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Article ; Online: Indirect effect of diabatic heating on Mei-yu frontogenesis

Hu, Yang / Deng, Yi / Lin, Yanluan / Zhou, Zhimin / Cui, Chunguang / Li, Chao / Dong, Xiquan

Clim Dyn. 2022 Aug., v. 59, no. 3-4 p.851-868

2022

Abstract: Mei-yu fronts are accompanied with the formation of frontal clouds. In addition to its direct ... effect on Mei-yu fronts through the modification of atmospheric temperature, diabatic heating related ... contributions to the Mei-yu frontogenesis. The indirect effect of diabatic heating on Mei-yu frontogenesis is ...

Abstract	Mei-yu fronts are accompanied with the formation of frontal clouds. In addition to its direct effect on Mei-yu fronts through the modification of atmospheric temperature, diabatic heating related to clouds formation also influences frontogenesis indirectly by changing local atmospheric circulation. To quantify such indirect effects, piecewise potential vorticity (PV) inversion is adopted to decompose the process of deformation frontogenesis into several parts associated with distinct PV anomalies. The balanced flow associated with the interior-level diabatic PV anomaly emerges as the most stable and important contributor to the total deformation frontogenesis with the effect of local diabatic PV anomaly in the frontal zone outweighing the effect of remote diabatic PV anomaly. Lower-boundary thermal anomaly (i.e., surface cooling associated with frontal clouds formation) and mean flow provide weak negative and positive contributions to the deformation frontogenesis, respectively. The balanced flow associated with the upper-level PV perturbations is weak at lower-levels, especially in the vicinity of the front zone and thus has negligible contributions to the Mei-yu frontogenesis. The indirect effect of diabatic heating on Mei-yu frontogenesis is generally weaker in magnitude compared to the direct effect of temperature modification as well as the impact of moisture depletion that is also tied to clouds formation. The results presented here add further evidences about the importance of cloud feedback to the evolution of Mei-yu fronts and suggest the necessity of improved model representations of cloud processes in achieving a better simulation and prediction of Mei-yu rainfall.
Keywords	air temperature ; atmospheric circulation ; cooling ; deformation ; evolution ; heat ; prediction ; rain
Language	English
Dates of publication	2022-08
Size	p. 851-868.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1471747-5
ISSN	1432-0894 ; 0930-7575
ISSN (online)	1432-0894
ISSN	0930-7575
DOI	10.1007/s00382-022-06159-7
Database	NAL-Catalogue (AGRICOLA)

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Article: Genome-Wide Discovery of DNA Polymorphisms in Mei (

Zhang, Jie / Zhao, Kai / Hou, Dan / Cai, Junhuo / Zhang, Qixiang / Cheng, Tangren / Pan, Huitang / Yang, Weiru

Plant molecular biology reporter

2016 Volume 35, Issue 1, Page(s) 37–46

Abstract: ... polymorphisms. In this study, we performed whole-genome re-sequencing of two mei cultivars with contrasting tree ... sequencing data of two former upright mei cultivars were applied for detecting DNA polymorphisms ... detected and found unevenly distributed within and among the mei chromosomes, which lead to the discovery ...

Abstract	Next-generation sequencing technologies provide opportunities to ascertain the genetic basis of phenotypic differences, even in the closely related cultivars via detection of large amount of DNA polymorphisms. In this study, we performed whole-genome re-sequencing of two mei cultivars with contrasting tree architecture. 75.87 million 100 bp pair-end reads were generated, with 92 % coverage of the genome. Re-sequencing data of two former upright mei cultivars were applied for detecting DNA polymorphisms, since we were more interested in variations conferring weeping trait. Applying stringent parameters, 157,317 mutual single nucleotide polymorphisms (SNPs) and 15,064 mutual insertions-deletions (InDels) were detected and found unevenly distributed within and among the mei chromosomes, which lead to the discovery of 220 high-density, 463 low-density SNP regions together with 80 high-density InDel regions. Additionally, 322 large-effect SNPs and 433 large-effect InDels were detected, and 10.09 % of the SNPs were observed in coding regions. 5.25 % SNPs in coding regions resulted in non-synonymous changes. Ninety SNPs were chosen randomly for validation using high-resolution melt analysis. 93.3 % of the candidate SNPs contained the predicted SNPs. Pfam analysis was further conducted to better understand SNP effects on gene functions. DNA polymorphisms of two known QTL loci conferring weeping trait and their functional effect were also analyzed thoroughly. This study highlights promising functional markers for molecular breeding and a whole-genome genetic basis of weeping trait in mei.
Language	English
Publishing date	2016-08-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2018592-3
ISSN	1572-9818 ; 0735-9640
ISSN (online)	1572-9818
ISSN	0735-9640
DOI	10.1007/s11105-016-1000-4
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Article ; Online: Comparative phytochemical property and antioxidant activity of sixteen Mei (Prunus mume) fruit cultivars from six provinces in China

Liu, Zhihua / Yang, Yezi / Sun, Chongzhi / Wu, Yang / Li, Xiaobo

International Journal of Food Properties. 2022 Dec. 31, v. 25, no. 1 p.617-633

2022

Abstract: Mei (Prunus mume) is widely planted in Eastern Asian countries. To evaluate the effect of cultivar ... and producing origin on the quality of Mei fruit, we studied the phytochemical properties and ... antioxidant activities of the 16 Mei fruit cultivars from 6 provinces in China, as well as their profiles ...

Abstract	Mei (Prunus mume) is widely planted in Eastern Asian countries. To evaluate the effect of cultivar and producing origin on the quality of Mei fruit, we studied the phytochemical properties and antioxidant activities of the 16 Mei fruit cultivars from 6 provinces in China, as well as their profiles of 121 volatile compounds, 5 organic acids, 13 minerals, 24 amino acids and 3 active peptides. Multivariate analysis revealed that the four Mei fruit cultivars with a drier climate in Yunnan province had the characteristics of low water moistures and proteins contents, high total acids, soluble solids, flavones, and phenols contents, and high antioxidant activities, which could be distinguished from fruits of other producing areas. Further component analysis showed that Mei fruits were rich in volatile compounds, organic acids (such as citric acid and malic acid), minerals (such as K, Ca, Mg, P, and Fe), and amino acids (such as Orn, Asn, and Asp), and the nutrient composition ratio in different cultivars was different. In conclusion, Mei fruits can be used as nutritious health food and different cultivars focus on different nutritional compositions.
Keywords	Prunus mume ; antioxidant activity ; antioxidants ; citric acid ; climate ; cultivars ; flavones ; fruits ; health foods ; malic acid ; multivariate analysis ; nutrient content ; peptides ; China ; origin ; cultivar ; phytochemical ; nutrient ; antioxidant ; amino acid ; organic acid ; volatile ; minerals
Language	English
Dates of publication	2022-1231
Size	p. 617-633.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	1402715-x
ISSN	1532-2386 ; 1094-2912
ISSN (online)	1532-2386
ISSN	1094-2912
DOI	10.1080/10942912.2022.2053707
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Article: Metabolic, Enzymatic Activity, and Transcriptomic Analysis Reveals the Mechanism Underlying the Lack of Characteristic Floral Scent in Apricot Mei Varieties.

Bao, Fei / Zhang, Tengxun / Ding, Anqi / Ding, Aiqin / Yang, Weiru / Wang, Jia / Cheng, Tangren / Zhang, Qixiang

Frontiers in plant science

2020 Volume 11, Page(s) 574982

Abstract: Apricot mei, a hybrid of ...

Abstract	Apricot mei, a hybrid of
Language	English
Publishing date	2020-10-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711035-7
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2020.574982
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Article: Super East Asian monsoon Mei-yu in June and July 2020 tied to dissimilar-shifting upper-level westerlies

Liu, Caihong / Hu, Chundi / Yang, Song / Lin, Lifei / Wu, Zeming

Atmospheric research. 2022 Aug. 15, v. 274

2022

Abstract: ... pattern in June and July 2020, with catastrophic Mei-yu floods in the Yangtze River Valley and severe ... compared to June, transporting abundant moisture to Korea and Japan and further strengthening the Mei-yu ...

Abstract	Extreme precipitation anomalies over the East Asia–western Pacific exhibited an unusually similar pattern in June and July 2020, with catastrophic Mei-yu floods in the Yangtze River Valley and severe droughts in southern China and the Bay of Bengal–the western North Pacific (BOB–WNP). However, the corresponding atmospheric circulation anomalies showed distinct characteristics, especially the meridional shifts of the East Asian westerly jet (EAWJ). In June 2020 the EAWJ displaced northward in response to a high-latitude Rossby wavetrain originated from the western North Atlantic, whereas in July 2020 the EAWJ shifted southward due to a robust Pacific–Japan (PJ) wavetrain. The linchpins of the PJ wavetrain are the rapid sea surface warming and the resultant strong convection over the Arabian Sea and the tropical eastern Indian Ocean in July, which considerably enhanced the divergence and sinking motion over the Philippine Sea and the convergence and rising motion over Korea and Japan, favorable for triggering the PJ wavetrain. Meanwhile, the enhanced WNP subtropical high was located further northward to Japan in July compared to June, transporting abundant moisture to Korea and Japan and further strengthening the Mei-yu/Baiu in July, which in turn maintained the PJ wavetrain.
Keywords	Japan ; atmospheric circulation ; convection ; latitude ; monsoon season ; research ; river valleys ; Arabian Sea ; China ; Indian Ocean ; Korean Peninsula ; Philippine Sea ; Yangtze River
Language	English
Dates of publication	2022-0815
Publishing place	Elsevier B.V.
Document type	Article
ISSN	0169-8095
DOI	10.1016/j.atmosres.2022.106213
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Article ; Online: The water extract of "Jiao Mei Gu" attenuates the lipopolysaccharide-induced inflammatory response via inhibiting NF-κB activity in mice.

Luo, Li / Zhang, Wei / Zhang, Zaiqi / Zhu, Junyu / Li, Wei / Yi, Yuhao / Yang, Xue / Ma, Wei / Liang, Huaping

Journal of ethnopharmacology

2020 Volume 259, Page(s) 112882

Abstract: Ethnopharmacological relevance: Jiao Mei Gu (JMG), Cayratia albifolia C.L.Li, is a type of Dong ...

Abstract	Ethnopharmacological relevance: Jiao Mei Gu (JMG), Cayratia albifolia C.L.Li, is a type of Dong plant widely growing in Dong autonomous counties, Hunan province, China. As a type of traditional herbal medicine, the root of JMG plant has been used to treat inflammatory-related diseases such as arthritis because of its prominent anti-inflammatory effects in Dong medicine. Aim of the study: This work investigated the anti-inflammatory effects and mechanisms of the water extract from the root of JMG on lipopolysaccharide (LPS)-induced inflammatory models. Methods: Endotoxemia was induced in C57BL/6 mice by intraperitoneal injection of LPS (20 mg/kg), meanwhile intraperitoneal administration of safe doses of JMG. The survival curve of mice was determined. Serum inflammatory cytokines were detected by the Bio-Plex Mouse Cytokine 23-Plex Panel Kit and enzyme-linked immunosorbent assay (ELISA) at 6 h after drug treatment. Hematoxylin-eosin (HE) staining of important organs was completed at 24 h after treatment. The mechanism of inflammatory action was investigated in vitro on LPS-stimulated macrophages. Macrophage inflammation was then induced using 10 μg/mL LPS. The anti-inflammatory effect of JMG was investigated by the quantitative polymerase chain reaction (qPCR) and ELISA. The anti-inflammatory mechanism was determined using western blotting, the electrophoretic mobility shift assay, and immunocytochemistry. Finally, the antimicrobial activity of JMG was verified by survival experiments in vivo and by bacterial culture experiments in vitro. Results: A 200 mg/kg water extract of JMG was safe for mice and had a significant protective effect on LPS-induced sepsis. Organ damage of heart, liver, lung and kidney was also significantly reduced at 24 h in the JMG group, when compared with the LPS group. The serum MIP-1α (CCL-3), MIP-1β (CCL-4), IL-1β, and TNFα cytokines were significantly decreased at 6 h in the JMG group, when compared with the LPS group. In a similar manner, 0.2μg/ml JMG significantly reduced mRNA and protein levels of MIP-1α (CCL-3), MIP-1β (CCL-4), IL-1β, and TNFα in LPS-stimulated macrophage. JMG treatment inhibited the phosphorylation of NF-κB p65 and reduced nuclear transduction, thus reducing transcriptional activity. At the same time, we showed that JMG had no protective effect on Escherichia coli-induced sepsis, as well as no antimicrobial activity. Conclusions: Our results showed that a water-soluble extract of JMG inhibited LPS-induced inflammation via attenuating the NF-κB signaling pathway, which provides an important rationale for the treatment of inflammation-related diseases.
MeSH term(s)	Animals ; Anti-Inflammatory Agents/pharmacology ; Cytokines/blood ; Cytokines/metabolism ; Drugs, Chinese Herbal/pharmacology ; Endotoxemia/chemically induced ; Endotoxemia/drug therapy ; Escherichia coli ; I-kappa B Proteins/metabolism ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Signal Transduction/drug effects ; Transcription Factor RelA/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Cytokines ; Drugs, Chinese Herbal ; I-kappa B Proteins ; Lipopolysaccharides ; NF-kappa B ; Transcription Factor RelA ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2020-04-20
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.112882
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Article ; Online: Effects of Qi-Bao-Mei-Ran-Dan on proliferative activity and expressions of apoptosis-related genes Bcl-2, Bax and autophagy-related protein LC3II in fibroblasts of aging skin.

Li, Heng / Yang, Ting / Tian, Li-Ming / Zhang, Peng-Cheng

Asian journal of surgery

2022 Volume 45, Issue 6, Page(s) 1319–1321

MeSH term(s)	Apoptosis ; Autophagy-Related Proteins ; Fibroblasts/metabolism ; Humans ; Skin Aging/genetics ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
Chemical Substances	Autophagy-Related Proteins ; bcl-2-Associated X Protein
Language	English
Publishing date	2022-03-30
Publishing country	China
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2022.01.043
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Article ; Online: Wu-Mei-wan protects pancreatic β cells by inhibiting NLRP3 Inflammasome activation in diabetic mice.

Yang, Xueping / Lu, Fuer / Li, Lingli / Li, Jingbin / Luo, Jinlong / Zhang, Siyi / Liu, Xinqiao / Chen, Guang

BMC complementary and alternative medicine

2019 Volume 19, Issue 1, Page(s) 35

Abstract: Background: Wu-Mei-Wan (WMW) is a traditional Chinese herbal formulation that is clinically ...

Abstract	Background: Wu-Mei-Wan (WMW) is a traditional Chinese herbal formulation that is clinically prescribed to treat diabetes mellitus in China. WMW has been shown to alleviate damage in pancreatic β cells, but the underlying mechanism remains unclear. This study aims to explore how WMW plays a protective role in pancreatic islets. Methods: Drug testing and mechanism analyses were performed on mice treated with three concentrations of WMW (4800, 9600, and 19,200 mg/kg/bw) for four consecutive weeks. Blood was collected from both db/db and wild-type mice to determine fasting blood glucose (FBG) and serum insulin levels. The expression of proteins related to apoptosis, cysteinyl aspartate-specific proteinase 12 (caspase-12) and B-cell leukemia 2 (Bcl-2), was measured by western blot. Interleukin-1β (IL-1β), interleukin-18 (IL-18), monocyte chemoattractant protein-1α (MCP-1α), and tumor necrosis factor-α (TNF-α) in the pancreas were tested with enzyme-linked immunosorbent assay (ELISA). Immunohistochemistry staining of F4/80 was performed to measure the pancreatic infiltration of macrophages. Western blot and immunofluorescence staining of the NLRP3 inflammasome were used to measure the expression of proteins related to apoptosis and inflammation. Results: WMW dose-dependently reduced FBG and promoted serum insulin secretion in db/db mice compared to the wild-type controls. WMW protected pancreatic β cells with a pattern of decreasing caspase-12 and increasing Bcl-2 expression. WMW also reversed the upregulated production of IL-1β, IL-18, MCP-1α, and macrophage-specific surface glycoprotein F4/80 in diabetic mice. In addition, the protein expression levels of NLRP3 inflammasome components NLRP3, ASC, and caspase-1 (P20) were higher in db/db mice than in wild-type controls. Conclusions: WMW inhibits the activation of the NLRP3 inflammasome to protect pancreatic β cells and prevent type 2 diabetes mellitus development.
MeSH term(s)	Animals ; Cells, Cultured ; Diabetes Mellitus, Experimental/metabolism ; Drugs, Chinese Herbal/pharmacology ; Inflammasomes/antagonists & inhibitors ; Inflammasomes/drug effects ; Inflammasomes/metabolism ; Insulin-Secreting Cells/drug effects ; Male ; Mice ; NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Protective Agents/pharmacology
Chemical Substances	Drugs, Chinese Herbal ; Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, mouse ; Protective Agents
Language	English
Publishing date	2019-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2050429-9
ISSN	1472-6882 ; 1472-6882
ISSN (online)	1472-6882
ISSN	1472-6882
DOI	10.1186/s12906-019-2443-6
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Article ; Online: Wu-Mei-Wan prevents high-fat diet-induced obesity by reducing white adipose tissue and enhancing brown adipose tissue function.

Wu, Fan / Yang, Xueping / Hu, Meilin / Shao, Qingqing / Fang, Ke / Li, Jingbin / Zhao, Yan / Xu, Lijun / Zou, Xin / Lu, Fuer / Chen, Guang

Phytomedicine : international journal of phytotherapy and phytopharmacology

2020 Volume 76, Page(s) 153258

Abstract: Background: Wu-Mei-Wan, a classic traditional Chinese herb medicine, is one of the most important ...

Abstract	Background: Wu-Mei-Wan, a classic traditional Chinese herb medicine, is one of the most important formulations to treat digestive diseases from ancient times to the present. Our previous study showed that WMW treatment can prevent T2DM in db/db mice, which motivating the application of WMW on metabolic disorders. Purpose: Obesity and its comorbid diseases have increased dramatically and are now a worldwide health problem. There is still a lack of satisfactory treatment strategies for obesity. This work was designed to assess the effect and related mechanism of WMW on high fat diet (HFD)-induced obese mice model. Methods: Obese mice were induced by HFD. Thetherapeutic effect of WMW were analyzed by examining body and adipose tissue weight, metabolic profile and energy expenditure. Adipose tissue phenotype was determined by histological staining and the mitochondrial content was examined by transmission electron microscopy (TEM). Immunohistochemical and immunofluorescence staining, RT-qPCR and Western blot analysis were used to evaluate expression of key molecules in adipose tissue. Results: WMW treatment significantly protects HFD-induced obesity. Here we showed that WMW limits weight gain, improves metabolic profile and increases energy expenditure. WMW inhibits the hypertrophy and hyperplasia of white adipocytes, the mechanism involving the inhibition of TLR3/IL-6/JAK1/STAT3 pathway. In brown adipose tissue (BAT), WMW promotes thermogenicprogramme without affecting cell proliferation. The activated BMP7/ Smad1/5/9 pathway is considered to be one of the explanations for the effect of WMW on BAT. Conclusion: Our results suggested that WMW can prevent obesity and its underlying mechanisms are associated with reducing white adipose tissue and enhancing brown adipose tissue function.
Language	English
Publishing date	2020-06-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2020.153258
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Article: Wu-Mei-Wan Reduces Insulin Resistance via Inhibition of NLRP3 Inflammasome Activation in HepG2 Cells.

Yang, Xueping / Li, Lingli / Fang, Ke / Dong, Ruolan / Li, Jingbin / Zhao, Yan / Dong, Hui / Yi, Ping / Huang, Zhaoyi / Chen, Guang / Lu, Fuer

Evidence-based complementary and alternative medicine : eCAM

2017 Volume 2017, Page(s) 7283241

Abstract: Wu-Mei-Wan (WMW) is a Chinese herbal formula used to treat type 2 diabetes. In this study, we aimed ...

Abstract	Wu-Mei-Wan (WMW) is a Chinese herbal formula used to treat type 2 diabetes. In this study, we aimed to explore the effects and mechanisms of WMW on insulin resistance in HepG2 cells. HepG2 cells were pretreated with palmitate (0.25 mM) to impair the insulin signaling pathway. Then, they were treated with different doses of WMW-containing medicated serum and stimulated with 100 nM insulin. Results showed that palmitate could reduce the glucose consumption rate in HepG2 cells and impair insulin signaling related to phosphorylation of insulin receptor (IR) and insulin receptor substrate-1 (IRS-1), thereby regulating the downstream signaling pathways. However, medicated serum of WMW restored impaired insulin signaling, upregulated the expression of phospho-IR (pIR), phosphatidylinositol 3-kinase p85 subunit, phosphoprotein kinase B, and glucose transporter 4, and decreased IRS serine phosphorylation. In addition, it decreased the expression of interleukin-1
Language	English
Publishing date	2017-08-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2017/7283241
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