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  1. Article ; Online: Are Antiplatelet Agents Beneficial in Essential Thrombocythemia? Maybe Yes, Probably No.

    Bennett, Joel S

    Annals of internal medicine

    2017  Volume 167, Issue 3, Page(s) 206–207

    MeSH term(s) Fibrinolytic Agents ; Humans ; Platelet Aggregation Inhibitors ; Risk Assessment ; Thrombocythemia, Essential ; Thrombosis
    Chemical Substances Fibrinolytic Agents ; Platelet Aggregation Inhibitors
    Language English
    Publishing date 2017-06-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M17-1378
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Shedding New Light on the Platelet Storage Lesion.

    Bennett, Joel S

    Arteriosclerosis, thrombosis, and vascular biology

    2016  Volume 36, Issue 9, Page(s) 1715–1716

    MeSH term(s) Blood Platelets ; Platelet Glycoprotein GPIb-IX Complex ; Platelet Transfusion
    Chemical Substances Platelet Glycoprotein GPIb-IX Complex
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.116.308095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A little bit of kindlin goes a long way.

    Bennett, Joel S

    Blood

    2015  Volume 126, Issue 24, Page(s) 2535–2536

    MeSH term(s) Animals ; Blood Platelets/physiology ; Cytoskeletal Proteins/physiology ; Leukocytes/immunology
    Chemical Substances Cytoskeletal Proteins
    Language English
    Publishing date 2015-12-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2015-10-675454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: ¿Como se llama?

    Bennett, Joel S

    Blood

    2011  Volume 118, Issue 3, Page(s) 487–488

    Language English
    Publishing date 2011-07-21
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2011-05-356568
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  5. Article ; Online: Regulation of integrins in platelets.

    Bennett, Joel S

    Biopolymers

    2015  Volume 104, Issue 4, Page(s) 323–333

    Abstract: Blood platelets prevent bleeding after trauma by forming occlusive aggregates at sites of vascular injury. Platelet aggregation is mediated by the integrin heterodimer αIIbβ3 and occurs when platelet agonists generated at the injury site convert αIIbβ3 ... ...

    Abstract Blood platelets prevent bleeding after trauma by forming occlusive aggregates at sites of vascular injury. Platelet aggregation is mediated by the integrin heterodimer αIIbβ3 and occurs when platelet agonists generated at the injury site convert αIIbβ3 from its resting to its active conformation. Active αIIbβ3 is then able to bind macromolecular ligands such as fibrinogen that crosslink adjacent platelets into hemostatic aggregates. Platelets circulate in a plasma milieu containing high concentrations of the principal αIIbβ3 ligand fibrinogen. Thus, αIIbβ3 activity is tightly regulated to prevent the spontaneous formation of platelet aggregates. αIIbβ3 activity is regulated at least three levels. First, intramolecular interactions involving motifs located in the membrane-proximal stalk regions, transmembrane domains, and the membrane-proximal cytosolic tails of αIIb and β3 maintain αIIbβ3 in its inactive conformation. Transmembrane domain interactions appear particularly important because disrupting these interactions causes constitutive αIIbβ3 activation. Second, the agonist-stimulated binding of the cytosolic proteins talin and kindlin-3 to the β3 cytosolic tail rapidly causes αIIbβ3 activation by disrupting the intramolecular interactions constraining αIIbβ3 activity. Third, the strength of ligand binding to active αIIbβ3 seems to be allosterically regulated. Thus, αIIbβ3 exists in a minimum of three interconvertible states: an inactive (resting) state that does not interact with ligands and two active ligand binding states that differ in their affinity for fibrinogen and in the mechanical stability of fibrinogen complexes they form.
    MeSH term(s) Amino Acid Motifs ; Animals ; Blood Platelets/metabolism ; Cell Membrane/metabolism ; Humans ; Platelet Aggregation/physiology ; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism ; Protein Structure, Tertiary
    Chemical Substances Platelet Glycoprotein GPIIb-IIIa Complex
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1123-x
    ISSN 1097-0282 ; 0006-3525
    ISSN (online) 1097-0282
    ISSN 0006-3525
    DOI 10.1002/bip.22679
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Platelet αIIbβ3 activation: filling in the pieces.

    Bennett, Joel S

    Blood

    2014  Volume 123, Issue 20, Page(s) 3065–3067

    Abstract: In this issue of Blood, Kasirer-Friede and colleagues show that the adhesion and degranulation promoter protein (ADAP) promotes αIIbβ3 activation by presenting the cytoplasmic proteins talin and kindlin to the β3 cytoplasmic tail. ...

    Abstract In this issue of Blood, Kasirer-Friede and colleagues show that the adhesion and degranulation promoter protein (ADAP) promotes αIIbβ3 activation by presenting the cytoplasmic proteins talin and kindlin to the β3 cytoplasmic tail.
    MeSH term(s) Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Cytoskeletal Proteins/metabolism ; Fibrinogen/metabolism ; Humans ; Membrane Proteins/metabolism ; Neoplasm Proteins/metabolism ; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism ; Talin/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; Cytoskeletal Proteins ; FERMT3 protein, human ; FYB1 protein, human ; Fyb protein, mouse ; Membrane Proteins ; Neoplasm Proteins ; Platelet Glycoprotein GPIIb-IIIa Complex ; Talin ; kindlin-3 protein, mouse ; Fibrinogen (9001-32-5)
    Language English
    Publishing date 2014-05-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2014-02-557355
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Configurable error correction of code-division multiplexed TES detectors with a cryotron switch.

    Weber, Joel C / Fowler, Joseph W / Durkin, Malcolm / Morgan, Kelsey M / Mates, John A B / Bennett, Doug A / Doriese, W Bertrand / Schmidt, Daniel R / Hilton, Gene C / Swetz, Daniel S / Ullom, Joel N

    Applied physics letters

    2023  Volume 114, Issue 23

    Abstract: The development of a superconducting analog to the transistor with extremely low power dissipation will accelerate the proliferation of low-temperature circuitry operating in the milliKelvin regime. The thin-film, magnetically actuated cryotron switch is ...

    Abstract The development of a superconducting analog to the transistor with extremely low power dissipation will accelerate the proliferation of low-temperature circuitry operating in the milliKelvin regime. The thin-film, magnetically actuated cryotron switch is a candidate building block for more complicated and flexible milliKelvin circuitry. We demonstrate its utility for implementing reconfigurable circuitry by integrating a cryotron switch into flux-summed code-division SQUID multiplexed readout for large arrays of transition-edge-sensor (TES) microcalorimeters. Code-division multiplexing eliminates the noise penalty of time-division multiplexing while being drop-in compatible with the latter's control electronics. However, code-division multiplexing is susceptible to single-point failure mechanisms which can result in an unconstrained demodulation matrix and the loss of information from many sensing elements. In the event of a failure, the integrated cryotron switch provides a zero-signal output from a single TES, enabling the demodulation matrix used to compute TES signals from SQUID signals to be constrained and data recovered from the remaining sensors. This demonstration of configurable error correction provides both a realworld application of the cryotron switch and a foundation for more complex circuitry at milliKelvin temperatures.
    Language English
    Publishing date 2023-10-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1469436-0
    ISSN 1077-3118 ; 0003-6951
    ISSN (online) 1077-3118
    ISSN 0003-6951
    DOI 10.1063/1.5089870
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The impact of concussion on subsequent injury risk in elite junior Australian football athletes.

    Bennett, Hunter / Chalmers, Samuel / Fuller, Joel

    Journal of science and medicine in sport

    2023  Volume 26, Issue 4-5, Page(s) 247–252

    Abstract: Objectives: Concussion increases injury risk. However, this has not been investigated in junior Australian football and it is unknown whether the location, severity, and mechanism of subsequent injuries differ after concussion vs. non-concussion injury.! ...

    Abstract Objectives: Concussion increases injury risk. However, this has not been investigated in junior Australian football and it is unknown whether the location, severity, and mechanism of subsequent injuries differ after concussion vs. non-concussion injury.
    Design: Prospective cohort.
    Methods: 1455 elite adolescent male Australian footballers were tracked across seven seasons to determine whether subsequent injury risk was greater after concussion compared to non-concussion index injury using multilevel survival analysis. Mixed-effects logistic regression compared location and mechanism. Mixed-effects Poisson regression compared severity.
    Results: Of 1455 athletes, 632 were injured and included in subsequent-injury analysis. There were no differences in injury incidence after a concussion compared to upper- (hazard ratio = 1.0, 0.6 to 1.9, P = 0.892; trivial effect) and lower (hazard ratio = 1.1, 0.6 to 1.9, P = 0.810; trivial effect) index injury, or in location. Subsequent injuries were more likely to be contact-based after a non-concussion injury than concussion (odds ratio = 4.6, 1.3 to 16.0; P = 0.017; large effect). There was no difference in subsequent injury severity after lower- (3.4 ± 3.0 missed matches; incidence rate ratio = 1.4, 0.9 to 2.1; P ≤ 0.117; small effect) and upper-limb injuries (3.4 ± 3.1 missed matches; incidence rate ratio = 1.4, 0.9 to 2.2; P = 0.189; small effect) compared to concussion (2.4 ± 2.0 missed matches).
    Conclusions: Subsequent injury risk, severity, and location in junior Australian football are similar following concussion compared to non-concussion index injuries, although contact injuries are less likely.
    MeSH term(s) Adolescent ; Humans ; Male ; Reinjuries ; Athletic Injuries/epidemiology ; Prospective Studies ; Australia/epidemiology ; Brain Concussion/epidemiology ; Athletes ; Incidence ; Team Sports
    Language English
    Publishing date 2023-04-04
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1437829-2
    ISSN 1878-1861 ; 1440-2440
    ISSN (online) 1878-1861
    ISSN 1440-2440
    DOI 10.1016/j.jsams.2023.03.013
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  9. Article ; Online: Pinning a tail on platelet thrombi.

    Bennett, Joel S

    Blood

    2009  Volume 113, Issue 15, Page(s) 3395

    Language English
    Publishing date 2009-04-09
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2008-12-193284
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  10. Article ; Online: Pulsed Electric Field Ablation of Esophageal Malignancies and Mitigating Damage to Smooth Muscle: An In Vitro Study.

    Gudvangen, Emily / Mangalanathan, Uma / Semenov, Iurii / Kiester, Allen S / Keppler, Mark A / Ibey, Bennett L / Bixler, Joel N / Pakhomov, Andrei G

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Cancer ablation therapies aim to be efficient while minimizing damage to healthy tissues. Nanosecond pulsed electric field (nsPEF) is a promising ablation modality because of its selectivity against certain cell types and reduced neuromuscular effects. ... ...

    Abstract Cancer ablation therapies aim to be efficient while minimizing damage to healthy tissues. Nanosecond pulsed electric field (nsPEF) is a promising ablation modality because of its selectivity against certain cell types and reduced neuromuscular effects. We compared cell killing efficiency by PEF (100 pulses, 200 ns-10 µs duration, 10 Hz) in a panel of human esophageal cells (normal and pre-malignant epithelial and smooth muscle). Normal epithelial cells were less sensitive than the pre-malignant ones to unipolar PEF (15-20% higher LD50,
    MeSH term(s) Humans ; Electricity ; Membrane Potentials ; Electroporation ; Carcinoma ; Muscle, Smooth ; Esophageal Neoplasms/therapy
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032854
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