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Article ; Online: Adverse childhood experience and persistent insomnia during emerging adulthood: do positive childhood experiences matter?

Wu, Meng-Hsuan / Chiao, Chi / Lin, Wen-Hsu

2024 Volume 24, Issue 1, Page(s) 287

Abstract: Background: Adverse childhood experiences (ACE) have been documented to have long-term impacts on sleep disturbances. However, less is known about how ACE co-occurs with positive childhood experiences (PCE) and modulate their effects on adult sleep ... ...

Abstract	Background: Adverse childhood experiences (ACE) have been documented to have long-term impacts on sleep disturbances. However, less is known about how ACE co-occurs with positive childhood experiences (PCE) and modulate their effects on adult sleep disturbances, particularly in the context of persistent insomnia. Building on resilience theory, this study aims to examine the interplay between ACE and PCE and their effects on persistent insomnia during emerging adulthood. Methods: A total of 2,841 emerging adults were recruited from the Taiwan Youth Project. Persistent insomnia during emerging adulthood was assessed using two adult surveys (mean age = 19.8 and 21.9). The ACE (10 items) and PCE (7 items) were obtained from the baseline survey (mean age = 13.8). A series of logistic regression analyses were conducted. Results: Among the emerging adults, 29.22% had persistent insomnia. Consistent with the compensatory model, ACE and PCE exerted opposing effects on persistent insomnia during emerging adulthood. In line with the protective model, the negative effect of ACE is mitigated when individuals have high PCE. However, consistent with the challenge model, the protective effect of PCE on persistent insomnia was inhibited in individuals with four or more ACE. Conclusions: PCE serves as a protective factor, shielding emerging adults from the adverse effects of ACE on persistent insomnia. It is essential to prioritize positive experiences during early life to promote lifelong sleep health.
MeSH term(s)	Adult ; Adolescent ; Humans ; Young Adult ; Sleep Initiation and Maintenance Disorders/epidemiology ; Adverse Childhood Experiences ; Sleep ; Drug-Related Side Effects and Adverse Reactions ; Protective Devices ; Sleep Wake Disorders
Language	English
Publishing date	2024-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-024-17774-w
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Article ; Online: Thermosensation and Temperature Preference: From Molecules to Neuronal Circuits in

Chiang, Meng-Hsuan / Lin, Yu-Chun / Wu, Tony / Wu, Chia-Lin

Cells

2023 Volume 12, Issue 24

Abstract: Temperature has a significant effect on all physiological processes of animals. Suitable temperatures promote responsiveness, movement, metabolism, growth, and reproduction in animals, whereas extreme temperatures can cause injury or even death. Thus, ... ...

Abstract	Temperature has a significant effect on all physiological processes of animals. Suitable temperatures promote responsiveness, movement, metabolism, growth, and reproduction in animals, whereas extreme temperatures can cause injury or even death. Thus, thermosensation is important for survival in all animals. However, mechanisms regulating thermosensation remain unexplored, mostly because of the complexity of mammalian neural circuits. The fruit fly
MeSH term(s)	Animals ; Temperature ; Drosophila/physiology ; Drosophila melanogaster/genetics ; Hot Temperature ; Behavior, Animal/physiology ; Mammals
Language	English
Publishing date	2023-12-08
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12242792
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Article ; Online: Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.

Lin, Cheng-Wei / Chiang, Meng-Hsuan / Tam, Ka-Wai

International journal of surgery (London, England)

2022 Volume 107, Page(s) 106964

Abstract: Background: Because the lesions of mammary Paget disease (MPD) are often limited to the nipple-areolar complex, the extension of optimal tumor excision is inconclusive. Moreover, the risk of potential tumor upstaging is unknown; therefore, the ... ...

Abstract	Background: Because the lesions of mammary Paget disease (MPD) are often limited to the nipple-areolar complex, the extension of optimal tumor excision is inconclusive. Moreover, the risk of potential tumor upstaging is unknown; therefore, the application of sentinel lymph node biopsy (SLNB) is required for analysis. We systematically reviewed the real-world data to evaluate the optimal treatment and potential predictors of poorer prognosis for MPD. Methods: The PubMed, Embase, and Cochrane Library databases were searched for relevant studies. Clinical studies were included if they evaluated the outcome of positive rates of SLNB, prognostic risk factors of MPD, and survival outcomes of treatments of interest for MPD, including mastectomy, breast-conserving surgery (BCS) with radiotherapy, and BCS alone. Results: A total of 38 studies with 24,062 patients were retrieved. Compared with BCS alone (21.2%), mastectomy (5.9%; P < 0.001) and BCS with radiotherapy (8; P = 0.001) had significantly lower local recurrence rates. Patients with palpable tumors (30.2%) had significantly worse prognoses than those with impalpable (3.4%) tumors in metastasis (P < 0.001), and significantly higher local recurrence rates were observed in patients with underlying invasive carcinoma (6.7%) than those with noninvasive carcinoma (4.5%; P = 0.032). The positive rate of SLNB was 17% (95% CI: 0.115-0.226). Conclusion: Except for MPD alone, BCS alone is not recommended for treating MPD with invasive ductal carcinoma and MPD with ductal carcinoma in situ. Moreover, a palpable mass, underlying invasive carcinoma, and positive lymph node status may lead to a poorer prognosis, which may be taken into consideration for the application of SLNB.
MeSH term(s)	Humans ; Female ; Paget's Disease, Mammary/surgery ; Mastectomy ; Breast Neoplasms/surgery ; Sentinel Lymph Node Biopsy ; Carcinoma, Intraductal, Noninfiltrating/pathology
Language	English
Publishing date	2022-10-26
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1016/j.ijsu.2022.106964
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Article ; Online: Mapping land-use and land-cover changes through the integration of satellite and airborne remote sensing data.

Lin, Meng-Hsuan / Lin, Ying-Tong / Tsai, Min-Lin / Chen, Yi-Ying / Chen, Yi-Chun / Wang, Hsueh-Ching / Wang, Chi-Kuei

Environmental monitoring and assessment

2024 Volume 196, Issue 3, Page(s) 246

Abstract: An integrated, remotely sensed approach to assess land-use and land-cover change (LULCC) dynamics plays an important role in environmental monitoring, management, and policy development. In this study, we utilized the advantage of land-cover seasonality, ...

Abstract	An integrated, remotely sensed approach to assess land-use and land-cover change (LULCC) dynamics plays an important role in environmental monitoring, management, and policy development. In this study, we utilized the advantage of land-cover seasonality, canopy height, and spectral characteristics to develop a phenology-based classification model (PCM) for mapping the annual LULCC in our study areas. Monthly analysis of normalized difference vegetation index (NDVI) and near-infrared (NIR) values derived from SPOT images enabled the detection of temporal characteristics of each land type, serving as crucial indices for land type classification. The integration of normalized difference built-up index (NDBI) derived from Landsat images and airborne LiDAR canopy height into the PCM resulted in an overall performance of 0.85, slightly surpassing that of random forest analysis or principal component analysis. The development of PCM can reduce the time and effort required for manual classification and capture annual LULCC changes among five major land types: forests, built-up land, inland water, agriculture land, and grassland/shrubs. The gross change LULCC analysis for the Taoyuan Tableland demonstrated fluctuations in land types over the study period (2013 to 2022). A negative correlation (r = - 0.79) in area changes between grassland/shrubs and agricultural land and a positive correlation (r = 0.47) between irrigation ponds and agricultural land were found. Event-based LULCC analysis for Taipei City demonstrated a balance between urbanization and urban greening, with the number of urbanization events becoming comparable to urban greening events when the spatial extent of LULCC events exceeds 1000 m
MeSH term(s)	Environmental Monitoring ; Remote Sensing Technology ; Agriculture ; Policy Making ; Ponds
Language	English
Publishing date	2024-02-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-024-12424-5
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Article ; Online: Independent insulin signaling modulators govern hot avoidance under different feeding states.

Meng-Hsuan Chiang / Yu-Chun Lin / Sheng-Fu Chen / Peng-Shiuan Lee / Tsai-Feng Fu / Tony Wu / Chia-Lin Wu

PLoS Biology, Vol 21, Iss 10, p e

2023 Volume 3002332

Abstract: Thermosensation is critical for the survival of animals. However, mechanisms through which nutritional status modulates thermosensation remain unclear. Herein, we showed that hungry Drosophila exhibit a strong hot avoidance behavior (HAB) compared to ... ...

Abstract	Thermosensation is critical for the survival of animals. However, mechanisms through which nutritional status modulates thermosensation remain unclear. Herein, we showed that hungry Drosophila exhibit a strong hot avoidance behavior (HAB) compared to food-sated flies. We identified that hot stimulus increases the activity of α'β' mushroom body neurons (MBns), with weak activity in the sated state and strong activity in the hungry state. Furthermore, we showed that α'β' MBn receives the same level of hot input from the mALT projection neurons via cholinergic transmission in sated and hungry states. Differences in α'β' MBn activity between food-sated and hungry flies following heat stimuli are regulated by distinct Drosophila insulin-like peptides (Dilps). Dilp2 is secreted by insulin-producing cells (IPCs) and regulates HAB during satiety, whereas Dilp6 is secreted by the fat body and regulates HAB during the hungry state. We observed that Dilp2 induces PI3K/AKT signaling, whereas Dilp6 induces Ras/ERK signaling in α'β' MBn to regulate HAB in different feeding conditions. Finally, we showed that the 2 α'β'-related MB output neurons (MBONs), MBON-α'3 and MBON-β'1, are necessary for the output of integrated hot avoidance information from α'β' MBn. Our results demonstrate the presence of dual insulin modulation pathways in α'β' MBn, which are important for suitable behavioral responses in Drosophila during thermoregulation under different feeding states.
Keywords	Biology (General) ; QH301-705.5
Subject code	590
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Probiotic

Ho, Shuk-Man / Tsai, Wan-Hua / Lai, Chih-Ho / Chiang, Meng-Hsuan / Lee, Wang-Po / Wu, Hui-Yu / Bai, Pei-Yi / Wu, Tony / Wu, Chia-Lin

Gut microbes

2024 Volume 16, Issue 1, Page(s) 2316533

Abstract: Probiotics are live microorganisms that offer potential benefits to their hosts and can occasionally influence behavioral responses. However, the detailed mechanisms by which probiotics affect the behavior of their hosts and the underlying biogenic ... ...

Abstract	Probiotics are live microorganisms that offer potential benefits to their hosts and can occasionally influence behavioral responses. However, the detailed mechanisms by which probiotics affect the behavior of their hosts and the underlying biogenic effects remain unclear. Lactic acid bacteria, specifically
MeSH term(s)	Animals ; Drosophila ; Lactobacillus ; Drosophila melanogaster ; Mushroom Bodies ; Gastrointestinal Microbiome ; Brain ; Lactate Dehydrogenases
Chemical Substances	Lactate Dehydrogenases (EC 1.1.-)
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2575755-6
ISSN	1949-0984 ; 1949-0984
ISSN (online)	1949-0984
ISSN	1949-0984
DOI	10.1080/19490976.2024.2316533
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Article ; Online: The risk factors and clinical outcomes in hepatitis B seropositive and seronegative renal transplant patients.

Tsai, Yu-Lien / Chung, Meng-Hsuan / Lin, Niang-Cheng / Chen, Cheng-Yen / Lin, Yao-Ping / Tsai, Ming-Tsun / Tsai, Hsin-Lin / Chen, Yee-An / Ou, Shuo-Ming / Chu, Chi-Jen / Wu, Tsai-Hung / Tsai, Chang-Youh

American journal of nephrology

2024

Abstract: Introduction: Hepatitis B virus (HBV) infection is prevalent in Asia including Taiwan. We retrospectively evaluated the risk of HBV reactivation and clinical outcomes in HBV+ and HBV- kidney transplant recipients.: Methods: Patients who underwent ... ...

Abstract	Introduction: Hepatitis B virus (HBV) infection is prevalent in Asia including Taiwan. We retrospectively evaluated the risk of HBV reactivation and clinical outcomes in HBV+ and HBV- kidney transplant recipients. Methods: Patients who underwent kidney transplantation between January 2004 and December 2021 were reviewed. The outcomes of interest included risks of HBV reactivation and patient/graft survival. Results: We identified 337 patients (47.5 ± 12 years) were enrolled in our final cohort. Fifty-two (15.4%) had HBsAg positive at the time of transplantation. Seventeen developed viral reactivations, with 41.2% of them accompanied by active hepatitis. The graft survival, acute rejection rate, and cancer development after kidney transplantation did not differ in terms of HBsAg status. The Cox multivariate analysis indicated the HBV reactivation risk was increased by a lack of pre-transplant anti-HBV medication [hazard ratio (HR), 5.95; 95% confidence interval (CI), 1.31-27.02; P = 0.021 or an absence of lifelong antiviral therapy [HR, 3.14; 95% CI, 1.01-9.74; P = 0.047] Conclusion: Individuals, independent of HBsAg status, had similar prognosis in terms of patient and graft survival, acute rejection rate, and cancer development. The absence of either pre-transplant anti-HBV medication or lifelong antiviral therapy was significantly associated with an increased risk of HBV reactivation.
Language	English
Publishing date	2024-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	604540-6
ISSN	1421-9670 ; 0250-8095
ISSN (online)	1421-9670
ISSN	0250-8095
DOI	10.1159/000538231
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Article ; Online: NMR assignments of the macro domain from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Lin, Meng-Hsuan / Huang, Yi-Ping / Chang, Chi-Fon / Hsu, Chun-Hua

Biomolecular NMR assignments

2021 Volume 15, Issue 1, Page(s) 137–142

Abstract: SARS-CoV-2 is a novel pathogen causing pneumonia named COVID-19 and leading to a severe pandemic since the end of 2019. The genome of SARS-CoV-2 contains a macro domain that may play an important role in regulating ADP-ribosylation in host cells and ... ...

Abstract	SARS-CoV-2 is a novel pathogen causing pneumonia named COVID-19 and leading to a severe pandemic since the end of 2019. The genome of SARS-CoV-2 contains a macro domain that may play an important role in regulating ADP-ribosylation in host cells and initiating viral replication. Here, we report the
MeSH term(s)	Carbon Isotopes ; Genome, Viral ; Hydrogen ; Hydrogen-Ion Concentration ; Magnetic Resonance Spectroscopy ; Nitrogen Isotopes ; Protein Binding ; Protein Domains ; Protein Structure, Secondary ; SARS-CoV-2/chemistry ; Temperature ; Viral Nonstructural Proteins/chemistry ; Viral Proteins/chemistry
Chemical Substances	Carbon Isotopes ; Nitrogen Isotopes ; Nitrogen-15 ; Viral Nonstructural Proteins ; Viral Proteins ; Hydrogen (7YNJ3PO35Z) ; Carbon-13 (FDJ0A8596D)
Language	English
Publishing date	2021-01-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2388861-1
ISSN	1874-270X ; 1874-2718
ISSN (online)	1874-270X
ISSN	1874-2718
DOI	10.1007/s12104-020-09996-x
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Article ; Online: Independent insulin signaling modulators govern hot avoidance under different feeding states.

Chiang, Meng-Hsuan / Lin, Yu-Chun / Chen, Sheng-Fu / Lee, Peng-Shiuan / Fu, Tsai-Feng / Wu, Tony / Wu, Chia-Lin

PLoS biology

2023 Volume 21, Issue 10, Page(s) e3002332

Abstract	Thermosensation is critical for the survival of animals. However, mechanisms through which nutritional status modulates thermosensation remain unclear. Herein, we showed that hungry Drosophila exhibit a strong hot avoidance behavior (HAB) compared to food-sated flies. We identified that hot stimulus increases the activity of α'β' mushroom body neurons (MBns), with weak activity in the sated state and strong activity in the hungry state. Furthermore, we showed that α'β' MBn receives the same level of hot input from the mALT projection neurons via cholinergic transmission in sated and hungry states. Differences in α'β' MBn activity between food-sated and hungry flies following heat stimuli are regulated by distinct Drosophila insulin-like peptides (Dilps). Dilp2 is secreted by insulin-producing cells (IPCs) and regulates HAB during satiety, whereas Dilp6 is secreted by the fat body and regulates HAB during the hungry state. We observed that Dilp2 induces PI3K/AKT signaling, whereas Dilp6 induces Ras/ERK signaling in α'β' MBn to regulate HAB in different feeding conditions. Finally, we showed that the 2 α'β'-related MB output neurons (MBONs), MBON-α'3 and MBON-β'1, are necessary for the output of integrated hot avoidance information from α'β' MBn. Our results demonstrate the presence of dual insulin modulation pathways in α'β' MBn, which are important for suitable behavioral responses in Drosophila during thermoregulation under different feeding states.
MeSH term(s)	Animals ; Drosophila/metabolism ; Drosophila melanogaster/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Insulin/metabolism ; Mushroom Bodies/physiology ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction
Chemical Substances	Drosophila Proteins ; Insulin ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; ILP2 protein, Drosophila ; Ilp6 protein, Drosophila
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.3002332
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Article ; Online: Multipathway regulation induced by 4-(phenylsulfonyl)morpholine derivatives against triple-negative breast cancer.

Yang, Fan-Wei / Mai, Te-Lun / Lin, Ying-Chung Jimmy / Chen, Yu-Chen / Kuo, Shang-Che / Lin, Chia-Ming / Lee, Meng-Hsuan / Su, Jung-Chen

Archiv der Pharmazie

2024 , Page(s) e2300435

Abstract: Phenotypic drug discovery (PDD) is an effective drug discovery approach by observation of therapeutic effects on disease phenotypes, especially in complex disease systems. Triple-negative breast cancer (TNBC) is composed of several complex disease ... ...

Abstract	Phenotypic drug discovery (PDD) is an effective drug discovery approach by observation of therapeutic effects on disease phenotypes, especially in complex disease systems. Triple-negative breast cancer (TNBC) is composed of several complex disease features, including high tumor heterogeneity, high invasive and metastatic potential, and a lack of effective therapeutic targets. Therefore, identifying effective and novel agents through PDD is a current trend in TNBC drug development. In this study, 23 novel small molecules were synthesized using 4-(phenylsulfonyl)morpholine as a pharmacophore. Among these derivatives, GL24 (4m) exhibited the lowest half-maximal inhibitory concentration value (0.90 µM) in MDA-MB-231 cells. To investigate the tumor-suppressive mechanisms of GL24, transcriptomic analyses were used to detect the perturbation for gene expression upon GL24 treatment. Followed by gene ontology (GO) analysis, gene set enrichment analysis (GSEA), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, multiple ER stress-dependent tumor suppressive signals were identified, such as unfolded protein response (UPR), p53 pathway, G2/M checkpoint, and E2F targets. Most of the identified pathways triggered by GL24 eventually led to cell-cycle arrest and then to apoptosis. In summary, we developed a novel 4-(phenylsulfonyl)morpholine derivative GL24 with a strong potential for inhibiting TNBC cell growth through ER stress-dependent tumor suppressive signals.
Language	English
Publishing date	2024-02-05
Publishing country	Germany
Document type	Journal Article
ZDB-ID	6381-2
ISSN	1521-4184 ; 0365-6233 ; 1437-1014
ISSN (online)	1521-4184
ISSN	0365-6233 ; 1437-1014
DOI	10.1002/ardp.202300435
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