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Article ; Online: Does the expression of granzyme B participate in inflammation, fibrosis, and fertility of hydatid cysts?

Sweed, Dina / Mohamady, Mohamed / Gouda, Marwa A / Fayed, Yahya / Saied, Sara A / Elhamed, Sara M Abd

2023 Volume 123, Issue 1, Page(s) 22

Abstract: Echinococcus granulosus (sensu lato), a cestode that is endemic in Egypt, causes cystic echinococcosis (CE), a significant but neglected zoonotic disease that is prevalent throughout the world. Infected hydatid cysts are classified as fertile or non- ... ...

Abstract	Echinococcus granulosus (sensu lato), a cestode that is endemic in Egypt, causes cystic echinococcosis (CE), a significant but neglected zoonotic disease that is prevalent throughout the world. Infected hydatid cysts are classified as fertile or non-fertile based on the presence of protoscoleces; nevertheless, the mechanism of non-fertile CE cysts remains unknown. The study aimed to assess whether granzyme B (GrB) expression and CD4 + /CD8 + could be related to the induction of non-fertile CE cysts. A total of fifty-eight individuals diagnosed with visceral hydatid cysts were selected, and they were further divided according to cyst fertility into fertile and non-fertile. Immunohistochemistry for CD4, CD8, and GrB was done. According to the results, hydatid cysts are common in adults and have no gender preference. The same clinical and laboratory data were shared by patients with fertile and non-fertile cysts (p = 0.186). GrB expression was not impacted by the fibrous deposition inside the hydatid cyst wall (p = 0.85); however, GrB was significantly correlated with the inflammatory density (p = 0.005). GrB expression was also found to be significantly higher in non-fertile cysts (p = 0.04). GrB expression is positively correlated with CD4 and CD8 expression. In conclusion, the expression of GrB in hydatid cysts may exacerbate the inflammatory response and impede cyst fertility while not affecting the fibrous deposition in the cyst wall.
MeSH term(s)	Animals ; Humans ; Cysts ; Echinococcosis/epidemiology ; Echinococcus ; Echinococcus granulosus/physiology ; Fertility ; Fibrosis ; Granzymes ; Inflammation
Chemical Substances	Granzymes (EC 3.4.21.-) ; GZMB protein, human (EC 3.4.21.-)
Language	English
Publishing date	2023-12-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	284966-5
ISSN	1432-1955 ; 0932-0113 ; 0044-3255
ISSN (online)	1432-1955
ISSN	0932-0113 ; 0044-3255
DOI	10.1007/s00436-023-08056-2
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Article ; Online: Phytoconstituent Isolation and Cytotoxicity Evaluation of the Egyptian Cassia occidentalis L. Possessing Selective Activity against Lung Carcinoma

Hanaa M. Sayed / Mahmoud A. Ramadan / Heba H. Salem / Marwa A. A. Fayed

Journal of Chemistry, Vol

2023 Volume 2023

Abstract: Ethyl acetate fraction column chromatographic analysis was used to isolate eleven compounds (numerically tagged 1–10) from Cassia occidentalis L. in this study. Two unique metabolites, including a neolignan compound designated as occidentalignan I (9) ... ...

Abstract	Ethyl acetate fraction column chromatographic analysis was used to isolate eleven compounds (numerically tagged 1–10) from Cassia occidentalis L. in this study. Two unique metabolites, including a neolignan compound designated as occidentalignan I (9) and a flavonoidal glycoside, chrysin-7-O-α-L-rhamnopyranosyl (10), were identified, while silybin A (8) was the first flavonolignan to be isolated from the Fabaceae family. Four compounds, including β-sitosterol-3-O-β-D-glucopyranoside (1), stigmasterol-3-O-β-D-glucopyranoside (2), betulinic acid (3), and vanillic acid (4) were isolated from C. occidentalis for the first time. In addition, four known compounds, cinnamic acid (5), p-hydroxybenzoic acid (6), β- resorcylic acid (7), and citric acid (11), were also detected. The in-vitro cytotoxicity assessment of the methanolic extract of C. occidentalis on seven cancer cell lines, including A-549, Colo-205, Huh-7, HCT-116, PANC-1, SKOV-3, and BNL, demonstrated its selective potent cytotoxicity on lung cancer cells without affecting normal BNL cells. In contrast, the methanolic extract showed moderate activity on Colo-205 and Huh-7 and nearly no activity on HCT-116, PANC-1, and SKOV-3 cell lines. These results suggest that the methanolic extract of C. occidentalis is an excellent candidate with potential antiproliferative activity against lung cancer; however, further studies are necessary to clarify its mechanism of action.
Keywords	Chemistry ; QD1-999
Subject code	540
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
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Article ; Online: Metabolic Profiling, GC-MS, LC-ESI-MS/MS Analysis, Phenolics Isolation and Biological Evaluation of the Aerial Parts Extracts of Felicia abyssinica L.

Elshorbagy, Ahmed M / Fayed, Marwa A A / Sallam, Amal / Badria, Farid A

Chemistry & biodiversity

2024 Volume 21, Issue 3, Page(s) e202301347

Abstract: Felicia abyssinica L., family Asteraceae, is widely used in folk medicine. This represents the first study to investigate its phytoconstituents and pharmacological effects. Phytoconstituents identified by GC-MS, LC-ESI-MS/MS-based metabolomics, and NMR ( ... ...

Abstract	Felicia abyssinica L., family Asteraceae, is widely used in folk medicine. This represents the first study to investigate its phytoconstituents and pharmacological effects. Phytoconstituents identified by GC-MS, LC-ESI-MS/MS-based metabolomics, and NMR (1D & 2D). GC-MS of the (FAMEs) revealed mainly the identification of 55 fatty acids. LC-ESI-MS/MS analysis resulted in the tentative identity of 13 compounds representing flavonoids, phenolics, and fatty acids. Ethyl acetate fraction exhibited the highest total flavonoids 66.19 mg/mL Rutin equivalent, while the methanolic fraction showed the highest phenolics 87.70 mg/mL gallic acid equivalent, and the total condensed tannins were 64.35 μg CE/mg catechins equivalent. A flavonoid and a cinnamic acid derivative were identified as quercetin 3-O-(2'''-O-acetyl) rutinoside (Mumikotin A) (1) and Methyl sinapate (2). Biological evaluation of antioxidant and cytotoxic activities was carried out. Cytotoxicity was examined on HepG-2 cell lines where the average cell viability was 91.42 % and 52.48 % for concentrations 10 and 100 μg/mL respectively. Methylene chloride and methanolic fractions showed the highest antioxidant activity 225 μg/mL Ascorbic acid equivalents. It is hypothesized that high phenolics, flavonoid content, and oxygenated identified compounds contribute to the antioxidant activity and can be regarded as a promising species for nutraceuticals active antioxidants with potential value for remedy.
MeSH term(s)	Gas Chromatography-Mass Spectrometry ; Antioxidants/chemistry ; Tandem Mass Spectrometry/methods ; Plant Extracts/chemistry ; Flavonoids/chemistry ; Phenols/chemistry ; Asteraceae ; Methanol ; Plant Components, Aerial/chemistry ; Fatty Acids/analysis
Chemical Substances	Antioxidants ; Plant Extracts ; Flavonoids ; Phenols ; Methanol (Y4S76JWI15) ; Fatty Acids
Language	English
Publishing date	2024-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202301347
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Article ; Online: A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of

Mohammed, Firdous Sayeed / Babu, Dinesh / Irfan, Zainab / Fayed, Marwa A A

PeerJ

2024 Volume 12, Page(s) e16928

Abstract: Momordica ... ...

Abstract	Momordica cymbalaria
MeSH term(s)	Female ; Pregnancy ; Humans ; Momordica ; Phytochemicals/pharmacology ; Caffeine ; Cucurbitaceae ; Vitamins
Chemical Substances	Phytochemicals ; Caffeine (3G6A5W338E) ; Vitamins
Language	English
Publishing date	2024-02-27
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.16928
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Article ; Online: Phytochemical Investigation, In silico/In vivo Analgesic, and Anti-inflammatory Assessment of the Egyptian Cassia occidentalis L.

Sayed, Hanaa M / Ramadan, Mahmoud A / Salem, Heba H / Ahmad, Iqrar / Patel, Harun / Fayed, Marwa A A

Steroids

2023 Volume 196, Page(s) 109245

Abstract: Cassia occidentalis L., from Fabaceae family phytochemical screening, revealed several biologically active principles mainly flavonoids and anthraquinones. GLC analysis of the lipoidal matter afforded 12 hydrocarbons: 9-dodecyl-tetradecahydro-anthracene ( ...

Abstract	Cassia occidentalis L., from Fabaceae family phytochemical screening, revealed several biologically active principles mainly flavonoids and anthraquinones. GLC analysis of the lipoidal matter afforded 12 hydrocarbons: 9-dodecyl-tetradecahydro-anthracene (48.97 %), 9-dodecyl-tetradecahydro-phenanthrene (14.43 %), and 6 sterols/triterpenes: isojaspisterol (11.99%) and fatty acids were palmitic acid (50 %), and Linoleic acid (16.06%). Column chromatography led to the isolation of fifteen compounds (1-15), elucidated using spectroscopic evidence. First report of undecanoic acid (4) from the family Fabaceae, while p-dimethyl amino-benzaldehyde (15) was first time isolated from a natural origin. Eight compounds isolated for the first time from C. occidentalis L.; β-amyrin (1), β-sitosterol (2), stigmasterol (3), camphor (5), lupeol (6), chrysin (7), pectolinargenin (8), and 1, 2, 5-trihydroxy anthraquinone (14) besides five known compounds previously isolated; apigenin (9), kaempferol (10), chrysophanol (11), physcion (12), and aloe-emodin (13). In-vivo evaluation of anti-inflammatory and analgesic effects of C. occidentalis L. extracts where the n-butanol and total extracts showed the highest activities. The percentage of the inhibitory effect of the n-butanol extract was 29.7 at a dose of 400 mg/Kg. Furthermore, identified phytoconstituents were docked into the active sites of enzymes nAChRs, COX-1, and COX-2 to evaluate binding affinity. Phyto-compounds Physcion, aloe-emodin, and chrysophanol were found to have a good affinity for targeted receptors compared to co-crystalized inhibitors, validating the analgesic and anti-inflammatory effects of the phytochemicals.
MeSH term(s)	Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Emodin ; Senna Plant/chemistry ; 1-Butanol ; Egypt ; Anthraquinones/pharmacology ; Anti-Inflammatory Agents/pharmacology ; Analgesics/pharmacology ; Phytochemicals/pharmacology
Chemical Substances	chrysophanic acid (N1ST8V8RR2) ; Plant Extracts ; physcione (H6PT94IV61) ; Emodin (KA46RNI6HN) ; 1-Butanol (8PJ61P6TS3) ; Anthraquinones ; Anti-Inflammatory Agents ; Analgesics ; aloe emodin (C8IYT9CR7C) ; Phytochemicals
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	80312-1
ISSN	1878-5867 ; 0039-128X
ISSN (online)	1878-5867
ISSN	0039-128X
DOI	10.1016/j.steroids.2023.109245
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Article: Heliotropium; a genus rich in pyrrolizidine alkaloids: A systematic review following its phytochemistry and pharmacology

Fayed, Marwa A.A.

Phytomedicine plus. 2021 May, v. 1, no. 2

2021

Abstract: A huge number of plants have remedial and therapeutic prospects throughout the world and are used in the treatment of diverse diseases. Heliotropium is a large genus of family Boraginaceae which widely distributed in tropical and temperate regions of ... ...

Abstract	A huge number of plants have remedial and therapeutic prospects throughout the world and are used in the treatment of diverse diseases. Heliotropium is a large genus of family Boraginaceae which widely distributed in tropical and temperate regions of hemispheres. The purpose of this review is to recapitulate the phytochemistry and pharmacological activities of the Heliotropium species to unveil future research prospects.Published data in this review were all gathered from the online bibliographical databases: PubMed, Elsevier, Scopus, Google Scholar and Web of Science.The plants of the Heliotropium genus in the history of traditional drugs provide remedies for gout, inflammation, skin disorders, menstrual dysfunction, rheumatism, and noxious bites. The active biochemical constituents extracted from the Heliotropium species comprise pyrrolizidine alkaloids, flavonoids, and terpenoids. Significant biological activities viz. antimicrobial, antiviral, antitumor, anti-inflammatory, cytotoxicity, phytotoxicity, and wound healing were revealed by an enormous number of extracts and biochemically active constituents of various species of the Heliotropium genus.Phytomedicines are now an important and beneficial zone of the recommended treatment and have high potentials in many countries. Although this clear evidence that plants of the Heliotropium genus have several medicinal importance in the treatment of diverse diseases. The medicinal use of these plants as phyto-pharmaceuticals would depend on the production of the required systematic procedures necessary to standardize the various bioactive secondary metabolites in such herbal formulations. Therefore, we conclude that in the coming period, plants of the Heliotropium genus would become an acceptable source of indigenous medicines.
Keywords	Heliotropium ; cytotoxicity ; flavonoids ; gout ; inflammation ; phytotoxicity ; rheumatoid arthritis ; secondary metabolites ; systematic review ; terpenoids ; therapeutics
Language	English
Dates of publication	2021-05
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2667-0313
DOI	10.1016/j.phyplu.2021.100036
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Heliotropium; a genus rich in pyrrolizidine alkaloids

Marwa A.A. Fayed

Phytomedicine Plus, Vol 1, Iss 2, Pp 100036- (2021)

A systematic review following its phytochemistry and pharmacology

2021

Abstract: Introduction: A huge number of plants have remedial and therapeutic prospects throughout the world and are used in the treatment of diverse diseases. Heliotropium is a large genus of family Boraginaceae which widely distributed in tropical and temperate ... ...

Abstract	Introduction: A huge number of plants have remedial and therapeutic prospects throughout the world and are used in the treatment of diverse diseases. Heliotropium is a large genus of family Boraginaceae which widely distributed in tropical and temperate regions of hemispheres. The purpose of this review is to recapitulate the phytochemistry and pharmacological activities of the Heliotropium species to unveil future research prospects. Methods: Published data in this review were all gathered from the online bibliographical databases: PubMed, Elsevier, Scopus, Google Scholar and Web of Science. Results: The plants of the Heliotropium genus in the history of traditional drugs provide remedies for gout, inflammation, skin disorders, menstrual dysfunction, rheumatism, and noxious bites. The active biochemical constituents extracted from the Heliotropium species comprise pyrrolizidine alkaloids, flavonoids, and terpenoids. Significant biological activities viz. antimicrobial, antiviral, antitumor, anti-inflammatory, cytotoxicity, phytotoxicity, and wound healing were revealed by an enormous number of extracts and biochemically active constituents of various species of the Heliotropium genus. Conclusion: Phytomedicines are now an important and beneficial zone of the recommended treatment and have high potentials in many countries. Although this clear evidence that plants of the Heliotropium genus have several medicinal importance in the treatment of diverse diseases. The medicinal use of these plants as phyto-pharmaceuticals would depend on the production of the required systematic procedures necessary to standardize the various bioactive secondary metabolites in such herbal formulations. Therefore, we conclude that in the coming period, plants of the Heliotropium genus would become an acceptable source of indigenous medicines.
Keywords	Heliotropium ; Boraginaceae ; Pyrrolizidine alkaloids ; Quercetin ; Phytochemistry ; Pharmacology ; Other systems of medicine ; RZ201-999
Subject code	580
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Walnut Kernel Oil and Defatted Extracts Enhance Mesenchymal Stem Cell Stemness and Delay Senescence.

Elsied, Marwa A / Sharawi, Zeina W / Al-Amrah, Hadba / Hegazy, Rabab A / Mohamed, Amro E / Saleh, Rasha M / El-Kholy, Sanad S / Farrag, Foad A / Fayed, Masoud H / El-Magd, Mohammed A

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 17

Abstract: Decreased stemness and increased cellular senescence impair the ability of mesenchymal stem cells (MSCs) to renew themselves, change into different cell types, and contribute to regenerative medicine. There is an urgent need to discover new compounds ... ...

Abstract	Decreased stemness and increased cellular senescence impair the ability of mesenchymal stem cells (MSCs) to renew themselves, change into different cell types, and contribute to regenerative medicine. There is an urgent need to discover new compounds that can boost MSCs' stemness and delay senescence. Therefore, this study aimed to investigate the impact of walnut kernel oil (WKO) and defatted (WKD) extracts on bone marrow (BM)-MSC stemness and senescence. Premature senescence and inflammation were induced in BM-MSCs using H
MeSH term(s)	Animals ; Rats ; AMP-Activated Protein Kinases ; Antioxidants/pharmacology ; Hydrogen Peroxide ; Juglans ; Sirtuin 1/genetics ; Tumor Suppressor Protein p53
Chemical Substances	AMP-Activated Protein Kinases (EC 2.7.11.31) ; Antioxidants ; Hydrogen Peroxide (BBX060AN9V) ; Sirtuin 1 (EC 3.5.1.-) ; Tumor Suppressor Protein p53
Language	English
Publishing date	2023-08-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28176281
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Article: Cardiovascular Risk Among Patients with Controlled and Uncontrolled Type 2 Diabetes: A Sub-Cohort Analysis from the Heart Health Promotion (HHP) Study.

Fayed, Amel / Alzeidan, Rasmieh / Elkouny, Roaa / Tawfik, Marwa / Naguib, Rania

International journal of general medicine

2023 Volume 16, Page(s) 1171–1180

Abstract: Objective: This study aimed to estimate the risk of cardiovascular disease (CVD) among patients with and without diabetes mellitus (DM) using the Framingham risk score (FRS) and to investigate the effect of DM control on CVD risk.: Methodology: A ... ...

Abstract	Objective: This study aimed to estimate the risk of cardiovascular disease (CVD) among patients with and without diabetes mellitus (DM) using the Framingham risk score (FRS) and to investigate the effect of DM control on CVD risk. Methodology: A total of 2432 participants who had their glycosylated hemoglobin (HbA1c) measured within the last three months were included in this study. The study cohort was divided into three categories: non-diabetic, participants with controlled DM (HbA1c<7%), and uncontrolled DM (HbA1c≥7%). The World Health Organization's stepwise approach to chronic disease risk factor Surveillance-Instrument v2.1 was used in this study to collect the anthropometric and biochemical measurements. The Framingham Coronary Heart Risk Score (FRS) was used to calculate the 10-year cardiovascular risk (CVR). The groups were compared concerning the prevalence of metabolic, socioeconomic, and cardiac risks. Results: Out of 2432 participants, 149 had controlled DM (6.1%), 286 had uncontrolled DM (11.8%), and 1997 participants were normoglycemic (82.1%). Compared to healthy participants, diabetic participants showed more high-risk characteristics across all CVR parameters. Uncontrolled diabetic patients had a graver laboratory and clinical profiles compared to the controlled DM group. As measured by FRS, nearly half of patients with controlled DM (49.9%) and two-thirds of patients with uncontrolled DM (63.3%) were classified as intermediate and high-risk compared to 4.6% of the healthy participants. Compared to healthy participants, patients with controlled DM showed a threefold increased CVR (OR = 3.02, 95% C.I. = 1.41-7.24) while this risk catapulted to 13 times among those with uncontrolled DM (OR = 13.57, 95% C.I. = 6.99-26.36). Conclusion: Participants with DM are at moderate to high CVR. Individuals with uncontrolled DM showed higher CVR profiles as measured by FRS and have a higher prevalence of obesity, unhealthy diet, and physical inactivity.
Language	English
Publishing date	2023-04-01
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S404054
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Article ; Online: Heliotropium ramosissimum metabolic profiling, in silico and in vitro evaluation with potent selective cytotoxicity against colorectal carcinoma.

Fayed, Marwa A A / Abouelela, Mohamed E / Refaey, Mohamed S

Scientific reports

2022 Volume 12, Issue 1, Page(s) 12539

Abstract: Heliotropium is a genus of the Boraginaceae family. Its members are used in many traditional and folklore medicines to treat several ailments. Despite this widespread usage, only a few evidence-based scientific studies investigated and identified its ... ...

Abstract	Heliotropium is a genus of the Boraginaceae family. Its members are used in many traditional and folklore medicines to treat several ailments. Despite this widespread usage, only a few evidence-based scientific studies investigated and identified its phytoconstituents. Herein, we documented the chemical profile of the Heliotropium ramosissimum methanolic extract using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) and assessed its antioxidant and cytotoxic effects. The methanolic extract exhibited high phenolic content (179.74 ± 0.58 µg/mL) and high flavonoid content (53.18 ± 0.60 µg/mL). The GC-MS analysis of the lipoidal matter allowed us to identify 41 compounds with high percentages of 1,2-benzenedicarboxylic acid, bis(2-methoxyethyl) ester (23.91%), and 6,10,14-trimethylpentadecan-2-one (18.74%). Thirty-two phytomolecules were tentatively identified from the methanolic extract of H. ramosissimum using LC-MS/MS. These compounds belonged to several phytochemical classes such as phenolic acids, alkaloids, coumarins, and flavonoids. Furthermore, we assessed the antioxidant activity of the methanolic extract by DPPH assay and oxygen radical absorbance capacity assay, which yielded IC
MeSH term(s)	Antioxidants/chemistry ; Chromatography, Liquid/methods ; Colonic Neoplasms ; Colorectal Neoplasms/drug therapy ; Heliotropium ; Humans ; Molecular Docking Simulation ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Tandem Mass Spectrometry/methods
Chemical Substances	Antioxidants ; Plant Extracts
Language	English
Publishing date	2022-07-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-16552-1
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