Result 1 - 10 of total 3292
1994
| Keywords | Ethics ; Medical ; Communication ; Informed consent ; Mass media ; Health Management and Planning |
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| Document type | Book ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
1994
| Keywords | Ethics ; Medical ; Communication ; Informed consent ; Mass media ; Health Management and Planning |
|---|---|
| Document type | Book ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
1994
| Keywords | Ethics ; Medical ; Communication ; Informed consent ; Mass media ; Health Management and Planning |
|---|---|
| Document type | Book ; Online |
| Database | BASE - Bielefeld Academic Search Engine (life sciences selection) |
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.
2009
Abstract: Foraminiferal analysis of Miocene to recent strata of the Northwest Shelf of Australia is used to chart West Pacific Warm Pool (WPWP) influence. The assemblage is typified by "larger" foraminifera with ingressions of the Indo-Pacific "smaller" taxa ... ...
| Abstract | Foraminiferal analysis of Miocene to recent strata of the Northwest Shelf of Australia is used to chart West Pacific Warm Pool (WPWP) influence. The assemblage is typified by "larger" foraminifera with ingressions of the Indo-Pacific "smaller" taxa Asterorotalia and Pseudorotalia at around 4 Ma and from 1.6 to 0.8 Ma. A review of recent and fossil biogeography of these taxa suggests their stratigraphic distribution can be used to document WPWP evolution. From 10 to 4.4 Ma a lack of biogeographic connectivity between the Pacific and Indian Ocean suggests Indonesian Throughflow (ITF) restriction. During this period, the collision of Australia and Asia trapped warmer waters in the Pacific, creating a central WPWP biogeographic province from the equator to 26°N. By 3 Ma Indo-Pacific species migrated to Japan with the initiation of the "modern" Kuroshio Current coinciding with the intensification of the North Pacific Gyre and Northern Hemisphere ice sheet expansion. Indo-Pacific taxa migrated to the northwest Australia from 4.4 to 4 Ma possibly because of limited ITF. The absence of Indo-Pacific taxa in northwest Australia indicates possible ITF restriction from 4 to 1.6 Ma. Full northwest Australian biogeographic connectivity with the WPWP from 1.6 to 0.8 Ma suggests an unrestricted stronger ITF (compared to today) and the initiation of the modern Leeuwin Current. The extinction of some Indo-Pacific species in northwest Australia after 0.8 Ma may be related to the effects of large glacial/interglacial oscillations and uplift of the Indonesian Archipelago causing Indonesian seaway restriction. |
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| Language | English |
| Dates of publication | 2009-9999 |
| Size | Online-Ressource |
| Publisher | PANGAEA - Data Publisher for Earth & Environmental Science |
| Publishing place | Bremen/Bremerhaven |
| Document type | Book ; Online |
| Note | This dataset is supplement to doi:10.1029/2008PA001660 |
| DOI | 10.1594/PANGAEA.758377 |
| Database | Library catalogue of the German National Library of Science and Technology (TIB), Hannover |
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The Journal of experimental medicine
2001 Volume 196, Issue 9, Page(s) 1163–1173
Abstract: ... determination V-J rearrangement status. Using multiplex genomic PCR assays and real time PCR analysis, we report ... a comprehensive and systematic analysis of the V-J recombination of TCR alpha chain in normal mouse thymocytes ... points describing the control of gene rearrangements. (a) The V-J recombination pattern is not random ...
| Abstract | Knowledge of the complete nucleotide sequence of the mouse TCRAD locus allows an accurate determination V-J rearrangement status. Using multiplex genomic PCR assays and real time PCR analysis, we report a comprehensive and systematic analysis of the V-J recombination of TCR alpha chain in normal mouse thymocytes during development. These respective qualitative and quantitative approaches give rise to four major points describing the control of gene rearrangements. (a) The V-J recombination pattern is not random during ontogeny and generates a limited TCR alpha repertoire; (b) V-J rearrangement control is intrinsic to the thymus; (c) each V gene rearranges to a set of contiguous J segments with a gaussian-like frequency; (d) there are more rearrangements involving V genes at the 3' side than 5' end of V region. Taken together, this reflects a preferential association of V and J gene segments according to their respective positions in the locus, indicating that accessibility of both V and J regions is coordinately regulated, but in different ways. These results provide a new insight into TCR alpha repertoire size and suggest a scenario for V usage during differentiation. |
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| MeSH term(s) | Animals ; Cell Differentiation ; Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor/genetics ; Mice ; Mice, Inbred BALB C ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Thymus Gland/cytology |
| Chemical Substances | Receptors, Antigen, T-Cell, alpha-beta |
| Language | English |
| Publishing date | 2001-05-07 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 218343-2 |
| ISSN | 1540-9538 ; 0022-1007 |
| ISSN (online) | 1540-9538 |
| ISSN | 0022-1007 |
| DOI | 10.1084/jem.20021074 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ua VI Zs.107: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Anatomical record (Hoboken, N.J. : 2007)
2022 Volume 306, Issue 7, Page(s) 1757–1761
Abstract: ... of the bones. This specimen is from the upper part of the New Egypt Formation, just below the K/T boundary ...
| Abstract | A set of fragmentary bones excavated from the Inversand Company Pit at Sewell, Gloucester County, NJ, contains portions of broken hollow femur bone that display unusual interior structure. Two hypotheses are considered; (1) the lumina represents the distinctive physical features of medullary bone as described by M. Schweitzer in a series of papers; or (2) the interior bone growth is a pathology. The specimen is attributed to the Theropoda on the basis of the possession of a pneumatic foramen in one of the bones. This specimen is from the upper part of the New Egypt Formation, just below the K/T boundary in the base of the overlying Hornerstown Formation. This stratigraphic horizon is the same as the type specimen of Dryptosaurus aquiluguis which was excavated from a marl pit nearby. |
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| MeSH term(s) | Animals ; New Jersey ; Dinosaurs ; Bone and Bones ; Femur/anatomy & histology ; Egypt |
| Language | English |
| Publishing date | 2022-11-18 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2269667-2 |
| ISSN | 1932-8494 ; 1932-8486 |
| ISSN (online) | 1932-8494 |
| ISSN | 1932-8486 |
| DOI | 10.1002/ar.25114 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ub I Zs.65: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2021 Volume 8, Issue 5, Page(s) 210108
Abstract: The method of regularized stokeslets is widely used in microscale biological fluid dynamics due to its ease of implementation, natural treatment of complex moving geometries, and removal of singular functions to integrate. The standard implementation of ... ...
| Abstract | The method of regularized stokeslets is widely used in microscale biological fluid dynamics due to its ease of implementation, natural treatment of complex moving geometries, and removal of singular functions to integrate. The standard implementation of the method is subject to high computational cost due to the coupling of the linear system size to the numerical resolution required to resolve the rapidly varying regularized stokeslet kernel. Here, we show how Richardson extrapolation with coarse values of the regularization parameter is ideally suited to reduce the quadrature error, hence dramatically reducing the storage and solution costs without loss of accuracy. Numerical experiments on the resistance and mobility problems in Stokes flow support the analysis, confirming several orders of magnitude improvement in accuracy and/or efficiency. |
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| Language | English |
| Publishing date | 2021-05-26 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2787755-3 |
| ISSN | 2054-5703 |
| ISSN | 2054-5703 |
| DOI | 10.1098/rsos.210108 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2024 Volume 111, Issue 3, Page(s) e16289
Abstract: Premise: Intraspecific variation may play a key role in shaping the relationships between plants and their interactions with soil microbial communities. The soil microbes of individual plants can generate intraspecific variation in the responsiveness of ...
| Abstract | Premise: Intraspecific variation may play a key role in shaping the relationships between plants and their interactions with soil microbial communities. The soil microbes of individual plants can generate intraspecific variation in the responsiveness of the plant offspring, yet have been much less studied. To address this need, we explored how the relatedness of seedlings from established clones of Solidago altissima altered the plant-soil interactions of the seedlings. Methods: Seedlings of known parentage were generated from a series of 24 clones grown in a common garden. Seedlings from these crosses were inoculated with soils from maternal, paternal, or unrelated clones and their performance compared to sterilized control inocula. Results: We found that soil inocula influenced by S. altissima clones had an overall negative effect on seedling biomass. Furthermore, seedlings inoculated with maternal or paternal soils tended to experience larger negative effects than seedlings inoculated with unrelated soils. However, there was much variation among individual crosses, with not all responding to relatedness. Conclusions: Our data argue that genetic relatedness to the plant from which the soil microbial inoculum was obtained may cause differential impacts on establishing seedlings, encouraging the regeneration of non-kin adjacent to established clones. Such intraspecific variation represents a potentially important source of heterogeneity in plant-soil microbe interactions with implications for maintaining population genetic diversity. |
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| MeSH term(s) | Soil ; Soil Microbiology ; Plants ; Seedlings/genetics ; Biomass |
| Chemical Substances | Soil |
| Language | English |
| Publishing date | 2024-02-19 |
| Publishing country | United States |
| Document type | Journal Article |
| ZDB-ID | 2935-x |
| ISSN | 1537-2197 ; 0002-9122 |
| ISSN (online) | 1537-2197 |
| ISSN | 0002-9122 |
| DOI | 10.1002/ajb2.16289 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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PNAS nexus
2023 Volume 2, Issue 3, Page(s) pgad072
Abstract: Flagellar motility is critical to natural and many forms of assisted reproduction. Rhythmic beating and wave propagation by the flagellum propels sperm through fluid and enables modulation between penetrative progressive motion, activated side-to-side ... ...
| Abstract | Flagellar motility is critical to natural and many forms of assisted reproduction. Rhythmic beating and wave propagation by the flagellum propels sperm through fluid and enables modulation between penetrative progressive motion, activated side-to-side yaw and hyperactivated motility associated with detachment from epithelial binding. These motility changes occur in response to the properties of the surrounding fluid environment, biochemical activation state, and physiological ligands, however, a parsimonious mechanistic explanation of flagellar beat generation that can explain motility modulation is lacking. In this paper, we present the Axonemal Regulation of Curvature, Hysteretic model, a curvature control-type theory based on switching of active moment by local curvature, embedded within a geometrically nonlinear elastic model of the flagellum exhibiting planar flagellar beats, together with nonlocal viscous fluid dynamics. The biophysical system is parameterized completely by four dimensionless parameter groupings. The effect of parameter variation is explored through computational simulation, revealing beat patterns that are qualitatively representative of penetrative (straight progressive), activated (highly yawing) and hyperactivated (nonprogressive) modes. Analysis of the flagellar limit cycles and associated swimming velocity reveals a cusp catastrophe between progressive and nonprogressive modes, and hysteresis in the response to changes in critical curvature parameter. Quantitative comparison to experimental data on human sperm exhibiting typical penetrative, activated and hyperactivated beats shows a good fit to the time-average absolute curvature profile along the flagellum, providing evidence that the model is capable of providing a framework for quantitative interpretation of imaging data. |
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| Language | English |
| Publishing date | 2023-03-09 |
| Publishing country | England |
| Document type | Journal Article |
| ISSN | 2752-6542 |
| ISSN (online) | 2752-6542 |
| DOI | 10.1093/pnasnexus/pgad072 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 10, Issue 11, Page(s) e01185
Abstract: Colonic varices typically occur in the setting of portal hypertension, and patients may present with rectal bleeding or occult anemia. Idiopathic colonic varices occur infrequently in the absence of cirrhosis and can involve the entire colon. We present ... ...
| Abstract | Colonic varices typically occur in the setting of portal hypertension, and patients may present with rectal bleeding or occult anemia. Idiopathic colonic varices occur infrequently in the absence of cirrhosis and can involve the entire colon. We present a case of a 54-year-old Eastern European woman who had undergone diagnostic colonoscopy for newly diagnosed sigmoid adenocarcinoma and was incidentally found to have colonic varices with normal portal pressure gradients. Her 38-year-old daughter was found to have similar varices, raising concerns for hereditary etiology. |
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| Language | English |
| Publishing date | 2023-11-02 |
| Publishing country | United States |
| Document type | Case Reports |
| ZDB-ID | 2814825-3 |
| ISSN | 2326-3253 |
| ISSN | 2326-3253 |
| DOI | 10.14309/crj.0000000000001185 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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