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Article ; Online: Styrax japonicus functional genomics: An efficient virus induced gene silencing (VIGS) system

Sun, Gangyu / Ju, Yiqian / Zhang, Cuiping / Li, Lulu / Jiang, Xinqiang / Xie, Xiaoman / Lu, Yizeng / Wang, Kuiling / Li, Wei

Chinese Society for Horticultural Science (CSHS) and Institute of Vegetables and Flowers (IVF), Chinese Academy of Agricultural Sciences (CAAS). Horticultural Plant Journal. 2023 May 19,

2023

Abstract: VIGS (Virus-induced gene silencing), a method for posttranscriptional gene silencing, is an effective technique for investigating the activities of genes in plants. Since there is no report for available VIGS system in Styrax japonicus, the application ... ...

Abstract	VIGS (Virus-induced gene silencing), a method for posttranscriptional gene silencing, is an effective technique for investigating the activities of genes in plants. Since there is no report for available VIGS system in Styrax japonicus, the application of a VIGS approach that results in a gene knockdown to study gene function is limited. In this study, we compared the characteristics that could affect the viability of VIGS in S. japonicus, including the acetosyringone (AS) concentration, the Agrobacterium's optical density and the inoculation method. The stable reference genes of S. japonicus were selected to validate the gene's knockdown by quantitative PCR. As a result, we successfully constructed 2 VIGS systems based on TRV virus: vacuum with AS concentration of 200 μmol·L⁻¹ and OD₆₀₀ of 0.5, and friction-osmosis with AS concentration of 200 μmol·L⁻¹ and OD₆₀₀ of 1.0, which silencing efficiency was 83.33% and 74.19%, respectively. The successfully applied VIGS method provides a rapid and effective reverse gene functional analysis approach in S. japonicus to identify unknown gene functions.
Keywords	Agrobacterium ; Styrax japonicus ; absorbance ; acetosyringone ; gene targeting ; genes ; genomics ; horticultural crops ; inoculation methods ; quantitative polymerase chain reaction ; viability ; viruses ; VIGS ; Reference gene
Language	English
Dates of publication	2023-0519
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ISSN	2468-0141
DOI	10.1016/j.hpj.2023.05.003
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Structural insights into SARS-CoV-2 infection and therapeutics development

Gangyu Sun / Lulu Xue / Qingjing He / Yue Zhao / Wenqing Xu / Zhizhi Wang

Stem Cell Research, Vol 52, Iss , Pp 102219- (2021)

2021

Abstract: The current COVID-19 pandemic is caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). By late October 2020, more than 43 million cases of infections, including over 1.15 million deaths, have been confirmed worldwide. This review ... ...

Abstract	The current COVID-19 pandemic is caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). By late October 2020, more than 43 million cases of infections, including over 1.15 million deaths, have been confirmed worldwide. This review focuses on our current understanding of SARS-CoV-2 from the perspective of the three-dimensional (3D) structures of SARS-CoV-2 viral proteins and their implications on therapeutics development against COVID-19.
Keywords	Structure ; SARS-CoV-2 ; Spike protein ; Main protease ; RdRp ; Nsp ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Structural insights into SARS-CoV-2 infection and therapeutics development.

Sun, Gangyu / Xue, Lulu / He, Qingjing / Zhao, Yue / Xu, Wenqing / Wang, Zhizhi

Stem cell research

2021 Volume 52, Page(s) 102219

Abstract	The current COVID-19 pandemic is caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). By late October 2020, more than 43 million cases of infections, including over 1.15 million deaths, have been confirmed worldwide. This review focuses on our current understanding of SARS-CoV-2 from the perspective of the three-dimensional (3D) structures of SARS-CoV-2 viral proteins and their implications on therapeutics development against COVID-19.
MeSH term(s)	Antibodies, Viral/chemistry ; COVID-19/epidemiology ; Genome, Viral ; Humans ; Ion Channels/chemistry ; Protein Conformation ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/chemistry ; COVID-19 Drug Treatment
Chemical Substances	Antibodies, Viral ; Ion Channels ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2021-02-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2393143-7
ISSN	1876-7753 ; 1873-5061
ISSN (online)	1876-7753
ISSN	1873-5061
DOI	10.1016/j.scr.2021.102219
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Article ; Online: Improving the Sensitivity of Nanofibrous Membrane-Based ELISA for On-Site Antibiotics Detection.

Zhao, Cunyi / Pan, Bofeng / Wang, Minyuan / Si, Yang / Taha, Ameer Y / Liu, Gangyu / Pan, Tingrui / Sun, Gang

ACS sensors

2022 Volume 7, Issue 5, Page(s) 1458–1466

Abstract: An ultrasensitive and portable colorimetric enzyme-linked immunosorbent assay (ELISA) sensor for antibiotics was fabricated by immobilizing antibodies inside the largely porous and highly hydrophilic nanofibrous membranes. Different from regular ... ...

Abstract	An ultrasensitive and portable colorimetric enzyme-linked immunosorbent assay (ELISA) sensor for antibiotics was fabricated by immobilizing antibodies inside the largely porous and highly hydrophilic nanofibrous membranes. Different from regular electrospun nanofibrous membranes where antibodies may frequently be blocked by the heterogeneous porous structure and sterically crowded loaded on the surface, the controlled microporous structure and increased hydrophilicity of nanofibrous membranes could improve the diffusion properties of antibodies, reduce the sterically crowding effect, and dramatically improve the sensitivity of the membrane-based ELISA. The limitation of detection (LOD) for chloramphenicol (CAP) reached 0.005 ng/mL, around 200 times lower than the conventional paper-based ELISA, making quantitative analysis and portable on-site detection achievable via the use of smartphones. The successful design and fabrication of the nanofibrous membrane-based ELISA with novel features overcome the structural drawbacks of regular electrospun nanofibrous membranes and provide new paths to develop highly sensitive on-site detection of hazardous chemical agents.
MeSH term(s)	Anti-Bacterial Agents/analysis ; Chloramphenicol/analysis ; Colorimetry ; Enzyme-Linked Immunosorbent Assay ; Nanofibers/chemistry
Chemical Substances	Anti-Bacterial Agents ; Chloramphenicol (66974FR9Q1)
Language	English
Publishing date	2022-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, Non-U.S. Gov't
ISSN	2379-3694
ISSN (online)	2379-3694
DOI	10.1021/acssensors.2c00208
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Genetic diversity and population genetic structure of Neillia incisa in China: implications for genetic conservation

Zhang, Cuiping / Sun, Gangyu / Wang, Hai / Jiang, Xinqiang / Li, Wei / Xie, Xiaoman / Lu, Yizeng / Wang, Kuiling

Trees. 2021 Dec., v. 35, no. 6

2021

Abstract: KEY MESSAGE: We analyzed the genetic diversity and population genetic structure of Neillia incisa (Thunb.) Zabel using EST-SSR markers. Neillia incisa (Thunb.) Zabel is an undomesticated plant species which is distributed along the coastal areas of East ... ...

Abstract	KEY MESSAGE: We analyzed the genetic diversity and population genetic structure of Neillia incisa (Thunb.) Zabel using EST-SSR markers. Neillia incisa (Thunb.) Zabel is an undomesticated plant species which is distributed along the coastal areas of East Asia. N. incisa has rarely been planted in cities despite its potential usefulness in removing particulate air pollution. Our study utilized EST-SSR markers to investigate the genetic diversity of 122 wild N. incisa individuals from five populations, including Anshan (AS), Zhuanghe (ZH), Changhai (CH), Kunyu (KU) and Laoshan (LS). All indexes measured indicated moderate polymorphism. The CH population was found to have the highest genetic diversity, while the AS population was observed to have the lowest. The average genetic differentiation coefficient (Fst) of the five N. incisa populations was found to be 0.2075. Analysis of molecular variance revealed that the genetic variation observed among various populations was only 16.99% of the total variation, while the genetic variation within populations accounted for 83.01% of the total variation. Principal coordinate analysis, unweighted pair group with arithmetic mean clustering and genetic structure analysis revealed that the five N. incisa populations could be differentiated into three groups. ZH was found to group with CH, LS grouped with KU and AS formed its own cluster. The results of this study provide a preliminary genetic basis for the use and conservation of N. incisa.
Keywords	Neillia ; air pollution ; genetic structure ; genetic variation ; germplasm conservation ; multidimensional scaling ; population genetics ; variance ; China
Language	English
Dates of publication	2021-12
Size	p. 2009-2018.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	90595-1
ISSN	1432-2285 ; 0931-1890
ISSN (online)	1432-2285
ISSN	0931-1890
DOI	10.1007/s00468-021-02168-x
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: 12-Deoxyphorbol 13-acetate inhibits RANKL-induced osteoclastogenesis via the attenuation of MAPK signaling and NFATc1 activation.

Chen, Delong / Chu, Feifan / Zhang, Gangyu / Wang, Qingqing / Li, Ying / Zhang, Meng / He, Qi / Yang, Junzheng / Wang, Haibin / Sun, Ping / Xu, Jiake / Chen, Peng

International immunopharmacology

2021 Volume 101, Issue Pt A, Page(s) 108177

Abstract: Osteoporosis, characterized by bone loss and microstructure damage, occurs when osteoclast activity outstrips osteoblast activity. Natural compounds with inhibitory effect on osteoclast differentiation and function have been evidenced to protect from ... ...

Abstract	Osteoporosis, characterized by bone loss and microstructure damage, occurs when osteoclast activity outstrips osteoblast activity. Natural compounds with inhibitory effect on osteoclast differentiation and function have been evidenced to protect from osteoporosis. After multiple compounds screening, 12-deoxyphorbol 13-acetate (DPA) was found to decline RANKL-induced osteoclastogenesis dose-dependently by attenuating activities of NFATc1 and c-Fos, followed by decreasing the level of osteoclast function-associated genes and proteins including Acp5, V-ATPase-d2 and CTSK. Mechanistically, we found that DPA suppressing RANKL-induced downstream signaling pathways, including MAPK signaling pathway and calcium oscillations. Furthermore, the in vivo efficacy of DPA was further confirmed in an OVX-induced osteoporosis mice model. Collectively, the results in our presentation reveal that DPA might be a promising compound to manage osteoporosis.
MeSH term(s)	Animals ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Female ; Humans ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/immunology ; Mice ; NFATC Transcription Factors/antagonists & inhibitors ; NFATC Transcription Factors/metabolism ; Osteoclasts/drug effects ; Osteoclasts/physiology ; Osteogenesis/drug effects ; Osteogenesis/immunology ; Osteoporosis/drug therapy ; Osteoporosis/immunology ; Phorbol Esters/pharmacology ; Phorbol Esters/therapeutic use ; RAW 264.7 Cells
Chemical Substances	NFATC Transcription Factors ; Nfatc1 protein, mouse ; Phorbol Esters ; prostratin (60857-08-1)
Language	English
Publishing date	2021-10-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2021.108177
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Article ; Online: Optimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity.

Liu, Huisi / Wu, Weiwei / Sun, Gangyu / Chia, Tiongsun / Cao, Lei / Liu, Xiaodan / Guan, Jian / Fu, Fenggen / Yao, Ying / Wu, Zhihai / Zhou, Shuaixiang / Wang, Jie / Lu, Jia / Kuang, Zhihui / Wu, Min / He, Luan / Shao, Zhiyuan / Wu, Dongdong / Chen, Bingliang /

Xu, Wenqing / Wang, Zhizhi / He, Kaijie

Cell reports. Medicine

2022 Volume 3, Issue 6, Page(s) 100660

Abstract: Glucocorticoid-induced tumor necrosis factor receptor (GITR) is a co-stimulatory receptor and an important target for cancer immunotherapy. We herein present a potent FcγR-independent GITR agonist IBI37G5 that can effectively activate effector T cells ... ...

Abstract	Glucocorticoid-induced tumor necrosis factor receptor (GITR) is a co-stimulatory receptor and an important target for cancer immunotherapy. We herein present a potent FcγR-independent GITR agonist IBI37G5 that can effectively activate effector T cells and synergize with anti-programmed death 1 (PD1) antibody to eradicate established tumors. IBI37G5 depends on both antibody bivalency and GITR homo-dimerization for efficient receptor cross-linking. Functional analyses reveal bell-shaped dose responses due to the unique 2:2 antibody-receptor stoichiometry required for GITR activation. Antibody self-competition is observed after concentration exceeded that of 100% receptor occupancy (RO), which leads to antibody monovalent binding and loss of activity. Retrospective pharmacokinetics/pharmacodynamics analysis demonstrates that the maximal efficacy is achieved at medium doses with drug exposure near saturating GITR occupancy during the dosing cycle. Finally, we propose an alternative dose-finding strategy that does not rely on the traditional maximal tolerated dose (MTD)-based paradigm but instead on utilizing the RO-function relations as biomarker to guide the clinical translation of GITR and similar co-stimulatory agonists.
MeSH term(s)	Cell Line, Tumor ; Glucocorticoid-Induced TNFR-Related Protein/agonists ; Glucocorticoids ; Ligands ; Receptors, IgG ; Receptors, Tumor Necrosis Factor/agonists ; Retrospective Studies ; Tumor Necrosis Factors
Chemical Substances	Glucocorticoid-Induced TNFR-Related Protein ; Glucocorticoids ; Ligands ; Receptors, IgG ; Receptors, Tumor Necrosis Factor ; Tumor Necrosis Factors
Language	English
Publishing date	2022-06-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2022.100660
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Willingness and beliefs associated with reporting travel history to high-risk coronavirus disease 2019 epidemic regions among the Chinese public

Lifeng Wei / Zhuowa Sha / Ying Wang / Gangyu Zhang / Haonan Jia / Shuang Zhou / Yuanheng Li / Yameng Wang / Chao Liu / Mingli Jiao / Shufan Sun / Qunhong Wu

BMC Public Health, Vol 20, Iss 1, Pp 1-

a cross-sectional study

2020 Volume 9

Abstract: Abstract Background The Coronavirus Disease 2019 (COVID-19) that first occurred in Wuhan, China, is currently spreading throughout China. The majority of infected patients either traveled to Wuhan or came into contact with an infected person from Wuhan. ... ...

Abstract	Abstract Background The Coronavirus Disease 2019 (COVID-19) that first occurred in Wuhan, China, is currently spreading throughout China. The majority of infected patients either traveled to Wuhan or came into contact with an infected person from Wuhan. Investigating members of the public with a travel history to Wuhan became the primary focus of the Chinese government’s epidemic prevention and control measures, but several instances of withheld histories were uncovered as localized clusters of infections broke out. This study investigated the public’s willingness and beliefs associated with reporting travel history to high-risk epidemic regions, to provide effective suggestions and measures for encouraging travel reporting. Methods A cross-sectional study was conducted online between February 12 and 19, 2020. Descriptive analysis, chi-squared test, and Fisher’s exact test were used to identify socio-demographic factors and beliefs associated with reporting, as well as their impact on the willingness to report on travel history to high-risk epidemic regions. Results Of the 1344 respondents, 91 (6.77%) expressed an inclination to deliberately withhold travel history. Those who understood the benefits of reporting and the legal consequences for deliberately withholding information, showed greater willingness to report their history (P < 0.05); conversely, those who believed reporting would stigmatize them and feared being quarantined after reporting showed less willingness to report (P < 0.05). Conclusions As any incident of withheld history can have unpredictable outcomes, the proportion of people who deliberately withhold information deserves attention. Appropriate public risk communication and public advocacy strategies should be implemented to strengthen the understanding that reporting on travel history facilitates infection screening and prompt treatment, and to decrease the fear of potentially becoming quarantined after reporting. Additionally, social support and policies should be established, and ...
Keywords	Coronavirus disease 2019 (COVID-19) ; Travel history report ; Withholding ; Public aspects of medicine ; RA1-1270 ; covid19
Subject code	900
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Willingness and beliefs associated with reporting travel history to high-risk coronavirus disease 2019 epidemic regions among the Chinese public: a cross-sectional study.

Wei, Lifeng / Sha, Zhuowa / Wang, Ying / Zhang, Gangyu / Jia, Haonan / Zhou, Shuang / Li, Yuanheng / Wang, Yameng / Liu, Chao / Jiao, Mingli / Sun, Shufan / Wu, Qunhong

BMC public health

2020 Volume 20, Issue 1, Page(s) 1164

Abstract: Background: The Coronavirus Disease 2019 (COVID-19) that first occurred in Wuhan, China, is currently spreading throughout China. The majority of infected patients either traveled to Wuhan or came into contact with an infected person from Wuhan. ... ...

Abstract	Background: The Coronavirus Disease 2019 (COVID-19) that first occurred in Wuhan, China, is currently spreading throughout China. The majority of infected patients either traveled to Wuhan or came into contact with an infected person from Wuhan. Investigating members of the public with a travel history to Wuhan became the primary focus of the Chinese government's epidemic prevention and control measures, but several instances of withheld histories were uncovered as localized clusters of infections broke out. This study investigated the public's willingness and beliefs associated with reporting travel history to high-risk epidemic regions, to provide effective suggestions and measures for encouraging travel reporting. Methods: A cross-sectional study was conducted online between February 12 and 19, 2020. Descriptive analysis, chi-squared test, and Fisher's exact test were used to identify socio-demographic factors and beliefs associated with reporting, as well as their impact on the willingness to report on travel history to high-risk epidemic regions. Results: Of the 1344 respondents, 91 (6.77%) expressed an inclination to deliberately withhold travel history. Those who understood the benefits of reporting and the legal consequences for deliberately withholding information, showed greater willingness to report their history (P < 0.05); conversely, those who believed reporting would stigmatize them and feared being quarantined after reporting showed less willingness to report (P < 0.05). Conclusions: As any incident of withheld history can have unpredictable outcomes, the proportion of people who deliberately withhold information deserves attention. Appropriate public risk communication and public advocacy strategies should be implemented to strengthen the understanding that reporting on travel history facilitates infection screening and prompt treatment, and to decrease the fear of potentially becoming quarantined after reporting. Additionally, social support and policies should be established, and measures should be taken to alleviate stigmatization and discrimination against potential patients and reporters of travel history. Reinforcing the legal accountability of withholding travel history and strengthening systematic community monitoring are the measures that China is currently taking to encourage reporting on travel history to high-risk epidemic regions. These non-pharmaceutical interventions are relevant for countries that are currently facing the spread of the epidemic and those at risk of its potential spread.
MeSH term(s)	Adult ; COVID-19 ; China/epidemiology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Cross-Sectional Studies ; Epidemics ; Female ; Government ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Middle Aged ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Quarantine/psychology ; Risk Assessment ; Travel/statistics & numerical data ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-07-25
Publishing country	England
Document type	Journal Article
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/s12889-020-09282-4
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Article: Willingness and beliefs associated with reporting travel history to high-risk coronavirus disease 2019 epidemic regions among the Chinese public: a cross-sectional study

Wei, Lifeng / Sha, Zhuowa / Wang, Ying / Zhang, Gangyu / Jia, Haonan / Zhou, Shuang / Li, Yuanheng / Wang, Yameng / Liu, Chao / Jiao, Mingli / Sun, Shufan / Wu, Qunhong

BMC Public Health

Abstract: BACKGROUND: The Coronavirus Disease 2019 (COVID-19) that first occurred in Wuhan, China, is currently spreading throughout China. The majority of infected patients either traveled to Wuhan or came into contact with an infected person from Wuhan. ... ...

Abstract	BACKGROUND: The Coronavirus Disease 2019 (COVID-19) that first occurred in Wuhan, China, is currently spreading throughout China. The majority of infected patients either traveled to Wuhan or came into contact with an infected person from Wuhan. Investigating members of the public with a travel history to Wuhan became the primary focus of the Chinese government's epidemic prevention and control measures, but several instances of withheld histories were uncovered as localized clusters of infections broke out. This study investigated the public's willingness and beliefs associated with reporting travel history to high-risk epidemic regions, to provide effective suggestions and measures for encouraging travel reporting. METHODS: A cross-sectional study was conducted online between February 12 and 19, 2020. Descriptive analysis, chi-squared test, and Fisher's exact test were used to identify socio-demographic factors and beliefs associated with reporting, as well as their impact on the willingness to report on travel history to high-risk epidemic regions. RESULTS: Of the 1344 respondents, 91 (6.77%) expressed an inclination to deliberately withhold travel history. Those who understood the benefits of reporting and the legal consequences for deliberately withholding information, showed greater willingness to report their history (P < 0.05); conversely, those who believed reporting would stigmatize them and feared being quarantined after reporting showed less willingness to report (P < 0.05). CONCLUSIONS: As any incident of withheld history can have unpredictable outcomes, the proportion of people who deliberately withhold information deserves attention. Appropriate public risk communication and public advocacy strategies should be implemented to strengthen the understanding that reporting on travel history facilitates infection screening and prompt treatment, and to decrease the fear of potentially becoming quarantined after reporting. Additionally, social support and policies should be established, and measures should be taken to alleviate stigmatization and discrimination against potential patients and reporters of travel history. Reinforcing the legal accountability of withholding travel history and strengthening systematic community monitoring are the measures that China is currently taking to encourage reporting on travel history to high-risk epidemic regions. These non-pharmaceutical interventions are relevant for countries that are currently facing the spread of the epidemic and those at risk of its potential spread.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #671878
Database	COVID19

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