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Article ; Online: A novel enzyme-based functional correlation algorithm for multi-omics reveals the potential mechanisms of traditional Chinese medicines: Taking Jian-Pi-Yi-Shen formula as an example.

Yin, Ying-Hao / Li, Chang-Hui / Huang, Hai-Piao / Zhang, Chi / Zhang, Shang-Bin / Li, Shun-Min / Chen, Jianping

Journal of pharmaceutical and biomedical analysis

2024 Volume 241, Page(s) 115973

Abstract: ... is successfully utilized to reveal the therapeutic mechanisms of Jian-Pi-Yi-Shen (JPYS) formula ...

Abstract	The integrated analysis of host metabolome and intestinal microbiome is an opportunity to explore the complex therapeutic mechanisms of traditional Chinese medicines. Currently, researchers mainly employ various statistical correlation analytical methods to investigate metabolome-microbiome correlations. However, these conventional correlation techniques often focus on statistical correlations and their biological meanings are always ignored, especially the functional relevance between them. Here, we developed a novel enzyme-based functional correlation (EBFC) algorithm to further improve the interpretability and the identified scope of microbe-metabolite correlations based on the conventional Spearman's analysis. The proposed EBFC algorithm is successfully utilized to reveal the therapeutic mechanisms of Jian-Pi-Yi-Shen (JPYS) formula on the treatment of adenine-induced chronic kidney disease (CKD) rats. JPYS, a TCM formula for treating CKD, has beneficial clinical effects. We tentatively revealed the potential mechanism of JPYS for treating CKD rats from the perspective of the serum metabolome, gut microbiome, and their interactions. Specifically, 11 metabolites and 19 bacterial genera in the CKD rats were significantly regulated to approaching normal status after JPYS treatment, suggesting that JPYS could ameliorate the pathological symptoms of CKD rats by reshaping the disturbed metabolome and gut microbiota. Further correlation analysis between the significantly perturbed metabolites, microbiota, and the related enzymes provided more strong evidence for the study of host metabolism-microbiota interactions and the therapeutic mechanism of JPYS on CKD rats. In conclusion, these findings will help us to deeply understand the pathogenesis of CKD and provide new insights into the therapeutic mechanism of JPYS.
MeSH term(s)	Rats ; Animals ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Multiomics ; Medicine, Chinese Traditional/methods ; Renal Insufficiency, Chronic/metabolism ; Metabolome
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2024.115973
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Zs.A 1850: Show issues

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Article ; Online: Jian-Yan-Ling capsules ameliorate cognitive impairment in mice with D-galactose-induced senescence and inhibit the oxidation-induced apoptosis of HT22 hippocampal cells by regulating the Nrf2-HO1 signaling pathway.

Lou, Qianyin / Meng, Xue-Er / Wei, Chongqi / Tong, Jiaxiang / Chen, Yang / Li, Mengting / Wang, Qingqing / Guo, Sheng / Duan, Jin-Ao / Shang, Er-Xin / Zhu, Yue

Journal of ethnopharmacology

2023 Volume 310, Page(s) 116356

Abstract: Ethnopharmacological relevance: The Jian-Yan-Ling (JYL) capsule is a famous anti-aging Chinese ...

Abstract	Ethnopharmacological relevance: The Jian-Yan-Ling (JYL) capsule is a famous anti-aging Chinese patent medicine. It is applied mainly to delay senescence to improve cognition in aging individuals. However, the action mechanisms of JYL for improving cognition have not been determined. Aim of the study: We will evaluate the effect of the JYL capsule at improving the cognition of aging mice by improving oxidative stress in the hippocampus and exploring its action mechanism. Materials and methods: A senescence mouse model was developed via intraperitoneal injection of D-galactose. The effect of the JYL capsule at improving the learning and memory abilities of mice was evaluated using the Morris water maze and novel object recognition tests. The apotosis of model mice hippocampus' were determined by TUNEL analysis. The antioxidant capacity of the JYL capsule was evaluated by determining the activities of antioxidant enzymes and expressions of oxidative products. The regulation of the Nrf2/HO-1 signaling pathway of the JYL capsule was evaluated by determining the expressions of related proteins via western blotting analysis. In vitro, H Results: JYL capsules enhanced the learning and memory abilities of model mice according to behavioral tests. The results of TUNEL analysis showed that the JYL capsule ameliorated hippocampal apoptosis in model mice. JYL capsules also exerted significant antioxidant capacity by increasing the activities of antioxidant enzymes while decreasing the levels of oxidative products both in the hippocampus and serum. The regulation of Nrf2/HO-1 pathway might contribute to the antioxidant function. In vitro, JYL-containing rat serum protected HT22 cells from H Conclusions: The amelioration of neuronal oxidative stress of hippocampus might contribute to the D-galactose-induced cognition impairment of senescence mice. These findings provide evidence for the application of JYL capsules to enhance cognition in aging individuals.
MeSH term(s)	Mice ; Rats ; Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Antioxidants/metabolism ; Galactose ; NF-E2-Related Factor 2/metabolism ; Hydrogen Peroxide/metabolism ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/metabolism ; Oxidative Stress ; Signal Transduction ; Apoptosis ; Hippocampus
Chemical Substances	Antioxidants ; Galactose (X2RN3Q8DNE) ; NF-E2-Related Factor 2 ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2023-03-14
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116356
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Zs.A 1494: Show issues

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Article ; Online: Network pharmacology analysis on mechanism of Jian Pi Qing Gan Yin decoction ameliorating high fat diet-induced non-alcoholic fatty liver disease and validated in vivo.

Liu, Weiwei / Shang, Jingyu / Deng, Yinxiang / Han, Xiuzhen / Chen, Yugen / Wang, Shuangshuang / Yang, Ruwen / Dong, Fan / Shang, Hongtao

Journal of ethnopharmacology

2022 Volume 295, Page(s) 115382

Abstract: Ethnopharmacological relevance: Jian Pi Qing Gan Yin (JPQGY) has been used clinically to relieve ...

Abstract	Ethnopharmacological relevance: Jian Pi Qing Gan Yin (JPQGY) has been used clinically to relieve non-alcoholic fatty liver disease (NAFLD) in China for decades; however, the underlying mechanisms of JPQGY remain unclear. Aim of the study: We evaluated the effects and mechanisms of JPQGY and hepatic steatosis caused by the middle stage of 13-week-high-fat-diet-induced NAFLD in mice. Materials and methods: Different dosages of JPQGY (5.5, 11, and 22 g/kg/day) were administered to NAFLD mice simultaneously. Body weight, body mass index (BMI), and liver lipid- and inflammation-related serum indicators were measured enzymatically. Liver samples were stained with Oil Red O and hematoxylin and eosin (H&E). Next, we performed a network pharmacology analysis and verified eight target genes mapping to NAFLD-related lipid metabolism pathways. The mRNA/protein expression was analyzed by real-time polymerase chain reaction (PCR) and western blotting. Results: JPQGY significantly relieved histological damage (steatosis-inflammation-fibrosis), prevented the downregulation of AMPK and Pparα, and upregulated LXRα, Srebp-1c, F4/80, Nf-κb, and Cyp2e1 in the HFD-induced NAFLD mouse model. Conclusions: The present results suggest that chronic treatment with JPQGY ameliorated HFD-induced NAFLD in mice by targeting the first and second phases of hepatic steatosis by stimulating the AMPK/PPARα pathway and inhibiting the LXRα/Srebp1/Nf-κb pathway. Our findings provide evidence that supports the clinical use of this formula for high-fat diet-induced fatty liver disease.
MeSH term(s)	AMP-Activated Protein Kinases/metabolism ; Animals ; Diet, High-Fat ; Inflammation/pathology ; Lipid Metabolism ; Liver ; Mice ; Mice, Inbred C57BL ; NF-kappa B/metabolism ; Network Pharmacology ; Non-alcoholic Fatty Liver Disease/metabolism ; PPAR alpha/genetics ; PPAR alpha/metabolism
Chemical Substances	NF-kappa B ; PPAR alpha ; AMP-Activated Protein Kinases (EC 2.7.11.31)
Language	English
Publishing date	2022-05-14
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115382
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Zs.A 1494: Show issues

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Article: Network pharmacology analysis on mechanism of Jian Pi Qing Gan Yin decoction ameliorating high fat diet-induced non-alcoholic fatty liver disease and validated in vivo

Liu, Weiwei / Shang, Jingyu / Deng, Yinxiang / Han, Xiuzhen / Chen, Yugen / Wang, Shuangshuang / Yang, Ruwen / Dong, Fan / Shang, Hongtao

Journal of ethnopharmacology. 2022 Sept. 15, v. 295

2022

Abstract: Jian Pi Qing Gan Yin (JPQGY) has been used clinically to relieve non-alcoholic fatty liver disease ...

Abstract	Jian Pi Qing Gan Yin (JPQGY) has been used clinically to relieve non-alcoholic fatty liver disease (NAFLD) in China for decades; however, the underlying mechanisms of JPQGY remain unclear. We evaluated the effects and mechanisms of JPQGY and hepatic steatosis caused by the middle stage of 13-week-high-fat-diet-induced NAFLD in mice. Different dosages of JPQGY (5.5, 11, and 22 g/kg/day) were administered to NAFLD mice simultaneously. Body weight, body mass index (BMI), and liver lipid- and inflammation-related serum indicators were measured enzymatically. Liver samples were stained with Oil Red O and hematoxylin and eosin (H&E). Next, we performed a network pharmacology analysis and verified eight target genes mapping to NAFLD-related lipid metabolism pathways. The mRNA/protein expression was analyzed by real-time polymerase chain reaction (PCR) and western blotting. JPQGY significantly relieved histological damage (steatosis-inflammation-fibrosis), prevented the downregulation of AMPK and Pparα, and upregulated LXRα, Srebp-1c, F4/80, Nf-κb, and Cyp2e1 in the HFD-induced NAFLD mouse model. The present results suggest that chronic treatment with JPQGY ameliorated HFD-induced NAFLD in mice by targeting the first and second phases of hepatic steatosis by stimulating the AMPK/PPARα pathway and inhibiting the LXRα/Srebp1/Nf-κb pathway. Our findings provide evidence that supports the clinical use of this formula for high-fat diet-induced fatty liver disease.
Keywords	blood serum ; body weight ; eosin ; fatty liver ; high fat diet ; histology ; lipid metabolism ; liver ; mice ; pharmacology ; protein synthesis ; quantitative polymerase chain reaction ; traditional medicine
Language	English
Dates of publication	2022-0915
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115382
Database	NAL-Catalogue (AGRICOLA)

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Z 90/710: Show issues

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Book: Zhongjing fang yao yan jiu ying yong jing jian

Shang, Chichang

1999

Title translation	Selected studies and applications of Zhang Zhongjing's materia medica.
Author's details	zhu bian Shang Chichang, Ji Chunru, Miao Mingsan
MeSH term(s)	Medicine, Chinese Traditional ; Materia Medica/pharmacology
Language	Chinese
Size	5, 1093 p.
Edition	Di 1 ban.
Publisher	Ren min jun yi chu ban she
Publishing place	Beijing
Document type	Book
ISBN	9787801570390 ; 7801570391
Database	Catalogue of the US National Library of Medicine (NLM)

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Article: Effect of laser remelting power on the microstructure and properties of vanadizing layer on AISI 52100 steel pin shaft.

Zeng, Zhizhong / Shang, Jian / Lin, Dan

Heliyon

2024 Volume 10, Issue 3, Page(s) e25452

Abstract: The surface of AISI 52100 steel was pre-treated by laser remelting with different powers, and the vanadizing layer were prepared on remelted steel by pack cementation. The microstructure and properties of vanadizing layer were investigated by XRD, ... ...

Abstract	The surface of AISI 52100 steel was pre-treated by laser remelting with different powers, and the vanadizing layer were prepared on remelted steel by pack cementation. The microstructure and properties of vanadizing layer were investigated by XRD, microhardness tester, metallographic microscope, scanning electron microscope, energy dispersive spectrometer, friction and wear tester. The critical load L
Language	English
Publishing date	2024-02-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e25452
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Differential Protein Expression between the Motor and Sensory Fascicles in Rat Femoral Nerve Injury.

Xianyu, Meng / Zhenggang, Bi / Jian, Shang / Laijin, Lu

Neurology India

2024 Volume 72, Issue 1, Page(s) 90–95

Abstract: Background and aims: It is important to distinguish between motor and sensory fascicles of the peripheral nerves for nerve alignment in surgery. However, there are no biomarkers currently available for effective identification of motor or sensory ... ...

Abstract	Background and aims: It is important to distinguish between motor and sensory fascicles of the peripheral nerves for nerve alignment in surgery. However, there are no biomarkers currently available for effective identification of motor or sensory fascicles. The objective of this study was to identify differentially expressed proteins between motor and sensory fascicles of rats in response to injury. Settings and design: The study was carried out using a rat femoral nerve injury model. Materials: A proteomic analysis was performed to detect differential protein expression using samples of bilateral motor and sensory branches of intact and injured rat femoral nerves through fluorescent two-dimensional difference gel electrophoresis and matrix-assisted laser desorption ionization-time of flight mass spectrometry. Statistical analysis: Chi-square tests and t-tests were performed for comparison between motor or sensory nerve groups. Results: The data identified six proteins that were differentially expressed between motor and sensory fascicles (>1.5-fold, P < 0.05), including apolipoprotein E, neurofilament light polypepticle, TEC kinase, serine protease inhibitor A3N, peroxiredoxin-2, and TPM1. The proteomic results were consistent with the mRNA expression levels of these genes as determined by quantitative reverse transcription polymerase chain reaction. Conclusions: Our study suggests that these proteins may play roles in nerve regeneration and repair. Importantly, apolipoprotein E and Serpina3n may serve as specific biomarkers for distinguishing motor and sensory fascicles of the peripheral nerves for nerve alignment in surgery.
MeSH term(s)	Animals ; Rats ; Femoral Nerve ; Proteomics ; Peripheral Nerve Injuries ; Nerve Regeneration
Language	English
Publishing date	2024-02-29
Publishing country	India
Document type	Journal Article
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/neuroindia.NI_315_19
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Zs.A 698: Show issues

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Article ; Online: Discovery of novel polyheterocyclic neuraminidase inhibitors with 1,3,4-oxadiazole thioetheramide as core backbone.

Shang, Lin Lin / Zhong, Zhi Jian / Cheng, Li Ping

European journal of medicinal chemistry

2024 Volume 269, Page(s) 116305

Abstract: Inspired by our earlier findings regarding neuraminidase (NA) inhibitors interacting with 150-cavity or 430-cavity of NA, sixteen novel polyheterocyclic NA inhibitors with 1,3,4-oxadiazole thioetheramide as core backbone were designed and synthesized ... ...

Abstract	Inspired by our earlier findings regarding neuraminidase (NA) inhibitors interacting with 150-cavity or 430-cavity of NA, sixteen novel polyheterocyclic NA inhibitors with 1,3,4-oxadiazole thioetheramide as core backbone were designed and synthesized based on the lead compound ZINC13401480. Of the synthesized compounds, compound N5 targeting 150-cavity exerts the best inhibitory activity against the wild-type H5N1 NA, with IC
MeSH term(s)	Neuraminidase ; Influenza A Virus, H5N1 Subtype ; Molecular Docking Simulation ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Oseltamivir/chemistry ; Oseltamivir/analogs & derivatives ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/chemistry ; Oxadiazoles/pharmacology ; Drug Resistance, Viral
Chemical Substances	Neuraminidase (EC 3.2.1.18) ; 1,3,4-oxadiazole (20O2F20OUR) ; Antiviral Agents ; oseltamivir carboxylate (K6106LV5Q8) ; Oseltamivir (20O93L6F9H) ; Enzyme Inhibitors ; Oxadiazoles
Language	English
Publishing date	2024-03-12
Publishing country	France
Document type	Journal Article
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2024.116305
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Zs.B 784: Show issues

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Article ; Online: Co-targeting ASK1 and THRβ synergistically improves steatohepatitis and fibrosis in a MASH animal model.

Shang, Shu / Wan, Qin / Chen, Faxiu / Hu, Jian

Biochemical and biophysical research communications

2024 Volume 705, Page(s) 149739

Abstract: Purpose: Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that has gained widespread attention globally. Unfortunately, there is no approved treatment for this condition yet. However, recent research has identified Apoptosis ... ...

Abstract	Purpose: Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that has gained widespread attention globally. Unfortunately, there is no approved treatment for this condition yet. However, recent research has identified Apoptosis signal-regulating kinase 1 (ASK1) and thyroid hormone receptor-β (THR-β) as potential targets for treating MASH. Although the individual effects of these two targets have been studied, their combinatory effect has not been well defined. Therefore, further research is needed to investigate the potential benefits of targeting both ASK1 and THR-β for treating MASH. Methods: We established a MASH model using the HFHFrC diet (high fat, high fructose, and cholesterol) and carbon tetrachloride (CCL4). Forty mice were evenly assigned to four groups: vehicle, GS4997 (an ASK1 inhibitor), MGL3196 (a THRβ agonist), GS4997+ MGL3196 combination (combo). The drugs were administered for 8 weeks, after which the mice were sacrificed for serum biochemical tests, liver TG and TC evaluation, liver histopathological study, and gene expression validation. Results: GS4997 and MGL3196, when used in combination, have been shown to have synergistic effects on various parameters. Firstly, they synergistically reduced body weight and liver body weight ratio. Secondly, this combination also synergistically lowered AST and TC. Thirdly, synergistic effects were also observed in liver TG and TC reduction. Fourthly, we further confirmed that GS4997 mildly improved liver inflammation, ballooning, and fibrosis, but exhibited incredible histopathological efficacy when combined with MGL3196. Finally, this combinatory effect can be interpreted by synergistically regulating lipid-related genes such as Dio1, Ctp1-α, and Cat, inflammation-related genes such as Il-6, Il-8, and Mcp-1, and fibrosis-related genes such as Tgf-β, Col1α1, and Col6α3. Conclusion: GS4997 and MGL3196, when used in combination, have been shown to have a comprehensive effect on MASH by synergistically regulating lipid, inflammation, and fibrosis-related gene expression through co-targeting ASK1 and THRβ.
MeSH term(s)	Mice ; Animals ; MAP Kinase Kinase Kinase 5/genetics ; MAP Kinase Kinase Kinase 5/metabolism ; Fatty Liver/metabolism ; Liver/metabolism ; Fibrosis ; Inflammation/pathology ; Models, Animal ; Liver Cirrhosis/pathology ; Body Weight ; Lipids ; Non-alcoholic Fatty Liver Disease/metabolism
Chemical Substances	MAP Kinase Kinase Kinase 5 (EC 2.7.11.25) ; Lipids
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2024.149739
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Zs.A 116: Show issues

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Article: Low-altitude small target detection in sea clutter background based on improved CEEMDAN-IZOA-ELM.

Shang, Shang / Zhu, Jian / Liu, Qiang / Shi, Yishan / Qiao, Tiezhu

Heliyon

2024 Volume 10, Issue 4, Page(s) e26500

Abstract: To effectively detect low-altitude small targets under complex sea surface environment, an innovative method has been developed. This method harnesses the chaotic characteristics of sea clutter and employs a combination of Adaptive Noise Complete ... ...

Abstract	To effectively detect low-altitude small targets under complex sea surface environment, an innovative method has been developed. This method harnesses the chaotic characteristics of sea clutter and employs a combination of Adaptive Noise Complete Ensemble Empirical Modal Decomposition (CEEMDAN), Adaptive Wavelet Thresholding (AWT), and Polynomial Fitting Filtering (SG) for denoising sea clutter data. Subsequently, the Improved Zebra Optimization Algorithm-Extreme Learning Machine (IZOA-ELM) detector is utilized to identify low-altitude small targets amidst the sea clutter background. To begin, the CEEMDAN method is applied to disentangle the measured sea clutter data into a set of Intrinsic Mode Functions (IMFs). Afterwords, the Refined Composite Multiscale Dispersion Entropy (RCMDE) is computed for each individual IMF. This process categorizes the IMFs into three distinct components: noise-dominant, signal-noise mixture, and signal-dominant segments. The noise-dominate of IMF component is subjected to denoising through AWT, the signal-noise mixture of IMF components are processed using SG filtering, while the signal-dominant of IMF remains unaltered. The denoised sea clutter signal is reconstructed by concatenating the denoised and unprocessed IMFs. Based on the chaotic nature of sea clutter signals, first-order sea clutter data is transformed into high-dimensional data through phase space reconstruction. The initial weights and thresholds of the ELM are optimized through the IZOA to establish an optimal prediction model. This model is then used to detect small, low-altitude targets by analyzing the prediction error. The algorithm's effectiveness in noise removal is validated using IPIX and SPRR measured sea clutter data, demonstrating a significant improvement in the root mean square of prediction error (RMSE) by one order of magnitude after denoising compared to the pre-denoising state. Furthermore, we observed that the IZOA-ELM method can be effectively applied to detect small targets at low altitudes across various sea conditions. However, when the sea state is complex and greatly affected by the surrounding noise, an effective approach is to first employ CEEMDAN-AWT-SG to denoise the original signal, and then utilize IZOA-ELM for target detection.
Language	English
Publishing date	2024-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26500
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