LIVIVO - Search results -

Search results

Result 1 - 10 of total 36

Search options

Article: Clinical Characteristics and Post-Operative Outcomes in Children with Very Severe Obstructive Sleep Apnea.

Saied, Nancy / Solis, Roberto Noel / Funamura, Jamie / Chen, Joy / Lammers, Cathleen / Nandalike, Kiran

2022 Volume 9, Issue 9

Abstract: Available information on clinical characteristics and post-operative outcomes in children with very severe obstructive sleep apnea (OSA) is limited. Our study evaluates the clinical features and polysomnographic (PSG) variables that predict post- ... ...

Abstract	Available information on clinical characteristics and post-operative outcomes in children with very severe obstructive sleep apnea (OSA) is limited. Our study evaluates the clinical features and polysomnographic (PSG) variables that predict post-operative outcomes in children with an obstructive apneal hypopnea index (AHI) of more than 25 events/hr. In this study from a single tertiary care center, we performed a retrospective chart review of patients with an AHI > 25/hr, who underwent tonsillectomy and adenoidectomy (T&A) between January 2016 and September 2021. In total, 50 children were included in the study: 26.0% (13/50) of children experienced post-operative respiratory events and four children needed intubation and ventilator support. Compared with children without respiratory events, children requiring post-operative respiratory interventions were younger (4.4 ± 5.2 vs. 8.0 ± 5.2 years; p = 0.04), had higher pre-operative AHI (73.6 ± 27.4 vs. 44.8 ± 24.9; p < 0.01), lower oxygen nadirs (70.0 ± 13.0% vs. 83.0 ± 7.0%; p < 0.01), and had lower body metabolic index Z-scores (−0.51 ± 2.1 vs. 0.66 ± 1.5; p < 0.04). Moderate to severe residual OSA was identified in 70% (24/34) of children with available post-operative PSG; younger children had better PSG outcomes. Our study shows that post-operative respiratory events are frequent in children with very severe OSA, particularly with an AHI > 40/h, younger children (<2 years of age), lower oxygen saturation (SpO2), and poor nutritional status, necessitating close monitoring.
Language	English
Publishing date	2022-09-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children9091396
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: IκBNS expression in B cells is dispensable for IgG responses to T cell-dependent antigens.

Khoenkhoen, Sharesta / Ádori, Monika / Solís-Sayago, Darío / Soulier, Juliette / Russell, Jamie / Beutler, Bruce / Pedersen, Gabriel K / Karlsson Hedestam, Gunilla B

Frontiers in immunology

2022 Volume 13, Page(s) 1000755

Abstract: Mice lacking the atypical inhibitory kappa B (IκB) protein, IκBNS, a regulator of the NF-κB pathway encoded by the ... nfkbid ... gene, display impaired antibody responses to both T cell-independent (TI) and T cell-dependent (TD) antigens. To better ... ...

Abstract	Mice lacking the atypical inhibitory kappa B (IκB) protein, IκBNS, a regulator of the NF-κB pathway encoded by the nfkbid gene, display impaired antibody responses to both T cell-independent (TI) and T cell-dependent (TD) antigens. To better understand the basis of these defects, we crossed mice carrying floxed nfkbid alleles with mice expressing Cre under the transcriptional control of the Cd79a gene to create mice that lacked IκBNS expression only in B cells. Analyses of these conditional knock-out mice revealed intact CD4<sup>+</sup> and CD8<sup>+</sup> T cell populations, including preserved frequencies of FoxP3<sup>+</sup> regulatory T cells, which are known to be reduced in IκBNS knock-out mice. Like IκBNS knock-out mice, mice with conditional IκBNS ablation in B cells displayed defective IgM responses to TI antigens and a severe reduction in peritoneal B-1a cells. However, in contrast to mice lacking IκBNS altogether, the conditional IκBNS knock-out mice responded well to TD antigens compared to the control mice, with potent IgG responses following immunization with the viral antigen, rSFV-βGal or the widely used hapten-protein model antigen, NP-CGG. Furthermore, B cell intrinsic IκBNS expression was dispensable for germinal center (GC) formation and T follicular helper cell responses to NP-CGG immunization. The results presented here suggest that the defect in antibody responses to TD antigens observed in IκBNS knock-out mice results from a B cell extrinsic defect.
MeSH term(s)	Mice ; Animals ; Cell Differentiation ; B-Lymphocytes ; Mice, Knockout ; Antigens ; NF-kappa B/metabolism ; Immunoglobulin G
Chemical Substances	Antigens ; NF-kappa B ; Immunoglobulin G
Language	English
Publishing date	2022-10-21
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1000755
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Neurotoxic properties of the Zika virus envelope protein.

Steiner, Joseph P / Bachani, Muznabanu / Malik, Nasir / Li, Wenxue / Tyagi, Richa / Sampson, Kevon / Abrams, Rachel P M / Kousa, Youssef / Solis, Jamie / Johnson, Tory P / Nath, Avindra

Experimental neurology

2023 Volume 367, Page(s) 114469

Abstract: Prenatal Zika virus (ZIKV) infection is a serious global concern as it can lead to brain injury and many serious birth defects, collectively known as congenital Zika syndrome. Brain injury likely results from viral mediated toxicity in neural progenitor ... ...

Abstract	Prenatal Zika virus (ZIKV) infection is a serious global concern as it can lead to brain injury and many serious birth defects, collectively known as congenital Zika syndrome. Brain injury likely results from viral mediated toxicity in neural progenitor cells. Additionally, postnatal ZIKV infections have been linked to neurological complications, yet the mechanisms driving these manifestations are not well understood. Existing data suggest that the ZIKV envelope protein can persist in the central nervous system for extended periods of time, but it is unknown if this protein can independently contribute to neuronal toxicity. Here we find that the ZIKV envelope protein is neurotoxic, leading to overexpression of poly adenosine diphosphate -ribose polymerase 1, which can induce parthanatos. Together, these data suggest that neuronal toxicity resulting from the envelope protein may contribute to the pathogenesis of post-natal ZIKV-related neurologic complications.
MeSH term(s)	Pregnancy ; Female ; Humans ; Zika Virus/metabolism ; Zika Virus Infection/complications ; Zika Virus Infection/pathology ; Viral Envelope Proteins/metabolism ; Neurons/pathology ; Nervous System Diseases ; Neurotoxicity Syndromes ; Brain Injuries
Chemical Substances	Viral Envelope Proteins
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	207148-4
ISSN	1090-2430 ; 0014-4886
ISSN (online)	1090-2430
ISSN	0014-4886
DOI	10.1016/j.expneurol.2023.114469
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 184: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Structural Vulnerability in the U.S. Revealed in Three Waves of COVID-19.

Solis, Jamie / Franco-Paredes, Carlos / Henao-Martínez, Andrés F / Krsak, Martin / Zimmer, Shanta M

The American journal of tropical medicine and hygiene

2020 Volume 103, Issue 1, Page(s) 25–27

Abstract: The novel coronavirus disease (COVID-19) pandemic has unveiled underlying health inequities throughout the United States. The pandemic has spread across U.S. states, affecting different vulnerable populations, including both inner-city and rural ... ...

Abstract	The novel coronavirus disease (COVID-19) pandemic has unveiled underlying health inequities throughout the United States. The pandemic has spread across U.S. states, affecting different vulnerable populations, including both inner-city and rural populations, and those living in congregate settings such as nursing homes and assisted-living facilities. In addition, since early April, there has been an increasing number of outbreaks of COVID-19 in jails and prisons. We describe three overlapping epidemiologic waves of spread of COVID-19 linked to three different kinds of structural vulnerabilities.
MeSH term(s)	Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Crowding ; Frail Elderly ; Humans ; Nursing Homes ; Occupational Exposure ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Prisons ; Rural Population ; SARS-CoV-2 ; United States/epidemiology ; Urban Population ; Vulnerable Populations
Keywords	covid19
Language	English
Publishing date	2020-05-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.20-0391
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.61: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Bio-impedance spectroscopy added to a fluid management protocol does not improve preservation of residual kidney function in incident hemodialysis patients in a randomized controlled trial.

Davies, Simon J / Coyle, David / Lindley, Elizabeth J / Keane, David / Belcher, John / Caskey, Fergus J / Dasgupta, Indranil / Davenport, Andrew / Farrington, Ken / Mitra, Sandip / Ormandy, Paula / Wilkie, Martin / MacDonald, Jamie / Zanganeh, Mandana / Andronis, Lazaros / Solis-Trapala, Ivonne / Sim, Julius

Kidney international

2023 Volume 104, Issue 3, Page(s) 587–598

Abstract: Avoiding excessive dialysis-associated volume depletion may help preserve residual kidney function (RKF). To establish whether knowledge of the estimated normally hydrated weight from bioimpedance measurements (BI-NHW) when setting the post-hemodialysis ... ...

Abstract	Avoiding excessive dialysis-associated volume depletion may help preserve residual kidney function (RKF). To establish whether knowledge of the estimated normally hydrated weight from bioimpedance measurements (BI-NHW) when setting the post-hemodialysis target weight (TW) might mitigate rate of loss of RKF, we undertook an open label, randomized controlled trial in incident patients receiving HD, with clinicians and patients blinded to bioimpedance readings in controls. A total of 439 patients with over 500 ml urine/day or residual GFR exceeding 3 ml/min/1.73m
MeSH term(s)	Humans ; Anuria ; Dielectric Spectroscopy/methods ; Renal Dialysis/adverse effects ; Renal Dialysis/methods ; Urea ; Kidney ; Kidney Failure, Chronic/diagnosis ; Kidney Failure, Chronic/therapy ; Randomized Controlled Trials as Topic
Chemical Substances	Urea (8W8T17847W)
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2023.05.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 797: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Therapeutic Approaches for Zika Virus Infection of the Nervous System.

Abrams, Rachel P M / Solis, Jamie / Nath, Avindra

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

2017 Volume 14, Issue 4, Page(s) 1027–1048

Abstract: Zika virus has spread rapidly in the Americas and has caused devastation of human populations affected in these regions. The virus causes teratogenic effects involving the nervous system, and in adults and children can cause a neuropathy similar to ... ...

Abstract	Zika virus has spread rapidly in the Americas and has caused devastation of human populations affected in these regions. The virus causes teratogenic effects involving the nervous system, and in adults and children can cause a neuropathy similar to Guillain-Barré syndrome, an anterior myelitis, or, rarely, an encephalitis. While major efforts have been undertaken to control mosquito populations that spread the virus and to develop a vaccine, drug development that directly targets the virus in an infected individual to prevent or treat the neurological manifestations is necessary. Rational and targeted drug development is possible since the viral life cycle and the structure of the key viral proteins are now well understood. While several groups have identified therapeutic candidates, their approaches differ in the types of screening processes and viral assays used. Animal studies are available for only a few compounds. Here we provide an exhaustive review and compare each of the classes of drugs discovered, the methods used for drug discovery, and their potential use in humans for the prevention or treatment of neurological complications of Zika virus infection.
MeSH term(s)	Animals ; Drug Discovery ; Humans ; Nervous System Diseases/drug therapy ; Nervous System Diseases/virology ; Zika Virus/genetics ; Zika Virus/physiology ; Zika Virus Infection/complications ; Zika Virus Infection/drug therapy ; Zika Virus Infection/metabolism
Language	English
Publishing date	2017-09-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2316693-9
ISSN	1878-7479 ; 1933-7213
ISSN (online)	1878-7479
ISSN	1933-7213
DOI	10.1007/s13311-017-0575-2
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6156: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Common Dermatologic Conditions in Returning Travelers.

Shepard, Zachary / Rios, Margarita / Solis, Jamie / Wand, Taylor / Henao-Martínez, Andrés F / Franco-Paredes, Carlos / Suarez, José Antonio

Current tropical medicine reports

2021 Volume 8, Issue 2, Page(s) 104–111

Abstract: Purpose of review: Travel medicine practitioners often are confronted with returning travelers with dermatologic disorders that could be of infectious causes or inflammatory or allergic. Some dermatologic processes are the result of exposure to insects ... ...

Abstract	Purpose of review: Travel medicine practitioners often are confronted with returning travelers with dermatologic disorders that could be of infectious causes or inflammatory or allergic. Some dermatologic processes are the result of exposure to insects or acquired due to environmental exposures. There is a broad range of dermatosis of infectious and non-infectious etiologies that clinicians need to consider in the differential diagnosis of dermatosis in travelers. Recent findings: With increasing international travel to tropical destinations, many individuals may be exposed to rickettsia (i.e., African tick bite fever, scrub typhus, or Mediterranean spotted fever), parasitic infections (i.e., cutaneous larva migrans, cutaneous leishmaniasis, African trypanosomiasis, or American trypanosomiasis), viral infections (i.e., measles or Zika virus infection), bacterial (i.e., Buruli ulcer) or ectoparasites (scabies or tungiasis), and myiasis. Cutaneous lesions provide clinical clues to the diagnosis of specific exposures during travel among returned travelers. Summary: Dermatologic disorders represent the third most common health problem in returned travelers, after gastrointestinal and respiratory illness. Many of these conditions may pose a risk of severe complications if there is any delay in diagnosis. Therefore, clinicians caring for travelers need to become familiar with the most frequent infectious and non-infectious skin disorders in travelers.
Language	English
Publishing date	2021-02-16
Publishing country	Switzerland
Document type	Journal Article
ISSN	2196-3045
ISSN	2196-3045
DOI	10.1007/s40475-021-00231-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: Utility of Screening for Obstructive Sleep Apnea with the Pediatric Sleep Questionnaire (PSQ) in Children with Craniofacial Anomalies.

Solis, Roberto N / Aulakh, Sukhkaran S / Velazquez-Castro, Oscar S / Farber, Nicole I / Olarewaju, Adebola M / Nandalike, Kiran / Tollefson, Travis T / Senders, Craig W / Funamura, Jamie L

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

2022 Volume 61, Issue 5, Page(s) 882–887

Abstract: Objective: To determine the accuracy of the Pediatric Sleep Questionnaire (PSQ) as a screening tool for obstructive sleep apnea in children with craniofacial anomalies.: Design: Retrospective cohort study.: Setting: Multidisciplinary cleft and ... ...

Abstract	Objective: To determine the accuracy of the Pediatric Sleep Questionnaire (PSQ) as a screening tool for obstructive sleep apnea in children with craniofacial anomalies. Design: Retrospective cohort study. Setting: Multidisciplinary cleft and craniofacial clinic at a tertiary care center. Patients: Children with craniofacial anomalies 2 to ≤18 years of age who both completed a PSQ screen and underwent polysomnography (PSG) without interval surgery. Main outcome measures: Sensitivity and specificity of the PSQ in detecting an obstructive apnea-hypopnea index (AHI) ≥ 5 events/hour. Results: Fifty children met study criteria, with 66% (n = 33) having an associated syndrome. Mean patient age at time of PSQ was 9.6 Conclusions: The PSQ was less sensitive and specific in detecting an AHI ≥ 5 in children with craniofacial anomalies than in a general population, and particularly poor in for children with syndrome-associated craniofacial conditions. Given the high prevalence of OSA in this patient population, a craniofacial-specific validated screening tool would be beneficial.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Adolescent ; Retrospective Studies ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/epidemiology ; Syndrome ; Surveys and Questionnaires ; Craniofacial Abnormalities/diagnosis ; Craniofacial Abnormalities/epidemiology ; Sleep
Language	English
Publishing date	2022-12-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	1069409-2
ISSN	1545-1569 ; 0009-8701 ; 1055-6656
ISSN (online)	1545-1569
ISSN	0009-8701 ; 1055-6656
DOI	10.1177/10556656221147815
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 451: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Standardization of Synthetic Biology Tools and Assembly Methods for

Malcı, Koray / Watts, Emma / Roberts, Tania Michelle / Auxillos, Jamie Yam / Nowrouzi, Behnaz / Boll, Heloísa Oss / Nascimento, Cibele Zolnier Sousa do / Andreou, Andreas / Vegh, Peter / Donovan, Sophie / Fragkoudis, Rennos / Panke, Sven / Wallace, Edward / Elfick, Alistair / Rios-Solis, Leonardo

ACS synthetic biology

2022 Volume 11, Issue 8, Page(s) 2527–2547

Abstract: As redesigning organisms using engineering principles is one of the purposes of synthetic biology (SynBio), the standardization of experimental methods and DNA parts is becoming increasingly a necessity. The synthetic biology community focusing on the ... ...

Abstract	As redesigning organisms using engineering principles is one of the purposes of synthetic biology (SynBio), the standardization of experimental methods and DNA parts is becoming increasingly a necessity. The synthetic biology community focusing on the engineering of
MeSH term(s)	Metabolic Engineering/methods ; Phylogeny ; Reference Standards ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Synthetic Biology/methods ; Yarrowia/genetics ; Yarrowia/metabolism
Language	English
Publishing date	2022-08-08
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	2161-5063
ISSN (online)	2161-5063
DOI	10.1021/acssynbio.1c00442
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Benefits of COVID-19 viral screening of formerly incarcerated individuals during community reentry.

Quan, Nicolas G / Latif, Hassan / Krsak, Martin / Corbisiero, Michaele Francesco / Solis, Jamie / Wand, Taylor / Mortaji, Parisa / Vrolijk, Michael Aaron / Kon, Shelley / Ghandnoosh, Nazgol / Franco-Paredes, Carlos

Therapeutic advances in infectious disease

2021 Volume 8, Page(s) 2049936120985951

Language	English
Publishing date	2021-01-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2728410-4
ISSN	2049-937X ; 2049-9361
ISSN (online)	2049-937X
ISSN	2049-9361
DOI	10.1177/2049936120985951
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito