ackd.2019.02.004
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    Zs.A 4627: Show issues Location:
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  9. Article ; Online: The Value in an Ambulatory Blood-Pressure Registry.

    Townsend, Raymond R

    The New England journal of medicine

    2018  Volume 378, Issue 16, Page(s) 1555–1556

    MeSH term(s) Blood Pressure ; Humans ; Hypertension ; Predictive Value of Tests ; Registries
    Language English
    Publishing date 2018--19
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1802369
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  10. Article ; Online: Arterial Stiffness in CKD: A Review.

    Townsend, Raymond R

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2018  Volume 73, Issue 2, Page(s) 240–247

    Abstract: This narrative review summarizes a decade of experience examining the cross-sectional and longitudinal relationships of arterial stiffness, as assessed using carotid-femoral pulse wave velocity, with outcomes in patients with chronic kidney disease ... ...

    Abstract This narrative review summarizes a decade of experience examining the cross-sectional and longitudinal relationships of arterial stiffness, as assessed using carotid-femoral pulse wave velocity, with outcomes in patients with chronic kidney disease enrolled in the Chronic Renal Insufficiency Cohort. Our goal is to review the importance of the pulse wave contour and pulse wave velocity and present data on the reproducibility of pulse wave velocity measurements, determinants of pulse wave velocity, and the relationship that velocity measurements have with longitudinal kidney and cardiovascular outcomes. Measures of arterial stiffness have contributed substantially to our understanding of mechanisms of cardiovascular disease, kidney disease progression, and all-cause mortality. Given the independent relationship of arterial stiffness to a variety of outcomes, it is our hope that future developments in behavioral, nutritional, and pharmacologic approaches to vascular destiffening will provide interventions that benefit patients with chronic kidney diseases.
    MeSH term(s) Age Factors ; Aged ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/therapy ; Comorbidity ; Cross-Sectional Studies ; Disease Progression ; Female ; Glomerular Filtration Rate ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Humans ; Kaplan-Meier Estimate ; Longitudinal Studies ; Male ; Middle Aged ; Prevalence ; Prognosis ; Pulse Wave Analysis/methods ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/therapy ; Risk Assessment ; Sex Factors ; Survival Analysis ; Vascular Stiffness
    Language English
    Publishing date 2018-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2018.04.005
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