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Article ; Online: A scoping review to inform the development of dementia care competencies.

Kay, Kelly / Metersky, Kateryna / Smye, Victoria / McGrath, Colleen / Johnson, Karen / Astell, Arlene / Sun, Winnie / Bartfay, Emma

Dementia (London, England)

2023 Volume 22, Issue 5, Page(s) 1138–1163

Abstract: ... of the core knowledge, skills, and abilities, (i.e., competencies) that should underpin dementia-related ...

Abstract	Health professionals and care partners of persons living with dementia have expressed that learning needs related to dementia care are a priority. There are currently a variety of training programs available in Ontario (Canada) to address aspects of dementia care, but no commonly accepted description of the core knowledge, skills, and abilities, (i.e., competencies) that should underpin dementia-related training and education in the province. The aim of this study was to review current evidence to inform the later development of competency statements describing the knowledge, skills and actions required for dementia care among care providers ranging from laypersons to health professionals. We also sought to validate existing dementia care principles and align new concepts to provide a useful organizing framework for future competency development. We distinguished between micro-, meso- and macro-level concepts to clarify the competencies required by individuals situated in different locations across the healthcare system, linking competency development in dementia care to broader system transformation. This review precedes the co-development of a holistic competency framework to guide approaches to dementia care training in Ontario.
MeSH term(s)	Humans ; Clinical Competence ; Dementia/therapy ; Health Personnel/education ; Curriculum ; Ontario
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	2084045-7
ISSN	1741-2684 ; 1471-3012
ISSN (online)	1741-2684
ISSN	1471-3012
DOI	10.1177/14713012231165568
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Article ; Online: Adaptations to support occupational engagement with age-related vision loss: A metasynthesis study.

McGrath, Colleen E / Corrado, Ann Marie

Canadian journal of occupational therapy. Revue canadienne d'ergotherapie

2019 Volume 86, Issue 5, Page(s) 377–387

Abstract: Background.: Age-related vision loss (ARVL) is a progressive process that adversely affects older adults' occupational engagement. As such, older adults often employ a variety of psychological adaptation strategies.: Purpose.: The purpose of this ... ...

Abstract	Background.: Age-related vision loss (ARVL) is a progressive process that adversely affects older adults' occupational engagement. As such, older adults often employ a variety of psychological adaptation strategies. Purpose.: The purpose of this study was to identify those psychological adaptation strategies employed by older adults aging with ARVL. Method.: This metasynthesis searched and identified 21 qualitative articles that described a link between psychological adaptation strategies and occupational engagement. Findings.: The psychological strategies identified were categorized into five themes. The strategies of persisting with hope, positivity, and acceptance and portraying a self-image consistent with independence, competence, and self-reliance were well established in the literature, while other themes were more emerging, such as using humour, relying on religious/spiritual beliefs, and comparing the self to others. Implications.: By understanding the psychological adaptation strategies employed by older adults with ARVL, occupational therapists will be better positioned to guide their clients toward positive adaptive patterns.
MeSH term(s)	Adaptation, Psychological ; Aged ; Aged, 80 and over ; Aging/psychology ; Blindness/psychology ; Blindness/rehabilitation ; Female ; Hope ; Humans ; Male ; Middle Aged ; Occupational Therapy/organization & administration ; Qualitative Research ; Self Efficacy
Language	English
Publishing date	2019-05-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	417302-8
ISSN	1911-9828 ; 0008-4174 ; 0315-1026
ISSN (online)	1911-9828
ISSN	0008-4174 ; 0315-1026
DOI	10.1177/0008417419834422
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Article ; Online: Marital Status, Living Arrangement, and Survival among Individuals with Advanced Prostate Cancer in the International Registry for Men with Advanced Prostate Cancer.

Chen, Naiyu / McGrath, Colleen B / Ericsson, Caroline I / Vaselkiv, Jane B / Rencsok, Emily M / Stopsack, Konrad H / Guard, Hannah E / Autio, Karen A / Rathkopf, Dana E / Enting, Deborah / Bitting, Rhonda L / Mateo, Joaquin / Githiaka, Charles W / Chi, Kim N / Cheng, Heather H / Davis, Ian D / Anderson, Simon G / Badal, Simone Ann Marie / Bjartell, Anders /

Russnes, Kjell M / Heath, Elisabeth I / Pomerantz, Mark M / Henegan, John C / Hyslop, Terry / Esteban, Emilio / Omlin, Aurelius / McDermott, Ray / Fay, Andre P / Popoola, Ademola Alabi / Ragin, Camille / Nowak, Joel / Gerke, Travis / Kantoff, Philip W / George, Daniel J / Penney, Kathryn L / Mucci, Lorelei A

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2024 Volume 33, Issue 3, Page(s) 419–425

Abstract: Background: Studies have shown improved survival among individuals with cancer with higher levels of social support. Few studies have investigated social support and overall survival (OS) in individuals with advanced prostate cancer in an international ... ...

Abstract	Background: Studies have shown improved survival among individuals with cancer with higher levels of social support. Few studies have investigated social support and overall survival (OS) in individuals with advanced prostate cancer in an international cohort. We investigated the associations of marital status and living arrangements with OS among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer (IRONMAN). Methods: IRONMAN is enrolling participants diagnosed with advanced prostate cancer (metastatic hormone-sensitive prostate cancer, mHSPC; castration-resistant prostate cancer, CRPC) from 16 countries. Participants in this analysis were recruited between July 2017 and January 2023. Adjusting for demographics and tumor characteristics, the associations were estimated using Cox regression and stratified by disease state (mHSPC, CRPC), age (<70, ≥70 years), and continent of enrollment (North America, Europe, Other). Results: We included 2,119 participants with advanced prostate cancer, of whom 427 died during up to 5 years of follow-up (median 6 months). Two-thirds had mHSPC. Most were married/in a civil partnership (79%) and 6% were widowed. Very few married participants were living alone (1%), while most unmarried participants were living alone (70%). Married participants had better OS than unmarried participants [adjusted HR: 1.44; 95% confidence interval (CI): 1.02-2.02]. Widowed participants had the worst survival compared with married individuals (adjusted HR: 1.89; 95% CI: 1.22-2.94). Conclusions: Among those with advanced prostate cancer, unmarried and widowed participants had worse OS compared with married participants. Impact: This research highlighted the importance of social support in OS within this vulnerable population.
MeSH term(s)	Male ; Humans ; Aged ; Prostatic Neoplasms, Castration-Resistant ; Marital Status ; Registries ; Europe ; Social Support
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-23-1207
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Article: Self-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity.

Molecular therapy. Nucleic acids

2022 Volume 29, Page(s) 923–940

Abstract: The current coronavirus disease 2019 (COVID-19) pandemic highlights the need for broad-spectrum antiviral therapeutics. Here we describe a new class of self-assembling immunostimulatory short duplex RNAs that potently induce production of type I and type ...

Abstract	The current coronavirus disease 2019 (COVID-19) pandemic highlights the need for broad-spectrum antiviral therapeutics. Here we describe a new class of self-assembling immunostimulatory short duplex RNAs that potently induce production of type I and type III interferon (IFN-I and IFN-III). These RNAs require a minimum of 20 base pairs, lack any sequence or structural characteristics of known immunostimulatory RNAs, and instead require a unique sequence motif (sense strand, 5'-C; antisense strand, 3'-GGG) that mediates end-to-end dimer self-assembly. The presence of terminal hydroxyl or monophosphate groups, blunt or overhanging ends, or terminal RNA or DNA bases did not affect their ability to induce IFN. Unlike previously described immunostimulatory small interfering RNAs (siRNAs), their activity is independent of Toll-like receptor (TLR) 7/8, but requires the RIG-I/IRF3 pathway that induces a more restricted antiviral response with a lower proinflammatory signature compared with immunostimulant poly(I:C). Immune stimulation mediated by these duplex RNAs results in broad-spectrum inhibition of infections by many respiratory viruses with pandemic potential, including severe acute respiratory syndrome coronavirus (SARS-CoV)-2, SARS-CoV, Middle East respiratory syndrome coronavirus (MERS-CoV), human coronavirus (HCoV)-NL63, and influenza A virus in cell lines, human lung chips that mimic organ-level lung pathophysiology, and a mouse SARS-CoV-2 infection model. These short double-stranded RNAs (dsRNAs) can be manufactured easily, and thus potentially could be harnessed to produce broad-spectrum antiviral therapeutics.
Language	English
Publishing date	2022-08-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	2662631-7
ISSN	2162-2531
ISSN	2162-2531
DOI	10.1016/j.omtn.2022.08.031
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Article ; Online: The Occupational Therapy Examination and Practice Preparation (OTepp) Program

Susan E. Baptiste / Shaminder Dhillon / Kathryn Decker / Nancy Lidstone / Leah Dix / Colleen E. McGrath / Pat McMahon / Elizabeth Steggles / Claudia von Sweck

Journal of Occupational Therapy Education, Vol 4, Iss

Development, Implementation and Evaluation of an Educational Program for Internationally-Educated Occupational Therapists

2020 Volume 3

Abstract: This paper provides a chronological overview of the development, implementation, and evaluation of an educational initiative aimed at ensuring internationally-educated occupational therapists are prepared to enter practice in their new country, Canada. ... ...

Abstract	This paper provides a chronological overview of the development, implementation, and evaluation of an educational initiative aimed at ensuring internationally-educated occupational therapists are prepared to enter practice in their new country, Canada. The three major phases of the program’s 12-year evolution are described, to distill the key lessons learned at each phase. Data related to the demographics of participants, program content, results of the national examination, registration, and employment outcomes are included. An enhanced understanding of the transition experience of internationally educated occupational therapists provides a strong foundation from which to support internationally-educated colleagues and strengthen the occupational therapy profession.
Keywords	occupational therapy ; foreign professional personnel ; employment ; professional practice ; Special aspects of education ; LC8-6691 ; Medicine (General) ; R5-920
Subject code	028
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	Eastern Kentucky University
Document type	Article ; Online
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Article ; Online: Treasure (Hunt for) Your Health! Addressing Pediatric Social Determinants of Health Through Child-Friendly Community Engagement Events.

McGrath, Eric / Dwaihy, Meghan / Smitherman, Lynn / Behar, Miriam / Benjamins, Laura / Cockern, Nikki / Meade, Jill / Smith, Jameel / Marshall, Sharon / Youngman, Christopher / Buggs-Saxton, Colleen / Houston, Keshaum / Jones, Natalie / Secord, Elizabeth

Clinical pediatrics

2023 , Page(s) 99228231218160

Abstract: Social determinants of health (SDoH), including factors such as education level, housing, poverty, racism, and food insecurity and their impact on health outcomes have been well documented. The "Wayne Pediatrics Health and Nutrition Expo" held at Detroit' ...

Abstract	Social determinants of health (SDoH), including factors such as education level, housing, poverty, racism, and food insecurity and their impact on health outcomes have been well documented. The "Wayne Pediatrics Health and Nutrition Expo" held at Detroit's Eastern Market was an activity-based health and nutrition event addressing pediatric SDoH. Partnering with community organizations, the event had 10 stations addressing SDoH: access to a primary-care pediatrician; HIV-care and prevention; childhood literacy; clothing & winter coats; mental health and childhood development; nutrition; staying active; vaccination; and food insecurity. The free, public event featured a child-themed treasure hunt and map, music, giveaways, and live demonstrations, all in a family-friendly park atmosphere. While SDoH are considered "non-medical" factors that contribute to health and may be difficult to completely address for any individual child, our practice addressed several key SDoH at a single-day, hands-on, child-friendly community event based on the local needs of children.
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/00099228231218160
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Article: Assessment tools for evaluating fitness to drive: a critical appraisal of evidence.

Vrkljan, Brenda H / McGrath, Colleen E / Letts, Lori J

Canadian journal of occupational therapy. Revue canadienne d'ergotherapie

2011 Volume 78, Issue 2, Page(s) 80–96

Abstract: Background: Many office-based assessment tools are used by occupational therapists to predict fitness to drive.: Purpose: To appraise psychometric properties of such tools, specifically predictive validity for on-road performance.: Methods: A ... ...

Abstract	Background: Many office-based assessment tools are used by occupational therapists to predict fitness to drive. Purpose: To appraise psychometric properties of such tools, specifically predictive validity for on-road performance. Methods: A literature search was conducted to identify assessment tools and studies involving on-road outcomes (behind-the-wheel evaluation, crashes, traffic violations). Using a standardized appraisal process, reviewers rated each tool's psychometric properties, including its predictive validity with on-road performance. Findings: Seventeen measures met the inclusion criteria. Evidence suggests many tools do not have cutoff scores linked with on-road outcomes, although some had stronger evidence than others. Implications. When making a determination regarding driver fitness, clinicians should consider the psychometric properties of the tool as well as existing evidence concerning its utility in predicting on-road performance. Caution is warranted in using any one office-based tool to predict driving fitness; rather, a multifactorial-based assessment approach that includes physical, cognitive, and visual-perceptual components, is recommended.
MeSH term(s)	Aged ; Aging/physiology ; Aging/psychology ; Automobile Driver Examination ; Geriatric Assessment/methods ; Humans ; Psychometrics ; Reproducibility of Results
Language	English
Publishing date	2011-05-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	417302-8
ISSN	0008-4174 ; 0315-1026
ISSN	0008-4174 ; 0315-1026
DOI	10.2182/cjot.2011.78.2.3
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Article ; Online: Low Vision Rehabilitation, Age-Related Vision Loss, and Risk: A Critical Interpretive Synthesis.

Laliberte Rudman, Debbie / Egan, Mary Y / McGrath, Colleen E / Kessler, Dorothy / Gardner, Paula / King, Judy / Ceci, Christine

The Gerontologist

2016 Volume 56, Issue 3, Page(s) e32–45

Abstract: Purpose: Given the centrality of risk in geriatric rehabilitation, it is critically important to attend to how conceptualizations of risk shape research, policies, and rehabilitation practices. This paper presents a critical interpretive synthesis (CIS) ...

Abstract	Purpose: Given the centrality of risk in geriatric rehabilitation, it is critically important to attend to how conceptualizations of risk shape research, policies, and rehabilitation practices. This paper presents a critical interpretive synthesis (CIS) of literature addressing risk and low vision rehabilitation for older adults with age-related vision loss (ARVL) to identify key guiding assumptions regarding risk and discuss implications for what gets attended to, and not attended to, within research and rehabilitation. Design and methods: This CIS combined guidelines proposed by Dixon-Woods and colleagues (2006-Conducting a critical interpretive synthesis of the literature on access to healthcare by vulnerable groups. BMC Medical Research Methodology, 6, 35) and Alvesson and Sandberg (2011-Generating research questions through problematization. Academy of Management Review, 36, 247-271; 2013-Constructing research questions: Doing interesting research. London: Sage). The iterative review process involved 3 steps: literature search and selection, data extraction, and syntheses to identify boundary assumptions. The dataset included 83 research and practice description articles. Results: Older adults with ARVL were constructed as "at risk" for various adverse outcomes, particularly dependency and self-harm, and as posing risks to others. An epidemiological approach to risk based in assumptions aligned with a technico-scientific perspective was dominant, with risk conceptualized as an embodied, individual-level phenomenon that is to be determined and managed through objective screening and expert monitoring. Implications: Key concerns include a lack of: attention to the tensions created when rehabilitation research and practice attempt to promote independence while simultaneously reducing risk, incorporation of aging adults' perspectives on risk, and analysis of environmental factors that shape risks. Research that starts by valuing older adults' experiences and attends to context can inform rehabilitation practices that support health-promoting, risk-taking, and facilitate collaborative approaches to risk management.
Language	English
Publishing date	2016-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	216760-8
ISSN	1758-5341 ; 0016-9013
ISSN (online)	1758-5341
ISSN	0016-9013
DOI	10.1093/geront/gnv685
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Article ; Online: Site-directed mutagenesis to probe catalysis by a Thermobifida fusca beta-1,3-glucanase (Lam81A).

McGrath, Colleen E / Vuong, Thu V / Wilson, David B

Protein engineering, design & selection : PEDS

2009 Volume 22, Issue 6, Page(s) 375–382

Abstract: Thermobifida fuscaLam81A is a single domain family-81 beta-1,3-endoglucanase, but no structure is known for this family. Site-directed mutagenesis of 14 conserved residues chosen from sequence alignments was used to identify those with critical roles in ... ...

Abstract	Thermobifida fuscaLam81A is a single domain family-81 beta-1,3-endoglucanase, but no structure is known for this family. Site-directed mutagenesis of 14 conserved residues chosen from sequence alignments was used to identify those with critical roles in catalysis, binding or substrate specificity. Mutant enzymes were assayed for their ability to bind and hydrolyze substrates with various glycosyl linkages. Residues D422, E499 and E503 were candidates for the catalytic acid or catalytic base, and E499 was shown to be the catalytic base by azide rescue. F425 was shown to have a major role in substrate binding possibly mediated by aromatic ring stacking with the sugar substrate. In addition, mutation of D424 to histidine altered the substrate specificity by increasing the rate of cleavage of mixed-linkage beta-glucan and carboxymethyl-cellulose, 60- and 16-fold, respectively, over the wild-type enzyme.
MeSH term(s)	Actinomycetales/enzymology ; Actinomycetales/genetics ; Actinomycetales/metabolism ; Amino Acid Sequence ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Biocatalysis ; Carboxymethylcellulose Sodium/metabolism ; Catalytic Domain ; Glucan Endo-1,3-beta-D-Glucosidase/chemistry ; Glucan Endo-1,3-beta-D-Glucosidase/genetics ; Glucan Endo-1,3-beta-D-Glucosidase/metabolism ; Kinetics ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Protein Binding ; Sequence Alignment ; Sodium Azide/pharmacology ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; beta-Glucans/metabolism
Chemical Substances	Bacterial Proteins ; beta-Glucans ; Sodium Azide (968JJ8C9DV) ; Glucan Endo-1,3-beta-D-Glucosidase (EC 3.2.1.39) ; Carboxymethylcellulose Sodium (K679OBS311)
Language	English
Publishing date	2009-06
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1466729-0
ISSN	1741-0134 ; 1460-213X ; 1741-0126 ; 0269-2139
ISSN (online)	1741-0134 ; 1460-213X
ISSN	1741-0126 ; 0269-2139
DOI	10.1093/protein/gzp015
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Article: Characterization of a Thermobifida fusca beta-1,3-glucanase (Lam81A) with a potential role in plant biomass degradation.

McGrath, Colleen E / Wilson, David B

Biochemistry

2006 Volume 45, Issue 47, Page(s) 14094–14100

Abstract: Thermobifida fusca is a filamentous soil bacterium that plays a major role in the breakdown of plant biomass. In this paper, we report the cloning, expression, purification, and characterization of the T. fusca enzyme, Lam81A. The Carbohydrate Active ... ...

Abstract	Thermobifida fusca is a filamentous soil bacterium that plays a major role in the breakdown of plant biomass. In this paper, we report the cloning, expression, purification, and characterization of the T. fusca enzyme, Lam81A. The Carbohydrate Active Enzymes Database (http://afmb.cnrs-mrs.fr/CAZY/) indicates that Lam81A belongs to a relatively uncharacterized family of beta-1,3-glucanases, family GH-81 [Coutinho, P. M., and Henrissat, B. (1999) in Recent Advances in Carbohydrate Bioengineering (Gilbert, H. J., Davies, G., Henrissat, B., and Svensson, B., Eds.) pp 3-12, The Royal Society of Chemistry, Cambridge, U.K.]. Microarray analysis suggests that Lam81A plays a role in biomass degradation, where its natural substrate may be the plant cell wall polysaccharide, callose, which is a polymer of beta-1,3-linked glucose. Characterization of Lam81A has shown that the enzyme is specific for beta-1,3-linked glucose polysaccharides, is endohydrolytic, and utilizes an inverting mechanism for substrate hydrolysis. In addition, the enzyme has a broad pH optimum from 5.5 to 10, a temperature optimum of 50 degrees C, and demonstrates substrate inhibition, as well as showing a high basal level of expression.
MeSH term(s)	Actinomycetales/enzymology ; Base Sequence ; Biomass ; Chromatography, Thin Layer ; DNA Primers ; Electrophoresis, Polyacrylamide Gel ; Glucan Endo-1,3-beta-D-Glucosidase/metabolism ; Nuclear Magnetic Resonance, Biomolecular ; Plants/metabolism ; Polymerase Chain Reaction
Chemical Substances	DNA Primers ; Glucan Endo-1,3-beta-D-Glucosidase (EC 3.2.1.39)
Language	English
Publishing date	2006-11-28
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/bi061757r
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