Article ; Online: Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.
Molecules (Basel, Switzerland)
2017 Volume 22, Issue 3
Abstract: Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1 (PTR1) inhibitors. Herein, we focus our attention on the chroman-4-one scaffold. Three chroman-4-one analogues ( ...
Abstract | Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1 (PTR1) inhibitors. Herein, we focus our attention on the chroman-4-one scaffold. Three chroman-4-one analogues ( |
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MeSH term(s) | Antiparasitic Agents/chemical synthesis ; Antiparasitic Agents/chemistry ; Antiparasitic Agents/pharmacology ; Binding Sites ; Chromans/chemical synthesis ; Chromans/chemistry ; Chromans/pharmacology ; Enzyme Activation/drug effects ; Inhibitory Concentration 50 ; Leishmania major/drug effects ; Leishmania major/enzymology ; Molecular Conformation ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Molecular Structure ; Oxidoreductases/antagonists & inhibitors ; Oxidoreductases/chemistry ; Protein Binding ; Trypanosoma brucei brucei/drug effects ; Trypanosoma brucei brucei/enzymology |
Chemical Substances | Antiparasitic Agents ; Chromans ; Oxidoreductases (EC 1.-) ; pteridine reductase (EC 1.1.1.33) |
Language | English |
Publishing date | 2017-03-08 |
Publishing country | Switzerland |
Document type | Journal Article |
ZDB-ID | 1413402-0 |
ISSN | 1420-3049 ; 1431-5165 ; 1420-3049 |
ISSN (online) | 1420-3049 |
ISSN | 1431-5165 ; 1420-3049 |
DOI | 10.3390/molecules22030426 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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