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Article ; Online: Twelve tips for public health education using social media.

Sehdev, Morgan / Huang, Melody / Joseph, Nicholos / Nabel, Katherine G / Vora, Kruti

MedEdPublish (2016)

2021 Volume 10, Page(s) 139

Abstract: This article was migrated. The article was marked as recommended. With nearly half the world's population using social media, platforms like Instagram, Twitter, and Facebook have become popular sources of information gathering and sharing for the general ...

Abstract	This article was migrated. The article was marked as recommended. With nearly half the world's population using social media, platforms like Instagram, Twitter, and Facebook have become popular sources of information gathering and sharing for the general public. In medicine, social media is increasingly used to educate patients due its wide reach and interactive nature. Early studies showed that these social media-based initiatives can even promote behavioral change by increasing public knowledge and self-efficacy. Several barriers such as time and technical skills, however, prevent healthcare workers from using social media platforms to promote public health education. The following twelve tips may help reduce these barriers and create more opportunities for patients to easily access quality medical information on social media. Creating an effective public health education platform on social media involves identifying clear goals, understanding the social context of all messaging, recruiting a motivated team, creating a style guide, vetting content for accuracy, and interacting with social media followers. These tips will help build an accurate and quality social media public health education campaign.
Language	English
Publishing date	2021-05-22
Publishing country	Scotland
Document type	Journal Article
ISSN	2312-7996
ISSN (online)	2312-7996
DOI	10.15694/mep.2021.000139.1
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Article ; Online: Twelve tips for public health education using social media

Morgan Sehdev / Melody Huang / Nicholos Joseph / Katherine G. Nabel / Kruti Vora

MedEdPublish, Vol 10, Iss

2021 Volume 1

Abstract: With nearly half the world’s population using social media, platforms like Instagram, Twitter, and Facebook have become popular sources of information gathering and sharing for the general public. In medicine, social media is increasingly used to educate ...

Abstract	With nearly half the world’s population using social media, platforms like Instagram, Twitter, and Facebook have become popular sources of information gathering and sharing for the general public. In medicine, social media is increasingly used to educate patients due its wide reach and interactive nature. Early studies showed that these social media-based initiatives can even promote behavioral change by increasing public knowledge and self-efficacy. Several barriers such as time and technical skills, however, prevent healthcare workers from using social media platforms to promote public health education. The following twelve tips may help reduce these barriers and create more opportunities for patients to easily access quality medical information on social media. Creating an effective public health education platform on social media involves identifying clear goals, understanding the social context of all messaging, recruiting a motivated team, creating a style guide, vetting content for accuracy, and interacting with social media followers. These tips will help build an accurate and quality social media public health education campaign.
Keywords	Social Media ; Public Health Education ; Twelve Tips ; Instagram ; Twitter ; Facebook ; Special aspects of education ; LC8-6691 ; Medicine ; R
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	F1000 Research Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Viral immunity: Basic mechanisms and therapeutic applications-a Keystone Symposia report.

Cable, Jennifer / Balachandran, Siddharth / Daley-Bauer, Lisa P / Rustagi, Arjun / Antony, Ferrin / Frere, Justin J / Strampe, Jamie / Kedzierska, Katherine / Cannon, Judy L / McGargill, Maureen A / Weiskopf, Daniela / Mettelman, Robert C / Niessl, Julia / Thomas, Paul G / Briney, Bryan / Valkenburg, Sophie A / Bloom, Jesse D / Bjorkman, Pamela J / Iketani, Sho /

Rappazzo, C Garrett / Crooks, Chelsea M / Crofts, Kali F / Pöhlmann, Stefan / Krammer, Florian / Sant, Andrea J / Nabel, Gary J / Schultz-Cherry, Stacey

Annals of the New York Academy of Sciences

2023 Volume 1521, Issue 1, Page(s) 32–45

Abstract: Viruses infect millions of people each year. Both endemic viruses circulating throughout the population as well as novel epidemic and pandemic viruses pose ongoing threats to global public health. Developing more effective tools to address viruses ... ...

Abstract	Viruses infect millions of people each year. Both endemic viruses circulating throughout the population as well as novel epidemic and pandemic viruses pose ongoing threats to global public health. Developing more effective tools to address viruses requires not only in-depth knowledge of the virus itself but also of our immune system's response to infection. On June 29 to July 2, 2022, researchers met for the Keystone symposium "Viral Immunity: Basic Mechanisms and Therapeutic Applications." This report presents concise summaries from several of the symposium presenters.
MeSH term(s)	Humans ; Pandemics ; Influenza, Human/epidemiology
Language	English
Publishing date	2023-01-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	211003-9
ISSN	1749-6632 ; 0077-8923
ISSN (online)	1749-6632
ISSN	0077-8923
DOI	10.1111/nyas.14960
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Article ; Online: The Effect of Vaccine Type and SARS-CoV-2 Lineage on Commercial SARS-CoV-2 Serologic and Pseudotype Neutralization Assays in mRNA Vaccine Recipients.

Tolan, Nicole V / Sherman, Amy C / Zhou, Guohai / Nabel, Katherine G / Desjardins, Michaël / Melanson, Stacy / Kanjilal, Sanjat / Moheed, Serina / Kupelian, John / Kaufman, Richard M / Ryan, Edward T / LaRocque, Regina C / Branda, John A / Dighe, Anand S / Abraham, Jonathan / Baden, Lindsey R / Charles, Richelle C / Turbett, Sarah E

Microbiology spectrum

2022 Volume 10, Issue 2, Page(s) e0021122

Abstract: The use of anti-spike (S) serologic assays as surrogate measurements of SARS-CoV-2 vaccine induced immunity will be an important clinical and epidemiological tool. The characteristics of a commercially available anti-S antibody assay (Roche Elecsys anti- ... ...

Abstract	The use of anti-spike (S) serologic assays as surrogate measurements of SARS-CoV-2 vaccine induced immunity will be an important clinical and epidemiological tool. The characteristics of a commercially available anti-S antibody assay (Roche Elecsys anti-SARS-CoV-2 S) were evaluated in a cohort of vaccine recipients. Levels were correlated with pseudotype neutralizing antibodies (NAb) across SARS-CoV-2 variants. We recruited adults receiving a two-dose series of mRNA-1273 or BNT162b2 and collected serum at scheduled intervals up to 8 months post-first vaccination. Anti-S and NAb levels were measured, and correlation was evaluated by (i) vaccine type and (ii) SARS-CoV-2 variant (wild-type, Alpha, Beta, Gamma, and three constructs Day 146, Day 152, and RBM-2). Forty-six mRNA vaccine recipients were enrolled. mRNA-1273 vaccine recipients had higher peak anti-S and NAb levels compared with BNT162b2 (
MeSH term(s)	2019-nCoV Vaccine mRNA-1273 ; Adult ; Antibodies, Neutralizing ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19/diagnosis ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; SARS-CoV-2/genetics ; Vaccines, Synthetic ; mRNA Vaccines
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; Vaccines, Synthetic ; mRNA Vaccines ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4) ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00211-22
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Article ; Online: VLDLR and ApoER2 are receptors for multiple alphaviruses.

Clark, Lars E / Clark, Sarah A / Lin, ChieYu / Liu, Jianying / Coscia, Adrian / Nabel, Katherine G / Yang, Pan / Neel, Dylan V / Lee, Hyo / Brusic, Vesna / Stryapunina, Iryna / Plante, Kenneth S / Ahmed, Asim A / Catteruccia, Flaminia / Young-Pearse, Tracy L / Chiu, Isaac M / Llopis, Paula Montero / Weaver, Scott C / Abraham, Jonathan

Nature

2021 Volume 602, Issue 7897, Page(s) 475–480

Abstract: Alphaviruses, like many other arthropod-borne viruses, infect vertebrate species and insect vectors separated by hundreds of millions of years of evolutionary history. Entry into evolutionarily divergent host cells can be accomplished by recognition of ... ...

Abstract	Alphaviruses, like many other arthropod-borne viruses, infect vertebrate species and insect vectors separated by hundreds of millions of years of evolutionary history. Entry into evolutionarily divergent host cells can be accomplished by recognition of different cellular receptors in different species, or by binding to receptors that are highly conserved across species. Although multiple alphavirus receptors have been described
MeSH term(s)	Animals ; LDL-Receptor Related Proteins ; Ligands ; Mice ; Mosquito Vectors ; Receptors, LDL ; Semliki forest virus/metabolism ; Sindbis Virus/physiology
Chemical Substances	LDL-Receptor Related Proteins ; Ligands ; Receptors, LDL ; VLDL receptor ; low density lipoprotein receptor-related protein 8
Language	English
Publishing date	2021-12-20
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-021-04326-0
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Article ; Online: Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain.

Nabel, Katherine G / Clark, Sarah A / Shankar, Sundaresh / Pan, Junhua / Clark, Lars E / Yang, Pan / Coscia, Adrian / McKay, Lindsay G A / Varnum, Haley H / Brusic, Vesna / Tolan, Nicole V / Zhou, Guohai / Desjardins, Michaël / Turbett, Sarah E / Kanjilal, Sanjat / Sherman, Amy C / Dighe, Anand / LaRocque, Regina C / Ryan, Edward T /

Tylek, Casey / Cohen-Solal, Joel F / Darcy, Anhdao T / Tavella, Davide / Clabbers, Anca / Fan, Yao / Griffiths, Anthony / Correia, Ivan R / Seagal, Jane / Baden, Lindsey R / Charles, Richelle C / Abraham, Jonathan

Science (New York, N.Y.)

2022 Volume 375, Issue 6578, Page(s) eabl6251

Abstract: Many studies have examined the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants on neutralizing antibody activity after they have become dominant strains. Here, we evaluate the consequences of further viral evolution. We ... ...

Abstract	Many studies have examined the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants on neutralizing antibody activity after they have become dominant strains. Here, we evaluate the consequences of further viral evolution. We demonstrate mechanisms through which the SARS-CoV-2 receptor binding domain (RBD) can tolerate large numbers of simultaneous antibody escape mutations and show that pseudotypes containing up to seven mutations, as opposed to the one to three found in previously studied variants of concern, are more resistant to neutralization by therapeutic antibodies and serum from vaccine recipients. We identify an antibody that binds the RBD core to neutralize pseudotypes for all tested variants but show that the RBD can acquire an N-linked glycan to escape neutralization. Our findings portend continued emergence of escape variants as SARS-CoV-2 adapts to humans.
MeSH term(s)	Angiotensin-Converting Enzyme 2/chemistry ; Angiotensin-Converting Enzyme 2/metabolism ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; BNT162 Vaccine/immunology ; Betacoronavirus/immunology ; COVID-19/immunology ; COVID-19/virology ; Cross Reactions ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Epitopes ; Evolution, Molecular ; Humans ; Immune Evasion ; Models, Molecular ; Mutation ; Polysaccharides/analysis ; Protein Binding ; Protein Domains ; Receptors, Coronavirus/chemistry ; Receptors, Coronavirus/metabolism ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/immunology ; Viral Pseudotyping
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Epitopes ; Polysaccharides ; Receptors, Coronavirus ; Spike Glycoprotein, Coronavirus ; spike glycoprotein, SARS-CoV ; spike protein, SARS-CoV-2 ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; BNT162 Vaccine (N38TVC63NU)
Language	English
Publishing date	2022-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abl6251
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Article ; Online: Brain-Derived Neurotrophic Factor Val66Met Polymorphism Affects the Relationship Between an Anxiety-Related Personality Trait and Resting Regional Cerebral Blood Flow.

Wei, Shau-Ming / Eisenberg, Daniel P / Nabel, Katherine G / Kohn, Philip D / Kippenhan, J Shane / Dickinson, Dwight / Kolachana, Bhaskar / Berman, Karen F

Cerebral cortex (New York, N.Y. : 1991)

2016 Volume 27, Issue 3, Page(s) 2175–2182

Abstract: Brain-derived neurotrophic factor (BDNF) is an important modulator of constitutive stress responses mediated by limbic frontotemporal circuits, and its gene contains a functional polymorphism (Val66Met) that may influence trait stress sensitivity. ... ...

Abstract	Brain-derived neurotrophic factor (BDNF) is an important modulator of constitutive stress responses mediated by limbic frontotemporal circuits, and its gene contains a functional polymorphism (Val66Met) that may influence trait stress sensitivity. Reports of an association of this polymorphism with anxiety-related personality traits have been controversial and without clear neurophysiological support. We, therefore, determined the relationship between resting regional cerebral blood flow (rCBF) and a well-validated measure of anxiety-related personality, the TPQ Harm Avoidance (HA) scale, as a function of BDNF Val66Met genotype. Sixty-four healthy participants of European ancestry underwent resting H215O positron emission tomography scans. For each genotype group separately, we first determined the relationship between participants' HA scores and their resting rCBF values in each voxel across the entire brain, and then directly compared these HA-rCBF relationships between Val66Met genotype groups. HA-rCBF relationships differed between Val homozygotes and Met carriers in several regions relevant to stress regulation: subgenual cingulate, orbital frontal cortex, and the hippocampal/parahippocampal region. In each of these areas, the relationship was positive in Val homozygotes and negative in Met carriers. These data demonstrate a coupling between trait anxiety and basal resting blood flow in frontolimbic neurocircuitry that may be determined in part by genetically mediated BDNF signaling.
MeSH term(s)	Adolescent ; Adult ; Anxiety/genetics ; Anxiety/physiopathology ; Brain/diagnostic imaging ; Brain/physiology ; Brain Mapping ; Brain-Derived Neurotrophic Factor/genetics ; Cerebrovascular Circulation/genetics ; Cerebrovascular Circulation/physiology ; European Continental Ancestry Group/genetics ; Female ; Heterozygote ; Homozygote ; Humans ; Male ; Middle Aged ; Personality/genetics ; Personality/physiology ; Personality Tests ; Polymorphism, Single Nucleotide ; Positron-Emission Tomography ; Rest ; Young Adult
Chemical Substances	Brain-Derived Neurotrophic Factor ; BDNF protein, human (7171WSG8A2)
Language	English
Publishing date	2016-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1077450-6
ISSN	1460-2199 ; 1047-3211
ISSN (online)	1460-2199
ISSN	1047-3211
DOI	10.1093/cercor/bhw072
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Article: Viral immunity

Cable, Jennifer / Balachandran, Siddharth / Daley-Bauer, Lisa P. / Rustagi, Arjun / Antony, Ferrin / Frere, Justin J. / Strampe, Jamie / Kedzierska, Katherine / Cannon, Judy L. / McGargill, Maureen A. / Weiskopf, Daniela / Mettelman, Robert C. / Niessl, Julia / Thomas, Paul G. / Briney, Bryan / Valkenburg, Sophie A. / Bloom, Jesse D. / Bjorkman, Pamela J. / Iketani, Sho /

Rappazzo, C. Garrett / Crooks, Chelsea M. / Crofts, Kali F. / Pöhlmann, Stefan / Krammer, Florian / Sant, Andrea J. / Nabel, Gary J. / Schultz-Cherry, Stacey

Annals of the New York Academy of Sciences

Basic mechanisms and therapeutic applications - A Keystone Symposia report

2023 Volume 1521, Issue 1, Page(s) 32–45

Title translation	Virale Immunität: Grundlegende Mechanismen und therapeutische Anwendungen - Ein Bericht des Keystone-Symposiums
Abstract	Viruses infect millions of people each year. Both endemic viruses circulating throughout the population as well as novel epidemic and pandemic viruses pose ongoing threats to global public health. Developing more effective tools to address viruses requires not only in-depth knowledge of the virus itself but also of our immune system's response to infection. On June 29 to July 2, 2022, researchers met for the Keystone symposium "Viral Immunity: Basic Mechanisms and Therapeutic Applications." This report presents concise summaries from several of the symposium presenters.
Keywords	Antibodies ; Antikörper ; COVID-19 ; Drohung ; Epidemics ; Epidemien ; Immune System ; Immunity (Disease) ; Immunität (Krankheit) ; Immunsystem ; Infectious Disorders ; Infektionskrankheiten ; Pandemics ; Pandemie ; Public Health ; Threat ; Viral Infections ; Viruserkrankungen ; Öffentliche Gesundheit
Language	English
Document type	Article
ZDB-ID	211003-9
ISSN	1749-6632 ; 0077-8923
ISSN (online)	1749-6632
ISSN	0077-8923
DOI	10.1111/nyas.14960
Database	PSYNDEX

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Article: Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response.

Chen, Jonathan H / Nieman, Linda T / Spurrell, Maxwell / Jorgji, Vjola / Richieri, Peter / Xu, Katherine H / Madhu, Roopa / Parikh, Milan / Zamora, Izabella / Mehta, Arnav / Nabel, Christopher S / Freeman, Samuel S / Pirl, Joshua D / Lu, Chenyue / Meador, Catherine B / Barth, Jaimie L / Sakhi, Mustafa / Tang, Alexander L / Sarkizova, Siranush /

Price, Colles / Fernandez, Nicolas F / Emanuel, George / He, Jiang / Raay, Katrina Van / Reeves, Jason W / Yizhak, Keren / Hofree, Matan / Shih, Angela / Sade-Feldman, Moshe / Boland, Genevieve M / Pelka, Karin / Aryee, Martin / Korsunsky, Ilya / Mino-Kenudson, Mari / Gainor, Justin F / Hacohen, Nir

bioRxiv : the preprint server for biology

2023

Abstract: The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially-localized multicellular 'immunity hubs' defined by expression of the T cell-attracting ... ...

Abstract	The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially-localized multicellular 'immunity hubs' defined by expression of the T cell-attracting chemokines
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.04.04.535379
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Article ; Online: Corrigendum: Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability.

Nature communications

2017 Volume 8, Page(s) 14710

Language	English
Publishing date	2017-02-16
Publishing country	England
Document type	Journal Article ; Published Erratum
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/ncomms14710
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