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Book ; Online: Antarctic ice sheet topography, cavity geometry, and global bathymetry (RTopo 1.0.5-beta), supplementary data to: Timmermann, Ralph; Le Brocq, Anne M; Deen, Tara J; Domack, Eugene W; Dutrieux, Pierre; Galton-Fenzi, Ben; Hellmer, Hartmut H; Humbert, Angelika; Jansen, Daniela; Jenkins, Adrian; Lambrecht, Astrid; Makinson, Keith; Niederjasper, Fred; Nitsche, Frank-Oliver; Nøst, Ole Anders; Smedsrud, Lars Henrik; Smith, Walter (2010): A consistent dataset of Antarctic ice sheet topography, cavity geometry, and global bathymetry. Earth System Science Data, 2(2), 261-273

Timmermann, Ralph / Deen, Tara J / Domack, Eugene W / Dutrieux, Pierre / Galton-Fenzi, Ben / Hellmer, Hartmut H / Humbert, Angelika / Jansen, Daniela / Le Brocq, Anne M / al., et

2010

Abstract: Sub-ice shelf circulation and freezing/melting rates in ocean general circulation models depend critically on an accurate and consistent representation of cavity geometry. Existing global or pan-Antarctic data sets have turned out to contain various ... ...

Abstract	Sub-ice shelf circulation and freezing/melting rates in ocean general circulation models depend critically on an accurate and consistent representation of cavity geometry. Existing global or pan-Antarctic data sets have turned out to contain various inconsistencies and inaccuracies. The goal of this work is to compile independent regional fields into a global data set. We use the S-2004 global 1-minute bathymetry as the backbone and add an improved version of the BEDMAP topography for an area that roughly coincides with the Antarctic continental shelf. Locations of the merging line have been carefully adjusted in order to get the best out of each data set. High-resolution gridded data for upper and lower ice surface topography and cavity geometry of the Amery, Fimbul, Filchner-Ronne, Larsen C and George VI Ice Shelves, and for Pine Island Glacier have been carefully merged into the ambient ice and ocean topographies. Multibeam survey data for bathymetry in the former Larsen B cavity and the southeastern Bellingshausen Sea have been obtained from the data centers of Alfred Wegener Institute (AWI), British Antarctic Survey (BAS) and Lamont-Doherty Earth Observatory (LDEO), gridded, and again carefully merged into the existing bathymetry map. The global 1-minute dataset (RTopo-1 Version 1.0.5) has been split into two netCDF files. The first contains digital maps for global bedrock topography, ice bottom topography, and surface elevation. The second contains the auxiliary maps for data sources and the surface type mask. A regional subset that covers all variables for the region south of 50 deg S is also available in netCDF format. Datasets for the locations of grounding and coast lines are provided in ASCII format.
Language	English
Dates of publication	2010-9999
Size	Online-Ressource
Publisher	PANGAEA - Data Publisher for Earth & Environmental Science
Publishing place	Bremen/Bremerhaven
Document type	Book ; Online
Note	This dataset is supplement to doi:10.5194/essd-2-261-2010
DOI	10.1594/PANGAEA.741917
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Does the Keele STarT MSK tool predict the risk of poor outcome in non-specific shoulder complaints in primary care in a Dutch population?

Vries, T M Bulté-de / Deen, W E / Lucas, C

Physiotherapy

2023 Volume 123, Page(s) 38–46

Abstract: Objectives: The Keele STarT MSK tool is a questionnaire to identify the prognostic factors for musculoskeletal conditions, such as shoulder complaints, developed by Keele University, UK. This study assessed whether the Keele STarT MSK tool can predict ... ...

Abstract	Objectives: The Keele STarT MSK tool is a questionnaire to identify the prognostic factors for musculoskeletal conditions, such as shoulder complaints, developed by Keele University, UK. This study assessed whether the Keele STarT MSK tool can predict the risk of poor outcome in non-specific shoulder complaints in a Dutch population. Design: Multicentre prospective cohort study. Setting: Fourteen primary care physiotherapy clinics in the Netherlands participated in this study. Participants: In total, 180 patients with non-specific shoulder complaints with complete data from the Keele STarT MSK tool (baseline), Short-Form 12 Health Survey (SF-12), Shoulder Pain and Disability Index (SPADI), Numeric Pain Rating Score (NPRS) and Global Perceived Effect (GPE) scale at week 6, week 12 or endpoint were included. Data were collected from January 2019 to January 2020. Of these, 180 patients were eligible for the study. Of these, 139 completed the study and were included in the analysis. Main outcome measures: Poor outcome was defined as: SF-12 score ≤33 (physical health), SPADI score ≥30% (disability in activity), NPRS score ≥3 (pain intensity) and GPE scale score ≥3 (patient-reported recovery). Results: The area under the receiver operating characteristic curves for prediction of outcome were excellent for the SF-12, acceptable for the SPADI and NPRS, and showed no discrimination for the GPE scale. The optimal cut-off value for the Keele STarT MSK score to discriminate between low and medium/high risk groups was ≥5. Conclusions: The Keele STarT MSK tool is able to predict the risk of poor outcome in patients with non-specific shoulder complaints in primary care physiotherapy clinics. Further research is needed to establish whether stratified care (subgrouping and targeted treatment) is more efficient. CONTRIBUTION OF PAPER.
MeSH term(s)	Humans ; Female ; Netherlands ; Male ; Shoulder Pain/rehabilitation ; Primary Health Care ; Middle Aged ; Prospective Studies ; Disability Evaluation ; Surveys and Questionnaires ; Pain Measurement ; Adult ; Aged ; Prognosis ; Physical Therapy Modalities
Language	English
Publishing date	2023-12-07
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	391109-3
ISSN	1873-1465 ; 0031-9406
ISSN (online)	1873-1465
ISSN	0031-9406
DOI	10.1016/j.physio.2023.10.008
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Article ; Online: CMOS Time-to-Digital Converters for Biomedical Imaging Applications.

Scott, Ryan / Jiang, Wei / Deen, M Jamal

IEEE reviews in biomedical engineering

2023 Volume 16, Page(s) 627–652

Abstract: Time-to-digital converters (TDCs) are high-performance mixed-signal circuits capable of timestamping events with sub-gate delay resolution. As a result of their high-performance, in recent years TDCs were integrated in complementary metal-oxide- ... ...

Abstract	Time-to-digital converters (TDCs) are high-performance mixed-signal circuits capable of timestamping events with sub-gate delay resolution. As a result of their high-performance, in recent years TDCs were integrated in complementary metal-oxide-semiconductor (CMOS) technology with highly sensitive photodetectors known as single-photon avalanche diodes (SPADs), to form digital silicon photomultipliers (dSiPMs) and SPAD imagers. Time-resolved SPAD-based sensors are capable of detecting the absorption of a single photon and timestamping it with picosecond resolution. As such, SPAD-based sensors are very useful in the field of biomedical imaging, using time-of-flight (ToF) information to produce data that can be used to reconstruct high-quality biological images. Additionally, the capability of integration in standard CMOS technologies, allows SPAD-based sensors to provide high-performance, while maintaining low cost. In this paper, we present an overview of fundamental TDC principles, and an analysis of state-of-the-art TDCs. Furthermore, the integration of TDCs into dSiPMs and SPAD imagers will be discussed, with an analysis of the current results of TDCs in different biomedical imaging applications. Finally, several important research challenges for TDCs in biomedical imaging applications are presented.
MeSH term(s)	Humans ; Semiconductors ; Photons ; Oxides ; Technology
Chemical Substances	Oxides
Language	English
Publishing date	2023-01-05
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1941-1189
ISSN (online)	1941-1189
DOI	10.1109/RBME.2021.3092197
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Article ; Online: Modeling for Single-Photon Avalanche Diodes: State-of-the-Art and Research Challenges.

Qian, Xuanyu / Jiang, Wei / Elsharabasy, Ahmed / Deen, M Jamal

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 7

Abstract: With the growing importance of single-photon-counting (SPC) techniques, researchers are now designing high-performance systems based on single-photon avalanche diodes (SPADs). SPADs with high performances and low cost allow the popularity of SPC-based ... ...

Abstract	With the growing importance of single-photon-counting (SPC) techniques, researchers are now designing high-performance systems based on single-photon avalanche diodes (SPADs). SPADs with high performances and low cost allow the popularity of SPC-based systems for medical and industrial applications. However, few efforts were put into the design optimization of SPADs due to limited calibrated models of the SPAD itself and its related circuits. This paper provides a perspective on improving SPAD-based system design by reviewing the development of SPAD models. First, important SPAD principles such as photon detection probability (PDP), dark count rate (DCR), afterpulsing probability (AP), and timing jitter (TJ) are discussed. Then a comprehensive discussion of various SPAD models focusing on each of the parameters is provided. Finally, important research challenges regarding the development of more advanced SPAD models are summarized, followed by the outlook for the future development of SPAD models and emerging SPAD modeling methods.
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23073412
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Article ; Online: "It made you feel like you've still got it": experiences of people with chronic low back pain undertaking a single session of body image training in virtual reality.

Kelly, Joan M / Coppieters, Michel W / Kluver, Joseph / Deen, Michael / Rio, Ebonie / Harvie, Daniel S

Physiotherapy theory and practice

2022 Volume 39, Issue 12, Page(s) 2651–2661

Abstract: Introduction: Embodying fit avatars in virtual reality (VR) is proposed as a possible treatment for cortical body representations and pain-related self-perceptions.: Objective: To explore consumer perceptions of a novel VR intervention (VR-BiT) for ... ...

Abstract	Introduction: Embodying fit avatars in virtual reality (VR) is proposed as a possible treatment for cortical body representations and pain-related self-perceptions. Objective: To explore consumer perceptions of a novel VR intervention (VR-BiT) for chronic low back pain. Methods: Adults (n = 17, mean age(SD) = 52(14)) with chronic low back pain who had undergone a single session of VR-BiT as part of a randomized controlled trial underwent a semi-structured interview using open-ended questions. Interviews were audio-recorded, transcribed verbatim, and analyzed thematically. Results: Data reduction identified four themes: clinically beneficial and beyond; helping and hindering use; desire for more; and individualized future. Participants experienced wide ranging effects, including improved physical self-efficacy, pain, ability to perform physical activity and psychological symptoms. The intervention was well tolerated, except for two reports of nausea, and a few participants indicating pain associated with unaccustomed movement. Most participants were motivated to use VR-BiT again, despite some having technical issues. Participants suggested that personalizing VR-BiT and regular use would be beneficial. Conclusions: There was strong consumer support for further use of VR-BiT. Future studies of VR-BiT effectiveness are warranted and should consider incorporating individual user preferences, including people with diverse pain presentations, and involving a multi-session design.
MeSH term(s)	Adult ; Humans ; Body Image ; Low Back Pain/therapy ; Pain Management/methods ; Pain Perception ; Virtual Reality
Language	English
Publishing date	2022-07-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1045333-7
ISSN	1532-5040 ; 0959-3985
ISSN (online)	1532-5040
ISSN	0959-3985
DOI	10.1080/09593985.2022.2095313
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Article: Early Diagnosis and Management of Congenital Afibrinogenemia: A Case Report of Umbilical Stump Bleeding.

Salah, Qais M / AlRashayda, Rami R / Heresh, Mohammad J / Abulehya, Aya / Salah Al-Deen, Leena W

Cureus

2023 Volume 15, Issue 7, Page(s) e42542

Abstract: Afibrinogenemia is an extremely rare bleeding disorder characterized by the absence or severe deficiency of fibrinogen, a major protein involved in the regulation of blood clotting. This disorder can have both hemorrhagic and/or thrombotic manifestations. ...

Abstract	Afibrinogenemia is an extremely rare bleeding disorder characterized by the absence or severe deficiency of fibrinogen, a major protein involved in the regulation of blood clotting. This disorder can have both hemorrhagic and/or thrombotic manifestations. We present the case of a female neonate who was diagnosed with congenital afibrinogenemia within the first two weeks of life. The patient presented with persistent bleeding from the umbilical stump, prompting a thorough investigation and workup. Early diagnosis and management were essential to preventing life-threatening bleeding events.
Language	English
Publishing date	2023-07-27
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.42542
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Article ; Online: Fidelity and Clinical Competence in Providing Illness Management and Recovery: An Explorative Study.

Roosenschoon, Bert-Jan / van Weeghel, Jaap / Deen, Mathijs L / van Esveld, Emmie W / Kamperman, Astrid M / Mulder, Cornelis L

Community mental health journal

2023 Volume 59, Issue 8, Page(s) 1508–1520

Abstract: ... on the IMR Fidelity Scale and IT-IS (M = 3.94, SD = 1.13, and M = 3.29, SD = 1.05, respectively). Twelve IMR ...

Abstract	Illness Management and Recovery (IMR) is a psychosocial intervention supporting people with serious mental illnesses. In this study, 15 IMR groups were assessed for fidelity and clinician competency to establish the implementation level of all IMR elements and explore complementarity of the IMR Treatment Integrity Scale (IT-IS) to the standard IMR Fidelity Scale. Use of the IT-IS was adapted, similar to the IMR Fidelity Scale. Descriptive statistics were applied. Implementation success of IMR elements varied widely on the IMR Fidelity Scale and IT-IS (M = 3.94, SD = 1.13, and M = 3.29, SD = 1.05, respectively). Twelve IMR elements (60%) were well-implemented, whereas eight (40%) were implemented insufficiently, including some critical cognitive-behavioral techniques (e.g., role-playing). The scales appeared largely complementary, though strongly correlated (r (13) = 0.74, p = 0.002). Providing all IMR elements adequately requires a variety of clinical skills. Specific additional training and supervision may be necessary.
MeSH term(s)	Humans ; Mental Disorders/therapy ; Clinical Competence
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	215855-3
ISSN	1573-2789 ; 0010-3853
ISSN (online)	1573-2789
ISSN	0010-3853
DOI	10.1007/s10597-023-01137-7
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Article ; Online: A reusable, reagent-less free chlorine sensor using gold thin film electrode.

Alam, Arif Ul / Clyne, Dennis / Lush, Will / Deen, M Jamal

The Analyst

2021 Volume 146, Issue 8, Page(s) 2626–2631

Abstract: Free chlorine is widely used as a disinfectant in the water industry. Accurate monitoring of the residual free chlorine concentration in water cycles is critical to maintain public health safety. Here, we report on a thin gold film-based reusable and ... ...

Abstract	Free chlorine is widely used as a disinfectant in the water industry. Accurate monitoring of the residual free chlorine concentration in water cycles is critical to maintain public health safety. Here, we report on a thin gold film-based reusable and reagent-less free chlorine sensor. A gold thin film of 300 nm thickness was deposited on a polyimide tape, which was placed on a glass substrate and a simple Styrofoam adhesive tape was used to cover the film and expose 0.36 cm2 circular area as the sensing surface. The sensor showed a high sensitivity of 0.327 μA ppm-1, with a linear range of 0 to 6 ppm, and an accuracy of <0.1 ppm with high selectivity in the presence of commonly interfering ions. The sensor response time was 50 s with a negligible hysteresis of 0.06 ppm. The sensor showed very little change in output current in the pH range between 5.2 to 8.4, and temperature range of 20 to 30 °C. Therefore, the sensor operation is reagent-less, does not need frequent calibration, and showed consistent sensing performance with real water samples. The simple fabrication, ease-of-use and reliable sensing performance of the proposed sensor shows feasibility for mass-production and application in remote and resource-limited areas.
Language	English
Publishing date	2021-03-03
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/d1an00038a
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Article ; Online: A randomized controlled pilot study examining immediate effects of embodying a virtual reality superhero in people with chronic low back pain.

Harvie, Daniel S / Kelly, Joan / Kluver, Joseph / Deen, Michael / Spitzer, Elizabeth / Coppieters, Michel W

Disability and rehabilitation. Assistive technology

2022 Volume 19, Issue 3, Page(s) 851–858

Abstract: Purpose: In virtual reality, avatar embodiment can spur perceptions and behaviours related the avatars' characteristics. We tested whether embodying superhero-like avatars can change self-perceptions in people with chronic low back pain (CLBP).: ... ...

Abstract	Purpose: In virtual reality, avatar embodiment can spur perceptions and behaviours related the avatars' characteristics. We tested whether embodying superhero-like avatars can change self-perceptions in people with chronic low back pain (CLBP). Design: A non-blinded pilot randomized controlled trial. Methods: Participants were randomly allocated to embody a superhero (VR-SH, Results: The VR-SH group reported gains in body image during ( Conclusion: A VR-SH session produced temporary positive effects on body image. Future research may consider whether larger and sustained effects can be obtained with multisession exposures or explore combined interventions. Implications for rehabilitationPhysical confidence and bodily trust can be significantly enhanced in people with chronic back pain using virtual reality.These positive body image effects may have implications for rehabilitation, such as in enhancing confidence with movementWhether a multisession intervention might produce more robust effects and changes in pain is yet to be determined.
MeSH term(s)	Humans ; Low Back Pain ; Pilot Projects ; Movement ; Virtual Reality ; Avatar ; Chronic Pain
Language	English
Publishing date	2022-10-18
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2221782-4
ISSN	1748-3115 ; 1748-3107
ISSN (online)	1748-3115
ISSN	1748-3107
DOI	10.1080/17483107.2022.2129846
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Article ; Online: Sensors for Positron Emission Tomography Applications.

Jiang, Wei / Chalich, Yamn / Deen, M Jamal

Sensors (Basel, Switzerland)

2019 Volume 19, Issue 22

Abstract: Positron emission tomography (PET) imaging is an essential tool in clinical applications for the diagnosis of diseases due to its ability to acquire functional images to help differentiate between metabolic and biological activities at the molecular ... ...

Abstract	Positron emission tomography (PET) imaging is an essential tool in clinical applications for the diagnosis of diseases due to its ability to acquire functional images to help differentiate between metabolic and biological activities at the molecular level. One key limiting factor in the development of efficient and accurate PET systems is the sensor technology in the PET detector. There are generally four types of sensor technologies employed: photomultiplier tubes (PMTs), avalanche photodiodes (APDs), silicon photomultipliers (SiPMs), and cadmium zinc telluride (CZT) detectors. PMTs were widely used for PET applications in the early days due to their excellent performance metrics of high gain, low noise, and fast timing. However, the fragility and bulkiness of the PMT glass tubes, high operating voltage, and sensitivity to magnetic fields ultimately limit this technology for future cost-effective and multi-modal systems. As a result, solid-state photodetectors like the APD, SiPM, and CZT detectors, and their applications for PET systems, have attracted lots of research interest, especially owing to the continual advancements in the semiconductor fabrication process. In this review, we study and discuss the operating principles, key performance parameters, and PET applications for each type of sensor technology with an emphasis on SiPM and CZT detectors-the two most promising types of sensors for future PET systems. We also present the sensor technologies used in commercially available state-of-the-art PET systems. Finally, the strengths and weaknesses of these four types of sensors are compared and the research challenges of SiPM and CZT detectors are discussed and summarized.
Language	English
Publishing date	2019-11-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s19225019
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