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  1. Article: Stromal-Epithelial Interactions in Cancer Progression and Therapy Response.

    Thiruvalluvan, Manish / Bhowmick, Neil A

    Cancers

    2023  Volume 15, Issue 11

    Abstract: Tumorigenesis is a result of cell-intrinsic epigenomic and genomic changes as well as cell-extrinsic factors [ ... ]. ...

    Abstract Tumorigenesis is a result of cell-intrinsic epigenomic and genomic changes as well as cell-extrinsic factors [...].
    Language English
    Publishing date 2023-06-01
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15113014
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  2. Article ; Online: RARγ: The Bone of Contention for Endothelial Cells in Prostate Cancer Metastasis.

    Bhowmick, Snigdha / Bhowmick, Neil A

    Cancer research

    2022  Volume 82, Issue 17, Page(s) 2975–2976

    Abstract: Excessive bone deposition associated with prostate cancer bone metastases is believed to aid in metastatic progression. One mechanism of osteoblast expansion is the transdifferentiation of bone marrow endothelial cells. Prostate cancer cells contribute ... ...

    Abstract Excessive bone deposition associated with prostate cancer bone metastases is believed to aid in metastatic progression. One mechanism of osteoblast expansion is the transdifferentiation of bone marrow endothelial cells. Prostate cancer cells contribute several secreted factors, including bone morphogenetic protein 4 (BMP4), to the microenvironment that support osteoblastic transdifferentiation. In this issue of Cancer Research, Yu and colleagues share their findings of how BMP-mediated endothelial conversion can be inhibited by treatment with retinoic acid receptor (RAR) agonists. Using agonists like the all-trans retinoic acid or palovarotene, the authors demonstrated the role of the interaction of BMP-activated SMAD1 with RARγ for osteoblastic differentiation. RARγ agonists potentiated the proteasomal degradation of the Smad1-RARγ complex, blocking BMP signaling. Because palovarotene is clinically effective in the treatment of aberrant bone formation found in fibrodysplasia ossificans progressiva, its repurposing for the treatment of osteoblastic cancer metastasis is promising. However, patient selection and dose-finding studies will be critical for the translation of these findings to complement standard of care for patients with bone metastatic prostate cancer. See related article by Yu et al., p. 3158.
    MeSH term(s) Endothelial Cells/pathology ; Humans ; Male ; Myositis Ossificans/metabolism ; Myositis Ossificans/pathology ; Osteoblasts/metabolism ; Prostatic Neoplasms/pathology ; Receptors, Retinoic Acid/metabolism ; Tumor Microenvironment
    Chemical Substances Receptors, Retinoic Acid
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-22-2251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.135/5: Show issues Location:
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  3. Article ; Online: Metabolic basis of cardiac dysfunction in cancer patients.

    Figueiredo, Jane C / Bhowmick, Neil Adri / Karlstaedt, Anja

    Current opinion in cardiology

    2024  Volume 39, Issue 3, Page(s) 138–147

    Abstract: Purpose of review: The relationship between metabolism and cardiovascular diseases is complex and bidirectional. Cardiac cells must adapt metabolic pathways to meet biosynthetic demands and energy requirements to maintain contractile function. During ... ...

    Abstract Purpose of review: The relationship between metabolism and cardiovascular diseases is complex and bidirectional. Cardiac cells must adapt metabolic pathways to meet biosynthetic demands and energy requirements to maintain contractile function. During cancer, this homeostasis is challenged by the increased metabolic demands of proliferating cancer cells.
    Recent findings: Tumors have a systemic metabolic impact that extends beyond the tumor microenvironment. Lipid metabolism is critical to cancer cell proliferation, metabolic adaptation, and increased cardiovascular risk. Metabolites serve as signals which provide insights for diagnosis and prognosis in cardio-oncology patients.
    Summary: Metabolic processes demonstrate a complex relationship between cancer cell states and cardiovascular remodeling with potential for therapeutic interventions.
    MeSH term(s) Humans ; Neoplasms/complications ; Neoplasms/drug therapy ; Metabolic Networks and Pathways ; Lipid Metabolism ; Heart Diseases ; Tumor Microenvironment
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645186-x
    ISSN 1531-7080 ; 0268-4705
    ISSN (online) 1531-7080
    ISSN 0268-4705
    DOI 10.1097/HCO.0000000000001118
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2556: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article: Antagonizing Glutamine Bioavailability Promotes Radiation Sensitivity in Prostate Cancer.

    Thiruvalluvan, Manish / Billet, Sandrine / Bhowmick, Neil A

    Cancers

    2022  Volume 14, Issue 10

    Abstract: Nearly half of localized prostate cancer (PCa) patients given radiation therapy develop recurrence. Here, we identified glutamine as a key player in mediating the radio-sensitivity of PCa. Glutamine transporters and glutaminase are upregulated by ... ...

    Abstract Nearly half of localized prostate cancer (PCa) patients given radiation therapy develop recurrence. Here, we identified glutamine as a key player in mediating the radio-sensitivity of PCa. Glutamine transporters and glutaminase are upregulated by radiation therapy of PCa cells, but respective inhibitors were ineffective in radio-sensitization. However, targeting glutamine bioavailability by L-asparaginase (L-ASP) led to a significant reduction in clonogenicity when combined with irradiation. L-ASP reduced extracellular asparagine and glutamine, but the sensitization effects were driven through its depletion of glutamine. L-ASP led to G2/M cell cycle checkpoint blockade. As evidence, there was a respective delay in DNA repair associated with RAD51 downregulation and upregulation of CHOP, contributing to radiation-induced cell death. A radio-resistant PCa cell line was developed, was found to bypass radiation-induced mitotic catastrophe, and was sensitive to L-ASP/radiation combination treatment. Previously, PCa-associated fibroblasts were reported as a glutamine source supporting tumor progression. As such, glutamine-free media were not effective in promoting radiation-induced PCa cell death when co-cultured with associated primary fibroblasts. However, the administration L-ASP catalyzed glutamine depletion with irradiated co-cultures and catalyzed tumor volume reduction in a mouse model. The clinical history of L-ASP for leukemia patients supports the viability for its repurposing as a radio-sensitizer for PCa patients.
    Language English
    Publishing date 2022-05-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14102491
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  5. Article ; Online: Pushing the Heart Over a KLF(15).

    Gottlieb, Roberta A / Bhowmick, Neil A

    Journal of the American College of Cardiology

    2019  Volume 74, Issue 14, Page(s) 1820–1822

    MeSH term(s) Animals ; Cardiomegaly ; Heart
    Language English
    Publishing date 2019-10-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2019.08.021
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1846: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 196: Show issues

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  6. Article ; Online: The adaptor protein SHCA launches cancer invasion.

    Borah, Supriya / Bhowmick, Neil A

    The Journal of biological chemistry

    2020  Volume 295, Issue 31, Page(s) 10560–10561

    Abstract: Cancer cell invasion and metastasis rely on invadopodia, important extensions of the cytoskeleton that initiate degradation of the basement membrane that holds a cell in place. Transforming growth factor-β (TGF-β) is well-known to induce breast cancer ... ...

    Abstract Cancer cell invasion and metastasis rely on invadopodia, important extensions of the cytoskeleton that initiate degradation of the basement membrane that holds a cell in place. Transforming growth factor-β (TGF-β) is well-known to induce breast cancer migration and invasion, but the mechanism by which TGF-β signaling converts into cell motility is not completely understood. A study from Kiepas
    MeSH term(s) Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Breast Neoplasms ; Cell Movement ; Collagen ; Humans ; Lipoma ; Podosomes/metabolism ; Src Homology 2 Domain-Containing, Transforming Protein 1 ; Transforming Growth Factor beta/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; Src Homology 2 Domain-Containing, Transforming Protein 1 ; Transforming Growth Factor beta ; Collagen (9007-34-5)
    Language English
    Publishing date 2020-07-31
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.H120.014283
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
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  7. Article: Glutamine Supplementation as an Anticancer Strategy: A Potential Therapeutic Alternative to the Convention.

    Muranaka, Hayato / Akinsola, Rasaq / Billet, Sandrine / Pandol, Stephen J / Hendifar, Andrew E / Bhowmick, Neil A / Gong, Jun

    Cancers

    2024  Volume 16, Issue 5

    Abstract: Glutamine, a multifaceted nonessential/conditionally essential amino acid integral to cellular metabolism and immune function, holds pivotal importance in the landscape of cancer therapy. This review delves into the intricate dynamics surrounding both ... ...

    Abstract Glutamine, a multifaceted nonessential/conditionally essential amino acid integral to cellular metabolism and immune function, holds pivotal importance in the landscape of cancer therapy. This review delves into the intricate dynamics surrounding both glutamine antagonism strategies and glutamine supplementation within the context of cancer treatment, emphasizing the critical role of glutamine metabolism in cancer progression and therapy. Glutamine antagonism, aiming to disrupt tumor growth by targeting critical metabolic pathways, is challenged by the adaptive nature of cancer cells and the complex metabolic microenvironment, potentially compromising its therapeutic efficacy. In contrast, glutamine supplementation supports immune function, improves gut integrity, alleviates treatment-related toxicities, and improves patient well-being. Moreover, recent studies highlighted its contributions to epigenetic regulation within cancer cells and its potential to bolster anti-cancer immune functions. However, glutamine implementation necessitates careful consideration of potential interactions with ongoing treatment regimens and the delicate equilibrium between supporting normal cellular function and promoting tumorigenesis. By critically assessing the implications of both glutamine antagonism strategies and glutamine supplementation, this review aims to offer comprehensive insights into potential therapeutic strategies targeting glutamine metabolism for effective cancer management.
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16051057
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  8. Article: Functional Diversity of Macropinocytosis.

    Mishra, Rajeev / Gupta, Yamini / Ghaley, Garima / Bhowmick, Neil A

    Sub-cellular biochemistry

    2022  Volume 98, Page(s) 3–14

    Abstract: Eukaryotic cells are capable of internalizing different types of cargo by plasma membrane ruffling and forming vesicles in a process known as endocytosis. The most extensively characterized endocytic pathways are clathrin-coated pits, lipid raft/caveolae- ...

    Abstract Eukaryotic cells are capable of internalizing different types of cargo by plasma membrane ruffling and forming vesicles in a process known as endocytosis. The most extensively characterized endocytic pathways are clathrin-coated pits, lipid raft/caveolae-mediated endocytosis, phagocytosis, and macropinocytosis. Macropinocytosis is unique among all the endocytic processes due to its nonselective internalization of extracellular fluid, solutes, and membrane in large endocytic vesicles known as macropinosomes with unique susceptibility toward Na+/H+ exchanger inhibitors. Range of cell types capable of macropinocytosis and known to play important role in different physiological processes, which include antigen presentation, nutrient sensing, migration, and signaling. Understanding the physiological function of macropinocytosis will be helpful in filling the gaps in our knowledge and which can be exploited to develop novel therapeutic targets. In this chapter, we discuss the different molecular mechanisms that initiate the process of macropinocytosis with special emphasis on proteins involved and their diversified role in different cell types.
    MeSH term(s) Endocytosis/physiology ; Endosomes ; Membrane Microdomains/metabolism ; Phagocytosis ; Pinocytosis
    Language English
    Publishing date 2022-04-04
    Publishing country United States
    Document type Journal Article
    ISSN 0306-0225 ; 0096-8757
    ISSN 0306-0225 ; 0096-8757
    DOI 10.1007/978-3-030-94004-1_1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Relationship Between Periodontal Disease and Breast Cancer: From Basic Mechanism to Clinical Management and Prevention.

    Zhang, Yuhan / Ren, Xiaolin / Hu, Tao / Cheng, Ran / Bhowmick, Neil A

    Oral health & preventive dentistry

    2023  Volume 21, Page(s) 49–60

    Abstract: Purpose: Periodontal disease is potentially related to certain kinds of cancer. This review aimed to summarize the relationship between periodontal disease and breast cancer, providing some strategies for the clinical treatment and periodontal health ... ...

    Abstract Purpose: Periodontal disease is potentially related to certain kinds of cancer. This review aimed to summarize the relationship between periodontal disease and breast cancer, providing some strategies for the clinical treatment and periodontal health care of breast cancer patients.
    Materials and methods: Systematic reviews, randomised controlled trials, prospective and retrospective clinical studies, case series and reports were collected using search terms entered into the PubMed, Google Scholar and JSTOR databases.
    Results: Research has provided some evidence that periodontal disease is related to the occurrence and development of breast cancer. Periodontal disease and breast cancer have some common pathogenic factors. Periodontal disease may affect the initiation and development of breast cancer involving microorganisms and inflammation. Periodontal health is affected by radiotherapy, chemotherapy, and endocrine therapy for breast cancer.
    Conclusions: Periodontal therapy for breast cancer patients should be performed differently according to the stage of cancer treatment. Adjuvant endocrine treatment (e.g. bisphosphonates) has a great impact on oral treatment. Periodontal therapy contributes to the primary prevention of breast cancer. Periodontal health care of breast cancer patients is worthy of clinician attention.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/therapy ; Breast Neoplasms/drug therapy ; Prospective Studies ; Retrospective Studies ; Periodontal Diseases/complications ; Periodontal Diseases/prevention & control
    Language English
    Publishing date 2023-02-16
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 2136786-3
    ISSN 1757-9996 ; 1602-1622
    ISSN (online) 1757-9996
    ISSN 1602-1622
    DOI 10.3290/j.ohpd.b3904343
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6526: Show issues Location:
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  10. Article: Visualization of Macropinocytosis in Prostate Fibroblasts.

    Mishra, Rajeev / Bhowmick, Neil A

    Bio-protocol

    2019  Volume 9, Issue 10

    Abstract: Macropinocytosis has emerged as an important mechanism for non-selective route to internalize extracellular fluids and dissolved molecules in eukaryotic cell. As fundamental cellular behavior, macropinocytosis plays specific and distinct roles in many ... ...

    Abstract Macropinocytosis has emerged as an important mechanism for non-selective route to internalize extracellular fluids and dissolved molecules in eukaryotic cell. As fundamental cellular behavior, macropinocytosis plays specific and distinct roles in many physiological and pathological processes, such as nutrients uptake, antigen presentation, pathogen capture, and tumorigenesis. It supports tumorigenesis by providing metabolic needs to dividing cells in Ras driven cancer. In recent years, macropinocytosis has gained considerable interest in physiology and various diseases, including cancer, neurodegenerative diseases and atherosclerosis, which in turn has led to the discovery of new endocytic recycling systems. Approaches to assess macropinocytosis will provide insight into its underlying regulatory molecular mechanisms and enable the physiological control of macropinocytosis for controlled drug delivery and targeted cancer therapy. Macropinocytosis is an important phenomenon in Ras-expressing cancer cells and, recently, we have revealed a functional role for macropinocytosis in cancer associated fibroblasts (CAFs) fueling cancer cell growth. Here, we describe a protocol for detection of macropinocytosis in prostatic fibroblasts
    Language English
    Publishing date 2019-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.3235
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