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  1. Article: POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance.

    Aramburu, Tomas / Kelich, Joseph / Rice, Cory / Skordalakes, Emmanuel

    Computational and structural biotechnology journal

    2022  Volume 20, Page(s) 675–684

    Abstract: Telomeric POT1-TPP1 binding is critical to telomere maintenance and disruption of this complex may lead to cancer. Current data suggests a reduction of intracellular POT1 levels in the absence of TPP1. Here we provide evidence of POT1 plasticity that ... ...

    Abstract Telomeric POT1-TPP1 binding is critical to telomere maintenance and disruption of this complex may lead to cancer. Current data suggests a reduction of intracellular POT1 levels in the absence of TPP1. Here we provide evidence of POT1 plasticity that contributes to its lack of stability in the absence of TPP1 binding. Structural data reveals inter- and intramolecular POT1C domain flexibility in the absence of TPP1. Thermostability and proteolytic resistance assays show that POT1C and the mutant complex POT1C(Q623H)-TPP1(PBD) are less stable than the wild type POT1C-TPP1(PBD), suggesting that TPP1 binding to POT1 stabilizes POT1C and makes it less accessible to proteasomal degradation in the cell. Disruption of the POT1-TPP1 complex such as through cancer-associated mutations leads to a reduction of intracellular POT1, telomere uncapping, and telomere associated DNA damage response (DDR). DDR in turn leads to senescence or genomic instability and oncogenesis.
    Language English
    Publishing date 2022-01-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: POT1-TPP1 binding stabilizes POT1, promoting efficient telomere maintenance

    Aramburu, Tomas / Kelich, Joseph / Rice, Cory / Skordalakes, Emmanuel

    Computational and Structural Biotechnology Journal. 2022, v. 20

    2022  

    Abstract: Telomeric POT1-TPP1 binding is critical to telomere maintenance and disruption of this complex may lead to cancer. Current data suggests a reduction of intracellular POT1 levels in the absence of TPP1. Here we provide evidence of POT1 plasticity that ... ...

    Abstract Telomeric POT1-TPP1 binding is critical to telomere maintenance and disruption of this complex may lead to cancer. Current data suggests a reduction of intracellular POT1 levels in the absence of TPP1. Here we provide evidence of POT1 plasticity that contributes to its lack of stability in the absence of TPP1 binding. Structural data reveals inter- and intramolecular POT1C domain flexibility in the absence of TPP1. Thermostability and proteolytic resistance assays show that POT1C and the mutant complex POT1C(Q623H)-TPP1(PBD) are less stable than the wild type POT1C-TPP1(PBD), suggesting that TPP1 binding to POT1 stabilizes POT1C and makes it less accessible to proteasomal degradation in the cell. Disruption of the POT1-TPP1 complex such as through cancer-associated mutations leads to a reduction of intracellular POT1, telomere uncapping, and telomere associated DNA damage response (DDR). DDR in turn leads to senescence or genomic instability and oncogenesis.
    Keywords DNA damage ; biotechnology ; carcinogenesis ; genetic instability ; mutants ; plasticity ; proteolysis ; telomeres ; thermal stability
    Language English
    Size p. 675-684.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2694435-2
    ISSN 2001-0370
    ISSN 2001-0370
    DOI 10.1016/j.csbj.2022.01.005
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Quantification of natural abundance NMR data differentiates the solution behavior of monoclonal antibodies and their fragments.

    Ban, David / Rice, Cory T / McCoy, Mark A

    mAbs

    2021  Volume 13, Issue 1, Page(s) 1978132

    Abstract: Biotherapeutics are an important class of molecules for the treatment of a wide range of diseases. They include low molecular weight peptides, highly engineered protein scaffolds and monoclonal antibodies. During their discovery and development, ... ...

    Abstract Biotherapeutics are an important class of molecules for the treatment of a wide range of diseases. They include low molecular weight peptides, highly engineered protein scaffolds and monoclonal antibodies. During their discovery and development, assessments of the biophysical attributes is critical to understanding the solution behavior of therapeutic proteins and for de-risking liabilities. Thus, methods that can quantify, characterize, and provide a basis to inform risks and drive the selection of more optimal antibody and alternative scaffolds are needed. Nuclear Magnetic Resonance (NMR) spectroscopy is a technique that provides a means to probe antibody and antibody-like molecules in solution, at atomic resolution, under any formulated conditions. Here, all samples were profiled at natural abundance requiring no isotope enrichment. We present a numerical approach that quantitates two-dimensional methyl spectra. The approach was tested with a reference dataset that contained different types of antibody and antibody-like molecules. This dataset was processed through a procedure we call a Random Sampling of NMR Peaks for Covariance Analysis. This analysis revealed that the first two components were well correlated with the hydrodynamic radius of the molecules included in the reference set. Higher-order principal components were also linked to dynamic features between different tethered antibody-like molecules and contributed to decisions around candidate selection. The reference set provides a basis to characterize molecules with unknown solution behavior and is sensitive to the behavior of a molecule formulated under different conditions. The approach is independent of protein design, scaffold, formulation and provides a facile method to quantify solution behavior.
    MeSH term(s) Antibodies, Monoclonal/chemistry ; Antineoplastic Agents, Immunological ; Magnetic Resonance Spectroscopy/methods ; Peptides
    Chemical Substances Antibodies, Monoclonal ; Antineoplastic Agents, Immunological ; Peptides
    Language English
    Publishing date 2021-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2537838-7
    ISSN 1942-0870 ; 1942-0870
    ISSN (online) 1942-0870
    ISSN 1942-0870
    DOI 10.1080/19420862.2021.1978132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Cerebrovascular Complication and Valve Surgery in Infective Endocarditis.

    Rice, Cory J / Kovi, Shivakrishna / Wisco, Dolora R

    Seminars in neurology

    2021  Volume 41, Issue 4, Page(s) 437–446

    Abstract: Infective endocarditis (IE) with neurologic complications is common in patients with active IE. The most common and feared neurological complication of left-sided IE is cerebrovascular, from septic emboli causing ischemic stroke, intracranial hemorrhage ( ...

    Abstract Infective endocarditis (IE) with neurologic complications is common in patients with active IE. The most common and feared neurological complication of left-sided IE is cerebrovascular, from septic emboli causing ischemic stroke, intracranial hemorrhage (ICH), or an infectious intracranial aneurysm with or without rupture. In patients with cerebrovascular complications, valve replacement surgery is often delayed for concern of further neurological worsening. However, in circumstances when an indication for valve surgery to treat IE is present, the benefits of early surgical treatment may outweigh the potential neurologic deterioration. Furthermore, valve surgery has been associated with lower in-hospital mortality than medical therapy with intravenous antibiotics alone. Early valve surgery can be performed within 7 days of transient ischemic attack or asymptomatic stroke when medically indicated. Timing of valve surgery for IE after symptomatic medium or large symptomatic ischemic stroke or ICH remains challenging, and current data in the literature are conflicting about the risks and benefits. A delay of 2 to 4 weeks from the time of the cerebrovascular event is often recommended, balancing the risks and benefits of surgery. The range of timing of valve surgery varies depending on the clinical scenario, and is best determined by a multidisciplinary decision between cardiothoracic surgeons, cardiologists, infectious disease experts, and vascular neurologists in an experienced referral center.
    MeSH term(s) Endocarditis/complications ; Endocarditis/surgery ; Endocarditis, Bacterial/complications ; Endocarditis, Bacterial/surgery ; Humans ; Stroke/etiology
    Language English
    Publishing date 2021-04-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0041-1726327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1737: Show issues Location:
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  5. Article ; Online: Diagnosis of Autism Spectrum Disorder Across the Lifespan.

    Shulman, Cory / Esler, Amy / Morrier, Michael J / Rice, Catherine E

    Child and adolescent psychiatric clinics of North America

    2020  Volume 29, Issue 2, Page(s) 253–273

    Abstract: Although autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders it is also one of the most heterogeneous conditions, making identification and diagnosis complex. The importance of a stable and consistent diagnosis cannot be ...

    Abstract Although autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders it is also one of the most heterogeneous conditions, making identification and diagnosis complex. The importance of a stable and consistent diagnosis cannot be overstated. An accurate diagnosis is the basis for understanding the individual and establishing an individualized treatment plan. We present those elements that should be included in any assessment for ASD and describe the ways in which ASD typically manifests itself at various developmental stages. The implications and challenges for assessment at different ages and levels of functioning are discussed.
    MeSH term(s) Adolescent ; Adult ; Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/physiopathology ; Child ; Child, Preschool ; Humans ; Infant ; Young Adult
    Language English
    Publishing date 2020-02-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1313996-4
    ISSN 1558-0490 ; 1056-4993
    ISSN (online) 1558-0490
    ISSN 1056-4993
    DOI 10.1016/j.chc.2020.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: The Role of Diagnostic Instruments in Dual and Differential Diagnosis in Autism Spectrum Disorder Across the Lifespan.

    Shulman, Cory / Rice, Catherine E / Morrier, Michael J / Esler, Amy

    The Psychiatric clinics of North America

    2020  Volume 43, Issue 4, Page(s) 605–628

    Abstract: The heterogeneity inherent in autism spectrum disorder (ASD) makes the identification and diagnosis of ASD complex. We survey a large number of diagnostic tools, including screeners and tools designed for in-depth assessment. We also discuss the ... ...

    Abstract The heterogeneity inherent in autism spectrum disorder (ASD) makes the identification and diagnosis of ASD complex. We survey a large number of diagnostic tools, including screeners and tools designed for in-depth assessment. We also discuss the challenges presented by overlapping symptomatology between ASD and other disorders and the need to determine whether a diagnosis of ASD or another diagnosis best explains the individual's symptoms. We conclude with a call to action for the next steps necessary for meeting the diagnostic challenges presented here to improve the diagnostic process and to help understand each individual's particular ASD profile.
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 431518-2
    ISSN 1558-3147 ; 0193-953X
    ISSN (online) 1558-3147
    ISSN 0193-953X
    DOI 10.1016/j.psc.2020.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 550: Show issues Location:
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  7. Article ; Online: Diagnosis of Autism Spectrum Disorder Across the Lifespan.

    Shulman, Cory / Esler, Amy / Morrier, Michael J / Rice, Catherine E

    The Psychiatric clinics of North America

    2020  Volume 43, Issue 4, Page(s) 583–603

    Abstract: Although autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders it is also one of the most heterogeneous conditions, making identification and diagnosis complex. The importance of a stable and consistent diagnosis cannot be ...

    Abstract Although autism spectrum disorder (ASD) is one of the most common neurodevelopmental disorders it is also one of the most heterogeneous conditions, making identification and diagnosis complex. The importance of a stable and consistent diagnosis cannot be overstated. An accurate diagnosis is the basis for understanding the individual and establishing an individualized treatment plan. We present those elements that should be included in any assessment for ASD and describe the ways in which ASD typically manifests itself at various developmental stages. The implications and challenges for assessment at different ages and levels of functioning are discussed.
    Language English
    Publishing date 2020-10-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 431518-2
    ISSN 1558-3147 ; 0193-953X
    ISSN (online) 1558-3147
    ISSN 0193-953X
    DOI 10.1016/j.psc.2020.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 550: Show issues Location:
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  8. Article ; Online: The authors reply.

    Shoskes, Aaron / Migdady, Ibrahim / Rice, Cory / Hassett, Catherine / Deshpande, Abhishek / Price, Carrie / Hernandez, Adrian V / Cho, Sung-Min

    Critical care medicine

    2021  Volume 49, Issue 3, Page(s) e344–e345

    Language English
    Publishing date 2021-02-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000004871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1261: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: The Role of Diagnostic Instruments in Dual and Differential Diagnosis in Autism Spectrum Disorder Across the Lifespan.

    Shulman, Cory / Rice, Catherine E / Morrier, Michael J / Esler, Amy

    Child and adolescent psychiatric clinics of North America

    2020  Volume 29, Issue 2, Page(s) 275–299

    Abstract: The heterogeneity inherent in autism spectrum disorder (ASD) makes the identification and diagnosis of ASD complex. We survey a large number of diagnostic tools, including screeners and tools designed for in-depth assessment. We also discuss the ... ...

    Abstract The heterogeneity inherent in autism spectrum disorder (ASD) makes the identification and diagnosis of ASD complex. We survey a large number of diagnostic tools, including screeners and tools designed for in-depth assessment. We also discuss the challenges presented by overlapping symptomatology between ASD and other disorders and the need to determine whether a diagnosis of ASD or another diagnosis best explains the individual's symptoms. We conclude with a call to action for the next steps necessary for meeting the diagnostic challenges presented here to improve the diagnostic process and to help understand each individual's particular ASD profile.
    MeSH term(s) Adolescent ; Adult ; Anxiety Disorders/diagnosis ; Anxiety Disorders/epidemiology ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/epidemiology ; Behavioral Symptoms/diagnosis ; Behavioral Symptoms/epidemiology ; Child ; Child, Preschool ; Comorbidity ; Diagnosis, Differential ; Humans ; Intellectual Disability/diagnosis ; Intellectual Disability/epidemiology ; Neuropsychological Tests
    Language English
    Publishing date 2020-02-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1313996-4
    ISSN 1558-0490 ; 1056-4993
    ISSN (online) 1558-0490
    ISSN 1056-4993
    DOI 10.1016/j.chc.2020.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 1345: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Cerebrovascular Complication and Valve Surgery in Infective Endocarditis

    Rice, Cory J. / Kovi, Shivakrishna / Wisco, Dolora R.

    Seminars in Neurology

    (Neurology of Cardiovascular Disease)

    2021  Volume 41, Issue 04, Page(s) 437–446

    Abstract: Infective endocarditis (IE) with neurologic complications is common in patients with active IE. The most common and feared neurological complication of left-sided IE is cerebrovascular, from septic emboli causing ischemic stroke, intracranial hemorrhage ( ...

    Series title Neurology of Cardiovascular Disease
    Abstract Infective endocarditis (IE) with neurologic complications is common in patients with active IE. The most common and feared neurological complication of left-sided IE is cerebrovascular, from septic emboli causing ischemic stroke, intracranial hemorrhage (ICH), or an infectious intracranial aneurysm with or without rupture. In patients with cerebrovascular complications, valve replacement surgery is often delayed for concern of further neurological worsening. However, in circumstances when an indication for valve surgery to treat IE is present, the benefits of early surgical treatment may outweigh the potential neurologic deterioration. Furthermore, valve surgery has been associated with lower in-hospital mortality than medical therapy with intravenous antibiotics alone. Early valve surgery can be performed within 7 days of transient ischemic attack or asymptomatic stroke when medically indicated. Timing of valve surgery for IE after symptomatic medium or large symptomatic ischemic stroke or ICH remains challenging, and current data in the literature are conflicting about the risks and benefits. A delay of 2 to 4 weeks from the time of the cerebrovascular event is often recommended, balancing the risks and benefits of surgery. The range of timing of valve surgery varies depending on the clinical scenario, and is best determined by a multidisciplinary decision between cardiothoracic surgeons, cardiologists, infectious disease experts, and vascular neurologists in an experienced referral center.
    Keywords infective endocarditis ; cerebrovascular complications ; valve surgery ; cerebral microbleed ; stroke
    Language English
    Publishing date 2021-04-13
    Publisher Thieme Medical Publishers, Inc.
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 603165-1
    ISSN 1098-9021 ; 0271-8235
    ISSN (online) 1098-9021
    ISSN 0271-8235
    DOI 10.1055/s-0041-1726327
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1737: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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