Article ; Online: Heme biosynthesis in prokaryotes.
Biochimica et biophysica acta. Molecular cell research
2020 Volume 1868, Issue 1, Page(s) 118861
Abstract: The cyclic tetrapyrrole heme is used as a prosthetic group in a broad variety of different proteins in almost all organisms. Often, it is essential for vital biochemical processes such as aerobic and anaerobic respiration as well as photosynthesis. In ... ...
| Abstract | The cyclic tetrapyrrole heme is used as a prosthetic group in a broad variety of different proteins in almost all organisms. Often, it is essential for vital biochemical processes such as aerobic and anaerobic respiration as well as photosynthesis. In Nature, heme is made from the common tetrapyrrole precursor 5-aminolevulinic acid, and for a long time it was assumed that heme is biosynthesized by a single, common pathway in all organisms. However, although this is indeed the case in eukaryotes, heme biosynthesis is more diverse in the prokaryotic world, where two additional pathways exist. The final elucidation of the two 'alternative' heme biosynthesis routes operating in some bacteria and archaea was achieved within the last decade. This review summarizes the three different heme biosynthesis pathways with a special emphasis on the two 'new' prokaryotic routes. |
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| MeSH term(s) | Aerobiosis/genetics ; Aminolevulinic Acid/metabolism ; Anaerobiosis/genetics ; Archaea/genetics ; Bacteria/genetics ; Heme/biosynthesis ; Heme/genetics ; Photosynthesis/genetics ; Prokaryotic Cells/metabolism ; Tetrapyrroles/genetics ; Tetrapyrroles/metabolism |
| Chemical Substances | Tetrapyrroles ; Heme (42VZT0U6YR) ; Aminolevulinic Acid (88755TAZ87) |
| Language | English |
| Publishing date | 2020-09-23 |
| Publishing country | Netherlands |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 60-7 |
| ISSN | 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399 |
| ISSN (online) | 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 |
| ISSN | 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399 |
| DOI | 10.1016/j.bbamcr.2020.118861 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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