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Article ; Online: PRELIMINARY REPORT ON THE PUTATIVE ASSOCIATION OF IL10 -3575 T/A GENETIC POLYMORPHISM WITH MALARIA SYMPTOMS.

Domingues, Wilson / Kanunfre, Kelly Aparecida / Rodrigues, Jonatas Cristian / Teixeira, Leandro Emidio / Yamamoto, Lidia / Okay, Thelma Suely

Revista do Instituto de Medicina Tropical de Sao Paulo

2016 Volume 58, Page(s) 30

Abstract: ... However, regarding the IL10 -3575 T/A SNP, there were significantly more AA and AT subjects, carrying the polymorphic ... suggested the possibility that the IL10 - 3575 T/A SNP might be associated with the presence and maintenance ...

Abstract	Only a small percentage of individuals living in endemic areas develop severe malaria suggesting that host genetic factors may play a key role. This study has determined the frequency of single nucleotide polymorphisms (SNPs) in some pro and anti-inflammatory cytokine gene sequences: IL6 (-174; rs1800795), IL12p40 (+1188; rs3212227), IL4 (+33; rs2070874), IL10 (-3575; rs1800890) and TGFb1 (+869; rs1800470), by means of PCR-RFLP. Blood samples were collected from 104 symptomatic and 37 asymptomatic subjects. Laboratory diagnosis was assessed by the thick blood smear test and nested-PCR. No association was found between IL6 (-174), IL12p40 (+1188), IL4 (+33), IL10 (- 3575), TGFb1 (+869) SNPs and malaria symptoms. However, regarding the IL10 -3575 T/A SNP, there were significantly more AA and AT subjects, carrying the polymorphic allele A, in the symptomatic group (c2 = 4.54, p = 0.01, OR = 0.40 [95% CI - 0.17- 0.94]). When the analysis was performed by allele, the frequency of the polymorphic allele A was also significantly higher in the symptomatic group (c2 = 4.50, p = 0.01, OR = 0.45 [95% CI - 0.21-0.95]). In conclusion, this study has suggested the possibility that the IL10 - 3575 T/A SNP might be associated with the presence and maintenance of malaria symptoms in individuals living in endemic areas. Taking into account that this polymorphism is related to decreased IL10 production, a possible role of this SNP in the pathophysiology of malaria is also suggested, but replication studies with a higher number of patients and evaluation of IL10 levels are needed for confirmation.
MeSH term(s)	Adolescent ; Adult ; Aged ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Interleukin-10/genetics ; Malaria/genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Young Adult
Chemical Substances	Interleukin-10 (130068-27-8)
Language	English
Publishing date	2016
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	128928-7
ISSN	1678-9946 ; 0036-4665
ISSN (online)	1678-9946
ISSN	0036-4665
DOI	10.1590/S1678-9946201658030
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Article ; Online: PRELIMINARY REPORT ON THE PUTATIVE ASSOCIATION OF IL10 -3575 T/A GENETIC POLYMORPHISM WITH MALARIA SYMPTOMS

Wilson DOMINGUES / Kelly Aparecida KANUNFRE / Jonatas Cristian RODRIGUES / Leandro Emidio TEIXEIRA / Lidia YAMAMOTO / Thelma Suely OKAY

Revista do Instituto de Medicina Tropical de São Paulo, Vol

2016 Volume 58

Abstract	Only a small percentage of individuals living in endemic areas develop severe malaria suggesting that host genetic factors may play a key role. This study has determined the frequency of single nucleotide polymorphisms (SNPs) in some pro and anti-inflammatory cytokine gene sequences: IL6 (-174; rs1800795), IL12p40 (+1188; rs3212227), IL4 (+33; rs2070874), IL10 (-3575; rs1800890) and TGFb1 (+869; rs1800470), by means of PCR-RFLP. Blood samples were collected from 104 symptomatic and 37 asymptomatic subjects. Laboratory diagnosis was assessed by the thick blood smear test and nested-PCR. No association was found between IL6 (-174), IL12p40 (+1188), IL4 (+33), IL10 (- 3575), TGFb1 (+869) SNPs and malaria symptoms. However, regarding the IL10 -3575 T/A SNP, there were significantly more AA and AT subjects, carrying the polymorphic allele A, in the symptomatic group (c2 = 4.54, p = 0.01, OR = 0.40 [95% CI - 0.17- 0.94]). When the analysis was performed by allele, the frequency of the polymorphic allele A was also significantly higher in the symptomatic group (c2 = 4.50, p = 0.01, OR = 0.45 [95% CI - 0.21-0.95]). In conclusion, this study has suggested the possibility that the IL10 - 3575 T/A SNP might be associated with the presence and maintenance of malaria symptoms in individuals living in endemic areas. Taking into account that this polymorphism is related to decreased IL10 production, a possible role of this SNP in the pathophysiology of malaria is also suggested, but replication studies with a higher number of patients and evaluation of IL10 levels are needed for confirmation.
Keywords	Malaria ; Genetic polymorphism ; Polymerase Chain Reaction ; Cytokines ; Restriction enzymes ; Arctic medicine. Tropical medicine ; RC955-962
Subject code	616
Language	English
Publishing date	2016-04-01T00:00:00Z
Publisher	Universidade de São Paulo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: PRELIMINARY REPORT ON THE PUTATIVE ASSOCIATION OF IL10 -3575 T/A GENETIC POLYMORPHISM WITH MALARIA SYMPTOMS

Wilson DOMINGUES / Kelly Aparecida KANUNFRE / Jonatas Cristian RODRIGUES / Leandro Emidio TEIXEIRA / Lidia YAMAMOTO / Thelma Suely OKAY

Revista do Instituto de Medicina Tropical de São Paulo, Vol 58, Iss

2016

Abstract	Only a small percentage of individuals living in endemic areas develop severe malaria suggesting that host genetic factors may play a key role. This study has determined the frequency of single nucleotide polymorphisms (SNPs) in some pro and anti-inflammatory cytokine gene sequences: IL6 (-174; rs1800795), IL12p40 (+1188; rs3212227), IL4 (+33; rs2070874), IL10 (-3575; rs1800890) and TGFb1 (+869; rs1800470), by means of PCR-RFLP. Blood samples were collected from 104 symptomatic and 37 asymptomatic subjects. Laboratory diagnosis was assessed by the thick blood smear test and nested-PCR. No association was found between IL6 (-174), IL12p40 (+1188), IL4 (+33), IL10 (- 3575), TGFb1 (+869) SNPs and malaria symptoms. However, regarding the IL10 -3575 T/A SNP, there were significantly more AA and AT subjects, carrying the polymorphic allele A, in the symptomatic group (c2 = 4.54, p = 0.01, OR = 0.40 [95% CI - 0.17- 0.94]). When the analysis was performed by allele, the frequency of the polymorphic allele A was also significantly higher in the symptomatic group (c2 = 4.50, p = 0.01, OR = 0.45 [95% CI - 0.21-0.95]). In conclusion, this study has suggested the possibility that the IL10 - 3575 T/A SNP might be associated with the presence and maintenance of malaria symptoms in individuals living in endemic areas. Taking into account that this polymorphism is related to decreased IL10 production, a possible role of this SNP in the pathophysiology of malaria is also suggested, but replication studies with a higher number of patients and evaluation of IL10 levels are needed for confirmation.
Keywords	Malaria ; Genetic polymorphism ; Polymerase Chain Reaction ; Cytokines ; Restriction enzymes ; Arctic medicine. Tropical medicine ; RC955-962
Subject code	616
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Universidade de São Paulo
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: La retracción del derecho a la educación en el marco de las restauraciones conservadoras

Gluz, Nora / Lima Rodrigues, Cibele María / Elías, Rodolfo

Una mirada nuestroamericana

2021

Keywords	Education ; Conservatism & right-of-centre democratic ideologies ; Political Science
Language	Spanish
Size	1 Online-Ressource
Publisher	CLACSO
Document type	Book ; Online
Note	Spanish
HBZ-ID	HT030609290
ISBN	9789878130156 ; 9878130150
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Nature and strength of group-14 A-A' bonds.

Rodrigues Silva, Daniela / Blokker, Eva / van der Schuur, J Martijn / Hamlin, Trevor A / Bickelhaupt, F Matthias

Chemical science

2024 Volume 15, Issue 5, Page(s) 1648–1656

Abstract: We have quantum chemically investigated the nature and stability of C-C and Si-Si bonds in ... ...

Abstract	We have quantum chemically investigated the nature and stability of C-C and Si-Si bonds in R
Language	English
Publishing date	2024-01-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc06215e
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Article ; Online: SARS-CoV-2 uses CD4 to infect T helper lymphocytes.

Brunetti, Natalia S / Davanzo, Gustavo G / de Moraes, Diogo / Ferrari, Allan J R / Souza, Gabriela F / Muraro, Stéfanie Primon / Knittel, Thiago L / Boldrini, Vinicius O / Monteiro, Lauar B / Virgílio-da-Silva, João Victor / Profeta, Gerson S / Wassano, Natália S / Nunes Santos, Luana / Carregari, Victor C / Dias, Artur H S / Veras, Flavio P / Tavares, Lucas A / Forato, Julia / Castro, Icaro M S /

Silva-Costa, Lícia C / Palma, André C / Mansour, Eli / Ulaf, Raisa G / Bernardes, Ana F / Nunes, Thyago A / Ribeiro, Luciana C / Agrela, Marcus V / Moretti, Maria Luiza / Buscaratti, Lucas I / Crunfli, Fernanda / Ludwig, Raissa G / Gerhardt, Jaqueline A / Munhoz-Alves, Natália / Marques, Ana Maria / Sesti-Costa, Renata / Amorim, Mariene R / Toledo-Teixeira, Daniel A / Parise, Pierina Lorencini / Martini, Matheus Cavalheiro / Bispos-Dos-Santos, Karina / Simeoni, Camila L / Granja, Fabiana / Silvestrini, Virgínia C / de Oliveira, Eduardo B / Faca, Vitor M / Carvalho, Murilo / Castelucci, Bianca G / Pereira, Alexandre B / Coimbra, Laís D / Dias, Marieli M G / Rodrigues, Patricia B / Gomes, Arilson Bernardo S P / Pereira, Fabricio B / Santos, Leonilda M B / Bloyet, Louis-Marie / Stumpf, Spencer / Pontelli, Marjorie C / Whelan, Sean / Sposito, Andrei C / Carvalho, Robson F / Vieira, André S / Vinolo, Marco A R / Damasio, André / Velloso, Licio / Figueira, Ana Carolina M / da Silva, Luis L P / Cunha, Thiago Mattar / Nakaya, Helder I / Marques-Souza, Henrique / Marques, Rafael E / Martins-de-Souza, Daniel / Skaf, Munir S / Proenca-Modena, Jose Luiz / Moraes-Vieira, Pedro M M / Mori, Marcelo A / Farias, Alessandro S

eLife

2023 Volume 12

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related ... ...

Abstract	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the agent of a major global outbreak of respiratory tract disease known as Coronavirus Disease 2019 (COVID-19). SARS-CoV-2 infects mainly lungs and may cause several immune-related complications, such as lymphocytopenia and cytokine storm, which are associated with the severity of the disease and predict mortality. The mechanism by which SARS-CoV-2 infection may result in immune system dysfunction is still not fully understood. Here, we show that SARS-CoV-2 infects human CD4
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19 ; CD8-Positive T-Lymphocytes ; T-Lymphocytes, Helper-Inducer ; Lung
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.84790
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Circulating antigen-primed cytotoxic T-cells in patients with renal tumors treated with surgery.

Rodrigues Pessoa, Rodrigo / Zhang, Henan / Zganjar, Andrew / Nabavizadeh, Reza / Packiam, Vignesh T / Lohse, Christine M / Cheville, John C / Pagliaro, Lance C / Costello, Brian A / Boorjian, Stephen A / Thompson, R Houston / Lucien, Fabrice / Dong, Haidong / Leibovich, Bradley C

Urologic oncology

2023 Volume 41, Issue 9, Page(s) 393.e1–393.e7

Abstract: ... Specifically, peripheral blood mononuclear cell (PBMC) profile and tumor reactive cytotoxic T ... the effect of nephrectomy on PMBC profile and circulating antigen-primed CD8+ T-cells for patients undergoing ... Results: Antigen-primed CX3CR1+GZMB+ T-cells significantly increased by 3 months after surgery ...

Abstract	Introduction: Systemic immunotherapy has changed the paradigm of treatment of advanced renal cell carcinoma, but nephrectomy continues to benefit selected patients. While we continue to identify mechanisms behind drug resistance, the effect of surgery on natural anti-tumor immunity is poorly understood. Specifically, peripheral blood mononuclear cell (PBMC) profile and tumor reactive cytotoxic T lymphocytes changes secondary to tumor resection have not been extensively characterized. Hence, we aimed to evaluate the effect of nephrectomy on PMBC profile and circulating antigen-primed CD8+ T-cells for patients undergoing solid renal mass resection. Methods: Patients with localized or metastatic solid renal masses who underwent nephrectomy from 2016 to 2018 were enrolled. Blood samples were collected at 3 timepoints for PBMCs analysis (pre-op, 1 day, and 3 months post-op). Flow cytometry was used to identify CD11a Results: Antigen-primed CX3CR1+GZMB+ T-cells significantly increased by 3 months after surgery among patients with RCC (0.8 × 10 Conclusions: Nephrectomy is associated with an increase in cytolytic antigen-primed CD8+ T-cells and specific PBMC profile changes. Further studies are warranted to ascertain the role surgery may have in the restoration of anti-tumor immunity.
MeSH term(s)	Humans ; T-Lymphocytes, Cytotoxic ; Programmed Cell Death 1 Receptor/metabolism ; Ki-67 Antigen/metabolism ; Kidney Neoplasms/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Carcinoma, Renal Cell/metabolism ; Lymphocytes, Tumor-Infiltrating
Chemical Substances	Programmed Cell Death 1 Receptor ; Ki-67 Antigen
Language	English
Publishing date	2023-07-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2023.05.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4817: Show issues

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Article: Abnormal electrocardiogram T wave pattern in ischaemic stroke.

Soares, C / Temtem, M / Sá, A / Rodrigues, R

Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation

2022 Volume 30, Issue 10, Page(s) 488–489

Language	English
Publishing date	2022-05-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2211468-3
ISSN	1876-6250 ; 1568-5888 ; 0929-7456
ISSN (online)	1876-6250
ISSN	1568-5888 ; 0929-7456
DOI	10.1007/s12471-022-01690-y
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Article: PINK1 is a target of T cell responses in Parkinson's disease.

Williams, Gregory P / Michaelis, Tanner / Lima-Junior, João Rodrigues / Frazier, April / Tran, Ngan K / Phillips, Elizabeth J / Mallal, Simon A / Litvan, Irene / Goldman, Jennifer G / Alcalay, Roy N / Sidney, John / Sulzer, David / Sette, Alessandro / Lindestam Arlehamn, Cecilia S

bioRxiv : the preprint server for biology

2024

Abstract: Parkinson's disease (PD) is associated with autoimmune T cells that recognize the protein ... alpha-synuclein in a subset of individuals. Multiple neuroantigens are targets of autoinflammatory T ... whether additional autoantigenic targets of T cells in PD. We generated 15-mer peptide pools spanning several PD ...

Abstract	Parkinson's disease (PD) is associated with autoimmune T cells that recognize the protein alpha-synuclein in a subset of individuals. Multiple neuroantigens are targets of autoinflammatory T cells in classical central nervous system autoimmune diseases such as multiple sclerosis (MS). Here, we explored whether additional autoantigenic targets of T cells in PD. We generated 15-mer peptide pools spanning several PD-related proteins implicated in PD pathology, including GBA, SOD1, PINK1, parkin, OGDH, and LRRK2. Cytokine production (IFNγ, IL-5, IL-10) against these proteins was measured using a fluorospot assay and PBMCs from patients with PD and age-matched healthy controls. This approach identified unique epitopes and their HLA restriction from the mitochondrial-associated protein PINK1, a regulator of mitochondrial stability, as an autoantigen targeted by T cells. The T cell reactivity was predominantly found in male patients with PD, which may contribute to the heterogeneity of PD. Identifying and characterizing PINK1 and other autoinflammatory targets may lead to antigen-specific diagnostics, progression markers, and/or novel therapeutic strategies for PD.
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.09.579465
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Article ; Online: The trajectories of CD4 T lymphocytes over time in patients who have defaulted on treatment for tuberculosis in a cohort of people living with HIV, Recife/PE.

Cunha, Rossana / Filho, Demócrito de B M / M Albuquerque, Maria de Fátima P / Lacerda, Heloísa R / Diniz, George T N / Montarroyos, Ulisses R / Rodrigues, Laura C / Vilela Moura, Líbia Cristina R / Ximenes, Ricardo A A

PloS one

2024 Volume 19, Issue 3, Page(s) e0299244

Abstract: Background: The CD4 T lymphocyte count in people living with HIV (PLHIV) is a predictor ... for the progression of the disease (AIDS), survival and response to antiretroviral treatment (ART). A CD4 T lymphocyte count of less ... of CD4 T lymphocyte counts over time.: Results: Latent class 1 (High CD4 trajectory) grouped ...

Abstract	Background: The CD4 T lymphocyte count in people living with HIV (PLHIV) is a predictor for the progression of the disease (AIDS), survival and response to antiretroviral treatment (ART). A CD4 T lymphocyte count of less than 200 cells/mm3 is indicative of a greater risk for the onset of opportunistic diseases and death. Defaulting on treatment for tuberculosis (TB) may impact immune recovery in PLHIV who are taking ART. The aim of this study was to investigate an association of the CD4 lymphocyte with TB treatment Trajectory and with death. Methods: A cohort of PLHIV over eighteen years of age and who were taking ART and who had defaulted on pulmonary TB treatment. Latent Class analysis was used to identify different trajectories of CD4 T lymphocyte counts over time. Results: Latent class 1 (High CD4 trajectory) grouped individuals together who were characterized as maintaining a low probability (0 to 29%) of a CD4 count ≤ 200 cells/mm3over time, while latent class 2 (Low CD4 trajectory) grouped individuals together with a high probability (93% to 60%), and latent class 3 (Fluctuating CD4 trajectory), grouped individuals with a fluctuating probability (66% to 0%). The chance of defaulting on treatment earlier (≤ 90 days) was four times higher in latent class 2 (Low CD4 trajectory). Although there was no statistical significance, there was a higher frequency of deaths in this same latent class. Conclusion: Individuals with a high probability of a CD4 count ≤ 200 cells/ mm3 should be monitored in order to avoid treatment default and thereby prevent death. New studies should be conducted with a larger sample size and a longer follow-up time in PLHIV who initiated ART treatment early so as to support clinical decisions for a better understanding of immune behavior.
MeSH term(s)	Humans ; HIV Infections/complications ; HIV Infections/drug therapy ; Tuberculosis/drug therapy ; Tuberculosis/complications ; CD4-Positive T-Lymphocytes ; Tuberculosis, Pulmonary/drug therapy ; Tuberculosis, Pulmonary/complications ; CD4 Lymphocyte Count ; Anti-Retroviral Agents/therapeutic use
Chemical Substances	Anti-Retroviral Agents
Language	English
Publishing date	2024-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299244
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