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Article ; Online: Association of neutrophil to lymphocyte ratio with bone mineral density in post-menopausal women: a systematic review and meta-analysis.

Salimi, Maryam / Khanzadeh, Monireh / Nabipoorashrafi, Seyed Ali / Seyedi, Seyed Arsalan / Yaghoobpoor, Shirin / Brismée, Jean-Michel / Lucke-Wold, Brandon / Ebadi, Mehrnoosh / Ghaedi, Arshin / Kumar, Varun Singh / Mirghaderi, Peyman / Rabie, Hamid / Khanzadeh, Shokoufeh

BMC women's health

2024 Volume 24, Issue 1, Page(s) 169

Abstract: Background: We conducted a systematic review and meta-analysis to compare the neutrophil lymphocyte ratio (NLR) levels between women with post-menopausal osteopenia or osteoporosis to those with normal bone mineral density (BMD).: Methods: We used ... ...

Abstract	Background: We conducted a systematic review and meta-analysis to compare the neutrophil lymphocyte ratio (NLR) levels between women with post-menopausal osteopenia or osteoporosis to those with normal bone mineral density (BMD). Methods: We used Web of Science, PubMed, and Scopus to conduct a systematic search for relevant publications published before June 19, 2022, only in English language. We reported standardized mean difference (SMD) with a 95% confidence interval (CI). Because a significant level of heterogeneity was found, we used the random-effects model to calculate pooled effects. We used the Newcastle-Ottawa scale for quality assessment. Results: Overall, eight articles were included in the analysis. Post-menopausal women with osteoporosis had elevated levels of NLR compared to those without osteoporosis (SMD = 1.03, 95% CI = 0.18 to 1.88, p = 0.017, I Conclusion: The results of this study point to NLR as a potential biomarker that may be easily introduced into clinical settings to help predict and prevent post-menopausal osteoporosis.
MeSH term(s)	Humans ; Female ; Bone Density ; Neutrophils ; Postmenopause ; Osteoporosis/etiology ; Bone Diseases, Metabolic/complications ; Lymphocytes ; Osteoporosis, Postmenopausal
Language	English
Publishing date	2024-03-09
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2050444-5
ISSN	1472-6874 ; 1472-6874
ISSN (online)	1472-6874
ISSN	1472-6874
DOI	10.1186/s12905-024-03006-1
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Article ; Online: Reproductive and whole-body toxicity of Ag-doped and -undoped ZIF-8 nanoparticles and the building blocks: An Artemia-based comparative bioassay.

Salari Joo, Hamid / Johari, Seyed Ali / Behzadi Tayemeh, Mohammad / Handy, Richard D / Abaei, Hesamoddin / Clark, Nathaniel / Seyedi, Javad / Jones, Megan Anne

Environmental pollution (Barking, Essex : 1987)

2023 Volume 342, Page(s) 123141

Abstract: The present research assessed, for the first time, toxicity of ZIF-8 (1 mg/L) and the building blocks (0.1 mg/L ... ...

Abstract	The present research assessed, for the first time, toxicity of ZIF-8 (1 mg/L) and the building blocks (0.1 mg/L Zn
MeSH term(s)	Humans ; Animals ; Female ; Infant, Newborn ; Artemia ; Reproduction ; Nanoparticles
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.123141
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Article: COVID-19 infection in an infant with cystic fibrosis: A case report and possible therapeutic effect of hypertonic saline.

Seyedi, Seyed Javad / Sadeghi, Hossein / Kianifar, Hamid-Reza / Hamedi, Abdolkarim / Saeidinia, Amin

Clinical case reports

2022 Volume 10, Issue 4, Page(s) e05782

Abstract: Pulmonary infections represent the major causes of morbidity and mortality in cystic fibrosis (CF). Here, we report a 3-month-old infant with pancreatic insufficient CF was hospitalized with positive RT-PCR test for COVID-19. He was treated successfully. ...

Abstract	Pulmonary infections represent the major causes of morbidity and mortality in cystic fibrosis (CF). Here, we report a 3-month-old infant with pancreatic insufficient CF was hospitalized with positive RT-PCR test for COVID-19. He was treated successfully. Hypertonic saline can be hypothesized as a treatment regimen against COVID-19 infection after further investigations.
Language	English
Publishing date	2022-04-26
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.5782
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Article ; Online: COVID‐19 infection in an infant with cystic fibrosis

Seyed Javad Seyedi / Hossein Sadeghi / Hamid‐Reza Kianifar / Abdolkarim Hamedi / Amin Saeidinia

Clinical Case Reports, Vol 10, Iss 4, Pp n/a-n/a (2022)

A case report and possible therapeutic effect of hypertonic saline

2022

Abstract: Abstract Pulmonary infections represent the major causes of morbidity and mortality in cystic fibrosis (CF). Here, we report a 3‐month‐old infant with pancreatic insufficient CF was hospitalized with positive RT‐PCR test for COVID‐19. He was treated ... ...

Abstract	Abstract Pulmonary infections represent the major causes of morbidity and mortality in cystic fibrosis (CF). Here, we report a 3‐month‐old infant with pancreatic insufficient CF was hospitalized with positive RT‐PCR test for COVID‐19. He was treated successfully. Hypertonic saline can be hypothesized as a treatment regimen against COVID‐19 infection after further investigations.
Keywords	children ; COVID‐19 ; cystic fibrosis ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article ; Online: Design, synthesis, and structure-activity relationship study of O-prenylated 3-acetylcoumarins as potent inhibitors of soybean 15-lipoxygenase.

Zerangnasrabad, Sara / Jabbari, Atena / Khavari Moghadam, Elahe / Sadeghian, Hamid / Seyedi, Seyed Mohammad

Drug development research

2021 Volume 82, Issue 6, Page(s) 826–834

Abstract: In this work, the design, synthesis, and structure-activity relationships of a novel array of geranyloxy and farnesyloxy 3-acetylcoumarins were reported as potent soybean 15-lipoxygenase inhibitors. Among the prepared coumarins, 7-farnesyloxy-3- ... ...

Abstract	In this work, the design, synthesis, and structure-activity relationships of a novel array of geranyloxy and farnesyloxy 3-acetylcoumarins were reported as potent soybean 15-lipoxygenase inhibitors. Among the prepared coumarins, 7-farnesyloxy-3-acetylcoumarin (12b) was found to be the most potent inhibitor by IC
MeSH term(s)	Arachidonate 15-Lipoxygenase/chemistry ; Arachidonate 15-Lipoxygenase/metabolism ; Coumarins/chemistry ; Molecular Docking Simulation ; Molecular Structure ; Glycine max/metabolism ; Structure-Activity Relationship
Chemical Substances	Coumarins ; 3-acetylcoumarin (3949-36-8) ; Arachidonate 15-Lipoxygenase (EC 1.13.11.33)
Language	English
Publishing date	2021-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604587-x
ISSN	1098-2299 ; 0272-4391
ISSN (online)	1098-2299
ISSN	0272-4391
DOI	10.1002/ddr.21787
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Article ; Online: Allylphenols as a new class of human 15-lipoxygenase-1 inhibitors.

Alavi, Seyed Jamal / Seyedi, Seyed Mohammad / Saberi, Satar / Safdari, Hadi / Eshghi, Hossein / Sadeghian, Hamid

Drug development research

2020 Volume 82, Issue 2, Page(s) 259–266

Abstract: In this study, a series of mono- and diallylphenol derivative were designed, synthesized, and evaluated as potential human 15-lipoxygenase-1 (15-hLOX-1) inhibitors. Radical scavenging potency of the synthetic allylphenol derivatives was assessed and the ... ...

Abstract	In this study, a series of mono- and diallylphenol derivative were designed, synthesized, and evaluated as potential human 15-lipoxygenase-1 (15-hLOX-1) inhibitors. Radical scavenging potency of the synthetic allylphenol derivatives was assessed and the results were in accordance with lipoxygenase (LOX) inhibition potency. It was found that the electronic natures of allyl moiety and para substituents play the main role in radical scavenging activity and subsequently LOX inhibition potency of the synthetic inhibitors. Among the synthetic compounds, 2,6-diallyl-4-(hexyloxy)phenol (42) and 2,6-diallyl-4-aminophenol (47) showed the best results for LOX inhibition (IC
MeSH term(s)	Arachidonate 15-Lipoxygenase/metabolism ; Cells, Cultured ; Dose-Response Relationship, Drug ; Humans ; Lipoxygenase Inhibitors/chemistry ; Lipoxygenase Inhibitors/pharmacology ; Phenols/chemistry ; Phenols/pharmacology
Chemical Substances	Lipoxygenase Inhibitors ; Phenols ; ALOX15 protein, human (EC 1.13.11.33) ; Arachidonate 15-Lipoxygenase (EC 1.13.11.33)
Language	English
Publishing date	2020-10-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	604587-x
ISSN	1098-2299 ; 0272-4391
ISSN (online)	1098-2299
ISSN	0272-4391
DOI	10.1002/ddr.21749
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Article ; Online: Investigating the effect of animation and pamphlet-based discharge program on the self-efficacy of children with asthma

Omolbanin Yaghoubi / Hamid Ahanchian / Aramesh Rezaeean / Seyed Javad Seyedi

مجله دانشگاه علوم پزشکی بیرجند, Vol 27, Iss 1, Pp 22-

2020 Volume 32

Abstract: Background and Aim: Asthma is the first cause of absenteeism and the third cause of hospitalization for children under the age of 15. It is causes psychological and emotional problems, decrease self-esteem. Lack of control of it can lead to frequent ... ...

Abstract	Background and Aim: Asthma is the first cause of absenteeism and the third cause of hospitalization for children under the age of 15. It is causes psychological and emotional problems, decrease self-esteem. Lack of control of it can lead to frequent hospitalization of affected children. Perhaps providing information in an attractive way about their illness will improve their self-efficacy. Therefore, the present study aims to evaluate the effect of animation and pamphlet-based discharge program on the self-efficacy of children with asthma was designed. Materials and Methods: This randomized clinical trial was conducted in Akbar Hospital in 2018, with participation of 90 patients that randomly allocated three groups of 30 animation, pamphlet and control. In the animation group, given educational CD and pamphlet group given pamphlet for twice a week about 2 months, and in the control group, information was provided in the routine section. Before and after intervention, self efficacy of children was measured. Data were analyzed by SPSS software version 16 and one way ANOVA, Kolmogorov–Smirnov, Kruskal Wallis, paired t-test, Chi-square tests and Tukey post hoc. Results: After the intervention, the self-efficacy score of the animation group was significantly higher than the pamphlet and control group (p <0.001). In comparison, intra-group self-efficacy was significantly increased in all three groups after two months compared to baseline (p<0.001). Conclusion: The discharge program based on animation promotes self-efficacy in children with asthma and recommends paying more attention to nursing care.
Keywords	animation ; asthma ; child ; self-efficacy ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	796
Language	Persian
Publishing date	2020-03-01T00:00:00Z
Publisher	Birjand University of Medical Sciences and Health Services
Document type	Article ; Online
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Article: Design and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors.

Sadeghian, Hamid / Seyedi, Seyed Mohammad / Jafari, Zeinab

Iranian journal of basic medical sciences

2018 Volume 21, Issue 7, Page(s) 738–744

Abstract: Objectives: 15-Lipoxygenases are one of the iron-containing proteins capable of performing peroxidation of unsaturated fatty acids in animals and plants. The critical role of enzymes in the formation of inﬂammations, sensitivities, and some cancers has ... ...

Abstract	Objectives: 15-Lipoxygenases are one of the iron-containing proteins capable of performing peroxidation of unsaturated fatty acids in animals and plants. The critical role of enzymes in the formation of inﬂammations, sensitivities, and some cancers has been demonstrated in mammals. The importance of enzymes has led to the development of mechanistic studies, product analysis, and synthesis of inhibitors. Materials and methods: The inhibitory activity of all synthetic compounds against SLO (soybean 15-lipoxygenase: L1; EC 1,13,11,12) was determined using the peroxide formation method. In this method, the basis of evaluation of lipoxygenase activity is measuring the concentration of fatty acid peroxide. All measurements were compared with 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine (4-MMPB) as one of the known lipoxygenase inhibitors. The radical scavenging ability of all synthetic compounds using stable free radicals (DPPH: 2,2-diphenyl-1-picrylhydrazyl) was measured for further investigation. Results: In this study, a series of esters from phenolic acids with terpenoid alcohols was synthesized and their inhibitory potency against soybean 15-lipoxygenase and their free radical scavenging properties were determined. Among the synthetic compounds, adamantyl protocatetuate 2j and bornyl protocatetuate 2o showed the most potent inhibitory activity with IC50 values of 0.95 and 0.78 μm, respectively. Conclusion: By changing the alcohol and acyl portions of stylosin, it was found that electronic properties play main role in lipoxygenase inhibition potency in contrast with steric features. Insertion of more reductive phenolic moiety such as catechuate and gallate lead to more lipoxygenase inhibition potency of the esters as observed in their radical scavenging activity.
Language	English
Publishing date	2018-07-31
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2500485-2
ISSN	2008-3874 ; 2008-3866
ISSN (online)	2008-3874
ISSN	2008-3866
DOI	10.22038/IJBMS.2018.27910.6794
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Article ; Online: Design and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors

Hamid Sadeghian / Seyed Mohammad Seyedi / Zeinab Jafari

Iranian Journal of Basic Medical Sciences, Vol 21, Iss 7, Pp 738-

2018 Volume 744

Abstract: Objective(s): 15-Lipoxygenases are one of the iron-containing proteins capable of performing peroxidation of unsaturated fatty acids in animals and plants. The critical role of enzymes in the formation of inﬂammations, sensitivities, and some cancers has ...

Abstract	Objective(s): 15-Lipoxygenases are one of the iron-containing proteins capable of performing peroxidation of unsaturated fatty acids in animals and plants. The critical role of enzymes in the formation of inﬂammations, sensitivities, and some cancers has been demonstrated in mammals. The importance of enzymes has led to the development of mechanistic studies, product analysis, and synthesis of inhibitors. Materials and Methods: The inhibitory activity of all synthetic compounds against SLO (soybean 15-lipoxygenase: L1; EC 1,13,11,12) was determined using the peroxide formation method. In this method, the basis of evaluation of lipoxygenase activity is measuring the concentration of fatty acid peroxide. All measurements were compared with 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine (4-MMPB) as one of the known lipoxygenase inhibitors. The radical scavenging ability of all synthetic compounds using stable free radicals (DPPH: 2,2-diphenyl-1-picrylhydrazyl) was measured for further investigation.Results: In this study, a series of esters from phenolic acids with terpenoid alcohols was synthesized and their inhibitory potency against soybean 15-lipoxygenase and their free radical scavenging properties were determined. Among the synthetic compounds, adamantyl protocatetuate 2j and bornyl protocatetuate 2o showed the most potent inhibitory activity with IC50 values of 0.95 and 0.78 μm, respectively.Conclusion: By changing the alcohol and acyl portions of stylosin, it was found that electronic properties play main role in lipoxygenase inhibition potency in contrast with steric features. Insertion of more reductive phenolic moiety such as catechuate and gallate lead to more lipoxygenase inhibition potency of the esters as observed in their radical scavenging activity.
Keywords	Inhibitors ; Phenolic acid ; Radical scavenging ; Terpenoids ; 15-lipoxygenase ; Medicine ; R
Subject code	540
Language	English
Publishing date	2018-07-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
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Article ; Online: Fatty acid alteration in liver, brain, muscle, and oocyte of zebrafish (Danio rerio) exposed to silver nanoparticles and mitigating influence of quercetin-supplemented diet.

Seyedi, Javad / Tayemeh, Mohammad Behzadi / Esmaeilbeigi, Milad / Joo, Hamid Salari / Langeroudi, Elnaz Keshtkar / Banan, Ashkan / Johari, Seyed Ali / Jami, Mohammad Javad

Environmental research

2021 Volume 194, Page(s) 110611

Abstract: No to less effort has been made to assess the toxicity of silver nanoparticles (AgNPs) to lipid composition in biological systems and also to discover a mitigating agent against their oxidative stress. Hence, this research evaluated the antioxidant ... ...

Abstract	No to less effort has been made to assess the toxicity of silver nanoparticles (AgNPs) to lipid composition in biological systems and also to discover a mitigating agent against their oxidative stress. Hence, this research evaluated the antioxidant capability of quercetin (Qu) against silver nanoparticles (AgNPs) toxicity towards the lipid contents of ovarian, nervous, and hepatic systems as well as skeletal muscles. To this end, zebrafish (n = 180) were assigned into four experimental dietary groups: negative and positive controls, without Qu supplementation; Qu-200, 200 mg Qu per kg diet; and Qu-400, 400 mg Qu per kg diet. At the end of the feeding trial (40 days), the experimental groups, except the negative control, were exposed to sublethal concentration of AgNPs (0.15 mg L
MeSH term(s)	Animals ; Brain ; Diet ; Dietary Supplements ; Fatty Acids ; Liver ; Metal Nanoparticles/toxicity ; Muscles ; Oocytes ; Quercetin/pharmacology ; Silver/toxicity ; Zebrafish
Chemical Substances	Fatty Acids ; Silver (3M4G523W1G) ; Quercetin (9IKM0I5T1E)
Language	English
Publishing date	2021-01-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2020.110611
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