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Book: RNA protein interactions

Nagai, Kiyoshi

(Frontiers in molecular biology ; [6])

1994

Title variant	RNA-protein
Author's details	ed. by Kiyoshi Nagai
Series title	Frontiers in molecular biology ; [6]
Collection
Keywords	RNA / metabolism ; RNA-Binding Proteins / metabolism ; Base Sequence ; Molecular Sequence Data ; Nucleic Acid Conformation ; Structure-Activity Relationship ; RNS ; Proteine ; Struktur ; Wechselwirkung
Subject	Wechselwirkungen ; Interaktion ; Eiweiss ; Protein ; Ribonucleinsäure ; Ribonukleinsäure ; RNA ; Ribonucleinsäuren ; Ribonukleinsäuren
Language	English
Size	XVIII, 272 S. : Ill., graph. Darst.
Edition	1. ed.
Publisher	IRL Press
Publishing place	Oxford u.a.
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT006571219
ISBN	0-19-963505-6 ; 0-19-963504-8 ; 978-0-19-963505-4 ; 978-0-19-963504-7
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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1996 A 123	order for loan	Magazin

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Article ; Online: In the beginning was the U1A protein: a personal reflection.

Nagai, Kiyoshi

RNA (New York, N.Y.)

2015 Volume 21, Issue 4, Page(s) 699–700

MeSH term(s)	HeLa Cells ; Humans ; RNA/chemistry ; RNA/genetics ; Ribonucleoprotein, U1 Small Nuclear/genetics ; Ribonucleoprotein, U1 Small Nuclear/metabolism
Chemical Substances	Ribonucleoprotein, U1 Small Nuclear ; U1A protein ; RNA (63231-63-0)
Language	English
Publishing date	2015-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1241540-6
ISSN	1469-9001 ; 1355-8382
ISSN (online)	1469-9001
ISSN	1355-8382
DOI	10.1261/rna.050344.115
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Zs.A 4777: Show issues

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Article ; Online: Evidence of tosufloxacin deposition in the kidneys of a patient presenting with crystal nephropathy.

Ito, Yuuki / Mori, Noriko / Matsuo, Ken / Tanaka, Satoshi / Mori, Kiyoshi / Kobayashi, Nao / Mizuno, Hajime / Todoroki, Kenichiro / Nagai, Kojiro

Internal medicine (Tokyo, Japan)

2024

Abstract: Tosufloxacin tosilate is classified as a new quinolone antibacterial agent, which has been reported to cause crystal nephropathy. However, the origin of these crystal deposits has not yet been elucidated. We encountered a case of renal failure that ... ...

Abstract	Tosufloxacin tosilate is classified as a new quinolone antibacterial agent, which has been reported to cause crystal nephropathy. However, the origin of these crystal deposits has not yet been elucidated. We encountered a case of renal failure that progressed slowly owing to crystal-forming interstitial nephritis after long-term exposure to tosufloxacin. Mass spectrometry of the renal specimens revealed that tosufloxacin was deposited in the kidneys. The patient's renal function improved slowly with the withdrawal of tosufloxacin and steroid therapy. This is the first case to demonstrate the presence of crystal deposits consisting of tosufloxacin.
Language	English
Publishing date	2024-03-04
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.3082-23
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Article: Individual Optimal Attentional Strategy in Motor Learning Tasks Characterized by Steady-State Somatosensory and Visual Evoked Potentials.

Sakurada, Takeshi / Yoshida, Masataka / Nagai, Kiyoshi

Frontiers in human neuroscience

2022 Volume 15, Page(s) 784292

Abstract: Focus of attention is one of the most influential factors facilitating motor performance. Previous evidence supports that the external focus (EF) strategy, which directs attention to movement outcomes, is associated with better motor performance than the ...

Abstract	Focus of attention is one of the most influential factors facilitating motor performance. Previous evidence supports that the external focus (EF) strategy, which directs attention to movement outcomes, is associated with better motor performance than the internal focus (IF) strategy, which directs attention to body movements. However, recent studies have reported that the EF strategy is not effective for some individuals. Furthermore, neuroimaging studies have demonstrated that the frontal and parietal areas characterize individual optimal attentional strategies for motor tasks. However, whether the sensory cortices are also functionally related to individual optimal attentional strategy remains unclear. Therefore, the present study examined whether an individual's sensory processing ability would reflect the optimal attentional strategy. To address this point, we explored the relationship between responses in the early sensory cortex and individuals' optimal attentional strategy by recording steady-state somatosensory evoked potentials (SSSEP) and steady-state visual evoked potentials (SSVEP). Twenty-six healthy young participants first performed a motor learning task with reaching movements under IF and EF conditions. Of the total sample, 12 individuals showed higher after-effects under the IF condition than the EF condition (IF-dominant group), whereas the remaining individuals showed the opposite trend (EF-dominant group). Subsequently, we measured SSSEP from bilateral primary somatosensory cortices while presenting vibrotactile stimuli and measured SSVEP from bilateral primary visual cortices while presenting checkerboard visual stimuli. The degree of increasing SSSEP response when the individuals in the IF-dominant group directed attention to vibrotactile stimuli was significantly more potent than those in the EF-dominant individuals. By contrast, the individuals in the EF-dominant group showed a significantly larger SSVEP increase while they directed attention to visual stimuli compared with the IF-dominant individuals. Furthermore, a significant correlation was observed such that individuals with more robust IF dominance showed more pronounced SSSEP attention modulation. These results suggest that the early sensory areas have crucial brain dynamics to characterize an individual's optimal attentional strategy during motor tasks. The response characteristics may reflect the individual sensory processing ability, such as control of priority to the sensory inputs. Considering individual cognitive traits based on the suitable attentional strategy could enhance adaptability in motor tasks.
Language	English
Publishing date	2022-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2425477-0
ISSN	1662-5161
ISSN	1662-5161
DOI	10.3389/fnhum.2021.784292
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Article ; Online: Isoliquiritigenin inhibits NLRP3 inflammasome activation with CAPS mutations by suppressing caspase-1 activation and mutated NLRP3 aggregation.

Usui-Kawanishi, Fumitake / Kani, Koudai / Karasawa, Tadayoshi / Honda, Hiroe / Takayama, Nobuyuki / Takahashi, Masafumi / Takatsu, Kiyoshi / Nagai, Yoshinori

Genes to cells : devoted to molecular & cellular mechanisms

2024

Abstract: The nucleotide-binding oligomerization domain leucine-rich repeat and pyrin domain containing 3 (NLRP3) inflammasome contributes to the development of inflammatory diseases. Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease ... ...

Abstract	The nucleotide-binding oligomerization domain leucine-rich repeat and pyrin domain containing 3 (NLRP3) inflammasome contributes to the development of inflammatory diseases. Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by NLRP3 gene mutations that results in excessive IL-1β production. We previously identified isoliquiritigenin (ILG), a component of Glycyrrhiza uralensis extracts, as a potent inhibitor of the NLRP3 inflammasome. Here, we aimed to investigate whether ILG inhibits the activation of NLRP3 inflammasome caused by NLRP3 gene mutations. We demonstrated that ILG significantly inhibited NLRP3 inflammasome-mediated lactate dehydrogenase (LDH) release and IL-1β production in two CAPS model THP-1 cell lines, NLRP3-D303N and NLRP3-L353P, in a dose-dependent manner. Interestingly, the NLRP3 inhibitor MCC950 inhibited LDH release and IL-1β production in NLRP3-D303N cells, but not in NLRP3-L353P cells. Western blotting and caspase-1 activity assays showed that ILG, as well as caspase inhibitors, including Z-VAD and YVAD, suppressed caspase-1 activation. Notably, ILG prevented cryo-sensitive foci formation of NLRP3 without affecting the levels of intracellular Ca
Language	English
Publishing date	2024-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	1330000-3
ISSN	1365-2443 ; 1356-9597
ISSN (online)	1365-2443
ISSN	1356-9597
DOI	10.1111/gtc.13108
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Zs.A 4539: Show issues

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Article ; Online: A phase II Japanese trial of 90-minute rituximab infusion for untreated B-cell lymphoma.

Saito, Toko / Nagai, Hirokazu / Izutsu, Koji / Ando, Kiyoshi / Igarashi, Tadahiko / Izumi, Tohru / Ohashi, Yasuo / Kamiyama, Shuhei / Ishizawa, Kenichi / Tobinai, Kensei

Japanese journal of clinical oncology

2024 Volume 54, Issue 4, Page(s) 444–451

Abstract: Objective: This phase II clinical trial evaluated feasibility and tolerability of 90-minute rituximab infusion and a concentration of 4 mg/mL rituximab infusion in Japanese patients with previously untreated follicular lymphoma or diffuse large B-cell ... ...

Abstract	Objective: This phase II clinical trial evaluated feasibility and tolerability of 90-minute rituximab infusion and a concentration of 4 mg/mL rituximab infusion in Japanese patients with previously untreated follicular lymphoma or diffuse large B-cell lymphoma. Methods: Treatment was rituximab with cyclophosphamide, doxorubicin, vincristine and prednisolone. In cycle 1, rituximab at a dose of 375 mg/m2 (4 mg/mL) was administered at the standard infusion rate stipulated in the package insert. On confirmed tolerance of rituximab, patients received 90-minute infusion in second and subsequent cycles. The primary endpoint was incidence of grade 3 or higher infusion-related reactions during 90-minute rituximab infusion in cycle 2 of rituximab with cyclophosphamide, doxorubicin, vincristine and prednisolone. Results: All 32 patients (median age 61.5 years, 16 males, 24 with diffuse large B-cell lymphoma) completed the prescribed six or eight cycles of treatment. One patient withdrew consent after cycle 1, and another developed grade 2 erythema and continued receiving 4 mg/mL at the standard infusion rate for cycle 2. The remaining 30 patients received 90-minute rituximab infusion; 28 (93.3%) completed cycle 2 at the scheduled infusion rate and dosage. No grade 3 or higher infusion-related reactions were associated with a concentration of 4 mg/mL rituximab dose or 90-min rituximab infusion in cycle 2. The most common infusion-related reaction symptoms were pruritus, hypertension and oropharyngeal discomfort. During the study, toxicities and adverse events were as expected, with no new safety signals. Conclusion: High-concentration dosing (4 mg/mL) and 90-minute infusion of rituximab are feasible and tolerable in Japanese patients with previously untreated follicular lymphoma or diffuse large B-cell lymphoma. Clinical trial number: JapicCTI-173 663.
MeSH term(s)	Male ; Humans ; Middle Aged ; Rituximab/therapeutic use ; Vincristine/adverse effects ; Lymphoma, Follicular/drug therapy ; Japan ; Prednisone/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Cyclophosphamide/adverse effects ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/pathology ; Doxorubicin/therapeutic use ; Prednisolone/therapeutic use
Chemical Substances	Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Prednisone (VB0R961HZT) ; Cyclophosphamide (8N3DW7272P) ; Doxorubicin (80168379AG) ; Prednisolone (9PHQ9Y1OLM)
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Clinical Trial, Phase II ; Journal Article
ZDB-ID	190978-2
ISSN	1465-3621 ; 0368-2811
ISSN (online)	1465-3621
ISSN	0368-2811
DOI	10.1093/jjco/hyad193
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Zs.A 1298: Show issues

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Article ; Online: Validation of asthma discrimination criteria using health insurance claims data in Japan: Additional proposals for more specific criteria.

Hamada, Yuto / Nakatani, Eiji / Nagahama, Takayoshi / Nagai, Katsuhiko / Nagayama, Kisako / Tomita, Yasuhiro / Kamide, Yosuke / Sekiya, Kiyoshi / Taniguchi, Masami / Fukutomi, Yuma

Allergology international : official journal of the Japanese Society of Allergology

2023 Volume 72, Issue 4, Page(s) 594–596

MeSH term(s)	Humans ; Japan ; Asthma/diagnosis ; Asthma/epidemiology ; Asthma/therapy ; Insurance, Health
Language	English
Publishing date	2023-05-17
Publishing country	England
Document type	Letter
ZDB-ID	1336498-4
ISSN	1440-1592 ; 1323-8930
ISSN (online)	1440-1592
ISSN	1323-8930
DOI	10.1016/j.alit.2023.05.002
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Article ; Online: Recruiting more proteins to the RNA world.

Scott, William G / Nagai, Kiyoshi

Science (New York, N.Y.)

2018 Volume 362, Issue 6415, Page(s) 644–645

MeSH term(s)	Proteins ; RNA ; RNA, Transfer ; Ribonuclease P ; Saccharomyces cerevisiae
Chemical Substances	Proteins ; RNA (63231-63-0) ; RNA, Transfer (9014-25-9) ; Ribonuclease P (EC 3.1.26.5)
Language	English
Publishing date	2018-11-08
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.aav4743
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Article ; Online: Structural basis for conformational equilibrium of the catalytic spliceosome.

Wilkinson, Max E / Fica, Sebastian M / Galej, Wojciech P / Nagai, Kiyoshi

Molecular cell

2021 Volume 81, Issue 7, Page(s) 1439–1452.e9

Abstract: The ATPase Prp16 governs equilibrium between the branching ( ... ...

Abstract	The ATPase Prp16 governs equilibrium between the branching (B
MeSH term(s)	Models, Chemical ; RNA Splicing ; RNA, Fungal/chemistry ; RNA, Fungal/genetics ; RNA, Fungal/metabolism ; RNA-Binding Proteins/chemistry ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Saccharomyces cerevisiae/chemistry ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Spliceosomes/chemistry ; Spliceosomes/genetics ; Spliceosomes/metabolism
Chemical Substances	RNA, Fungal ; RNA-Binding Proteins ; Saccharomyces cerevisiae Proteins
Language	English
Publishing date	2021-03-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2021.02.021
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Zs.A 5055: Show issues

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Article ; Online: Lumbar Spinal Canal Stenosis in Acromegaly: A Case Report and Literature Review.

Yoshizawa, Miyako / Nagai, Kosuke / Asano, Shoko / Hori, Takeshi / Takagawa, Kiyoshi / Shimatsu, Akira

Internal medicine (Tokyo, Japan)

2022 Volume 62, Issue 14, Page(s) 2093–2098

Abstract: A 60-year-old Japanese man diagnosed with acromegaly at 28 years old had difficulty walking due to worsening back pain. He had been treated with somatostatin analog since 57 years old, but his pain and numbness continued to worsen. Lumbar magnetic ... ...

Abstract	A 60-year-old Japanese man diagnosed with acromegaly at 28 years old had difficulty walking due to worsening back pain. He had been treated with somatostatin analog since 57 years old, but his pain and numbness continued to worsen. Lumbar magnetic resonance imaging showed disc bulging at L3/4 and L4/5, and he was diagnosed with lumbar spinal canal stenosis due to hypertrophy of the yellow ligament. Patients with acromegaly may complain of osteoarthropathy, so we must pay attention to the symptoms of spinal canal stenosis in collaboration with orthopedic specialists.
MeSH term(s)	Male ; Humans ; Adult ; Middle Aged ; Acromegaly/complications ; Acromegaly/diagnosis ; Constriction, Pathologic ; Lumbar Vertebrae/diagnostic imaging ; Spinal Stenosis/complications ; Spinal Stenosis/diagnostic imaging ; Back Pain ; Magnetic Resonance Imaging ; Spinal Canal/diagnostic imaging
Language	English
Publishing date	2022-12-07
Publishing country	Japan
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.0763-22
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