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  1. Article ; Online: Verification of the Abbott Alinity m Resp-4-Plex assay for detection of SARS-CoV-2, influenza A/B, and respiratory syncytial virus.

    Cheng, Annie / Riedel, Stefan / Arnaout, Ramy / Kirby, James E

    Diagnostic microbiology and infectious disease

    2021  Volume 102, Issue 2, Page(s) 115575

    Abstract: ... Alinity m Resp-4-Plex assay is a multiplex PCR assay that simultaneously detects and differentiates ... In the context of sample-to-answer, near random access automation on the Alinity m platform, we believe ...

    Abstract COVID-19 symptomology may overlap with other circulating respiratory viruses that may also cause severe disease and for which there are specific and potentially life-saving treatments. The Abbott Alinity m Resp-4-Plex assay is a multiplex PCR assay that simultaneously detects and differentiates infection with SARS-CoV-2, influenza A, influenza B, and respiratory syncytial virus (RSV). We characterized its accuracy, precision, and analytical sensitivity. All were found to be robust for measures examined. In the context of sample-to-answer, near random access automation on the Alinity m platform, we believe that the Resp-4-Plex assay offers significant utility in addressing the current needs of the SARS-CoV-2 pandemic and future needs during anticipated endemic circulation of SARS-CoV-2 with other respiratory viruses.
    MeSH term(s) COVID-19/diagnosis ; Female ; Humans ; Influenza A virus/genetics ; Influenza B virus/genetics ; Influenza, Human/diagnosis ; Limit of Detection ; Male ; Middle Aged ; Molecular Diagnostic Techniques ; Multiplex Polymerase Chain Reaction ; Nucleic Acid Amplification Techniques ; Respiratory Syncytial Virus Infections/diagnosis ; Respiratory Syncytial Virus, Human/genetics ; SARS-CoV-2/genetics ; Sensitivity and Specificity
    Language English
    Publishing date 2021-10-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604920-5
    ISSN 1879-0070 ; 0732-8893
    ISSN (online) 1879-0070
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2021.115575
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  2. Article: INTEGRINS: A BEDSIDE TO BENCH TO BEDSIDE STORY.

    Arnaout, M Amin

    Transactions of the American Clinical and Climatological Association

    2023  Volume 133, Page(s) 34–55

    Abstract: I provide a narrative of the path I took to discover the membrane receptors that mediate leukocyte adhesion, now known as β2 integrins or CD11/CD18. We followed this discovery with the first determination of the 3-D structures of integrins. The latter ... ...

    Abstract I provide a narrative of the path I took to discover the membrane receptors that mediate leukocyte adhesion, now known as β2 integrins or CD11/CD18. We followed this discovery with the first determination of the 3-D structures of integrins. The latter advance provided the foundation for understanding the unique features of integrins as divalent cation-dependent signaling receptors and as mechanosensitive conduits between the extracellular matrix and the intracellular cytoskeleton. Our structural studies are now opening new paths for taming overactive integrins in disease while minimizing the collateral damage associated with the faulty pharmacodynamics of current integrin inhibitory drugs.
    MeSH term(s) Humans ; Integrins ; Signal Transduction
    Chemical Substances Integrins
    Language English
    Publishing date 2023-09-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603823-2
    ISSN 0065-7778
    ISSN 0065-7778
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  3. Article ; Online: A commentary on "impact of hyperglycemia on neuronal apoptosis after subarachnoid hemorrhage in rodent brain: An experimental research" (international journal of surgery, 2020. Ephu ahead of print).

    Arnaout, Mohamed M

    International journal of surgery (London, England)

    2020  Volume 83, Page(s) 143

    MeSH term(s) Animals ; Apoptosis ; Brain ; Hyperglycemia/etiology ; Rodentia ; Subarachnoid Hemorrhage/surgery
    Language English
    Publishing date 2020-09-11
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2212038-5
    ISSN 1743-9159 ; 1743-9191
    ISSN (online) 1743-9159
    ISSN 1743-9191
    DOI 10.1016/j.ijsu.2020.09.001
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    Zs.A 6502: Show issues Location:
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  4. Article ; Online: Effects of Prediabetes on Long-term Risk of Developing Cardiac Events in Patients Presenting With Acute Coronary Syndrome.

    Xue, Mark / Dutton, Heidi / Arnaout, Amel

    Canadian journal of diabetes

    2023  Volume 47, Issue 6, Page(s) 490–496

    Abstract: Objectives: The aim of this work was to identify the long-term risk associated with prediabetes and developing subsequent cardiac events in patients presenting with acute coronary syndrome (ACS) at a tertiary health-care centre.: Methods: In this ... ...

    Abstract Objectives: The aim of this work was to identify the long-term risk associated with prediabetes and developing subsequent cardiac events in patients presenting with acute coronary syndrome (ACS) at a tertiary health-care centre.
    Methods: In this retrospective cohort study, we analyzed patients admitted with ACS between January and December 2013. Two hundred thirty patients with prediabetes were matched to a comparison cohort of patients with no diabetes based on age, sex, and diagnosis code of the International Statistical Classification of Diseases and Related Health Problems---10th revision. The primary outcome was incidence of ACS readmission over a 5-year period.
    Results: There were 46 (20%) readmissions for ACS in the prediabetes cohort and 33 (14.3%) in the no-diabetes cohort. Univariable conditional logistic regression showed that prediabetes was not a significant risk factor for ACS readmission (odds ratio, 1.481; 95% confidence interval, 0.909 to 2.414; p=0.115). After accounting for other major risk factors for coronary disease, prediabetes was not shown to be a significant risk factor for ACS readmission (odds ratio, 1.333; 95% confidence interval, 0.795 to 2.233; p=0.276).
    Conclusions: Among patients presenting with ACS, prediabetes was not associated with increased risk of readmission for subsequent cardiac events compared with patients with no diabetes after 5 years of follow-up. A longer follow-up duration is needed.
    MeSH term(s) Humans ; Acute Coronary Syndrome/epidemiology ; Acute Coronary Syndrome/etiology ; Retrospective Studies ; Risk Factors ; Prediabetic State/epidemiology ; Prediabetic State/diagnosis ; Hospitalization
    Language English
    Publishing date 2023-04-26
    Publishing country Canada
    Document type Journal Article
    ISSN 2352-3840
    ISSN (online) 2352-3840
    DOI 10.1016/j.jcjd.2023.04.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Lunate Pseudarthrosis: Our Clinical Experience.

    Teodonno, Francesca / Arnaout, Ahlam / Merlini, Lorenzo / Gras, Mathilde

    The journal of hand surgery Asian-Pacific volume

    2023  Volume 28, Issue 4, Page(s) 467–471

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-09-25
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2848651-1
    ISSN 2424-8363 ; 2424-8355
    ISSN (online) 2424-8363
    ISSN 2424-8355
    DOI 10.1142/S2424835523500534
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    Zs.A 5911: Show issues Location:
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  6. Article: Unusual presentation of intraductal papilloma on the nipple: A case report.

    Rahman, Noura Abdul / Arnaout, Ibrahim / Krimsti, Mariam / Mardini, Amira / Rahme, Kanan / Ishkhanian, Silva

    International journal of surgery case reports

    2024  Volume 117, Page(s) 109483

    Abstract: Introduction and significance: Intraductal papilloma (IDP) is a benign breast lesion characterized by a small, delicate wart-like growth found within the milk ducts. Typically located centrally behind the nipple, IDP often presents with a serous, ... ...

    Abstract Introduction and significance: Intraductal papilloma (IDP) is a benign breast lesion characterized by a small, delicate wart-like growth found within the milk ducts. Typically located centrally behind the nipple, IDP often presents with a serous, serosanguinous, or bloody discharge from the nipple, making it a common cause of abnormal nipple discharge. Differential diagnosis is crucial as it can be mistaken for other conditions such as pigmented Paget's disease and pigmented basal cell carcinoma.
    Case presentation: This case study depicts a 35-year-old female with a painless, pigmented mass on the nipple of her right breast that had been present for four months. Physical examination revealed a well-defined blue nodule measuring 13 × 8 mm. Although mammography and ultrasound did not detect any abnormalities in the breast tissue, a biopsy confirmed the diagnosis of intraductal papilloma. The lesion was surgically excised under local anesthesia without complications.
    Clinical discussion: In this case, IDP presented as a blue nodule near the nipple. Despite the patient's young age and unique presentation, the diagnosis of intraductal papilloma was made based on the identified risk factors for breast tumors. Differential diagnoses considered included mammary Paget disease, nipple duct adenoma, and erosive adenomatosis of the nipple.
    Conclusion: This case report underscores the uncommon occurrence of IDP manifesting on the nipple. A thorough evaluation incorporating medical history, physical examination, imaging studies, and cytological analysis is essential for an accurate diagnosis and to exclude malignancy. Surgical excision was successful in removing the lesion.
    Language English
    Publishing date 2024-03-08
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2024.109483
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  7. Article ; Online: Perspectives on Endoscopic Transseptal Interforniceal Approach for Retroforaminal Colloid Cysts.

    Arnaout, Mohamed M / Elsamman, Amr K

    World neurosurgery

    2021  Volume 152, Page(s) e71–e80

    Abstract: Background: Although the interforniceal approach with the preservation of the fornix is useful during the endoscopic approach for retroforaminal colloid cysts, it carries a significant risk of memory and cognitive difficulties. Because most reports have ...

    Abstract Background: Although the interforniceal approach with the preservation of the fornix is useful during the endoscopic approach for retroforaminal colloid cysts, it carries a significant risk of memory and cognitive difficulties. Because most reports have reported the endoscopic approach to colloid cysts through the foramen with little emphasis on retroforaminal cysts, the aim of this study was to investigate colloid cysts as a special entity with regard to their different characteristics and surgical approaches and outcomes.
    Methods: In this retrospective study, 12 patients with third ventricular colloid cysts with retroforaminal extensions were included. All patients underwent endoscopic transseptal interforniceal approach with tumor resection. The surgical technique was briefly described, and preoperative and postoperative data were evaluated.
    Results: Among the 12 patients included in this study, most of our patients were males. Average diameter of the colloid cyst was relatively large (average 22 mm). Gross total resection was achieved in 10 cases (83.3%). The stable images showed no local recurrence in the long-term follow-up period except in 1 case at the 28-month follow-up period.
    Conclusions: Retroforaminal colloid cyst represents a unique entity that requires special attention to its mode of growth. The endoscopic approach for retroforaminal colloid cysts is nearly the same as that for foraminal cysts. It has a lower incidence rate of postoperative memory changes, lower chances of total resection, and lower incidence rate of hard contents. Moreover, sufficient knowledge on morbid anatomy is important to avoid fornix injury.
    MeSH term(s) Adolescent ; Adult ; Colloid Cysts/diagnostic imaging ; Colloid Cysts/surgery ; Female ; Follow-Up Studies ; Fornix, Brain/diagnostic imaging ; Fornix, Brain/surgery ; Humans ; Male ; Neuroendoscopy/methods ; Retrospective Studies ; Septum of Brain/diagnostic imaging ; Septum of Brain/surgery ; Young Adult
    Language English
    Publishing date 2021-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2021.05.004
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    Zs.A 1159: Show issues Location:
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  8. Article: A rare case of small bowel obstruction caused by Meckel's diverticulum: case report.

    Najm, Mahmoud / Kelzia, Aya / Arnaout, Ibrahim / Kadoura, Lama / Ghazal, Ahmad

    Journal of surgical case reports

    2023  Volume 2023, Issue 6, Page(s) rjad332

    Abstract: Meckel's diverticulum MD is the most common congenital deformity of the gastrointestinal tract. It has a very low reported incidence. We reported a 9-year-old child complaining of symptoms of small bowel obstruction. He had no medical or surgical history. ...

    Abstract Meckel's diverticulum MD is the most common congenital deformity of the gastrointestinal tract. It has a very low reported incidence. We reported a 9-year-old child complaining of symptoms of small bowel obstruction. He had no medical or surgical history. There is no signs of peritonitis and appendicitis. Simple abdominal X-ray diagnosed the obstruction, during surgery we found an MD located 30 cm from the ileocecal valve, fibrous band may be as complication for MD to the anterior abdominal wall at the umbilicus, the small intestines were wrapped around the band, causing the obstruction. The MD and the band were excised with end-to-end anastomosis. We diagnosed our case during surgery. Early surgery is important to preserve bowel from gangrene or necrosis. The patient's well-being improved, and he was discharged from the hospital in good condition.
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Case Reports
    ZDB-ID 2580919-2
    ISSN 2042-8812
    ISSN 2042-8812
    DOI 10.1093/jscr/rjad332
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  9. Article: Multiple Distal Femoral Osteochondromas Encasing Popliteal Neurovascular Bundle.

    Habeeb, Amir / Roszpopa, Jaroszlav / Arnaout, Ali / Grant, Ian / Latimer, Mark

    Cureus

    2023  Volume 15, Issue 10, Page(s) e46396

    Abstract: Multiple hereditary exostosis syndrome is a rare diagnosis with approximately 1:50000 incidence prevailing in males. The exostoses or osteochondromas are benign but have the potential for malignant transformation in 1-5%. There is a strong genetic ... ...

    Abstract Multiple hereditary exostosis syndrome is a rare diagnosis with approximately 1:50000 incidence prevailing in males. The exostoses or osteochondromas are benign but have the potential for malignant transformation in 1-5%. There is a strong genetic component, with exostosis (EXT) signaling pathways being an underlying cause. They can be symptomatic, with pain and functional deficit as the main complaints. We present a case of a 17-year-old male who presented with pain and anatomical deformity in his left lower femur. Magnetic resonance imaging revealed multiple osteochondromas compressing the popliteal neurovascular bundle. Excision of the osteochondromas was performed to decompress the neurovascular bundle in a multidisciplinary approach. Histological examination demonstrated no evidence of malignancy. Currently, there is no consensus for patients diagnosed with multiple osteochondromas regarding further investigation and/or screening for malignant transformation.
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.46396
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  10. Article: Radiologic Evolution after Scapholunate Dorsal Capsulodesis for Chronic Tears.

    Borrel, François / Gras, Mathilde / Arnaout, Ahlam / Mathoulin, Christophe / Merlini, Lorenzo

    Journal of wrist surgery

    2023  Volume 12, Issue 5, Page(s) 433–438

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2678060-4
    ISSN 2163-3924 ; 2163-3916
    ISSN (online) 2163-3924
    ISSN 2163-3916
    DOI 10.1055/s-0043-1764159
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