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  1. Article ; Online: Blood tests for Alzheimer's disease: The impact of disease prevalence on test performance.

    DeMarco, Mari L / Algeciras-Schimnich, Alicia / Budelier, Melissa M

    Alzheimer's & dementia : the journal of the Alzheimer's Association

    2024  

    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Letter
    ZDB-ID 2211627-8
    ISSN 1552-5279 ; 1552-5260
    ISSN (online) 1552-5279
    ISSN 1552-5260
    DOI 10.1002/alz.13762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6316: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 540: Show issues

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  2. Article ; Online: Eye Catching Advancement for Creutzfeldt-Jakob Disease Diagnostics.

    Helbling, Cyril / DeMarco, Mari L

    Clinical chemistry

    2023  Volume 70, Issue 4, Page(s) 574–576

    MeSH term(s) Humans ; Creutzfeldt-Jakob Syndrome/diagnosis
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvad154
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.171: Show issues Location:
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  3. Article ; Online: Amplification of Misfolded Prion Proteins in Blood and Cerebrospinal Fluid for Detection of Creutzfeldt-Jakob Disease.

    DeMarco, Mari L

    Clinical chemistry

    2017  Volume 63, Issue 11, Page(s) 1671–1673

    MeSH term(s) Animals ; Creutzfeldt-Jakob Syndrome/diagnosis ; Hematologic Tests/methods ; Humans ; Mice ; PrPSc Proteins/blood ; PrPSc Proteins/cerebrospinal fluid ; Protein Folding
    Chemical Substances PrPSc Proteins
    Language English
    Publishing date 2017-07-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2017.272229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.171: Show issues Location:
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  4. Article ; Online: At the Intersection of Proteomics and Big Data Science.

    Foster, Leonard J / DeMarco, Mari L

    Clinical chemistry

    2020  Volume 63, Issue 10, Page(s) 1663

    Language English
    Publishing date 2020-02-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1373/clinchem.2017.277087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.171: Show issues Location:
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  5. Article ; Online: Early increases in anti-SARS-CoV-2 antibody isotypes associated with organ dysfunction and mortality in patients hospitalized with COVID-19.

    Best, John R / Wang, Meng / Lee, Terry / Russell, James A / DeMarco, Mari L

    Intensive care medicine

    2022  Volume 48, Issue 5, Page(s) 616–618

    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; Immunoglobulin Isotypes ; Multiple Organ Failure/etiology ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; Immunoglobulin Isotypes
    Language English
    Publishing date 2022-04-02
    Publishing country United States
    Document type Letter
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06662-9
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1089: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Proteoforms and their expanding role in laboratory medicine.

    Forgrave, Lauren M / Wang, Meng / Yang, David / DeMarco, Mari L

    Practical laboratory medicine

    2021  Volume 28, Page(s) e00260

    Abstract: The term "proteoforms" describes the range of different structures of a protein product of a single gene, including variations in amino acid sequence and post-translational modifications. This diversity in protein structure contributes to the biological ... ...

    Abstract The term "proteoforms" describes the range of different structures of a protein product of a single gene, including variations in amino acid sequence and post-translational modifications. This diversity in protein structure contributes to the biological complexity observed in living organisms. As the concentration of a particular proteoform may increase or decrease in abnormal physiological states, proteoforms have long been used in medicine as biomarkers of health and disease. Notably, the analytical approaches used to analyze proteoforms have evolved considerably over the years. While ligand binding methods continue to play a large role in proteoform measurement in the clinical laboratory, unanticipated or unknown post-translational modifications and sequence variants can upend even extensively tested and vetted assays that have successfully made it through the medical regulatory process. As an alternate approach, mass spectrometry-with its high molecular selectivity-has become an essential tool in detection, characterization, and quantification of proteoforms in biological fluids and tissues. This review explores the analytical techniques used for proteoform detection and quantification, with an emphasis on mass spectrometry and its various applications in clinical research and patient care including, revealing new biomarker targets, helping improve the design of contemporary ligand binding
    Language English
    Publishing date 2021-11-27
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2834973-8
    ISSN 2352-5517
    ISSN 2352-5517
    DOI 10.1016/j.plabm.2021.e00260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Grave Clinicopathologic Correlation: A Case of Hyperthyroxinemia.

    Mattman, Andre / DeMarco, Mari L / Wong, Sophia / Holmes, Daniel T / Lee, Julie

    The journal of applied laboratory medicine

    2021  Volume 1, Issue 3, Page(s) 310–314

    Language English
    Publishing date 2021-02-25
    Publishing country England
    Document type Journal Article
    ISSN 2576-9456
    ISSN 2576-9456
    DOI 10.1373/jalm.2016.020966
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Molecular dynamics simulations of membrane- and protein-bound glycolipids using GLYCAM.

    DeMarco, Mari L

    Methods in molecular biology (Clifton, N.J.)

    2015  Volume 1273, Page(s) 379–390

    Abstract: This chapter outlines protocols for the preparation, execution, and analysis of molecular dynamics (MD) simulations of glycolipids in biologically relevant environments, i.e., imbedded in lipid bilayers or bound to proteins, with the goal of generating ... ...

    Abstract This chapter outlines protocols for the preparation, execution, and analysis of molecular dynamics (MD) simulations of glycolipids in biologically relevant environments, i.e., imbedded in lipid bilayers or bound to proteins, with the goal of generating biologically relevant structural and dynamic information. Also included is a description of ensemble average (EA) charge set development consistent with the GLYCAM06 force field and its implementation using the AMBER molecular dynamics software suite.
    MeSH term(s) Cell Membrane/metabolism ; Disaccharides/chemistry ; G(M3) Ganglioside/chemistry ; Glycolipids/chemistry ; Molecular Dynamics Simulation ; Protein Binding ; Software
    Chemical Substances Disaccharides ; G(M3) Ganglioside ; Glycolipids
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-2343-4_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: MALDI-MS: Emerging roles in pathology and laboratory medicine.

    Duncan, Mark / DeMarco, Mari L

    Clinical mass spectrometry (Del Mar, Calif.)

    2019  Volume 13, Page(s) 1–4

    Abstract: MALDI-MS is a valuable analytical tool in pathology and laboratory medicine.•Advantages of MALDI-MS include ease of sample preparation and analysis.•Uses include ID of pathogens, monoclonal proteins, variants and diseased tissue. ...

    Abstract •MALDI-MS is a valuable analytical tool in pathology and laboratory medicine.•Advantages of MALDI-MS include ease of sample preparation and analysis.•Uses include ID of pathogens, monoclonal proteins, variants and diseased tissue.
    Language English
    Publishing date 2019-05-18
    Publishing country Netherlands
    Document type Journal Article ; Review
    ISSN 2376-9998
    ISSN (online) 2376-9998
    DOI 10.1016/j.clinms.2019.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Personal value of Alzheimer's disease biomarker testing and result disclosure from the patient and care partner perspective.

    Patel, Khushbu J / Yang, David / Feldman, Howard H / Hsiung, Ging-Yuek R / Nygaard, Haakon B / Best, John R / Dwosh, Emily / Robillard, Julie M / DeMarco, Mari L

    Alzheimer's & dementia (New York, N. Y.)

    2024  Volume 10, Issue 2, Page(s) e12463

    Abstract: Introduction: We described patients' and care partners' experiences with Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker testing and result disclosure in routine care.: Methods: IMPACT-AD BC is an observational study of clinic patients ... ...

    Abstract Introduction: We described patients' and care partners' experiences with Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker testing and result disclosure in routine care.
    Methods: IMPACT-AD BC is an observational study of clinic patients who underwent AD CSF biomarker testing as part of their routine medical care (
    Results: A majority of patients (90%) rated their decision to undergo testing as "easy." Post-disclosure, the majority (82%) reported overall positive feelings from having greater certainty and the ability to plan ahead, and results spurred them to adopt/continue healthy behaviors such as exercise (84%) and cognitive activities (54%). Care partners expressed relief from having more diagnostic certainty, increased appreciation of future caregiving responsibilities, and a desire to connect with support resources.
    Discussion: Perspectives of persons with lived experience in dementia provide new insight into the value of biomarker testing and should be included as part of evidence-guided considerations for pre-test counseling and result disclosure. Moreover, study findings identify an interval when patients and care partners are highly receptive to positive lifestyle and medical interventions.
    Language English
    Publishing date 2024-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2832891-7
    ISSN 2352-8737 ; 2352-8737
    ISSN (online) 2352-8737
    ISSN 2352-8737
    DOI 10.1002/trc2.12463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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