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Article ; Online: Association between programmed death-1 pathway and major depression.

Huang, Kuan-Wei / Huang, Tiao-Lai

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

2023 Volume 24, Issue 9, Page(s) 822–828

Abstract: Objectives: Major depression (MD) may be associated with inflammation and immunity. PD-1 (programmed death-1), PD-L1 (programmed death-ligand 1) and PD-L2 (programmed death-ligand 2) are among the inhibitory immune mediators on the PD-1 pathway. However, ...

Abstract	Objectives: Major depression (MD) may be associated with inflammation and immunity. PD-1 (programmed death-1), PD-L1 (programmed death-ligand 1) and PD-L2 (programmed death-ligand 2) are among the inhibitory immune mediators on the PD-1 pathway. However, previous data regarding the association between MD and PD-1 pathway were still scarce; therefore, we investigated the association of PD-1 pathway with MD. Methods: During a period of 2 years, patients with MD and healthy controls were recruited from a medical centre in this study. The diagnosis of MD was established according to the DSM-5 criteria. The severity of MD was assessed with 17-item Hamilton Depression Rating Scale. PD-1, PD-L1 and PD-L2 were detected in peripheral blood from MD patients after 4 weeks of treatment with antidepressant drugs. Results: A total of 54 patients with MD and 38 healthy controls were recruited. According to the analyses, there is a significantly higher PD-L2 level in MD than in healthy controls and lower PD-1 level after age and BMI adjustment. Besides, moderately positive correlation between HAM-D scores and PD-L2 level was found. Conclusions: It was found that PD-1 pathway might play an important role in MD. We need a large sample to prove these results in the future.
MeSH term(s)	Humans ; B7-H1 Antigen ; Depression ; Depressive Disorder, Major ; Diagnostic and Statistical Manual of Mental Disorders ; Programmed Cell Death 1 Receptor
Chemical Substances	B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; CD274 protein, human
Language	English
Publishing date	2023-05-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2051402-5
ISSN	1814-1412 ; 1562-2975
ISSN (online)	1814-1412
ISSN	1562-2975
DOI	10.1080/15622975.2023.2209876
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Article: Attenuation of Endoplasmic Reticulum Stress Enhances Carvacrol-Induced Apoptosis in Osteosarcoma Cell Lines.

Chiu, Kuan-Wei / Chen, Hsuan-Ying / Chen, Chiu-Liang / Hsieh, Cheng-Pu / Huang, Yi-Fu

Life (Basel, Switzerland)

2023 Volume 13, Issue 3

Abstract: Carvacrol is a monoterpenoid phenol that has excellent antimicrobial, antiviral, and anti-inflammatory activities. It can also improve wound healing. However, few studies have explored its antitumor effect on osteosarcoma. In this report, we tried to ... ...

Abstract	Carvacrol is a monoterpenoid phenol that has excellent antimicrobial, antiviral, and anti-inflammatory activities. It can also improve wound healing. However, few studies have explored its antitumor effect on osteosarcoma. In this report, we tried to determine the potential efficacy of carvacrol against osteosarcoma cell lines. Our data revealed that carvacrol exposure inhibited the proliferation of osteosarcoma HOS and U-2 OS cells. In addition, carvacrol exposure enhanced the levels of cleaved PARP and caspase 3 and increased annexin V-positive cells, indicating that carvacrol exposure triggers apoptosis in osteosarcoma cell lines. Furthermore, the levels of reactive oxygen species (ROS) were enhanced after carvacrol exposure and cotreatment with NAC, the ROS scavenger, decreased the levels of cleaved PARP and caspase 3, suggesting the involvement of ROS in carvacrol-induced apoptosis. Importantly, we found that carvacrol exposure triggered several protein expressions related to endoplasmic reticulum (ER) stress, including GRP78/Bip, IRE1a, PERK, and CHOP, in HOS and U-2 OS cells, indicating that carvacrol exposure could result in ER stress in these cell lines. Cotreatment with the ER stress inhibitor 4-PBA increased the levels of cleaved PARP and caspase 3 and further suppressed cellular proliferation in carvacrol-exposed osteosarcoma cell lines. Overall, the results indicate that induced ER stress can protect cells from apoptosis, but increased ROS contributes to apoptosis in carvacrol-treated cells. In this report, we first demonstrate the role of ER stress in carvacrol-induced apoptosis and suggest that ER stress could be targeted to enhance the antitumor activity of carvacrol in osteosarcoma cell lines.
Language	English
Publishing date	2023-03-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13030744
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Article ; Online: Novel Delay-Dependent Stabilization for Fuzzy Stochastic Systems with Multiplicative Noise Subject to Passivity Constraint

Cheung-Chieh Ku / Wen-Jer Chang / Kuan-Wei Huang

Processes, Vol 9, Iss 1445, p

2021 Volume 1445

Abstract: A novel delay-dependent stability criterion for Takagi-Sugeno (T-S) fuzzy systems with multiplicative noise is addressed in this paper subject to passivity performance. The general case of interval time-varying delay is considered for the practical ... ...

Abstract	A novel delay-dependent stability criterion for Takagi-Sugeno (T-S) fuzzy systems with multiplicative noise is addressed in this paper subject to passivity performance. The general case of interval time-varying delay is considered for the practical control issue. For the criterion, an integral Lyapunov-Krasovskii function is proposed to derive some sufficient relaxed conditions and to avoid the derivative of the membership function. Moreover, a free-matrix inequality is adopted to deal with the delay terms such that the available derivative of time-varying delay is bigger than one. In order to employ a convex optimization algorithm to find the control gain, a projection lemma is applied to acquire the Linear Matrix Inequality (LMI) form of the sufficient conditions. With the obtained gains, a fuzzy controller is designed by the concept of Parallel Distributed Compensation (PDC) such that the delayed T-S fuzzy systems with multiplicative noise are asymptotically stable and passive in the mean square. Finally, a stabilization problem of the ship’s autopilot dynamic system and some comparisons are discussed during the simulation results.
Keywords	T-S fuzzy system ; integral Lyapunov function ; free-matrix inequality ; passivity theory ; projection lemma ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	629
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Improved Electrical Characteristics of AlGaN/GaN High-Electron-Mobility Transistor with Al

Huang, Cheng-Yu / Mazumder, Soumen / Lin, Pu-Chou / Lee, Kuan-Wei / Wang, Yeong-Her

Materials (Basel, Switzerland)

2022 Volume 15, Issue 19

Abstract: A metal-oxide-semiconductor high-electron-mobility transistor (MOS-HEMT) is proposed based on using a ... ...

Abstract	A metal-oxide-semiconductor high-electron-mobility transistor (MOS-HEMT) is proposed based on using a Al
Language	English
Publishing date	2022-10-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15196895
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Article ; Online: Attenuation of Endoplasmic Reticulum Stress Enhances Carvacrol-Induced Apoptosis in Osteosarcoma Cell Lines

Kuan-Wei Chiu / Hsuan-Ying Chen / Chiu-Liang Chen / Cheng-Pu Hsieh / Yi-Fu Huang

Life, Vol 13, Iss 744, p

2023 Volume 744

Abstract	Carvacrol is a monoterpenoid phenol that has excellent antimicrobial, antiviral, and anti-inflammatory activities. It can also improve wound healing. However, few studies have explored its antitumor effect on osteosarcoma. In this report, we tried to determine the potential efficacy of carvacrol against osteosarcoma cell lines. Our data revealed that carvacrol exposure inhibited the proliferation of osteosarcoma HOS and U-2 OS cells. In addition, carvacrol exposure enhanced the levels of cleaved PARP and caspase 3 and increased annexin V-positive cells, indicating that carvacrol exposure triggers apoptosis in osteosarcoma cell lines. Furthermore, the levels of reactive oxygen species (ROS) were enhanced after carvacrol exposure and cotreatment with NAC, the ROS scavenger, decreased the levels of cleaved PARP and caspase 3, suggesting the involvement of ROS in carvacrol-induced apoptosis. Importantly, we found that carvacrol exposure triggered several protein expressions related to endoplasmic reticulum (ER) stress, including GRP78/Bip, IRE1a, PERK, and CHOP, in HOS and U-2 OS cells, indicating that carvacrol exposure could result in ER stress in these cell lines. Cotreatment with the ER stress inhibitor 4-PBA increased the levels of cleaved PARP and caspase 3 and further suppressed cellular proliferation in carvacrol-exposed osteosarcoma cell lines. Overall, the results indicate that induced ER stress can protect cells from apoptosis, but increased ROS contributes to apoptosis in carvacrol-treated cells. In this report, we first demonstrate the role of ER stress in carvacrol-induced apoptosis and suggest that ER stress could be targeted to enhance the antitumor activity of carvacrol in osteosarcoma cell lines.
Keywords	apoptosis ; carvacrol ; ER stress ; osteosarcoma ; Science ; Q
Subject code	610
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Comparison between botulinum toxin and steroid septal injection in the treatment of allergic rhinitis.

Huang, Cheng-Chieh / Chen, Kuan-Wei / Twu, Chih-Wen / Huang, Hung-Meng / Hsu, Hsin-Chien

Laryngoscope investigative otolaryngology

2022 Volume 7, Issue 1, Page(s) 12–21

Abstract: Objective: To compare the effects of botulinum toxin and steroid septal injections in treating allergic rhinitis (AR) by evaluating improvements in the rhinitis control assessment test (RCAT), visual analog scale (VAS), nasal obstruction symptom ... ...

Abstract	Objective: To compare the effects of botulinum toxin and steroid septal injections in treating allergic rhinitis (AR) by evaluating improvements in the rhinitis control assessment test (RCAT), visual analog scale (VAS), nasal obstruction symptom evaluation (NOSE) scores, and active anterior rhinomanometry (RMM) measurements. Methods: This prospective, single-blinded cohort study was conducted at the Department of Otolaryngology, Taipei City Hospital between January 2017 and December 2018. Ninety-five patients were randomized to receive botulinum toxin, dexamethasone, or normal saline (group A, group B, and placebo, respectively). The main outcome measures were pretreatment subjective nasal symptoms (RCAT, VAS, and NOSE) and active anterior RMM measurements. All measurements were repeated during posttreatment 1, 2, and 3 months. Results: No significant difference was observed in pretreatment questionnaire scores and RMM values between the study and placebo groups. The mean posttreatment RCAT, VAS, and NOSE scores after 1 and 2 months significantly improved in the treatment groups compared to placebo. The VAS and NOSE at posttreatment 2 months and RCAT, VAS, and NOSE at posttreatment 3 months were significantly different comparing group A to group B. All RMM parameters showed better values in group A than in group B at 1, 2, and 3 months posttreatment, with significant differences in four parameters in posttreatment 3 months. Conclusions: Botulinum toxin septal injection is a safe treatment option for AR and improves subjective nasal symptoms for 3 months. Botulinum toxin A injection tended to be more effective than steroid septal injection in terms of duration and degree.Level of Evidence: 2b, individual cohort study.
Language	English
Publishing date	2022-01-06
Publishing country	United States
Document type	Journal Article
ISSN	2378-8038
ISSN	2378-8038
DOI	10.1002/lio2.726
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Article ; Online: Effect of co-medications and potential risk factors of high-dose methotrexate-mediated acute hepatotoxicity in patients with osteosarcoma.

Wang, Sheng-Fan / Huang, Kuan-Wei / Chou, Yueh-Ching / Lee, Hsin-Chen / Wu, Po-Kuei / Chen, Wei-Ming / Hung, Giun-Yi / Chang, Yuh-Lih

Cancer medicine

2023 Volume 12, Issue 11, Page(s) 12354–12364

Abstract: Background: Taiwanese patients frequently experience severe hepatotoxicity associated with high-dose methotrexate (HD-MTX) treatment, which interferes with subsequent treatment. Drug-drug interactions occur when MTX is used in combination with proton ... ...

Abstract	Background: Taiwanese patients frequently experience severe hepatotoxicity associated with high-dose methotrexate (HD-MTX) treatment, which interferes with subsequent treatment. Drug-drug interactions occur when MTX is used in combination with proton pump inhibitors (PPIs), trimethoprim-sulfamethoxazole (TMP-SMX), or non-steroidal anti-inflammatory drugs (NSAIDs). In East Asia, real-world analyses on the effects of co-medication and other potential risk factors on the clinical course of HD-MTX-mediated acute hepatotoxicity in patients with osteogenic sarcoma (OGS) are limited. Methods: This cohort study included patients with newly diagnosed OGS who were treated with HD-MTX between 2009 and 2017 at Taipei Veterans General Hospital. We collected data on the clinical course of HD-MTX-mediated acute hepatotoxicity, co-medications, and other potential risk factors, and analyzed the effects of these factors on the clinical course of HD-MTX-mediated acute hepatotoxicity. Results: Almost all patients with OGS treated with HD-MTX developed acute hepatotoxicity with elevated alanine aminotransferase (ALT) levels. Most patients with Grade 3-4 ALT elevation failed to recover to Grade 2 within 7 days. Women and children are high-risk subgroups for HD-MTX-mediated elevation of ALT levels. Age is a factor that contributes to the pharmacokinetic differences of HD-MTX. However, the concurrent use of PPIs, TMP-SMX, or NSAIDs did not affect the elimination of MTX when administered with adequate supportive therapy. Conclusions: Co-administration of PPIs, TMP-SMX, or NSAIDs may have limited effects on acute hepatotoxicity in well-monitored and adequately pre-medicated patients with OGS undergoing chemotherapy with HD-MTX. Clinicians should pay particular attention to ALT levels when prescribing HD-MTX to children and women.
MeSH term(s)	Child ; Humans ; Female ; Methotrexate ; Trimethoprim, Sulfamethoxazole Drug Combination/adverse effects ; Cohort Studies ; Osteosarcoma/drug therapy ; Anti-Inflammatory Agents, Non-Steroidal ; Proton Pump Inhibitors/therapeutic use ; Bone Neoplasms/drug therapy ; Risk Factors ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/etiology ; Chemical and Drug Induced Liver Injury/drug therapy ; Disease Progression
Chemical Substances	Methotrexate (YL5FZ2Y5U1) ; Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2) ; Anti-Inflammatory Agents, Non-Steroidal ; Proton Pump Inhibitors
Language	English
Publishing date	2023-04-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.5936
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Article ; Online: Cochlear Obliteration after Translabyrinthine Resection for Large Cerebellopontine Angle Tumor.

Huang, Yen-Chieh / Hsu, Sanford P C / Chiang, Kuan-Wei / Wang, Mao-Che

Audiology & neuro-otology

2022 Volume 28, Issue 1, Page(s) 63–74

Abstract: Introduction: The aim of this study was to better understand the onset time and factors associated with cochlear obliteration following translabyrinthine approach (TLA) surgery for large cerebellopontine angle tumors.: Methods: This retrospective ... ...

Abstract	Introduction: The aim of this study was to better understand the onset time and factors associated with cochlear obliteration following translabyrinthine approach (TLA) surgery for large cerebellopontine angle tumors. Methods: This retrospective cohort study included 117 patients with large cerebellopontine angle tumor (tumor diameter >2 cm) treated by TLA surgery from June 2011 to March 2019 in a single tertiary referral center. The Kaplan-Meier method with log-rank test was used to estimate cochlear patency survival and the association between survival and covariates, and the Cox proportional hazards regression analysis was used to identify possible factors associated with cochlear obliteration. Results: Of the 117 patients included in our analysis, the median follow-up was 24.8 months. There were 30 (25.6%) patients in the cochlear obliteration group, and 87 (74.4%) in the patent cochlear group. Various degrees of cochlear obliteration was found in 25.6% patients in final MRI scan, comprised of 50% grade I, 30% grade II, and 20% grade III. Cochlear patency survival curves showed 94.0% at 3 months, 73.0% at 18 months, which plateaued after 20 months with a survival rate of 71.6%. In the multivariate Cox proportional hazards model, patients presented with postoperative hyperintense T1W cochlear signal had poorer cochlear patency survival compared to isointense T1W (HR = 4.15). Similarly, postoperative deteriorated facial function (HR = 4.52) and full IAC involvement of tumor (HR = 2.33) demonstrated a higher risks of cochlear obliteration after TLA surgery. Conclusion: The 2-year estimated cochlear patency rate was 71.6% in patients that received TLA. Cochlear obliteration can develop as early as 3 months post-surgery, with no new obliteration 20 months after the surgery and half of these patients got severe obliteration. Three factors associated with cochlear obliteration were identified including full IAC involvement of tumor, postoperative facial function deterioration, and postoperative hyperintense T1W cochlear signal.
MeSH term(s)	Humans ; Neuroma, Acoustic/surgery ; Retrospective Studies ; Cochlea/surgery ; Cochlear Implantation/methods ; Magnetic Resonance Imaging/methods
Language	English
Publishing date	2022-09-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1314086-3
ISSN	1421-9700 ; 1420-3030
ISSN (online)	1421-9700
ISSN	1420-3030
DOI	10.1159/000524820
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Article ; Online: Effect of 1,2,4,5-Benzenetetracarboxylic Acid on Unsaturated Poly(butylene adipate-

Chen, Chin-Wen / Hsu, Te-Sheng / Huang, Kuan-Wei / Rwei, Syang-Peng

Polymers

2020 Volume 12, Issue 5

Abstract: Unsaturated poly (butylene adipate-co-butylene itaconate) (PBABI) copolyesters were synthesized through melt polymerization composed of 1,4-butanediol (BDO), adipic acid (AA), itaconic acid (IA) and 1,2,4,5-benzenetetracarboxylic acid (BTCA) as a cross- ... ...

Abstract	Unsaturated poly (butylene adipate-co-butylene itaconate) (PBABI) copolyesters were synthesized through melt polymerization composed of 1,4-butanediol (BDO), adipic acid (AA), itaconic acid (IA) and 1,2,4,5-benzenetetracarboxylic acid (BTCA) as a cross-linking modifier. The melting point, crystallization and glass transition temperature of the PBABI copolyesters were detected around 29.8-49 °C, 7.2-29 °C and -51.1 and -58.1 °C, respectively. Young's modulus can be modified via partial cross-linking by BTCA in the presence of IA, ranging between 32.19-168.45 MPa. Non-isothermal crystallization kinetics were carried out to explore the crystallization behavior, revealing the highest crystallization rate was placed in the BA/BI = 90/10 at a given molecular weight. Furthermore, the thermal, mechanical properties, and crystallization rate of PBABI copolyesters can be tuned through the adjustment of BTCA and IA concentrations.
Language	English
Publishing date	2020-05-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527146-5
ISSN	2073-4360 ; 2073-4360
ISSN (online)	2073-4360
ISSN	2073-4360
DOI	10.3390/polym12051160
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Article ; Online: Investigation of the Stability of Methylammonium Lead Iodide (MAPbI

Huang, Pao-Hsun / Wang, Chi-Wei / Lien, Shui-Yang / Lee, Kuan-Wei / Wang, Na-Fu / Huang, Chien-Jung

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 9

Abstract: In this study, we describe composited perovskite films based on the doping of lead cesium triiodide ( ... ...

Abstract	In this study, we describe composited perovskite films based on the doping of lead cesium triiodide (CsPbI
Language	English
Publishing date	2021-05-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26092678
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