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Article ; Online: Structural genomics and the Protein Data Bank.

Michalska, Karolina / Joachimiak, Andrzej

2021 Volume 296, Page(s) 100747

Abstract: The field of Structural Genomics arose over the last 3 decades to address a large and rapidly growing divergence between microbial genomic, functional, and structural data. Several international programs took advantage of the vast genomic sequence ... ...

Abstract	The field of Structural Genomics arose over the last 3 decades to address a large and rapidly growing divergence between microbial genomic, functional, and structural data. Several international programs took advantage of the vast genomic sequence information and evaluated the feasibility of structure determination for expanded and newly discovered protein families. As a consequence, structural genomics has developed structure-determination pipelines and applied them to a wide range of novel, uncharacterized proteins, often from "microbial dark matter," and later to proteins from human pathogens. Advances were especially needed in protein production and rapid de novo structure solution. The experimental three-dimensional models were promptly made public, facilitating structure determination of other members of the family and helping to understand their molecular and biochemical functions. Improvements in experimental methods and databases resulted in fast progress in molecular and structural biology. The Protein Data Bank structure repository played a central role in the coordination of structural genomics efforts and the structural biology community as a whole. It facilitated development of standards and validation tools essential for maintaining high quality of deposited structural data.
MeSH term(s)	Animals ; Computational Biology/history ; Databases, Protein ; Genomics/history ; History, 20th Century ; History, 21st Century ; Humans ; Models, Molecular
Language	English
Publishing date	2021-05-03
Publishing country	United States
Document type	Historical Article ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2021.100747
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Article: In health and disease – microRNA in skeletal muscles function

Romańczuk, Karolina / Mierzejewski, Bartosz / Michalska, Zuzanna / Florkowska, Anita

Postepy biochemii

2022 Volume 67, Issue 4, Page(s) 420–435

Abstract: MicroRNAs (miRNAs), although do not encode proteins, they are involved in many biological processes. Here we focus on their role in skeletal muscle development and function. In health, they play an important role during skeletal muscle regeneration by ... ...

Title translation	W zdrowiu i chorobie – mikroRNA w funkcjonowaniu mięśni szkieletowych.
Abstract	MicroRNAs (miRNAs), although do not encode proteins, they are involved in many biological processes. Here we focus on their role in skeletal muscle development and function. In health, they play an important role during skeletal muscle regeneration by regulating satellite cells quiescence, activation, proliferation, differentiation into myoblasts, and finally formation of myotubes. Moreover, miRNAs play a role in muscles disease development. For this reason, they can be used as disease biomarkers or potential therapeutic targets. Moreover, physical activity also influences the changes in miRNA expression. Certain types of exercises, their duration, and intensity differently impact the expression of many miRNAs.
MeSH term(s)	Cell Differentiation ; Cell Proliferation ; MicroRNAs ; Muscle Development ; Muscle, Skeletal
Chemical Substances	MicroRNAs
Language	Polish
Publishing date	2022-01-14
Publishing country	Poland
Document type	Journal Article
ZDB-ID	414019-9
ISSN	0032-5422
ISSN	0032-5422
DOI	10.18388/pb.2021_419
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Article ; Online: Analiza oferty biur podróży skierowanej do dzieci i młodzieży w województwie zachodniopomorskim

Karolina Michalska

Ekonomiczne Problemy Turystyki, Vol

2016 Volume 34

Abstract: The aim of the article is to specify the number of travel agencies dealing with the organization of trips for children and young people in West Pomeranian voivodeship and the indication of the most popular deals for this segment. The article contains ... ...

Abstract	The aim of the article is to specify the number of travel agencies dealing with the organization of trips for children and young people in West Pomeranian voivodeship and the indication of the most popular deals for this segment. The article contains such elements as an introduction, three substantive parts and a summary. The first part includes theoretical aspects concerning the nature and importance of the operation of travel agencies with regard to children and young people. The other presents the most common types of tourist offers in the market for this target group, together with the tuple of their characteristics. The third presents an analysis the specific offices and most commonly offers in the local market.
Keywords	children's and youth tourism ; travel agency ; tourist offer ; West Pomeranian Voivodeship ; Social Sciences ; H
Language	English
Publishing date	2016-01-01T00:00:00Z
Publisher	Wydawnictwo Naukowe Uniwersytetu Szczecińskiego
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Genus

Sobolewska, Danuta / Michalska, Klaudia / Wróbel-Biedrawa, Dagmara / Grabowska, Karolina / Owczarek-Januszkiewicz, Aleksandra / Olszewska, Monika Anna / Podolak, Irma

International journal of molecular sciences

2023 Volume 24, Issue 7

Abstract: ... ...

Abstract	Cuphea
MeSH term(s)	Phytotherapy ; Cuphea ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Plant Extracts/chemistry ; Medicine, Traditional ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Phytochemicals/chemistry
Chemical Substances	Plant Extracts ; Phytochemicals
Language	English
Publishing date	2023-04-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24076614
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Article ; Online: Constituents of

Malarz, Janusz / Michalska, Klaudia / Galanty, Agnieszka / Kiss, Anna Karolina / Stojakowska, Anna

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 2

Abstract: Plants of the genus Pulicaria are known for providing traditional medicines, spices, herbal teas, and insect deterrents. Pulicaria inuloides (Poir.). DC. is one of the less chemically studied species within the genus. Hydroalcoholic extracts from roots ... ...

Abstract	Plants of the genus Pulicaria are known for providing traditional medicines, spices, herbal teas, and insect deterrents. Pulicaria inuloides (Poir.). DC. is one of the less chemically studied species within the genus. Hydroalcoholic extracts from roots and aerial parts of P. inuloides were analyzed using the UHPLC-PAD-MSn technique and revealed the presence of six caffeoylquinic and eleven caffeoylhexaric conjugates together with hydroxykaempferol dimethyl ether and quercetagetin trimethyl ether. Moreover, constituents of chloroform extract from the whole P. inuloides plants were isolated and identified by spectroscopic methods. One new and four known caryophyllene derivatives, three thymol derivatives, and four polymethoxylated flavonols were found in the analyzed extract. The structure of the new compound was established by spectroscopic methods (HRESIMS, 1H NMR, 13C NMR, COSY, HSQC, HMBC, NOESY). The cytotoxicity of 6-Hydroxykaempferol 3,7-dimethyl ether and quercetagetin 3,7,3’-trimethyl ether (chrysosplenol C), which are major flavonols isolated from the plant, were tested on prostate epithelial cells (PNT2), prostate cancer cells (DU145 and PC3), human keratinocytes (HaCaT), and melanoma cells (HTB140 and A375). Both flavonols demonstrated moderate cytotoxic activity against PC3 cells (IC50 = 59.5 µM and 46.6 µM, respectively). The remaining cell lines were less affected (IC50 > 150 µM).
MeSH term(s)	Humans ; Flavonols/pharmacology ; Pulicaria/chemistry ; Methyl Ethers ; Antineoplastic Agents ; Plant Extracts/pharmacology ; Plant Extracts/chemistry
Chemical Substances	Flavonols ; dimethyl ether (AM13FS69BX) ; Methyl Ethers ; Antineoplastic Agents ; Plant Extracts
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28020480
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Article: The Clinical Significance of Serum Biomarkers of the Intestinal Barrier in Systemic Sclerosis: A Cross-Sectional Study.

Stec, Albert / Maciejewska, Magdalena / Zaremba, Michał / Paralusz-Stec, Karolina / Michalska, Milena / Rudnicka, Lidia / Sikora, Mariusz

Journal of personalized medicine

2023 Volume 13, Issue 4

Abstract: Systemic sclerosis (SSc) is an immune-mediated connective tissue disease. Recent studies reported differences in the composition of intestinal microbiota (dysbiosis) in patients with SSc compared to nonsclerodermic subjects. Dysbiosis may disrupt the ... ...

Abstract	Systemic sclerosis (SSc) is an immune-mediated connective tissue disease. Recent studies reported differences in the composition of intestinal microbiota (dysbiosis) in patients with SSc compared to nonsclerodermic subjects. Dysbiosis may disrupt the intestinal barrier, which leads to immunological activation via microbial antigen and metabolite translocation. The study aimed to assess the differences in intestinal permeability between SSc patients and controls and to examine the correlation between intestinal permeability and complications of SSc. The study comprised 50 patients with SSc and 30 matched subjects. Serum intestinal permeability markers: intestinal fatty acid binding protein, claudin-3, and lipopolysaccharides (LPS) were determined using an enzyme-linked immunosorbent assay. SSc patients had a significantly increased concentration of LPS compared to control subjects (232.30 [149.00-347.70] versus 161.00 [83.92-252.20] pg/mL,
Language	English
Publishing date	2023-04-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13040678
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Article ; Online: Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases.

Stec, Albert / Sikora, Mariusz / Maciejewska, Magdalena / Paralusz-Stec, Karolina / Michalska, Milena / Sikorska, Ewa / Rudnicka, Lidia

International journal of molecular sciences

2023 Volume 24, Issue 4

Abstract: Dysbiosis has been identified in many dermatological conditions (e.g., psoriasis, atopic dermatitis, systemic lupus erythematosus). One of the ways by which the microbiota affect homeostasis is through microbiota-derived molecules (metabolites). There ... ...

Abstract	Dysbiosis has been identified in many dermatological conditions (e.g., psoriasis, atopic dermatitis, systemic lupus erythematosus). One of the ways by which the microbiota affect homeostasis is through microbiota-derived molecules (metabolites). There are three main groups of metabolites: short-chain fatty acids (SCFAs), tryptophan metabolites, and amine derivatives including trimethylamine N-oxide (TMAO). Each group has its own uptake and specific receptors through which these metabolites can exert their systemic function. This review provides up-to-date knowledge about the impact that these groups of gut microbiota metabolites may have in dermatological conditions. Special attention is paid to the effect of microbial metabolites on the immune system, including changes in the profile of the immune cells and cytokine disbalance, which are characteristic of several dermatological diseases, especially psoriasis and atopic dermatitis. Targeting the production of microbiota metabolites may serve as a novel therapeutic approach in several immune-mediated dermatological diseases.
MeSH term(s)	Humans ; Gastrointestinal Microbiome/physiology ; Dermatitis, Atopic ; Microbiota ; Bacteria/metabolism ; Fatty Acids, Volatile/metabolism ; Dysbiosis/microbiology
Chemical Substances	Fatty Acids, Volatile
Language	English
Publishing date	2023-02-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24043494
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Article ; Online: Structure and enzymatic characterization of CelD endoglucanase from the anaerobic fungus Piromyces finnis.

Dementiev, Alexey / Lillington, Stephen P / Jin, Shiyan / Kim, Youngchang / Jedrzejczak, Robert / Michalska, Karolina / Joachimiak, Andrzej / O'Malley, Michelle A

Applied microbiology and biotechnology

2023 Volume 107, Issue 19, Page(s) 5999–6011

Abstract: Anaerobic fungi found in the guts of large herbivores are prolific biomass degraders whose genomes harbor a wealth of carbohydrate-active enzymes (CAZymes), of which only a handful are structurally or biochemically characterized. Here, we report the ... ...

Abstract	Anaerobic fungi found in the guts of large herbivores are prolific biomass degraders whose genomes harbor a wealth of carbohydrate-active enzymes (CAZymes), of which only a handful are structurally or biochemically characterized. Here, we report the structure and kinetic rate parameters for a glycoside hydrolase (GH) family 5 subfamily 4 enzyme (CelD) from Piromyces finnis, a modular, cellulosome-incorporated endoglucanase that possesses three GH5 domains followed by two C-terminal fungal dockerin domains (double dockerin). We present the crystal structures of an apo wild-type CelD GH5 catalytic domain and its inactive E154A mutant in complex with cellotriose at 2.5 and 1.8 Å resolution, respectively, finding the CelD GH5 catalytic domain adopts the (β/α)
MeSH term(s)	Cellulase/metabolism ; Anaerobiosis ; Glucans/metabolism ; Piromyces/metabolism
Chemical Substances	endoglucanase CelD (EC 3.2.1.-) ; Cellulase (EC 3.2.1.4) ; Glucans
Language	English
Publishing date	2023-08-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	392453-1
ISSN	1432-0614 ; 0171-1741 ; 0175-7598
ISSN (online)	1432-0614
ISSN	0171-1741 ; 0175-7598
DOI	10.1007/s00253-023-12684-0
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Article ; Online: Epitopes recognition of SARS-CoV-2 nucleocapsid RNA binding domain by human monoclonal antibodies.

Kim, Youngchang / Maltseva, Natalia / Tesar, Christine / Jedrzejczak, Robert / Endres, Michael / Ma, Heng / Dugan, Haley L / Stamper, Christopher T / Chang, Changsoo / Li, Lei / Changrob, Siriruk / Zheng, Nai-Ying / Huang, Min / Ramanathan, Arvind / Wilson, Patrick / Michalska, Karolina / Joachimiak, Andrzej

iScience

2024 Volume 27, Issue 2, Page(s) 108976

Abstract: Coronavirus nucleocapsid protein (NP) of SARS-CoV-2 plays a central role in many functions important for virus proliferation including packaging and protecting genomic RNA. The protein shares sequence, structure, and architecture with nucleocapsid ... ...

Abstract	Coronavirus nucleocapsid protein (NP) of SARS-CoV-2 plays a central role in many functions important for virus proliferation including packaging and protecting genomic RNA. The protein shares sequence, structure, and architecture with nucleocapsid proteins from betacoronaviruses. The N-terminal domain (NP
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.108976
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Article ; Online: Rectal neuroendocrine tumors in a colon cancer screening colonoscopy program. Sixteen-year single institution experience.

Dąbkowski, Krzysztof / Michalska, Karolina / Rusiniak-Rosińska, Natalia / Urasińska, Elżbieta / Bielicki, Dariusz / Starzyńska, Teresa

Scandinavian journal of gastroenterology

2022 Volume 58, Issue 3, Page(s) 310–313

Abstract: Objectives: Rectal neuroendocrine tumors (rNETs) are potentially malignant lesions. In our study, we aimed to retrospectively check whether the rectal neuroendocrine tumors were found in colonoscopy examinations carried out as a part of Polish ... ...

Abstract	Objectives: Rectal neuroendocrine tumors (rNETs) are potentially malignant lesions. In our study, we aimed to retrospectively check whether the rectal neuroendocrine tumors were found in colonoscopy examinations carried out as a part of Polish colonoscopy screening program (PCSP). Materials and methods: We retrospectively analyzed the colonoscopy and histopathological database of examinations conducted as a part of PCSP in our institution in the years 2005-2021. We also checked the method by which the tumor was removed, its characteristics based on photo documentations and followed up the patients. Results: The 10568 colonoscopy examinations were performed in PCSP in the years 2005-2021. Seven patients with a mean age of 53 with rNETs (1 in every 1510 colonoscopy) were detected. The polyp mean size was 5 mm. All the lesions were well differentiated tumors. First half of the colonoscopy examinations was performed in the years 2005-2012 and in that time three rNETs were detected, four rNETs were detected in the years 2012-2021. Even despite their typical appearance the neuroendocrine origin was not suspected in majority of cases and all tumors, except one, were removed with improper method. One of the patients underwent transanal endoscopic microsurgery of the scar. All patients are disease free in median follow-up of 108 months. Conclusion: Rectal NETs are detected in the screening colonoscopy program. In majority of cases, they are not suspected by endoscopists on colonoscopy, but diagnosed after removal in histopathological examinations. There is a need of education of endoscopists in recognition and methods of treatment of rNETs.
MeSH term(s)	Humans ; Middle Aged ; Retrospective Studies ; Neuroendocrine Tumors/diagnosis ; Neuroendocrine Tumors/surgery ; Neuroendocrine Tumors/pathology ; Early Detection of Cancer ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/surgery ; Rectal Neoplasms/pathology ; Colonoscopy/methods ; Colonic Neoplasms/diagnosis
Language	English
Publishing date	2022-09-19
Publishing country	England
Document type	Journal Article
ZDB-ID	82042-8
ISSN	1502-7708 ; 0036-5521
ISSN (online)	1502-7708
ISSN	0036-5521
DOI	10.1080/00365521.2022.2124539
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