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Article ; Online: GOLPH3 keeps the Golgi residents at home.

Lowe, Martin

2021 Volume 220, Issue 10

Abstract: In this issue of JCB, Welch et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202106115) show that GOLPH3 mediates the sorting of numerous Golgi proteins into recycling COPI transport vesicles. This explains how many resident proteins are retained ... ...

Abstract	In this issue of JCB, Welch et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202106115) show that GOLPH3 mediates the sorting of numerous Golgi proteins into recycling COPI transport vesicles. This explains how many resident proteins are retained at the Golgi and reveals a key role for GOLPH3 in maintaining Golgi homeostasis.
MeSH term(s)	Golgi Apparatus/metabolism ; Protein Transport
Language	English
Publishing date	2021-09-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	218154-x
ISSN	1540-8140 ; 0021-9525
ISSN (online)	1540-8140
ISSN	0021-9525
DOI	10.1083/jcb.202108147
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Article: Coherent mapping to aid interpretation of multiple intraatrial reentrant tachycardias in an atrio-pulmonary Fontan patient.

Whittaker-Axon, Sarah / Ezzat, Vivienne / Lowe, Martin / Sawhney, Vinit

Indian pacing and electrophysiology journal

2024 Volume 24, Issue 2, Page(s) 114–118

Language	English
Publishing date	2024-01-09
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2123606-9
ISSN	0972-6292
ISSN	0972-6292
DOI	10.1016/j.ipej.2024.01.002
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Article: Metabolisches Syndrom und Depression

Löwe, Bernd

(In: Herpertz, Stephan; de Zwaan, Martina; Zipfel, Stephan (Ed.), Handbuch Essstörungen und Adipositas (S. 501-508). Berlin, Heidelberg: Springer)

2022

Abstract: Depression und metabolisches Syndrom sind in den letzten Jahrzehnten häufiger geworden und treten überzufällig häufig gemeinsam auf. Depression und metabolisches Syndrom, beides Risikofaktoren für kardiovaskuläre Mortalität, können sich im Sinne eines ... ...

Title translation	Metabolic syndrome and depression (DeepL)
Series title	In: Herpertz, Stephan; de Zwaan, Martina; Zipfel, Stephan (Ed.), Handbuch Essstörungen und Adipositas (S. 501-508). Berlin, Heidelberg: Springer
Abstract	Depression und metabolisches Syndrom sind in den letzten Jahrzehnten häufiger geworden und treten überzufällig häufig gemeinsam auf. Depression und metabolisches Syndrom, beides Risikofaktoren für kardiovaskuläre Mortalität, können sich im Sinne eines Circulus vitiosus durch Faktoren wie Inaktivität, sozialen Rückzug, Fehlernährung, chronischen Stress, motivationale Schwierigkeiten bei Verhaltensänderungen und metabolische Parameter wechselseitig verstärken. Deshalb müssen diagnostische und therapeutische Maßnahmen simultan das metabolische Syndrom und die Depression berücksichtigen. Ziel der Behandlung ist nicht nur eine Remission der Depression, sondern auch, den Patienten in die Lage zu versetzen, die gesundheitlichen Herausforderungen des metabolischen Syndroms erfolgreich und eigenverantwortlich zu managen. (c) Der/die Autor(en), exklusiv lizenziert durch Springer-Verlag GmbH
Keywords	Cardiovascular Disorders ; Epidemiologie ; Epidemiology ; Kardiovaskuläre Störungen ; Major Depression ; Metabolic Syndrome ; Metabolisches Syndrom ; Therapie ; Therapieergebnisse ; Treatment ; Treatment Outcomes
Language	German
Document type	Article
DOI	10.1007/978-3-662-63544-5_64
Database	PSYNDEX

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Article: The Physiological Functions of the Golgin Vesicle Tethering Proteins.

Lowe, Martin

Frontiers in cell and developmental biology

2019 Volume 7, Page(s) 94

Abstract: The golgins comprise a family of vesicle tethering proteins that act in a selective manner to tether transport vesicles at the Golgi apparatus. Tethering is followed by membrane fusion to complete the delivery of vesicle-bound cargo to the Golgi. ... ...

Abstract	The golgins comprise a family of vesicle tethering proteins that act in a selective manner to tether transport vesicles at the Golgi apparatus. Tethering is followed by membrane fusion to complete the delivery of vesicle-bound cargo to the Golgi. Different golgins are localized to different regions of the Golgi, and their ability to selectively tether transport vesicles is important for the specificity of vesicle traffic in the secretory pathway. In recent years, our mechanistic understanding of golgin-mediated tethering has greatly improved. We are also beginning to appreciate how the loss of golgin function can impact upon physiological processes through the use of animal models and the study of human disease. These approaches have revealed that loss of a golgin causes tissue-restricted phenotypes, which can vary in severity and the cell types affected. In many cases, it is possible to attribute these phenotypes to a defect in vesicular traffic, although why certain tissues are sensitive to loss of a particular golgin is still, in most cases, unclear. Here, I will summarize recent progress in our understanding of golgins, focusing on the physiological roles of these proteins, as determined from animal models and the study of disease in humans. I will describe what these
Language	English
Publishing date	2019-06-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2019.00094
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Article ; Online: Response: Superficial parotidectomy versus extracapsular dissection.

Martin, H / Lowe, T

International journal of oral and maxillofacial surgery

2021 Volume 51, Issue 4, Page(s) 577

MeSH term(s)	Adenoma, Pleomorphic ; Dissection/methods ; Humans ; Parotid Neoplasms/surgery
Language	English
Publishing date	2021-08-21
Publishing country	Denmark
Document type	Letter ; Comment
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2021.08.004
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Zs.A 931: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Sexual quality of life in young gynaecological cancer survivors: a qualitative study.

Roussin, Melanie / Lowe, John / Hamilton, Anita / Martin, Lisa

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

2023 Volume 32, Issue 7, Page(s) 2107–2115

Abstract: Purpose: The impact of cancer diagnosis and treatment on sexual quality of life (SQoL) is a significant and often neglected issue in the treatment and survivorship period of young gynaecological cancer survivors (YGCS). This study sought to explore ... ...

Abstract	Purpose: The impact of cancer diagnosis and treatment on sexual quality of life (SQoL) is a significant and often neglected issue in the treatment and survivorship period of young gynaecological cancer survivors (YGCS). This study sought to explore women's lived experiences to understand how to protect and improve SQoL. Methods: A qualitative study with women aged 18-45 and pre- or perimenopausal at diagnosis (n = 15). A thematic analysis was performed in NVivo. Participants also completed a pre-interview questionnaire and The Female Sexual Distress Scale-Revised (FSDS-R). Results: YGCS experienced high psychosexual distress. Notably, seven themes were identified: adjustment, confidence, fear, loss, shame, trauma, and communication. Gynaecological cancer (GC) treatment interfered with everyday life and had a long-term impact on mental, physical, and emotional health, with many reporting an altered sense of self, body image and sexual identity. Single women felt vulnerable in new relationships, while partnered women reported low sexual desire and guilt about sexual difficulties. Open communication, emotional intimacy, and an acceptance of the 'new normal' buffered the trauma of cancer and were vital to relationship satisfaction. Lastly, absent, or blunt patient-clinician communication contributed to psychosexual distress. Conclusion: GC interferes with sexual function, partner relationships, psychosexual wellbeing, and quality of life. A better understanding of the lived experiences of YGCS can help healthcare providers to adopt a holistic, patient-centric, and multidisciplinary approach to SQoL. YGCS want psychosexual communication and support, across all stages of treatment and care. Healthcare providers should initiate and normalise conversations on the impact of treatment on SQoL.
MeSH term(s)	Female ; Humans ; Quality of Life/psychology ; Cancer Survivors ; Sexual Behavior/psychology ; Emotions ; Neoplasms
Language	English
Publishing date	2023-03-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1161148-0
ISSN	1573-2649 ; 0962-9343
ISSN (online)	1573-2649
ISSN	0962-9343
DOI	10.1007/s11136-023-03386-1
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Zs.A 3796: Show issues

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Article ; Online: Sexual quality of life after gynaecological cancer: what young women want.

Roussin, Melanie / Hamilton, Anita / Lowe, John / Martin, Lisa

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation

2023 Volume 33, Issue 3, Page(s) 679–689

Abstract: Purpose: Psychosexual distress is known to be a common complication of treatment for gynaecological cancer (GC), affecting the sexual quality of life (SQoL) for an increasing number of young gynaecological cancer survivors (YGCS). The SQoL in YGCS study ...

Abstract	Purpose: Psychosexual distress is known to be a common complication of treatment for gynaecological cancer (GC), affecting the sexual quality of life (SQoL) for an increasing number of young gynaecological cancer survivors (YGCS). The SQoL in YGCS study aimed to identify strategies that are acceptable and helpful to YGCS in protecting and improving SQoL, using a salutogenic approach. Methods: A qualitative study was undertaken with young women aged 18-45 and pre- or perimenopausal at diagnosis. Semi-structured interviews were conducted on Zoom and a thematic analysis of transcripts was completed in NVivo. Results: Fifteen interviews with YGCS revealed three themes for strategy development: psychosexual education, psychosocial support, and healthcare policy and strategy to establish SQoL as standard care in gynaecologic oncology. Conclusion: The strategies put forward by YGCS showed the need for a holistic, patient-centric, and multidisciplinary approach to SQoL. A better understanding of the strategies acceptable to YGCS, including the importance of using a trauma-informed approach to communication and care, can help healthcare providers play a vital role in protecting and improving SQoL.
MeSH term(s)	Humans ; Female ; Genital Neoplasms, Female/psychology ; Quality of Life/psychology ; Sexual Behavior/psychology ; Cancer Survivors/psychology
Language	English
Publishing date	2023-11-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1161148-0
ISSN	1573-2649 ; 0962-9343
ISSN (online)	1573-2649
ISSN	0962-9343
DOI	10.1007/s11136-023-03553-4
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Article ; Online: The Physiological Functions of the Golgin Vesicle Tethering Proteins

Martin Lowe

Frontiers in Cell and Developmental Biology, Vol

2019 Volume 7

Abstract	The golgins comprise a family of vesicle tethering proteins that act in a selective manner to tether transport vesicles at the Golgi apparatus. Tethering is followed by membrane fusion to complete the delivery of vesicle-bound cargo to the Golgi. Different golgins are localized to different regions of the Golgi, and their ability to selectively tether transport vesicles is important for the specificity of vesicle traffic in the secretory pathway. In recent years, our mechanistic understanding of golgin-mediated tethering has greatly improved. We are also beginning to appreciate how the loss of golgin function can impact upon physiological processes through the use of animal models and the study of human disease. These approaches have revealed that loss of a golgin causes tissue-restricted phenotypes, which can vary in severity and the cell types affected. In many cases, it is possible to attribute these phenotypes to a defect in vesicular traffic, although why certain tissues are sensitive to loss of a particular golgin is still, in most cases, unclear. Here, I will summarize recent progress in our understanding of golgins, focusing on the physiological roles of these proteins, as determined from animal models and the study of disease in humans. I will describe what these in vivo analyses have taught us, as well as highlight less understood aspects, and areas for future investigations.
Keywords	Golgi apparatus ; golgin ; vesicle traffic ; tether ; animal model ; secretion ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2019-06-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: A Pilot Study of Metacognitive Training in U.S. Republican Leaners: Reducing Polarization Toward LGBTIQ+ Persons.

Reininger, Klaus Michael / Koulen, Helena / Biel, Hannah Marie / Hennig, Timo / Pietras, Laura / Kokot, Martin Rochus / Löwe, Bernd / Briken, Peer / Moritz, Steffen

Archives of sexual behavior

2024

Abstract: Negative attitudes and stigmatization toward sexual minorities is a cause of minority stress of non-heterosexual persons on an individual level and has a negative impact on democratic coexistence in postmodern, plural society on a societal level. Derived ...

Abstract	Negative attitudes and stigmatization toward sexual minorities is a cause of minority stress of non-heterosexual persons on an individual level and has a negative impact on democratic coexistence in postmodern, plural society on a societal level. Derived from clinical research, we developed a short metacognitive training (MCT) intended to induce doubt toward inaccurate beliefs about LGBTIQ+ persons. We expected this MCT to reduce homonegativity, threat perceptions of LGBTIQ+ persons, and to foster extended outgroup tolerance compared to an education and a no-treatment control condition. We tested this hypothesis in U.S. Republican leaners who represent a social group that is likely to hold homonegative attitudes. We randomly assigned 490 U.S. Republican leaners to an MCT condition comprising 16 questions and respective answers (n = 166) vs. an education control condition (n = 164) vs. a no-treatment control condition (n = 160). We found that Republican leaners after receiving MCT (1) had a significant reduction of homonegativity (ds ≥ 0.28), (2) significantly perceived LGBTIQ+ persons as less threatening (ds ≥ 0.30), and (3) were significantly more tolerant of various outgroups such as LGBTIQ+ persons, feminists, liberals, and climate activists (ds ≥ 0.23) relative to both control conditions. The small effects of this short intervention and the possibility of systematically applying MCT in social discourse to reduce homonegativity with its potential significance for LGBTIQ+ individuals' mental health are discussed. Furthermore, we highlight this pilot study's significance toward intervention possibilities regarding political division and polarization in postmodern, democratic societies.
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	184221-3
ISSN	1573-2800 ; 0004-0002
ISSN (online)	1573-2800
ISSN	0004-0002
DOI	10.1007/s10508-024-02856-y
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Zs.A 1106: Show issues

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Article: Less Complexity in Hemodialysis Machines Reduces Time and Physical Load for Operator Actions.

Gründler, Uwe / Ekesbo, Eva / Löwe, Martin / Gauly, Adelheid

Medical devices (Auckland, N.Z.)

2021 Volume 14, Page(s) 379–387

Abstract: Purpose: Innovative hemodialysis systems are designed to ensure user safety and reduce operational time to allow health-care personnel to focus on patient care. The 6008 CareSystem has been developed to simplify the extracorporeal circuit of the system ... ...

Abstract	Purpose: Innovative hemodialysis systems are designed to ensure user safety and reduce operational time to allow health-care personnel to focus on patient care. The 6008 CareSystem has been developed to simplify the extracorporeal circuit of the system through a disposable cassette, automate operation steps, and facilitate handling in comparison to its predecessor - the 5008 CorDiax. The present investigations were performed with the aim of evaluating usability, safety, and ergonomic aspects of the new therapy system. Methods: A time-motion study compared these two hemodialysis systems with video and time recording of handling steps required to prepare, operate, and dismantle a dialysis machine. The ergonomic burden on hands and finger joints was evaluated in a second study, again by video-recording the simulated operation of both dialysis systems. Results: The number of handling steps required for the 6008 CareSystem and critical contact points were reduced by 26% in comparison to the 5008 CorDiax for patients with arteriovenous fistula used for vascular access and by 22% for those with a catheter used for vascular access. Total process time was reduced by 2.83 and 2.57 minutes using fistulae and catheters for vascular access, respectively. The number of hand grips and finger and thumb presses was reduced by approximately 50% and required less strength to execute. Conclusion: The most recent hemodialysis system confirmed its ease of use and user safety through fewer handling steps and less physical burden on the user. Shorter operational time should enable more patient-focused care.
Language	English
Publishing date	2021-11-17
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2520731-3
ISSN	1179-1470
ISSN	1179-1470
DOI	10.2147/MDER.S316610
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