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  1. Article ; Online: Metabolic Molecular Diagnosis of Inflammatory Bowel Disease by Synergistical Promotion of Layered Titania Nanosheets with Graphitized Carbon.

    Hu, Xufang / Zhang, Yang / Deng, Chunhui / Sun, Nianrong / Wu, Hao

    Phenomics (Cham, Switzerland)

    2022  Volume 2, Issue 4, Page(s) 261–271

    Abstract: Due to inefficient diagnostic methods, inflammatory bowel disease (IBD) normally progresses into severe complications including cancer. Highly efficient extraction and identification of metabolic fingerprints are of significance for disease surveillance. ...

    Abstract Due to inefficient diagnostic methods, inflammatory bowel disease (IBD) normally progresses into severe complications including cancer. Highly efficient extraction and identification of metabolic fingerprints are of significance for disease surveillance. In this work, we synthesized a layered titania nanosheet doped with graphitized carbon (2D-GC-mTNS) through a simple one-step assembly process for assisting laser desorption ionization mass spectrometry (LDI-MS) for metabolite analysis. Based on the synergistic effect of graphitized carbon and mesoporous titania, 2D-GC-mTNS exhibits good extraction ability including high sensitivity (< 1 fmol µL
    Supplementary information: The online version contains supplementary material available at 10.1007/s43657-022-00055-0.
    Language English
    Publishing date 2022-06-01
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2730-5848
    ISSN (online) 2730-5848
    DOI 10.1007/s43657-022-00055-0
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  2. Article ; Online: Hollow Crystallization COF Capsuled MOF Hybrids Depict Serum Metabolic Profiling for Precise Early Diagnosis and Risk Stratification of Acute Coronary Syndrome.

    Yang, Chenjie / Pan, Yilong / Yu, Hailong / Hu, Xufang / Li, Xiaodong / Deng, Chunhui

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2023  Volume 10, Issue 24, Page(s) e2302109

    Abstract: Acute coronary syndrome (ACS), comprising unstable angina (UA) and acute myocardial infarction (AMI), is the leading cause of death worldwide. Currently, lacking effective strategies for classifying ACS hinders the prognosis improvement of ACS patients. ... ...

    Abstract Acute coronary syndrome (ACS), comprising unstable angina (UA) and acute myocardial infarction (AMI), is the leading cause of death worldwide. Currently, lacking effective strategies for classifying ACS hinders the prognosis improvement of ACS patients. Disclosing the nature of metabolic disorders holds the potential to reflect disease progress and high-throughput mass spectrometry-based metabolic analysis is a promising tool for large-scale screening. Herein, a hollow crystallization COF capsuled MOF hybrids (UiO-66@HCOF) assisted serum metabolic analysis is developed for the early diagnosis and risk stratification of ACS. UiO-66@HCOF exhibits unrivaled chemical and structural stability as well as endowing satisfying desorption/ionization efficiency in the detection of metabolites. Paired with machine learning algorithms, early diagnosis of ACS is achieved with the area under the curve (AUC) value of 0.945 for validation sets. Besides, a comprehensive ACS risk stratification method is established, and the AUC value for the discrimination of ACS from healthy controls, and AMI from UA are 0.890, and 0.928. Moreover, the AUC value of the subtyping of AMI is 0.964. Finally, the potential biomarkers exhibit high sensitivity and specificity. This study makes metabolic molecular diagnosis a reality and provided new insight into the progress of ACS.
    MeSH term(s) Humans ; Acute Coronary Syndrome/diagnosis ; Crystallization ; Myocardial Infarction/diagnosis ; Angina, Unstable/diagnosis ; Early Diagnosis ; Risk Assessment/methods
    Chemical Substances UiO-66
    Language English
    Publishing date 2023-06-20
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202302109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Application of an alkali destruction technique and natural deep eutectic solvent for greener extraction from peanut shells: optimization and extraction kinetics study.

    Deng, Meifeng / Wang, Hailong / Geng, Shuwen / Guan, Xufang / Liang, Ning

    Analytical methods : advancing methods and applications

    2022  Volume 14, Issue 16, Page(s) 1594–1602

    Abstract: Peanut shells are an agricultural by-product rich in flavonoids, but their utilization is not high at present. This research developed a method for the rational utilization of flavonoids in peanut shells, which could enhance the comprehensive utilization ...

    Abstract Peanut shells are an agricultural by-product rich in flavonoids, but their utilization is not high at present. This research developed a method for the rational utilization of flavonoids in peanut shells, which could enhance the comprehensive utilization of peanut resources. A green and efficient natural extraction technique based on a natural deep eutectic solvent (NADES) and alkaline destruction was exploited for the extraction of the flavonoids from peanut shells. NADES synthesized with DL-menthol (Me) and DL-lactic acid (LA) was selected as the solvent. KOH was used as a destructive agent that could destroy the structure of Me/LA, which could aid not only recovering the flavonoids, but also aid Me recovery and recycling. The NADES with the molar ratio of Me to LA of 1 : 4 showed a higher extraction capacity for flavonoids and better maintenance of antioxidant activity than water and ethanol. The maximum extraction efficiency was 23.33 mg rutin equivalents per g. In addition, the mass-transfer kinetics model of flavonoids extraction was established using Fick's second law, which well fitted the experimental results and proved that the temperature had a significant effect on the extraction efficiency. These results offered some insights for the research and exploitation of an environmentally friendly method to extract bio-active flavonoids for future applications in actual industrial manufacturing.
    MeSH term(s) Alkalies ; Arachis ; Deep Eutectic Solvents ; Flavonoids/chemistry ; Kinetics ; Solvents/chemistry
    Chemical Substances Alkalies ; Deep Eutectic Solvents ; Flavonoids ; Solvents
    Language English
    Publishing date 2022-04-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d1ay02033a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model.

    Tan, Bin / Zhang, Xiaoming / Ansari, Ahmadullah / Jadhav, Prakash / Tan, Haozhou / Li, Kan / Chopra, Ashima / Ford, Alexandra / Chi, Xiang / Ruiz, Francesc Xavier / Arnold, Eddy / Deng, Xufang / Wang, Jun

    Science (New York, N.Y.)

    2024  Volume 383, Issue 6690, Page(s) 1434–1440

    Abstract: The emergence of SARS-CoV-2 variants and drug-resistant mutants calls for additional oral antivirals. The SARS-CoV-2 papain-like protease ( ... ...

    Abstract The emergence of SARS-CoV-2 variants and drug-resistant mutants calls for additional oral antivirals. The SARS-CoV-2 papain-like protease (PL
    MeSH term(s) Animals ; Mice ; Coronavirus Papain-Like Proteases/antagonists & inhibitors ; Coronavirus Papain-Like Proteases/chemistry ; COVID-19 ; Disease Models, Animal ; SARS-CoV-2/drug effects ; SARS-CoV-2/enzymology ; Coronavirus Protease Inhibitors/administration & dosage ; Coronavirus Protease Inhibitors/chemistry ; Coronavirus Protease Inhibitors/pharmacology ; Drug Design ; COVID-19 Drug Treatment ; Administration, Oral ; Crystallography, X-Ray ; Structure-Activity Relationship ; Viral Load/drug effects ; Male ; Mice, Inbred C57BL ; Mice, Inbred BALB C
    Chemical Substances Coronavirus Papain-Like Proteases (EC 3.4.22.2) ; papain-like protease, SARS-CoV-2 (EC 3.4.22.2) ; Coronavirus Protease Inhibitors
    Language English
    Publishing date 2024-03-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adm9724
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 27: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 77: Show issues

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  5. Article ; Online: Specific enrichment and glycosylation discrepancy profiling of cellular exosomes using a dual-affinity probe.

    Zhang, Ning / Hu, Xufang / Chen, Haolin / Deng, Chunhui / Sun, Nianrong

    Chemical communications (Cambridge, England)

    2021  Volume 57, Issue 51, Page(s) 6249–6252

    Abstract: A hydrophilic probe is employed to enrich exosomes from three kinds of cancer cells by TiO2-phosphate interaction and exosomal glycoproteins by hydrophilic interaction in succession. The probe performs efficiently in both the enrichment processes. And ... ...

    Abstract A hydrophilic probe is employed to enrich exosomes from three kinds of cancer cells by TiO2-phosphate interaction and exosomal glycoproteins by hydrophilic interaction in succession. The probe performs efficiently in both the enrichment processes. And the analytical results confirm that unique exosomal glycoproteins can distinguish parent exosomes from others.
    MeSH term(s) Cell Line, Tumor ; Exosomes/metabolism ; Ferrosoferric Oxide/chemistry ; Glutathione/chemistry ; Glutathione/metabolism ; Glycoproteins/analysis ; Glycoproteins/metabolism ; Glycosylation ; Humans ; Hydrophobic and Hydrophilic Interactions ; Magnetite Nanoparticles/chemistry ; Molecular Probes/chemistry ; Molecular Probes/metabolism ; Proteomics/methods ; Titanium/chemistry
    Chemical Substances Glycoproteins ; Magnetite Nanoparticles ; Molecular Probes ; titanium dioxide (15FIX9V2JP) ; Titanium (D1JT611TNE) ; Glutathione (GAN16C9B8O) ; Ferrosoferric Oxide (XM0M87F357)
    Language English
    Publishing date 2021-05-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc01530c
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  6. Article ; Online: Dual metal cations coated magnetic mesoporous silica probe for highly selective capture of endogenous phosphopeptides in biological samples.

    Hu, Xufang / Li, Yilin / Miao, Aizhu / Deng, Chunhui

    Mikrochimica acta

    2020  Volume 187, Issue 7, Page(s) 400

    Abstract: For the first time, dual metal ions ( ... ...

    Abstract For the first time, dual metal ions (Ti
    MeSH term(s) Animals ; Caseins/isolation & purification ; Cattle ; Chemical Fractionation/methods ; Ferrosoferric Oxide/chemistry ; Humans ; Indoles/chemistry ; Magnetic Phenomena ; Microspheres ; Nanocomposites/chemistry ; Peptide Fragments/isolation & purification ; Phosphopeptides/isolation & purification ; Polymers/chemistry ; Porosity ; Saliva/chemistry ; Serum Albumin, Bovine/isolation & purification ; Silicon Dioxide/chemistry ; Titanium/chemistry ; Zirconium/chemistry
    Chemical Substances Caseins ; Indoles ; Peptide Fragments ; Phosphopeptides ; Polymers ; polydopamine ; Serum Albumin, Bovine (27432CM55Q) ; Silicon Dioxide (7631-86-9) ; Zirconium (C6V6S92N3C) ; Titanium (D1JT611TNE) ; Ferrosoferric Oxide (XM0M87F357)
    Language English
    Publishing date 2020-06-22
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 89-9
    ISSN 1436-5073 ; 0026-3672
    ISSN (online) 1436-5073
    ISSN 0026-3672
    DOI 10.1007/s00604-020-04323-6
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    In stock of ZB MED Bonn / Germany

    Z 56/171: Show issues
    Z 8.1: Show issues

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  7. Article: Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir.

    Hu, Yanmei / Lewandowski, Eric M / Tan, Haozhou / Zhang, Xiaoming / Morgan, Ryan T / Zhang, Xiujun / Jacobs, Lian M C / Butler, Shane G / Gongora, Maura V / Choy, John / Deng, Xufang / Chen, Yu / Wang, Jun

    ACS central science

    2023  Volume 9, Issue 8, Page(s) 1658–1669

    Abstract: The SARS-CoV-2 main protease ( ... ...

    Abstract The SARS-CoV-2 main protease (M
    Language English
    Publishing date 2023-07-24
    Publishing country United States
    Document type Journal Article
    ISSN 2374-7943
    ISSN 2374-7943
    DOI 10.1021/acscentsci.3c00538
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  8. Article: Design of SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model.

    Tan, Bin / Zhang, Xiaoming / Ansari, Ahmadullah / Jadhav, Prakash / Tan, Haozhou / Li, Kan / Chopra, Ashima / Ford, Alexandra / Chi, Xiang / Ruiz, Francesc Xavier / Arnold, Eddy / Deng, Xufang / Wang, Jun

    bioRxiv : the preprint server for biology

    2023  

    Abstract: The emergence of SARS-CoV-2 variants and drug-resistant mutants calls for additional oral antivirals. The SARS-CoV-2 papain-like protease ( ... ...

    Abstract The emergence of SARS-CoV-2 variants and drug-resistant mutants calls for additional oral antivirals. The SARS-CoV-2 papain-like protease (PL
    Language English
    Publishing date 2023-12-03
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.01.569653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Diagnosing, Typing, and Staging of Renal Cell Carcinoma by Designer Matrix-Based Urinary Metabolic Analysis.

    Hu, Xufang / Wang, Zongping / Chen, Haolin / Zhao, An / Sun, Nianrong / Deng, Chunhui

    Analytical chemistry

    2022  Volume 94, Issue 43, Page(s) 14846–14853

    Abstract: Molecular diagnosing, typing, and staging have been considered to be the ideal alternatives of imaging-based detection methods in clinics. Designer matrix-based analytical tools, with high speed, throughout, efficiency and low/noninvasiveness, have ... ...

    Abstract Molecular diagnosing, typing, and staging have been considered to be the ideal alternatives of imaging-based detection methods in clinics. Designer matrix-based analytical tools, with high speed, throughout, efficiency and low/noninvasiveness, have attracted much attention recently for in vitro metabolite detection. Herein, we develop an advanced metabolic analysis tool based on highly porous metal oxides derived from available metal-organic frameworks (MOFs), which elaborately inherit the morphology and porosity of MOFs and newly incorporate laser adsorption capacity of metal oxides. Through optimized conditions, direct high-quality fingerprinting spectra in 0.5 μL of urine are acquired. Using these fingerprinting spectra, we can discriminate the renal cell carcinoma (RCC) from healthy controls with higher than 0.99 of area under the curve (AUC) values (
    MeSH term(s) Humans ; Carcinoma, Renal Cell/metabolism ; Kidney Neoplasms/diagnostic imaging ; Kidney Neoplasms/metabolism ; Diagnosis, Differential ; Urinalysis ; Oxides ; Neoplasm Staging
    Chemical Substances Oxides
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.2c01563
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4033: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  10. Article: Functionalized nanomaterials in separation and analysis of extracellular vesicles and their contents

    Zhang, Ning / Chen, Haolin / Yang, Chenjie / Hu, Xufang / Sun, Nianrong / Deng, Chunhui

    Trends in analytical chemistry. 2022 Aug., v. 153

    2022  

    Abstract: Extracellular vesicles are closely related to most of physiological and pathological events in organisms, and can be applied as therapeutic targets or disease indicators. Whereas the complex physiological environment where they face makes it difficult to ...

    Abstract Extracellular vesicles are closely related to most of physiological and pathological events in organisms, and can be applied as therapeutic targets or disease indicators. Whereas the complex physiological environment where they face makes it difficult to conduct direct analysis. In order to solve this problem, many efforts have been made during the past years, among which nanomaterials attract much attention because of their outstanding flexibility in preparation and operation. This article reviews the recent progress of nanomaterials in the separation and analysis of extracellular vesicles, focusing on the applications of nanomaterials in the enrichment of extracellular vesicles and their contents. Also, some tips for exosome separation and analysis are briefly suggested.
    Keywords analytical chemistry ; exosomes ; therapeutics
    Language English
    Dates of publication 2022-08
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2014041-1
    ISSN 0165-9936
    ISSN 0165-9936
    DOI 10.1016/j.trac.2022.116652
    Database NAL-Catalogue (AGRICOLA)

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