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Article: Heterostructured g-CN/TiO

Tatykayev, Batukhan / Chouchene, Bilel / Balan, Lavinia / Gries, Thomas / Medjahdi, Ghouti / Girot, Emilien / Uralbekov, Bolat / Schneider, Raphaël

Nanomaterials (Basel, Switzerland)

2020 Volume 10, Issue 7

Abstract: Photocatalysts composed of graphitic carbon nitride (g-CN) and TiO ...

Abstract	Photocatalysts composed of graphitic carbon nitride (g-CN) and TiO
Language	English
Publishing date	2020-07-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano10071387
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Article ; Online: Selective optogenetic control of G

Wagdi, Ahmed / Malan, Daniela / Sathyanarayanan, Udhayabhaskar / Beauchamp, Janosch S / Vogt, Markus / Zipf, David / Beiert, Thomas / Mansuroglu, Berivan / Dusend, Vanessa / Meininghaus, Mark / Schneider, Linn / Kalthof, Bernd / Wiegert, J Simon / König, Gabriele M / Kostenis, Evi / Patejdl, Robert / Sasse, Philipp / Bruegmann, Tobias

Nature communications

2022 Volume 13, Issue 1, Page(s) 1765

Abstract: G ...

Abstract	G
MeSH term(s)	Animals ; Humans ; Light ; Mammals ; Optogenetics ; Signal Transduction/physiology ; TRPC6 Cation Channel
Chemical Substances	TRPC6 Cation Channel
Language	English
Publishing date	2022-04-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-29265-w
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Article ; Online: German Cardiac Arrest Registry: rationale and design of G-CAR.

Clinical research in cardiology : official journal of the German Cardiac Society

2022 Volume 112, Issue 4, Page(s) 455–463

Abstract: ... warranted.: Study design: The German Cardiac Arrest Registry (G-CAR) is an observational, prospective ... Parallel to and after the pilot phase, scaling up of G-CAR to a national level is envisaged.: Conclusion ... G-CAR is the first national registry including a long-term follow-up for adult OHCA patients ...

Abstract	Background: In Germany, 70,000-100,000 persons per year suffer from out-of-hospital cardiac arrest (OHCA). Despite medical progress, survival rates with good neurological outcome remain low. For many important clinical issues, no or only insufficient evidence from randomised trials is available. Therefore, a systemic and standardised acquisition of the treatment course and of the outcome of OHCA patients is warranted. Study design: The German Cardiac Arrest Registry (G-CAR) is an observational, prospective, multicentre registry. It will determine the characteristics, initial treatment strategies, invasive procedures, revascularisation therapies and the use of mechanical circulatory support devices with a focus on extracorporeal cardiopulmonary resuscitation. A special feature is the prospective 12-month follow-up evaluating mortality, neurological outcomes and several patient-reported outcomes in the psychosocial domain (health-related quality of life, cognitive impairment, depression/anxiety, post-traumatic stress disorder and social reintegration). In a pilot phase of 24 months, 15 centres will include approximately 400 consecutive OHCA patients ≥ 18 years. Parallel to and after the pilot phase, scaling up of G-CAR to a national level is envisaged. Conclusion: G-CAR is the first national registry including a long-term follow-up for adult OHCA patients. Primary aim is a better understanding of the determinants of acute and long-term outcomes with the perspective of an optimised treatment. Trial registry: NCT05142124. German Cardiac Arrest Registry (G-CAR).
MeSH term(s)	Adult ; Humans ; Prospective Studies ; Treatment Outcome ; Quality of Life ; Extracorporeal Membrane Oxygenation/methods ; Cardiopulmonary Resuscitation/methods ; Out-of-Hospital Cardiac Arrest/therapy ; Registries
Language	English
Publishing date	2022-06-21
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-022-02044-9
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Article ; Online: Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1.

Seeling, Michaela / Pöhnl, Matthias / Kara, Sibel / Horstmann, Nathalie / Riemer, Carolina / Wöhner, Miriam / Liang, Chunguang / Brückner, Christin / Eiring, Patrick / Werner, Anja / Biburger, Markus / Altmann, Leon / Schneider, Martin / Amon, Lukas / Lehmann, Christian H K / Lee, Sooyeon / Kunz, Meik / Dudziak, Diana / Schett, Georg /

Bäuerle, Tobias / Lux, Anja / Tuckermann, Jan / Vögtle, Timo / Nieswandt, Bernhardt / Sauer, Markus / Böckmann, Rainer A / Nimmerjahn, Falk

Immunity

2023 Volume 56, Issue 5, Page(s) 1046–1063.e7

Abstract: Immunoglobulin G (IgG) antibodies are major drivers of inflammation during infectious and ...

Abstract	Immunoglobulin G (IgG) antibodies are major drivers of inflammation during infectious and autoimmune diseases. In pooled serum IgG (IVIg), however, antibodies have a potent immunomodulatory and anti-inflammatory activity, but how this is mediated is unclear. We studied IgG-dependent initiation of resolution of inflammation in cytokine- and autoantibody-driven models of rheumatoid arthritis and found IVIg sialylation inhibited joint inflammation, whereas inhibition of osteoclastogenesis was sialic acid independent. Instead, IVIg-dependent inhibition of osteoclastogenesis was abrogated in mice lacking receptors Dectin-1 or FcγRIIb. Atomistic molecular dynamics simulations and super-resolution microscopy revealed that Dectin-1 promoted FcγRIIb membrane conformations that allowed productive IgG binding and enhanced interactions with mouse and human IgG subclasses. IVIg reprogrammed monocytes via FcγRIIb-dependent signaling that required Dectin-1. Our data identify a pathogen-independent function of Dectin-1 as a co-inhibitory checkpoint for IgG-dependent inhibition of mouse and human osteoclastogenesis. These findings may have implications for therapeutic targeting of autoantibody and cytokine-driven inflammation.
MeSH term(s)	Animals ; Humans ; Mice ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/immunology ; Cell Membrane/metabolism ; Immunoglobulins, Intravenous/administration & dosage ; Lectins, C-Type/metabolism ; Mice, Inbred C57BL ; Osteoclasts/metabolism ; Protein Processing, Post-Translational ; Receptors, IgG/metabolism
Chemical Substances	CLEC7A protein, human ; Clec7a protein, mouse ; Fc gamma receptor IIB ; Immunoglobulins, Intravenous ; Lectins, C-Type ; Receptors, IgG
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2023.02.019
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Article ; Online: Clinical testing guidance for histoplasmosis in patients with community-acquired pneumonia for primary and urgent care providers: Role of enzyme immunoassay Histoplasma-specific immunoglobulin G and immunoglobulin M testing.

Christenson, John C / Barros, Nicolas / Kirkpatrick, Lindsey / Schneider, Jack G

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024

Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciad790
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Article: Association between carriers of the G allele of the + 45T> G variant of the ADIPOQ gene (

Bruno, Jamila Benvegnú / Dal Ponte, Emanuelle Schneider / Retamoso, Vanessa / Maurer, Patrícia / Berro, Lyana Feijoó / Manfredini, Vanusa / da Costa Escobar Piccoli, Jacqueline

Heliyon

2021 Volume 7, Issue 3, Page(s) e06443

Abstract: Aims: investigate the association between the +45T > G variant of the ADIPOQ gene and ... participated in the study. Lower levels of HDL and adiponectin were observed in patients with G allele and ... association between the +45T > G variant of the ADIPOQ gene and MS risk allele.: Materials and methods ...

Abstract	Aims: investigate the association between the +45T > G variant of the ADIPOQ gene and the metabolic syndrome (MS) in patients with sickle cell trait (SCT). 33 patients with SCT and 35 control group participated in the study. Lower levels of HDL and adiponectin were observed in patients with G allele and sickle cell trait. There were no differences between the prevalence of MS between the groups and there was no association between the +45T > G variant of the ADIPOQ gene and MS risk allele. Materials and methods: Participants with and without sickle cell anemia answered a questionnaire, performed anthropometric and laboratory analyzes. They were genotyped for the +45T > G variant of the ADIPOQ gene and evaluated for the presence or absence of metabolic syndrome. The study was approved by the Research Ethics Committee of UNIPAMPA (RS/Brazil). Key findings: The GG + TG genetic model, it was associated with lower levels of adiponectin and HDL cholesterol in the SCT group. There was no association between the other studied markers and MS. Significance: For the first time, an association was demonstrated between the G allele of the +45T > G variant of the ADIPOQ gene and a worse cardiometabolic profile (lower serum concentrations of adiponectin and HDL cholesterol) in patients with sickle cell trait.
Language	English
Publishing date	2021-03-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2021.e06443
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Article ; Online: Molecular Characterization of the Dual Effect of the GPER Agonist G-1 in Glioblastoma.

Hirtz, Alex / Bailly, Yann / Rech, Fabien / Pierson, Julien / Dumond, Hélène / Dubois-Pot-Schneider, Hélène

International journal of molecular sciences

2022 Volume 23, Issue 22

Abstract: ... GPER1 (G-protein-coupled estrogen receptor) expression is associated with better survival, especially ... of the GPER agonist G-1 in vivo and characterized its molecular mechanism of action in vitro. First ... the antiproliferative effect of G-1 was confirmed in a model of xenografted nude mice. A transcriptome analysis of GBM ...

Abstract	Glioblastoma (GBM) is the most common primary brain tumor in adults. Despite conventional treatment, consisting of a chirurgical resection followed by concomitant radio-chemotherapy, the 5-year survival rate is less than 5%. Few risk factors are clearly identified, but women are 1.4-fold less affected than men, suggesting that hormone and particularly estrogen signaling could have protective properties. Indeed, a high GPER1 (G-protein-coupled estrogen receptor) expression is associated with better survival, especially in women who produce a greater amount of estrogen. Therefore, we addressed the anti-tumor effect of the GPER agonist G-1 in vivo and characterized its molecular mechanism of action in vitro. First, the antiproliferative effect of G-1 was confirmed in a model of xenografted nude mice. A transcriptome analysis of GBM cells exposed to G-1 was performed, followed by functional analysis of the differentially expressed genes. Lipid and steroid synthesis pathways as well as cell division processes were both affected by G-1, depending on the dose and duration of the treatment. ANGPTL4, the first marker of G-1 exposure in GBM, was identified and validated in primary GBM cells and patient samples. These data strongly support the potential of G-1 as a promising chemotherapeutic compound for the treatment of GBM.
MeSH term(s)	Mice ; Animals ; Female ; Glioblastoma/drug therapy ; Glioblastoma/genetics ; Glioblastoma/metabolism ; Mice, Nude ; Receptors, G-Protein-Coupled/metabolism ; Estrogens/therapeutic use ; Signal Transduction
Chemical Substances	Receptors, G-Protein-Coupled ; Estrogens
Language	English
Publishing date	2022-11-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms232214309
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Article: Impact of G-CSF Therapy on Leukopenia and Acute Rejection Following Kidney Transplantation.

Schneider, J / Henningsen, M / Pisarski, P / Walz, G / Jänigen, B

International journal of organ transplantation medicine

2021 Volume 12, Issue 2, Page(s) 1–8

Abstract: ... of rejection and allograft loss. Granulocyte colony-stimulating factor (G-CSF) is used as a therapeutic option ... The goal of this study is to examine the incidence of acute rejections following G-CSF therapy.: Methods ... count in a matched pair analysis.: Results: We identified 12 patients, who received G-CSF therapy ...

Abstract	Background: Leukopenia is a common problem after kidney transplantation. The therapeutic approach typically includes a reduction of the immunosuppressive therapy, which is associated with an increased risk of rejection and allograft loss. Granulocyte colony-stimulating factor (G-CSF) is used as a therapeutic option to raise the leukocyte blood count; however, the effect on acute rejections is controversial. Objective: The goal of this study is to examine the incidence of acute rejections following G-CSF therapy. Methods: We retrospectively evaluated patients with leukopenia following kidney transplantation and GCSF therapy between January 2007 and December 2017 at our center compared to controls with matched minimal leucocyte blood count in a matched pair analysis. Results: We identified 12 patients, who received G-CSF therapy with a cumulative dose of 10.74 µg/kg body weight over a time frame of 4.3 days. G-CSF therapy resulted in a significantly shorter time period with leucocytes <3,000/µL (9.5 vs. 16.6 days), but also trended towards an increased risk of rejection within the next 30 days with three patients in the G-CSF group and no patient in the control group (p=0.06) developing an acute biopsy-proven rejection. Infection and mortality rate in the subsequent year were not different between groups. Conclusion: G-CSF therapy decreases the duration of leukopenia post-kidney transplantation, but may also increase the risk of an acute rejection.
Language	English
Publishing date	2021-07-23
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2580907-6
ISSN	2008-6490 ; 2008-6482
ISSN (online)	2008-6490
ISSN	2008-6482
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Article ; Online: Serotonin G Protein-Coupled Receptor-Based Biosensing Modalities in Yeast.

Lengger, Bettina / Hoch-Schneider, Emma E / Jensen, Christina N / Jakočiu Nas, Tadas / Petersen, Anja A / Frimurer, Thomas M / Jensen, Emil D / Jensen, Michael K

ACS sensors

2022 Volume 7, Issue 5, Page(s) 1323–1335

Abstract: ... of human pathologies. In humans, serotonin sensing and signaling can occur by 12 G protein-coupled receptors (GPCRs ...

Abstract	Serotonin is a key neurotransmitter involved in numerous physiological processes and serves as an important precursor for manufacturing bioactive indoleamines and alkaloids used in the treatment of human pathologies. In humans, serotonin sensing and signaling can occur by 12 G protein-coupled receptors (GPCRs) coupled to Gα proteins. In yeast, human serotonin GPCRs coupled to Gα proteins have previously been shown to function as whole-cell biosensors of serotonin. However, systematic characterization of serotonin biosensing modalities between variant serotonin GPCRs and application thereof for high-resolution serotonin quantification is still awaiting. To systematically assess GPCR signaling in response to serotonin, we characterized reporter gene expression at two different pHs of a 144-sized library encoding all 12 human serotonin GPCRs in combination with 12 different Gα proteins engineered in yeast. From this screen, we observed changes in the biosensor sensitivities of >4 orders of magnitude. Furthermore, adopting optimal biosensing designs and pH conditions enabled high-resolution high-performance liquid chromatography-validated sensing of serotonin produced in yeast. Lastly, we used the yeast platform to characterize 19 serotonin GPCR polymorphisms found in human populations. While major differences in signaling were observed among the individual polymorphisms when studied in yeast, a cross-comparison of selected variants in mammalian cells showed both similar and disparate results. Taken together, our study highlights serotonin biosensing modalities of relevance to both biotechnological and potential human health applications.
MeSH term(s)	Biosensing Techniques/methods ; Humans ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Serotonin/analysis ; Signal Transduction
Chemical Substances	Receptors, G-Protein-Coupled ; Serotonin (333DO1RDJY)
Language	English
Publishing date	2022-04-22
Publishing country	United States
Document type	Journal Article
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.1c02061
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Article ; Online: Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin.

Harada, Naoki / Okuyama, Mai / Teraoka, Yoshiaki / Arahori, Yumi / Shinmori, Yoh / Horiuchi, Hiroko / Luis, Paula B / Joseph, Akil I / Kitakaze, Tomoya / Matsumura, Shigenobu / Hira, Tohru / Yamamoto, Norio / Iuni, Takashi / Goshima, Naoki / Schneider, Claus / Inui, Hiroshi / Yamaji, Ryoichi

NPJ science of food

2022 Volume 6, Issue 1, Page(s) 4

Abstract: ... us to determine the activation of G protein-coupled receptors (GPCRs) by food components and have identified GPR55 ...

Abstract	The identification of molecular targets of bioactive food components is important to understand the mechanistic aspect of their physiological functions. Here, we have developed a screening system that enables us to determine the activation of G protein-coupled receptors (GPCRs) by food components and have identified GPR55 as a target for curcumin. Curcumin activated GPR55 and induced serum-response element- and serum-response factor-mediated transcription, which were inhibited by Rho kinase and GPR55 antagonists. Both the methoxy group and the heptadienone moiety of curcumin were required for GPR55 activation. The F190
Language	English
Publishing date	2022-01-14
Publishing country	England
Document type	Journal Article
ISSN	2396-8370
ISSN (online)	2396-8370
DOI	10.1038/s41538-021-00119-x
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