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Article ; Online: A proteomic overview of the major venom components from Tityus championi from Panama.

Salazar, Marcos H / Ortíz, Magdalena Hernández / Encarnación, Sergio / Zamudio, Fernando / Possani, Lourival D / Cleghorn, John / Morán, Maricruz / Acosta, Hildaura / Corzo, Gerardo

Toxicon : official journal of the International Society on Toxinology

2023 Volume 227, Page(s) 107082

Abstract: In recent years, morbidity caused by scorpion sting of the species Tityus championi has increased in Panama. Therefore, the ... ...

Abstract	In recent years, morbidity caused by scorpion sting of the species Tityus championi has increased in Panama. Therefore, the LD
MeSH term(s)	Animals ; Mice ; Venoms/metabolism ; Scorpions/chemistry ; Proteomics ; Tandem Mass Spectrometry ; Peptides/chemistry ; Scorpion Venoms/chemistry ; Mammals/metabolism
Chemical Substances	Venoms ; Peptides ; Scorpion Venoms
Language	English
Publishing date	2023-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2023.107082
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Article ; Online: New Zealand's Climate Change Commission report: the critical need to address the missing health co-benefits of reducing emissions.

Chambers, Tim / Hales, Simon / Shaw, Caroline / Baker, Michael / Ball, Jude / Cleghorn, Christine / Wilson, Nick

The New Zealand medical journal

2021 Volume 134, Issue 1542, Page(s) 109–118

Abstract: The Climate Change Commission's draft report and recommendations provide a pathway towards achieving the New Zealand Government's commitment to net zero emissions by 2050. However, the Commission has not adequately considered the health co-benefits of ... ...

Abstract	The Climate Change Commission's draft report and recommendations provide a pathway towards achieving the New Zealand Government's commitment to net zero emissions by 2050. However, the Commission has not adequately considered the health co-benefits of climate change mitigation. In this viewpoint, we assess how the Commission has considered health co-benefits in the key response domains. Extrapolating UK evidence to the New Zealand context suggests climate change mitigation strategies that reduce air pollution, transition the population towards plant-based diets and increase physical activity via active transport could prevent thousands of deaths per year in coming decades. Substantial health co-benefits would also arise from improved housing, cleaner water, noise reductions, afforestation and more compact cities. The Commission's draft report only briefly mentions many of these health co-benefits, and some are completely absent. We recommend the Commission's final report: (i) use health co-benefits as an explicit frame; (ii) ensure the government's Treaty of Waitangi obligations are met in all the domains covered to maximise benefits for Māori health and wellbeing; (iii) build on the successful COVID-19 response that demonstrated rapid, science-informed and vigorous government action can address major global health threats; (iv) include both public health expertise and Māori health expertise among its commissioners; (v) explain how health co-benefits are likely to generate major cost-savings to the health system.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; Climate Change ; Humans ; New Zealand/epidemiology ; Pandemics/prevention & control ; Public Health/trends ; SARS-CoV-2
Language	English
Publishing date	2021-09-17
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	390590-1
ISSN	1175-8716 ; 0028-8446 ; 0110-7704
ISSN (online)	1175-8716
ISSN	0028-8446 ; 0110-7704
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Article ; Online: Catch-up growth in children with chronic kidney disease started on enteral feeding after 2 years of age.

Marlais, Matko / Stojanovic, Jelena / Jones, Helen / Cleghorn, Shelley / Rees, Lesley

Pediatric nephrology (Berlin, Germany)

2019 Volume 35, Issue 1, Page(s) 113–118

Abstract: ... 34 predialysis patients had a median (range) eGFR of 22 (6-88) ml/min/1.73 m: Conclusions: Enteral ...

Abstract	Background: Enteral feeding by tube in chronic kidney disease (CKD) before 2 years of age improves growth. Whether it is effective after this age is unknown. We assessed whether height and weight SDS changed after tube feeding was started in children with CKD above 2 years of age. Methods: Retrospective study of pre-transplant, pre-pubertal children (< 11 years) with CKD stages 2-5 started on nasogastric tube or gastrostomy feeds for the first time after age 2 years. Children were identified by searching dietetic records and the renal database. Children on growth hormone were excluded. Height, weight, and BMI were documented 1 year prior to and at the start of tube feeds, and after 1 and 2 years. Data collection ceased at transplantation. Results: Fifty children (25 male) were included. The median (range) age at start of tube feeds was 5.6 (2.1-10.9) years. Sixteen children were dialysed (1 haemodialysis, 15 peritoneal dialysis); 34 predialysis patients had a median (range) eGFR of 22 (6-88) ml/min/1.73 m Conclusions: Enteral tube feeding commenced after 2 years of age in prepubertal children with CKD improves height and weight SDS, with stability of BMI during the second year. Younger children and those not on dialysis had the greatest benefit.
MeSH term(s)	Age Factors ; Body Height/physiology ; Body Mass Index ; Child ; Child Development/physiology ; Child, Preschool ; Enteral Nutrition/methods ; Enteral Nutrition/statistics & numerical data ; Female ; Follow-Up Studies ; Humans ; Male ; Peritoneal Dialysis/statistics & numerical data ; Renal Dialysis/statistics & numerical data ; Renal Insufficiency, Chronic/physiopathology ; Renal Insufficiency, Chronic/therapy ; Retrospective Studies ; Time-to-Treatment/statistics & numerical data ; Treatment Outcome
Language	English
Publishing date	2019-10-24
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-019-04382-9
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Article ; Online: Interprofessional service-learning definition.

Higbea, Raymond J / Elder, Jodie / VanderMolen, Julia / Cleghorn, Susan M / Brew, Ranelle / Branch, Katie

Journal of interprofessional care

2019 Volume 34, Issue 2, Page(s) 283–286

Abstract: In 2010, the World Health Organization (WHO) published the WHO' ... ...

Abstract	In 2010, the World Health Organization (WHO) published the WHO's
MeSH term(s)	Cooperative Behavior ; Humans ; Interprofessional Relations ; Problem-Based Learning/organization & administration ; Quality Improvement/organization & administration ; World Health Organization
Language	English
Publishing date	2019-09-13
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1099758-1
ISSN	1469-9567 ; 0884-3988 ; 1356-1820
ISSN (online)	1469-9567
ISSN	0884-3988 ; 1356-1820
DOI	10.1080/13561820.2019.1650729
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Article ; Online: Diagnosis and management of mineral and bone disorders in infants with CKD: clinical practice points from the ESPN CKD-MBD and Dialysis working groups and the Pediatric Renal Nutrition Taskforce.

Bacchetta, Justine / Schmitt, Claus Peter / Bakkaloglu, Sevcan A / Cleghorn, Shelley / Leifheit-Nestler, Maren / Prytula, Agnieszka / Ranchin, Bruno / Schön, Anne / Stabouli, Stella / Van de Walle, Johan / Vidal, Enrico / Haffner, Dieter / Shroff, Rukshana

Pediatric nephrology (Berlin, Germany)

2023 Volume 38, Issue 9, Page(s) 3163–3181

Abstract: Background: Infants with chronic kidney disease (CKD) form a vulnerable population who are highly prone to mineral and bone disorders (MBD) including biochemical abnormalities, growth retardation, bone deformities, and fractures. We present a position ... ...

Abstract	Background: Infants with chronic kidney disease (CKD) form a vulnerable population who are highly prone to mineral and bone disorders (MBD) including biochemical abnormalities, growth retardation, bone deformities, and fractures. We present a position paper on the diagnosis and management of CKD-MBD in infants based on available evidence and the opinion of experts from the European Society for Paediatric Nephrology (ESPN) CKD-MBD and Dialysis working groups and the Pediatric Renal Nutrition Taskforce. Methods: PICO (Patient, Intervention, Comparator, Outcomes) questions were generated, and relevant literature searches performed covering a population of infants below 2 years of age with CKD stages 2-5 or on dialysis. Clinical practice points (CPPs) were developed and leveled using the American Academy of Pediatrics grading matrix. A Delphi consensus approach was followed. Results: We present 34 CPPs for diagnosis and management of CKD-MBD in infants, including dietary control of calcium and phosphate, and medications to prevent and treat CKD-MBD (native and active vitamin D, calcium supplementation, phosphate binders). Conclusion: As there are few high-quality studies in this field, the strength of most statements is weak to moderate, and may need to be adapted to individual patient needs by the treating physician. Research recommendations to study key outcome measures in this unique population are suggested. A higher resolution version of the Graphical abstract is available as Supplementary information.
MeSH term(s)	Infant ; Humans ; Child ; Chronic Kidney Disease-Mineral and Bone Disorder/diagnosis ; Chronic Kidney Disease-Mineral and Bone Disorder/etiology ; Chronic Kidney Disease-Mineral and Bone Disorder/therapy ; Calcium/therapeutic use ; Nephrology ; Renal Dialysis/adverse effects ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/therapy ; Bone Diseases ; Phosphates ; Minerals
Chemical Substances	Calcium (SY7Q814VUP) ; Phosphates ; Minerals
Language	English
Publishing date	2023-02-14
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-022-05825-6
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Article ; Online: Framing the wider determinants of health: Reflections and learning from a knowledge mobilisation exercise with an English local authority.

Such, Elizabeth / Akakpo, Daniel / Cleghorn, Lauren / Eddleston, Faith / Eyoma, Jesse / Fish, Lucy / Jan-Khan, Manawar / Khattran, Sukhi / Leitner, Victoria / Young, Carol / Laurent, Claire

Public health in practice (Oxford, England)

2023 Volume 6, Page(s) 100410

Abstract: Background: Health inequalities remain a persistent problem in the UK. One contributing factor may be how health inequalities are framed in professional and public debate. Dominant understandings of health focus on the individual, personal choice, ... ...

Abstract	Background: Health inequalities remain a persistent problem in the UK. One contributing factor may be how health inequalities are framed in professional and public debate. Dominant understandings of health focus on the individual, personal choice, lifestyle and (un)healthy behaviour. This project sought to reframe health inequalities as a 'systemic' or structural problem using extant guidance. This was intended to support the work of a local authority in England working to address health inequalities. Project design: An academic-practitioner participatory knowledge mobilisation exercise with a local authority public health team using recent guidance and reflective feedback and the iterative development of actionable tools. There were four discrete stages to the exercise. Methods: Two on-line and one face-to-face participatory, deliberative workshops designed to co-create reframed public health challenges and solutions based on team portfolios. Iterative feedback provided by the researcher to support the development of actionable tools. Results: Six topic areas were developed with a systemic framing: 1. Food insecurity, 2. Obesity, 3. Prostate cancer among Black men, 4. Cost of living, 5. Mental health, suicide prevention and Gypsy, Roma, Traveller communities, 6. Healthy streets. Reflections from the process revealed some perceived advantages of engaging in a systemic framing of the wider determinants of health, some limitations and issues to consider in a local setting. Benefits included: Clarity in a complex field; structured thinking about what to communicate and how; eliminated jargon; could be made locally relevant. Challenges included: Sustaining a consistent framing; maintaining the technique; knowing if was making a difference; slipping back into dominant (individualised) framings, especially in free-flowing discussion. Conclusions: The process of reframing the wider determinants of health using recent guidance in a local authority setting was broadly helpful in developing coherence and consistency across the public health team. There were challenges to adopting the approach and evaluation of its impact locally would be beneficial.
Language	English
Publishing date	2023-08-01
Publishing country	England
Document type	Journal Article
ISSN	2666-5352
ISSN (online)	2666-5352
DOI	10.1016/j.puhip.2023.100410
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Article ; Online: Influence of habitual physical activity on gastric emptying in healthy males and relationships with body composition and energy expenditure.

Horner, Katy M / Byrne, Nuala M / Cleghorn, Geoffrey J / King, Neil A

The British journal of nutrition

2015 Volume 114, Issue 3, Page(s) 489–496

Abstract: Although a number of studies have examined the role of gastric emptying (GE) in obesity, the influences of habitual physical activity level, body composition and energy expenditure (EE) on GE have received very little consideration. In the present study, ...

Abstract	Although a number of studies have examined the role of gastric emptying (GE) in obesity, the influences of habitual physical activity level, body composition and energy expenditure (EE) on GE have received very little consideration. In the present study, we compared GE in active and inactive males, and characterised relationships with body composition (fat mass and fat-free mass) and EE. A total of forty-four males (active n 22, inactive n 22; BMI 21-36 kg/m2; percentage of fat mass 9-42%) were studied, with GE of a standardised (1676 kJ) pancake meal being assessed by the [13C]octanoic acid breath test, body composition by air displacement plethysmography, RMR by indirect calorimetry, and activity EE (AEE) by accelerometry. The results showed that GE was faster in active compared with inactive males (mean half-time (t 1/2): active 157 (sd 18) and inactive 179 (sd 21) min, P< 0.001). When data from both groups were pooled, GE t 1/2 was associated with percentage of fat mass (r 0.39, P< 0.01) and AEE (r - 0.46, P< 0.01). After controlling for habitual physical activity status, the association between AEE and GE remained, but not that for percentage of fat mass and GE. BMI and RMR were not associated with GE. In summary, faster GE is considered to be a marker of a habitually active lifestyle in males, and is associated with a higher AEE level and a lower percentage of fat mass. The possibility that GE contributes to a gross physiological regulation (or dysregulation) of food intake with physical activity level deserves further investigation.
MeSH term(s)	Adolescent ; Adult ; Basal Metabolism ; Body Composition/physiology ; Body Mass Index ; Energy Metabolism/physiology ; Exercise/physiology ; Gastric Emptying/physiology ; Humans ; Life Style ; Male ; Middle Aged ; Motor Activity/physiology ; Obesity/physiopathology
Language	English
Publishing date	2015-08-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114515002044
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Article ; Online: 'Out of the frying pan': the challenges of prescribing for insomnia in psychiatric patients.

Huthwaite, Mark / Cleghorn, Mark / MacDonald, Joanna

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

2014 Volume 22, Issue 3, Page(s) 288–291

Abstract: Objectives: Managing insomnia is a common challenge for psychiatrists and their patients. We have observed an increasing use of quetiapine as a hypnosedative.: Methods: We conducted an audit with the aim of establishing the prescribing patterns of ... ...

Abstract	Objectives: Managing insomnia is a common challenge for psychiatrists and their patients. We have observed an increasing use of quetiapine as a hypnosedative. Methods: We conducted an audit with the aim of establishing the prescribing patterns of local general psychiatrists in New Zealand, comparing them with established guidelines and determining the extent of the prescribing of quetiapine as a hypnosedative. Participant psychiatrists were recruited from peer review groups. Each participant provided anonymised prescribing information from 10 patients and noted their intention when prescribing. Results: Twenty-five clinicians (58% response rate) responded with prescriptions for 100 in-patients and 177 community mental health patients. 60% of in-patients and 62% of community patients were prescribed medications to aid with sleep. The most commonly prescribed medications were zopiclone, quetiapine and benzodiazepines. Prescribing adhered with the recommended guidelines for 20% of benzodiazepine and 35% of zopiclone prescriptions. Two thirds (60%) of the community prescriptions for quetiapine were primarily for hypnosedation. Conclusions: There is little concordance between guidelines for hypnosedative prescribing and the practices of general psychiatrists. Less zopiclone and fewer benzodiazepines were prescribed than in other studies, while more quetiapine was prescribed. The 'off-label' use of quetiapine and the duration of zopiclone and benzodiazepine use are discussed.
Language	English
Publishing date	2014-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2213198-X
ISSN	1440-1665 ; 1039-8562
ISSN (online)	1440-1665
ISSN	1039-8562
DOI	10.1177/1039856214530015
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Article ; Online: Zika virus and the 2016 Olympic Games - Editors' reply.

McConnell, John / de Ambrogi, Marco / Cleghorn, Sean / Sekkides, Onisillos

The Lancet. Infectious diseases

2016 Volume 16, Issue 9, Page(s) 1003–1004

Language	English
Publishing date	2016-09
Publishing country	United States
Document type	Letter
ZDB-ID	2061641-7
ISSN	1474-4457 ; 1473-3099
ISSN (online)	1474-4457
ISSN	1473-3099
DOI	10.1016/S1473-3099(16)30266-3
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Article ; Online: Reproducibility of gastric emptying in overweight and obese males.

Horner, Katy M / Byrne, Nuala M / Cleghorn, Geoffrey J / King, Neil A

Clinical nutrition (Edinburgh, Scotland)

2014 Volume 33, Issue 4, Page(s) 684–688

Abstract: ... in overweight and obese males.: Methods: Fifteen overweight and obese males [body mass index 30.3 (4.9) kg/m ...

Abstract	Background & aim: To understand whether any change in gastric emptying (GE) is physiologically relevant, it is important to identify its variability. Information regarding the variability of GE in overweight and obese individuals is lacking. The aim of this study was to determine the reproducibility of GE in overweight and obese males. Methods: Fifteen overweight and obese males [body mass index 30.3 (4.9) kg/m(2)] completed two identical GE tests 7 days apart. GE of a standard pancake breakfast was assessed by (13)C-octanoic acid breath test. Data are presented as mean (±SD). Results: There were no significant differences in GE between test days (half time (t1/2): 179 (15) and 176 (19 min), p = 0.56; lag time (tlag): 108 (14) and 104 (8) min, p = 0.26). Mean intra-individual coefficient of variation for t1/2 was 7.9% and tlag 7.5%. Based on these findings, to detect a treatment effect in a paired design with a power of 80% and α = 0.05, minimum mean effect sizes for t1/2 would need to be ≥14.4 min and tlag ≥ 8.1 min. Conclusions: These data show that GE is reproducible in overweight and obese males and provide minimum mean effect sizes required to detect a hypothetical treatment effect in this population.
MeSH term(s)	Adipose Tissue/metabolism ; Adult ; Body Mass Index ; Breath Tests ; Caprylates/analysis ; Carbon Isotopes/analysis ; Gastric Emptying/physiology ; Humans ; Male ; Middle Aged ; Nonlinear Dynamics ; Obesity ; Overweight ; Reproducibility of Results ; Young Adult
Chemical Substances	Caprylates ; Carbon Isotopes ; octanoic acid (OBL58JN025)
Language	English
Publishing date	2014-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2013.09.002
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