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Article ; Online: Physical Origin of Negative Differential Resistance in V

Das, Sujan Kumar / Nandi, Sanjoy Kumar / Marquez, Camilo Verbel / Rúa, Armando / Uenuma, Mutsunori / Puyoo, Etienne / Nath, Shimul Kanti / Albertini, David / Baboux, Nicolas / Lu, Teng / Liu, Yun / Haeger, Tobias / Heiderhoff, Ralf / Riedl, Thomas / Ratcliff, Thomas / Elliman, Robert Glen

Advanced materials (Deerfield Beach, Fla.)

2022 Volume 35, Issue 8, Page(s) e2208477

Abstract: ... with transition temperatures above room temperature. Here the structural, electrical, and thermal properties of V ...

Abstract	Oxides that exhibit an insulator-metal transition can be used to fabricate energy-efficient relaxation oscillators for use in hardware-based neural networks but there are very few oxides with transition temperatures above room temperature. Here the structural, electrical, and thermal properties of V
Language	English
Publishing date	2022-12-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202208477
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Book: OPD-2 Modul Abhängigkeitserkrankungen

Albertini, Valentina

Das Diagnostik-Manual

2013

Title variant	Operationalisierung psychodynamischer Diagnostik-2 Modul Abhängigkeitserkrankungen
Institution	Arbeitskreis zur Operationalisierung Psychodynamischer Diagnostik
Author's details	Arbeitskreis OPD. Unter Mitarb. von V. Albertini
Keywords	Sucht ; OPD-2
Subject	Suchtkrankheit ; Suchterkrankung
Language	German
Size	141 S. : Ill., 225 mm x 155 mm
Edition	1. Aufl.
Publisher	Huber
Publishing place	Bern
Publishing country	Switzerland
Document type	Book
HBZ-ID	HT017776008
ISBN	978-3-456-85317-8 ; 3-456-85317-3 ; 9783456753171 ; 9783456953175 ; 3456753179 ; 3456953178
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Article ; Online: Differentially methylated genes involved in reproduction and ploidy levels in recent diploidized and tetraploidized Eragrostis curvula genotypes.

Carballo, J / Achilli, A / Hernández, F / Bocchini, M / Pasten, M C / Marconi, G / Albertini, E / Zappacosta, D / Echenique, V

Plant reproduction

2023

Abstract: Epigenetics studies changes in gene activity without changes in the DNA sequence. Methylation is an epigenetic mechanism important in many pathways, such as biotic and abiotic stresses, cell division, and reproduction. Eragrostis curvula is a grass ... ...

Abstract	Epigenetics studies changes in gene activity without changes in the DNA sequence. Methylation is an epigenetic mechanism important in many pathways, such as biotic and abiotic stresses, cell division, and reproduction. Eragrostis curvula is a grass species reproducing by apomixis, a clonal reproduction by seeds. This work employed the MCSeEd technique to identify deferentially methylated positions, regions, and genes in the CG, CHG, and CHH contexts in E. curvula genotypes with similar genomic backgrounds but with different reproductive modes and ploidy levels. In this way, we focused the analysis on the cvs. Tanganyika INTA (4x, apomictic), Victoria (2x, sexual), and Bahiense (4x, apomictic). Victoria was obtained from the diploidization of Tanganyika INTA, while Bahiense was produced from the tetraploidization of Victoria. This study showed that polyploid/apomictic genotypes had more differentially methylated positions and regions than the diploid sexual ones. Interestingly, it was possible to observe fewer differentially methylated positions and regions in CG than in the other contexts, meaning CG methylation is conserved across the genotypes regardless of the ploidy level and reproductive mode. In the comparisons between sexual and apomictic genotypes, we identified differentially methylated genes involved in the reproductive pathways, specifically in meiosis, cell division, and fertilization. Another interesting observation was that several differentially methylated genes between the diploid and the original tetraploid genotype recovered their methylation status after tetraploidization, suggesting that methylation is an important mechanism involved in reproduction and ploidy changes.
Language	English
Publishing date	2023-12-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2700598-7
ISSN	2194-7961 ; 2194-7953
ISSN (online)	2194-7961
ISSN	2194-7953
DOI	10.1007/s00497-023-00490-7
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Article: Release of Bet v 1 from birch pollen from 5 European countries. Results from the HIALINE study

Buters, Jeroen T.M / Thibaudon, Michel / Smith, Matt / Kennedy, Roy / Rantio-Lehtimäki, Auli / Albertini, Roberto / Reese, Gerald / Weber, Bernhard / Galan, Carmen / Brandao, Rui / Antunes, Celia M / Jäger, Siegfried / Berger, Uwe / Celenk, Sevcan / Grewling, Łukasz / Jackowiak, Bogdan / Sauliene, Ingrida / Weichenmeier, Ingrid / Pusch, Gudrun /

Sarioglu, Hakan / Ueffing, Marius / Behrendt, Heidrun / Prank, Marje / Sofiev, Mikhail / Cecchi, Lorenzo

Atmospheric environment. 2012 Aug., v. 55

2012

Abstract: ... concentrations of birch pollen grains and the matched major birch pollen allergen Bet v 1 simultaneously across ... also 2.5 μm > PM > 0.12 μm. The major birch pollen allergen Bet v 1 was determined with an allergen ... specific ELISA. Bet v 1 isoform patterns were analyzed by 2D-SDS-PAGE blots and mass spectrometric ...

Institution	The HIALINE working group
Abstract	Exposure to allergens is pivotal in determining sensitization and allergic symptoms in individuals. Pollen grain counts in ambient air have traditionally been assessed to estimate airborne allergen exposure. However, the exact allergen content of ambient air is unknown. We therefore monitored atmospheric concentrations of birch pollen grains and the matched major birch pollen allergen Bet v 1 simultaneously across Europe within the EU-funded project HIALINE (Health Impacts of Airborne Allergen Information Network). Pollen count was assessed with Hirst type pollen traps at 10 l min⁻¹ at sites in France, United Kingdom, Germany, Italy and Finland. Allergen concentrations in ambient air were sampled at 800 l min⁻¹ with a Chemvol® high-volume cascade impactor equipped with stages PM > 10 μm, 10 μm > PM > 2.5 μm, and in Germany also 2.5 μm > PM > 0.12 μm. The major birch pollen allergen Bet v 1 was determined with an allergen specific ELISA. Bet v 1 isoform patterns were analyzed by 2D-SDS-PAGE blots and mass spectrometric identification. Basophil activation was tested in an FcɛR1-humanized rat basophil cell line passively sensitized with serum of a birch pollen symptomatic patient. Compared to 10 previous years, 2009 was a representative birch pollen season for all stations. About 90% of the allergen was found in the PM > 10 μm fraction at all stations. Bet v 1 isoforms pattern did not vary substantially neither during ripening of pollen nor between different geographical locations. The average European allergen release from birch pollen was 3.2 pg Bet v 1/pollen and did not vary much between the European countries. However, in all countries a >10-fold difference in daily allergen release per pollen was measured which could be explained by long-range transport of pollen with a deviating allergen release. Basophil activation by ambient air extracts correlated better with airborne allergen than with pollen concentration. Although Bet v 1 is a mixture of different isoforms, its fingerprint is constant across Europe. Bet v 1 was also exclusively linked to pollen. Pollen from different days varied >10-fold in allergen release. Thus exposure to allergen is inaccurately monitored by only monitoring birch pollen grains. Indeed, a humanized basophil activation test correlated much better with allergen concentrations in ambient air than with pollen count. Monitoring the allergens themselves together with pollen in ambient air might be an improvement in allergen exposure assessment.
Keywords	Betula ; air ; allergens ; atmospheric chemistry ; blood serum ; enzyme-linked immunosorbent assay ; exposure assessment ; mass spectrometry ; monitoring ; patients ; pollen ; rats ; ripening ; spore traps ; Finland ; France ; Germany ; Italy ; United Kingdom
Language	English
Dates of publication	2012-08
Size	p. 496-505.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	216368-8
ISSN	0004-6981 ; 1352-2310
ISSN	0004-6981 ; 1352-2310
DOI	10.1016/j.atmosenv.2012.01.054
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Tailoring the release of drugs having different water solubility by hybrid polymer-lipid microparticles with a biphasic structure.

Bertoni, Serena / Albertini, Beatrice / Ronowicz-Pilarczyk, Joanna / Passerini, Nadia

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

2023 Volume 190, Page(s) 171–183

Abstract: The aim of this study is to investigate the potential of hybrid polymer-lipid microparticles with a biphasic structure (b-MPs) as drug delivery system. Hybrid b-MPs of Compritol®888 ATO as main lipid constituent of the shell and polyethylene glycol 400 ... ...

Abstract	The aim of this study is to investigate the potential of hybrid polymer-lipid microparticles with a biphasic structure (b-MPs) as drug delivery system. Hybrid b-MPs of Compritol®888 ATO as main lipid constituent of the shell and polyethylene glycol 400 as core material were produced by an innovative solvent-free approach based on spray congealing. To assess the suitability of hybrid b-MPs to encapsulate various types of APIs, three model drugs (fluconazole, tolbutamide and nimesulide) with extremely different water solubility were loaded into the polymeric core. The hybrid systems were characterized in terms of particle size, morphology and physical state. Various techniques (e.g. optical, Confocal Raman and Scanning Electron Microscopy) were used to investigate the influence of the drugs on different aspects of the b-MPs, including external and internal morphology, properties at the lipid/polymer interface and drug distribution. Hybrid b-MPs were suitable for the encapsulation of all drugs (encapsulation efficiency > 90 %) regardless the drug hydrophobic/hydrophilic properties. Finally, the drug release behaviors from hybrid b-MPs were studied and compared with traditional solid lipid MPs (consisting of only the lipid carrier). Due to the combination of lipid and polymeric materials, hybrid b-MPs showed a wide array of release profiles that depends on their composition, the type of loaded drug, the drug loading amount and location, providing a versatile platform and allowing the formulators to finely balance the release performance of drugs intended for oral administration. Overall, the study demonstrates that hybrid, solvent-free b-MPs produced by spray congealing are an extremely versatile delivery platform able to efficiently encapsulate and release very different types of drug compounds.
MeSH term(s)	Pharmaceutical Preparations ; Solubility ; Polymers/chemistry ; Drug Compounding/methods ; Particle Size ; Lipids/chemistry ; Water
Chemical Substances	Pharmaceutical Preparations ; Polymers ; Lipids ; Water (059QF0KO0R)
Language	English
Publishing date	2023-07-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1065368-5
ISSN	1873-3441 ; 0939-6411
ISSN (online)	1873-3441
ISSN	0939-6411
DOI	10.1016/j.ejpb.2023.07.017
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Article: Development and Application of a Cleaved Amplified Polymorphic Sequence Marker (

Bongiorno, Giacomo / Di Noia, Annamaria / Ciancaleoni, Simona / Marconi, Gianpiero / Cassibba, Vincenzo / Albertini, Emidio

Plants (Basel, Switzerland)

2023 Volume 12, Issue 15

Abstract: Phytophthora ... ...

Abstract	Phytophthora capsici
Language	English
Publishing date	2023-07-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants12152757
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Article ; Online: Legal action for access to resources inefficiently made available in health care systems in Brazil: a case study on obstructive sleep apnea.

Pachito, Daniela V / Finkelstein, Beny / Albertini, Claudia / Gaspar, Antonio / Pereira, Carolina / Vaz, Paulo / Eckeli, Alan Luiz / Drager, Luciano F

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

2023 Volume 49, Issue 2, Page(s) e20220092

Abstract: Objective: Obstructive sleep apnea (OSA) is a highly prevalent chronic disease, associated with morbidity and mortality. Although effective treatment for OSA is commercially available, their provision is not guaranteed by lines of care throughout Brazil, ...

Abstract	Objective: Obstructive sleep apnea (OSA) is a highly prevalent chronic disease, associated with morbidity and mortality. Although effective treatment for OSA is commercially available, their provision is not guaranteed by lines of care throughout Brazil, making legal action necessary. This study aimed at presenting data related to the volume of legal proceedings regarding the access to diagnosis and treatment of OSA in Brazil. Methods: This was a descriptive study of national scope, evaluating the period between January of 2016 and December of 2020. The number of lawsuits was analyzed according to the object of the demand (diagnosis or treatment). Projections of total expenses were carried out according to the number of lawsuits. Results: We identified 1,462 legal proceedings (17.6% and 82.4% related to diagnosis and treatment, respectively). The projection of expenditure for OSA diagnosis in the public and private spheres were R$575,227 and R$188,002, respectively. The projection of expenditure for OSA treatment in the public and private spheres were R$2,656,696 and R$253,050, respectively. There was a reduction in the number of lawsuits between 2017 and 2019. Conclusions: Legal action as a strategy for accessing diagnostic and therapeutic resources related to OSA is a recurrent practice, resulting in inefficiency and inequity. The reduction in the number of lawsuits between 2017 and 2019 might be explained by the expansion of local health care policies or by barriers in the journey of patients with OSA, such as difficulties in being referred to specialized health care and low availability of diagnostic resources.
MeSH term(s)	Humans ; Brazil ; Sleep Apnea, Obstructive/diagnosis ; Delivery of Health Care
Language	Portuguese
Publishing date	2023-02-20
Publishing country	Brazil
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2223157-2
ISSN	1806-3756 ; 1806-3713
ISSN (online)	1806-3756
ISSN	1806-3713
DOI	10.36416/1806-3756/e20220092
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Article ; Online: The ovarian sensitivity index is predictive of live birth chances after IVF in infertile patients.

Weghofer, A / Barad, D H / Darmon, S K / Kushnir, V A / Albertini, D F / Gleicher, N

Human reproduction open

2020 Volume 2020, Issue 4, Page(s) hoaa049

Abstract: ... Reproduction and the Foundation for Reproductive Medicine. A.W., V.A.K., D.F.A., D.H.B. and N.G. have received ...

Abstract	Study question: Does the ovarian sensitivity index (OSI) predict embryo quality, pregnancy and live birth in patients undergoing FSH/hMG stimulation for IVF? Summary answer: The OSI is predictive of pregnancy and live birth in older women with a more unfavorable prognosis undergoing FSH/hMG stimulation for IVF. What is known already: The OSI was previously reported to reflect gonadotrophin requirements among high, normal and poor responders and to predict pregnancy potential in younger patients undergoing ovarian stimulation with FSH. Study design size duration: A retrospective cohort study that included 1282 women undergoing IVF with FSH/hMG stimulation was carried out between January 2010 and December 2016. Participants/materials setting methods: We evaluated 1282 women who underwent fertility treatment with FSH/hMG stimulation and oocyte retrieval at an academically affiliated private fertility center. OSI was calculated as (oocytes ×1000)/total gonadotrophin dose and grouped into two classes based on a receiver operating characteristic (ROC) curve analysis of a randomly selected development sample comprising one-third of the cycles. The remaining cycles comprised the validation group. ROC curves were also used to compare the predictive value of OSI to that of baseline FSH and anti-Müllerian hormone (AMH). Logistic regression models evaluated the effect of high (OSI >0.83) and low (OSI ≤0.83) on clinical pregnancy and live birth in the validation group. Models were adjusted for female age, baseline FSH, AMH and oocyte yield and gonadotrophin dose. Main results and the role of chance: Women presented with a mean ±SD age of 38.6 ± 5.4 years and showed median AMH levels of 0.65 (95% CI 0.61-0.74) ng/ml. They received 5145 ± 2477 IU of gonadotrophins and produced a median 5.2 (95% CI 5.0-5.5) oocytes. Pregnancy and live birth rates per oocyte retrieval for all women were 20.6% and 15.8%, respectively. Patients with higher OSI (less gonadotrophin required per oocyte retrieved) produced significantly more high-quality embryos than patients with low OSI (3.5 (95% CI 3.2-3.8) versus 0.6 (95% CI 0.5-0.7) ( Limitations reasons for caution: The results may not be applicable to women with excellent pregnancy potential or FSH-only stimulation. Wider implications of the findings: The predictive capacity of OSI for embryo quality, pregnancy and live birth, which is independent of AMH or FSH, may help in counseling patients about their pregnancy potential and live birth chances. Study funding/competing interests: Intramural funding from the Center for Human Reproduction and the Foundation for Reproductive Medicine. A.W., V.A.K., D.F.A., D.H.B. and N.G. have received research grant support, travel funds and speaker honoraria from various pharmaceutical and medical device companies: none, however, related to the topic presented here. D.H.B. and N.G. are listed as inventors on already awarded and still pending US patents, claiming beneficial effects on diminished ovarian reserve and embryo ploidy from dehydroepiandrosterone supplementation. Trial registration number: N/A.
Language	English
Publishing date	2020-12-22
Publishing country	England
Document type	Journal Article
ISSN	2399-3529
ISSN (online)	2399-3529
DOI	10.1093/hropen/hoaa049
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Article ; Online: Neutrophil-to-eosinophil ratio as a biomarker for clinical outcomes in advanced stage melanoma patients treated with anti-PD-1 therapy.

Pozorski, Vincent / Park, Yeonhee / Mohamoud, Yusuf / Tesfamichael, Dahlia / Emamekhoo, Hamid / Birbrair, Alexander / Albertini, Mark R / Ma, Vincent T

Pigment cell & melanoma research

2023 Volume 36, Issue 6, Page(s) 501–511

Abstract: Neutrophil-to-lymphocyte ratios (NLR) and eosinophil counts are associated with improved survival in melanoma patients treated with immune checkpoint inhibitors, but no study has investigated neutrophil-to-eosinophil ratios (NER) as a predictive ... ...

Abstract	Neutrophil-to-lymphocyte ratios (NLR) and eosinophil counts are associated with improved survival in melanoma patients treated with immune checkpoint inhibitors, but no study has investigated neutrophil-to-eosinophil ratios (NER) as a predictive indicator in this population. In this retrospective study evaluating anti-PD-1 treated patients with advanced melanoma, progression-free survival (PFS), overall survival (OS), objective response rates (ORR), and risk of high-grade (grade ≥3) immune-related adverse events (irAEs) were compared between groups defined by median pretreatment NLR and NER as well as median NLR and NER at 1-month post-treatment. Lower baseline NLR and NER were associated with improved OS [HR: 0.504, 95% CI: 0.328-0.773, p = .002 and HR: 0.442, 95% CI: 0.288-0.681, p < .001, respectively] on univariate testing. After accounting for multiple covariates, our multivariate analysis found that lower pretreatment NER was associated with better ORR (by irRECIST) (OR: 2.199, 95% CI: 1.071-4.582, p = .033) and improved OS (HR: 0.480, 95% CI: 0.296-0.777, p = .003). Baseline NLR, 1-month NLR, and 1-month NER were not associated with ORR, PFS, or OS outcomes; but 1-month NER correlated with lower risk of grade ≥3 irAEs (OR: 0.392, 95% CI: 0.165-0.895, p = .029). Our findings suggest baseline NER merits additional investigation as a novel prognostic marker for advanced melanoma patients receiving anti-PD-1-based regimens.
MeSH term(s)	Humans ; Neutrophils ; Eosinophils ; Retrospective Studies ; Treatment Outcome ; Melanoma ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-07-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2409570-9
ISSN	1755-148X ; 1600-0749 ; 0893-5785 ; 1755-1471
ISSN (online)	1755-148X ; 1600-0749
ISSN	0893-5785 ; 1755-1471
DOI	10.1111/pcmr.13109
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Book: Praxisbuch Verhaltenssucht

Albertini, Valentina / Bilke-Hentsch, Oliver

Symptomatik, Diagnostik und Therapie bei Kindern, Jugendlichen und Erwachsenen

2014

Author's details	hrsg. von Oliver Bilke-Hentsch ... Mit Beitr. von Valentina Albertini
Keywords	Stoffungebundene Sucht
Subject	Nichtstoffgebundene Sucht ; Stoffunabhängige Sucht ; Rauschmittellose Sucht ; Verhaltensgebundene Abhängigkeit ; Substanzungebundene Abhängigkeit ; Verhaltenssucht
Language	German
Size	260 S. : graph. Darst.
Publisher	Thieme
Publishing place	Stuttgart u.a.
Publishing country	Germany
Document type	Book
HBZ-ID	HT018336188
ISBN	978-3-13-171581-4 ; 3-13-171581-2 ; 9783131715913 ; 9783132002111 ; 313171591X ; 3132002119
Database	Catalogue ZB MED Medicine, Health

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2014 A 3908	available for loan (reading room)	Lesesaal EG

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