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  1. Article ; Online: Newman and Twentieth-Century French Theology. The Presence of J. H. Newman in Y. M. Congar, H. de Lubac y J. Daniélou

    James Patrick Hurley

    Anuario de Historia de la Iglesia, Vol 20, Pp 473-

    2011  Volume 478

    Keywords History (General) ; D1-2009 ; History (General) and history of Europe ; D
    Language Spanish
    Publishing date 2011-01-01T00:00:00Z
    Publisher Universidad de Navarra
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Toward a standard model for autophagosome biogenesis.

    Cook, Annan S I / Hurley, James H

    The Journal of cell biology

    2023  Volume 222, Issue 7

    Abstract: ... biogenesis in mammals. The first, Olivas et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202208088 ... while the second, Broadbent et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202210078), uses particle ...

    Abstract Two papers in this issue resolve a long-standing obstacle to a "standard model" for autophagosome biogenesis in mammals. The first, Olivas et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202208088), uses biochemistry to confirm that the lipid scramblase ATG9A is a bona fide autophagosome component, while the second, Broadbent et al. (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202210078), uses particle tracking to show that the dynamics of autophagy proteins are consistent with the concept.
    MeSH term(s) Animals ; Autophagosomes ; Autophagy ; Macroautophagy ; Mammals ; Autophagy-Related Proteins
    Chemical Substances Autophagy-Related Proteins
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202304011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Surface colonization by

    Magesh, Shruthi / Hurley, Amanda I / Nepper, Julia F / Chevrette, Marc G / Schrope, Jonathan H / Li, Chao / Beebe, David J / Handelsman, Jo

    mBio

    2024  Volume 15, Issue 3, Page(s) e0342823

    Abstract: Flavobacterium johnsoniae: Importance: Microbial communities direct key environmental processes through multispecies interactions. Understanding these interactions is vital for manipulating microbiomes to promote health in human, environmental, and ... ...

    Abstract Flavobacterium johnsoniae
    Importance: Microbial communities direct key environmental processes through multispecies interactions. Understanding these interactions is vital for manipulating microbiomes to promote health in human, environmental, and agricultural systems. However, microbiome complexity can hinder our understanding of the underlying mechanisms in microbial community interactions. As a first step toward unraveling these interactions, we explored the role of surface colonization in microbial community interactions using
    MeSH term(s) Humans ; Health Promotion ; Sand ; Flavobacterium/genetics ; Microbiota ; Bacterial Proteins/metabolism
    Chemical Substances Sand ; Bacterial Proteins
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.03428-23
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  4. Article ; Online: Bile acids and neurological disease.

    Hurley, Michael J / Bates, Rachel / Macnaughtan, Jane / Schapira, Anthony H V

    Pharmacology & therapeutics

    2022  Volume 240, Page(s) 108311

    Abstract: This review will focus on how bile acids are being used in clinical trials to treat neurological diseases due to their central involvement with the gut-liver-brain axis and their physiological and pathophysiological roles in both normal brain function ... ...

    Abstract This review will focus on how bile acids are being used in clinical trials to treat neurological diseases due to their central involvement with the gut-liver-brain axis and their physiological and pathophysiological roles in both normal brain function and multiple neurological diseases. The synthesis of primary and secondary bile acids species and how the regulation of the bile acid pool may differ between the gut and brain is discussed. The expression of several bile acid receptors in brain and their currently known functions along with the tools available to manipulate them pharmacologically are examined, together with discussion of the interaction of bile acids with the gut microbiome and their lesser-known effects upon brain glucose and lipid metabolism. How dysregulation of the gut microbiome, aging and sex differences may lead to disruption of bile acid signalling and possible causal roles in a number of neurological disorders are also considered. Finally, we discuss how pharmacological treatments targeting bile acid receptors are currently being tested in an array of clinical trials for several different neurodegenerative diseases.
    MeSH term(s) Female ; Humans ; Male ; Bile Acids and Salts ; Nervous System Diseases/drug therapy ; Gastrointestinal Microbiome ; Brain ; Aging
    Chemical Substances Bile Acids and Salts
    Language English
    Publishing date 2022-11-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 194735-7
    ISSN 1879-016X ; 0163-7258
    ISSN (online) 1879-016X
    ISSN 0163-7258
    DOI 10.1016/j.pharmthera.2022.108311
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    Zs.A 1183: Show issues Location:
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  5. Article ; Online: Validation of a commercially available photometric analytical system for assessment of plasma oxidative status in healthy horses.

    Vaughn, Sarah A / Norton, Natalie A / Hurley, David J / Hart, Kelsey A

    Veterinary immunology and immunopathology

    2023  Volume 265, Page(s) 110665

    Abstract: ... expected, dose-dependent increases in dROM generated by adding increasing concentrations of H ...

    Abstract Reactive oxygen species (ROS) are the end-products of physiologic functions in health. Oxidative stress occurs when endogenous antioxidants are insufficient to neutralize ROS in the system. As a result, ROS can damage DNA, RNA, proteins, lipids, and cell organelles. To obtain accurate measurements of plasma oxidative stress, levels of both oxidants and antioxidants must be measured. This study validates a commercially available, semi-quantitative, photometric analytical system that measures systemic determinants of reactive oxygen metabolites (dROM) and plasma antioxidant capacity (PAC) in stored equine plasma. The objectives of this work were: 1) to validate a photometric analytical system to quantify dROM and PAC in equine plasma; and 2) to determine expected results for these tests in healthy adult horses. We hypothesized that this system would reliably and reproducibly assess dROM and PAC in equine plasma. We observed expected, dose-dependent increases in dROM generated by adding increasing concentrations of H
    MeSH term(s) Animals ; Horses ; Reactive Oxygen Species/metabolism ; Hydrogen Peroxide ; Antioxidants/metabolism ; Oxidative Stress ; Oxidants
    Chemical Substances Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V) ; Antioxidants ; Oxidants
    Language English
    Publishing date 2023-10-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 754160-0
    ISSN 1873-2534 ; 0165-2427
    ISSN (online) 1873-2534
    ISSN 0165-2427
    DOI 10.1016/j.vetimm.2023.110665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2177: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Towards actinide heterostructure synthesis and science.

    Dennett, Cody A / Poudel, Narayan / Simmonds, Paul J / Tiwari, Ashutosh / Hurley, David H / Gofryk, Krzysztof

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 2221

    MeSH term(s) Actinoid Series Elements/chemistry
    Chemical Substances Actinoid Series Elements
    Language English
    Publishing date 2022-04-25
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-29817-0
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  7. Article ; Online: A firehose for phospholipids.

    Prinz, William A / Hurley, James H

    The Journal of cell biology

    2020  Volume 219, Issue 5

    Abstract: ... In this issue, Li et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202001161) show that Vps13 has ...

    Abstract All lipid transport proteins in eukaryotes are thought to shuttle lipids between cellular membranes. In this issue, Li et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202001161) show that Vps13 has a channel-like domain that may allow lipids to flow between closely apposed membranes at contact sites.
    MeSH term(s) Cell Membrane ; Cryoelectron Microscopy ; Membranes ; Mitochondrial Membranes ; Phospholipids
    Chemical Substances Phospholipids
    Language English
    Publishing date 2020-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.202003132
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    Ub I Zs.190: Show issues Location:
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  8. Article ; Online: Magnetic Resonance Arthrography in Rugby Players Undergoing Shoulder Stabilization for Glenohumeral Instability: Professionals Have Higher Frequencies of More Pathologies.

    Davey, Martin S / Hurley, Eoghan T / Hurley, Daire J / Pauzenberger, Leo / Mullett, Hannan

    Arthroscopy, sports medicine, and rehabilitation

    2021  Volume 3, Issue 2, Page(s) e543–e547

    Abstract: Purpose: To quantify the magnetic resonance arthrography (MRA) findings in rugby players during preoperative workup for anterior surgical stabilization for glenohumeral instability.: Methods: All patients who underwent glenohumeral instability ... ...

    Abstract Purpose: To quantify the magnetic resonance arthrography (MRA) findings in rugby players during preoperative workup for anterior surgical stabilization for glenohumeral instability.
    Methods: All patients who underwent glenohumeral instability surgery in our institution between 2008 and 2018 were considered for inclusion. Rugby players were identified using the patient's medical notes, with subsequent identification of all professional players. All rugby player's preoperative MRA findings were recorded and analyzed.
    Results: Overall, 267 rugby players were included, 261 of whom were male (97.8%), with a mean age of 22.7 years (range 13-55 years). There were 58 professional rugby players (21.7%). The mean number of pathologies in nonprofessional rugby players was 5.0 pathologies versus 6.2 pathologies in the professional rugby players, with a significant difference in nonprofessional rugby players with up to 3 pathologies versus professional rugby players (26.3% vs 10.3%,
    Conclusions: Rugby players undergoing surgical stabilization for glenohumeral instability often have a significant number of pathologies identified on MRA at the time of surgery. Professional rugby players showed concerningly greater frequencies of early degenerative changes when compared with nonprofessional rugby players.
    Level of evidence: III; Retrospective Cohort Study.
    Language English
    Publishing date 2021-02-23
    Publishing country United States
    Document type Journal Article
    ISSN 2666-061X
    ISSN (online) 2666-061X
    DOI 10.1016/j.asmr.2020.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: In-Situ Transmission Electron Microscopy Study of the Evolution of Extended Defects in Oxide Nuclear Fuels.

    Bawane, Kaustubh / He, Lingfeng / Kombaiah, Boopathy / Mann, J Matthew / Shao, Lin / Khafizov, Marat / Hurley, David H

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue Supplement_1, Page(s) 1561–1562

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.803
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  10. Article ; Online: Trust criteria for artificial intelligence in health: normative and epistemic considerations.

    Kostick-Quenet, Kristin / Lang, Benjamin H / Smith, Jared / Hurley, Meghan / Blumenthal-Barby, Jennifer

    Journal of medical ethics

    2023  

    Abstract: Rapid advancements in artificial intelligence and machine learning (AI/ML) in healthcare raise pressing questions about how much users should trust AI/ML systems, particularly for high stakes clinical decision-making. Ensuring that user trust is properly ...

    Abstract Rapid advancements in artificial intelligence and machine learning (AI/ML) in healthcare raise pressing questions about how much users should trust AI/ML systems, particularly for high stakes clinical decision-making. Ensuring that user trust is properly calibrated to a tool's computational capacities and limitations has both practical and ethical implications, given that overtrust or undertrust can influence over-reliance or under-reliance on algorithmic tools, with significant implications for patient safety and health outcomes. It is, thus, important to better understand how variability in trust criteria across stakeholders, settings, tools and use cases may influence approaches to using AI/ML tools in real settings. As part of a 5-year, multi-institutional Agency for Health Care Research and Quality-funded study, we identify trust criteria for a survival prediction algorithm intended to support clinical decision-making for left ventricular assist device therapy, using semistructured interviews (n=40) with patients and physicians, analysed via thematic analysis. Findings suggest that physicians and patients share similar empirical considerations for trust, which were primarily
    Language English
    Publishing date 2023-11-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 194927-5
    ISSN 1473-4257 ; 0306-6800
    ISSN (online) 1473-4257
    ISSN 0306-6800
    DOI 10.1136/jme-2023-109338
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