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  1. Article: The role of 401a>G polymorphism of methylenetetrahydrofolate dehydrogenase gene (MTHFD1) in fetal hypotrophy.

    Lorenc, Anna / Seremak-Mrozikiewicz, Agnieszka / Barlik, Magdalena / Wolski, Hubert / Drews, Krzysztof

    Ginekologia polska

    2014  Volume 85, Issue 7, Page(s) 494–499

    Abstract: ... development. The aim of the study was to investigate the connection of 401A>G polymorphism ... with birth weight < 1500 g, 89 mothers of newborns with birth weight > or = 1500 g). The genetic analysis was ... who delivered hypotrophic children weighted more than 1500 g the presence of 401A allele was higher (28,7 vs. 18 ...

    Abstract Introduction: Important role is attributed to genetic polymorphisms influencing enzymatic activity in folate metabolism. These inherited genetic variants may influence fetal growth and fetal hypotrophy development. The aim of the study was to investigate the connection of 401A>G polymorphism of methyleneterahydrofolate dehydrogenase gene (MTHFD1) with increased risk of fetal hypotrophy.
    Material and methods: To the study group 120 women who delivered children with fetal hypotrophy and to the control group 120 healthy women were enrolled. Study group was divided into subgroups according to gestational age at delivery (52 patients < 37 weeks, 68 patients > or = 37 weeks) and to the neonatal weight (31 mothers of newborns with birth weight < 1500 g, 89 mothers of newborns with birth weight > or = 1500 g). The genetic analysis was performed with the use of PCR/RFLP method.
    Results: We observed statistically higher occurrence of mutated 401A allele in hypotrophy group (401A: 27,1 vs. 18,8%, OR = 1,61, p = 0,02). At mothers who delivered hypotrophic children weighted more than 1500 g the presence of 401A allele was higher (28,7 vs. 18,8%, OR = 1,74, p = 0,01). Additionally in mothers who delivered hypotrophic children before 37 gestational week statistically higher frequency of 401A allele has been noted (31,7 vs. 18,8%, OR = 2,01, p = 0,007).
    Conclusions: Our results indicated that mutated 401A allele of MTHFD1 gene is essential risk factor of fetal hypotrophy in population of Polish women. Appropriate folate supplementation could be particularly essential in women carriers the genetic polymorphism influencing the folate metabolism.
    MeSH term(s) Adult ; Birth Weight/genetics ; Female ; Fetal Development/genetics ; Fetal Growth Retardation/genetics ; Folic Acid/metabolism ; Gene Frequency ; Genotype ; Gestational Age ; Humans ; Infant, Newborn ; Male ; Methylenetetrahydrofolate Dehydrogenase (NADP)/genetics ; Methylenetetrahydrofolate Dehydrogenase (NADP)/metabolism ; Minor Histocompatibility Antigens ; Mutation ; Polymorphism, Genetic ; Pregnancy
    Chemical Substances Minor Histocompatibility Antigens ; Folic Acid (935E97BOY8) ; MTHFD1 protein, human (EC 1.5.1.5) ; Methylenetetrahydrofolate Dehydrogenase (NADP) (EC 1.5.1.5)
    Language English
    Publishing date 2014-08-11
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 130894-4
    ISSN 0017-0011
    ISSN 0017-0011
    DOI 10.17772/gp/1759
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  2. Article ; Online: A promoter polymorphism -945C>G in the connective tissue growth factor in heart failure patients with mechanical circulatory support: a new marker for bridge to recovery?

    Posch, Maximilian G / Schmidt, Gunther / Steinhoff, Laura / Perrot, Andreas / Drews, Thorsten / Dandel, Michael / Krabatsch, Thomas / Hetzer, Roland / Potapov, Evgenij V

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

    2014  Volume 47, Issue 1, Page(s) e29–33

    Abstract: ... without cardiac recovery on MCS were genotyped.: Methods: The CTGF promoter variant (c.-945C>G) was analysed ... characteristics and outcome on MCS were correlated with the respective genotypes.: Results: The c.-945C>G ... Intriguingly, 50% of patients who were weaned from MCS (Group II) were homozygous for the G allele compared ...

    Abstract Objectives: Mechanical circulatory support (MCS) creates improvement of cardiac function in a small portion of patients with idiopathic dilated cardiomyopathy (iDCM). Among other factors, cardiomyocyte hypertrophy seems to represent an important prerequisite for MCS-related cardiac recovery. We have previously shown that connective tissue growth factor (CTGF) leads to adaptive cardiomyocyte hypertrophy associated with a protective cardiac function in transgenic mice. To test whether a functional genetic variant in the CTGF promoter impacts MCS-related cardiac recovery, three groups of iDCM patients with and without cardiac recovery on MCS were genotyped.
    Methods: The CTGF promoter variant (c.-945C>G) was analysed in 314 patients with iDCM receiving medical treatment only (Group I). Forty-nine iDCM patients who were either weaned from MCS for more than 6 months (Group II; n=20) or bridged to cardiac transplantation (Group III: n=29) were also genotyped. Patients on MCS were followed up for at least 12 months. Clinical characteristics and outcome on MCS were correlated with the respective genotypes.
    Results: The c.-945C>G allele frequencies in 314 iDCM patients (Group I) were similar to controls deposited in the HapMap database or those published in a recent study. There were no differences in allele prevalence between patients with mild to moderate iDCM (Group I) compared with patients with severe iDCM requiring MCS (Groups II and III). Intriguingly, 50% of patients who were weaned from MCS (Group II) were homozygous for the G allele compared with only 17.2% of patients included in Group III, which is a significant difference (P=0.03).
    Conclusions: Homozygosity of the promoter-activating G allele in the CTGF_c.-945C>G variant is overrepresented in patients with cardiac recovery on MCS when compared with iDCM patients without cardiac recovery. Further studies are needed to evaluate c.-945C>G as a genetic predictor for clinical outcome on MCS.
    MeSH term(s) Adult ; Cardiomyopathy, Dilated/genetics ; Cardiomyopathy, Dilated/surgery ; Connective Tissue Growth Factor/genetics ; Female ; Gene Frequency/genetics ; Genetic Markers/genetics ; Genotype ; Heart-Assist Devices ; Homozygote ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Promoter Regions, Genetic/genetics ; Treatment Outcome
    Chemical Substances CCN2 protein, human ; Genetic Markers ; Connective Tissue Growth Factor (139568-91-5)
    Language English
    Publishing date 2014-10-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 639293-3
    ISSN 1873-734X ; 1010-7940 ; 1567-4258
    ISSN (online) 1873-734X
    ISSN 1010-7940 ; 1567-4258
    DOI 10.1093/ejcts/ezu402
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  3. Article: The contribution of Hind III C>G PAI-1 gene polymorphism in etiology of recurrent miscarriages.

    Barlik, Magdalena / Wolski, Hubert / Drews, Krzysztof / Pieńkowski, Wojciech / Klejewski, Andrzej / Seremak-Mrozikiewicz, Agnieszka

    Ginekologia polska

    2015  Volume 86, Issue 4, Page(s) 274–279

    Abstract: Objectives: The goal of the study was to assess the relationship of HindIII C>G PAI-1 gene ... G allele was also observed more frequently in the whole study group (45.7% vs. 42.2% in controls, OR ... miscarriages (31.6% vs. 20.0% in controls, OR= 1.85, p=0.09). HindIII G allele was also noted more frequently ...

    Abstract Objectives: The goal of the study was to assess the relationship of HindIII C>G PAI-1 gene polymorphism with increased risk of recurrent miscarriages.
    Material and methods: A whole of 152 women with a history of at least two miscarriages were classified into analysis. The study group was divided twice (114 subjects with 2 miscarriages and 38 subjects with >3 miscarriages, 123 subjects with miscarriages at <13gw, and 29 subjects with miscarriages in <21 gw). The controls consisted of 180 women with a positive history of at least one pregnancy and birth of a healthy term newborn, and a negative history of miscarriage. The analysed polymorphisms were determined by PCR/RFLP methods.
    Results: The occurrence of HindIII GG genotype in the whole study group was 25.7% and 20.0% in controls (OR= 1.38, p=0. 14). HindIII G allele was also observed more frequently in the whole study group (45.7% vs. 42.2% in controls, OR=1. 15, p=0.20). The occurrence of HindIII GG genotype was higher in the subgroup of women with >3 miscarriages (31.6% vs. 20.0% in controls, OR= 1.85, p=0.09). HindIII G allele was also noted more frequently in the subgroup of women with >3 miscarriages (50.0% vs. 42.2% in controls, OR=1.37, p=0. 13). A tendency of higher frequency of HindIII GG genotype and HindIII G allele was also noted in the subgroup of patients with miscarriages in the first and second trimester (HindIII GG: 31.0% vs. 20.0% in controls, OR= 1.80, p=O. 14, HindIII G: 51.7% vs. 42.2% in controls, OR=1.4 7, p=0.11).
    Conclusions: Mutated HindIII G allele and HindIII GG genotype of HindIII C>G polymorphism probably augment the risk of recurrent miscarriages.
    MeSH term(s) Abortion, Habitual/diagnosis ; Abortion, Habitual/genetics ; Alleles ; Female ; Gene Frequency ; Humans ; Infant, Newborn ; Plasminogen Activator Inhibitor 1/genetics ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Pregnancy ; Pregnancy Trimester, First/genetics ; Risk Factors
    Chemical Substances Plasminogen Activator Inhibitor 1
    Language English
    Publishing date 2015-06-28
    Publishing country Poland
    Document type Comparative Study ; Journal Article
    ZDB-ID 130894-4
    ISSN 0017-0011
    ISSN 0017-0011
    DOI 10.17772/gp/2073
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  4. Article: Analysis of -11391G>A and +45>G polymorphisms of ADIPOQ gene in women with excessive weight gain during pregnancy.

    Wolski, Hubert / Kraśnik, Witold / Bogacz, Anna / Bartkowiak-Wieczorek, Joanna / Drews, Krzysztof / Greber, Agnieszka / Czerny, Bogusław / Piątek, Krzysztof / Seremak-Mrozikiewicz, Agnieszka

    Ginekologia polska

    2015  Volume 86, Issue 5, Page(s) 352–356

    Abstract: ... of the -11391G>A and +45T>G polymorphisms of the ADIPOQ gene in Polish women with excessive weight gain during ... of the +45T>G polymorphism with body mass at the end of pregnancy and pre-pregnancy WHR values (p < 0.05 ... gain. It is claimed that the mutated +45G allele of the +45T>G ADIPOQ polymorphism shows a possible ...

    Abstract Objectives: The aim of our study was to evaluate the frequency of genotypes and alleles of the -11391G>A and +45T>G polymorphisms of the ADIPOQ gene in Polish women with excessive weight gain during pregnancy. A possible correlation between these polymorphisms and selected clinical and anthropometric parameters has been analyzed.
    Material and methods: A total of 153 pregnant Caucasian women of Polish origin with normal pre-pregnancy body mass were analyzed: 78 women with excessive weight gain (study group) and 75 women with normal weight gain during pregnancy (control group). The analysis of the polymorphisms was performed by PCR/RFLP.
    Results: The influence of the -11391G>A polymorphism on body mass and BMI values at the end of pregnancy (p < 0.05) was observed. We also detected a correlation of the +45T>G polymorphism with body mass at the end of pregnancy and pre-pregnancy WHR values (p < 0.05).
    Conclusions: The observed effect of the -11391G>A polymorphism on the parameters assessed at the end of pregnancy (BMI and body mass), suggests a protective role of the -11391A genetic variant in excessive weight gain. It is claimed that the mutated +45G allele of the +45T>G ADIPOQ polymorphism shows a possible connection with higher pre-pregnancy WHR values and body mass at the end of pregnancy Our findings suggest a possible contribution of the -11391G>A and +45T>G polymorphisms of the ADIPOQ gene to the pathomechanism of excessive weight gain in pregnant women from the Polish population. This observation should be confirmed in a larger sample size study
    MeSH term(s) Adiponectin/genetics ; Adult ; Alleles ; Body Mass Index ; European Continental Ancestry Group/genetics ; Female ; Genotype ; Humans ; Overweight/genetics ; Poland ; Polymorphism, Genetic ; Pregnancy ; Pregnancy Complications/genetics ; Risk Factors ; Weight Gain/genetics ; Young Adult
    Chemical Substances ADIPOQ protein, human ; Adiponectin
    Language English
    Publishing date 2015-06-28
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 130894-4
    ISSN 0017-0011
    ISSN 0017-0011
    DOI 10.17772/gp/2421
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  5. Article: Polimorfizmy 20210G>A i 19911A>G genu protrombiny a wystepowanie poronień nawracajacych.

    Barlik, Magdalena / Seremak-Mrozikiewicz, Agnieszka / Kraśnik, Witold / Drews, Krzysztof

    Ginekologia polska

    2013  Volume 84, Issue 10, Page(s) 830–834

    Abstract: Objectives: The aim of the study was to evaluate the frequency of 20210G>A and 19911A>G ... as overrepresentation of 20210A allele (1.3% vs. 0.6% in the control group, WR = 2.42, ns). Considering the 19911A>G ... of correlation of 20210G>A and 19911A>G prothrombin gene polymorphisms with the risk of recurrent miscarriages ...

    Title translation The 20210G>A and 19911A>G polymorphisms of prothrombin gene and recurrent miscarriages.
    Abstract Objectives: The aim of the study was to evaluate the frequency of 20210G>A and 19911A>G prothrombin gene polymorphisms in a group of women with 2 or more miscarriages in the first trimester of pregnancy
    Material and methods: The study involved 150 women with two or more miscarriages in the first trimester of pregnancy (mean age 31.5 +/- 4.1 years). The control group consisted of 180 healthy women (mean age 28.7 +/- 4.0 years). The frequency of genotypes and alleles of the investigated polymorphisms was evaluated by polymerase chain reaction/restriction fragments length polymorphism method (PCR/RFLP).
    Results: As to the 20210G>A prothrombin gene polymorphism, overrepresentations of 20210GA genotype have been observed in the group of women with miscarriages (2.7% vs. 1.1% in the control group, WR = 2.44, ns), as well as overrepresentation of 20210A allele (1.3% vs. 0.6% in the control group, WR = 2.42, ns). Considering the 19911A>G polymorphism, a similar frequency of mutated homozygous 19911GG genotype has been noted (22.6 vs. 21.1% in controls, OR= 1.10, ns). Also, frequency of mutated 19911G allele was similar in both investigated groups with miscarriages and controls (48.6% vs. 45.7%, OR = 0.89, ns).
    Conclusions: Our findings suggest lack of correlation of 20210G>A and 19911A>G prothrombin gene polymorphisms with the risk of recurrent miscarriages in the first trimester of pregnancy Further studies, concerning other genetic variants conditioning inherited thrombophilia and environmental factors influencing the risk of recurrent abortions, are needed. Therefore, further research with more numerous group of women with recurrent miscarriages and taking into account other polymorphisms of thrombophilia and influence of environmental factors is required.
    MeSH term(s) Abortion, Habitual/genetics ; Adult ; Alleles ; Female ; Gene Frequency ; Genotype ; Humans ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Pregnancy ; Pregnancy Trimester, First/genetics ; Prothrombin/genetics ; Prothrombin/metabolism
    Chemical Substances Prothrombin (9001-26-7)
    Language Polish
    Publishing date 2013-11-08
    Publishing country Poland
    Document type English Abstract ; Journal Article
    ZDB-ID 130894-4
    ISSN 0017-0011
    ISSN 0017-0011
    DOI 10.17772/gp/1647
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  6. Article: Wpływ czynników metabolicznych na wzrastanie płodu u ciezarnych z cukrzyca typu 1 oraz wariantem homozygotycznym polimorfizmu -2548 G/A genu leptyny i 668 A/G receptora leptyny.

    Iciek, Rafał / Wender-Ozegowska, Ewa / Zawiejska, Agnieszka / Seremak-Mrozikiewicz, Agnieszka / Drews, Krzysztof / Brazert, Jacek

    Ginekologia polska

    2010  Volume 81, Issue 8, Page(s) 571–577

    Abstract: ... subjects with homozygotic variants in leptin gene (-2548 G/A) and leptin gene receptor (668 G ... in the analyzed group was 3600 g. The following parameters were found to have influence on fetal weight ...

    Title translation The influence of metabolic parameters on fetal development weight in women with type 1 diabetes and homozygotic variant in -2548 G/A of leptin gene and its 668 A/G receptor polymorphism.
    Abstract Introduction: Leptin, as many other hormones and metabolic factors, may play a role in fetal development in pregnancy complicated by type 1 diabetes. Different genetic variants in leptin gene and leptin gene receptor may have influence on leptin synthesis in the course of pregnancy and metabolic state of the mother.
    Aim: To assess the possible influence of metabolic factors on fetal weight in type 1 diabetic subjects with homozygotic variants in leptin gene (-2548 G/A) and leptin gene receptor (668 G/A).
    Methods: 30 diabetic and homozygotic subjects (out of 100 diabetic subjects) were qualified to the study Genotyping was performed by PCR-RFLR The following factors were assessed: glycemia, leptin concentration, glycated hemoglobin, lipid profile (total cholesterol, LDL, HDL, triglycerides), maternal body weight. Multiple regression models were developed and ROC curves were used in the analysis.
    Results: Mean fetal weight in the analyzed group was 3600 g. The following parameters were found to have influence on fetal weight: I trimester leptin (R2-0.80741288, p < 0.05), I trimester glycemia (R2-0.80741288, p < 0.05), III trimester glycemia (R2-0.80741288, p < 0.05), I trimester HbA1C (R2-0.80741288, p < 0.05), III trimester LDL (R2 = 0.63192254, p < 0.05). Moreover the influence of LDL and maternal BMI (R2-0.81869348, p < 0.05) was found. ROC curve analysis revealed the influence of I trimester leptin--AUC 0.62; sensitivity 0.75; specificity 0.5; cut-off 28.127 ng/ml, III trimester HbA1C AUC 0.66; sensitivity 0.23; specificity 0.91; cut-off 7.9%, III trimester mothers weight AUC 0.63; sensitivity 0.25; specificity 0.93; cut-off 98 kg.
    Conclusion: Apart from well-known metabolic factors influencing fetal weight, I trimester leptin concentration was found to have an impact on fetal growth.
    MeSH term(s) Adult ; Body Mass Index ; Body Weight/genetics ; Case-Control Studies ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/metabolism ; Female ; Fetal Weight/genetics ; Genotype ; Humans ; Infant, Newborn ; Leptin/genetics ; Obesity/genetics ; Polymerase Chain Reaction/methods ; Polymorphism, Genetic ; Pregnancy ; Pregnancy in Diabetics/genetics ; Pregnancy in Diabetics/metabolism ; Receptors, Leptin/genetics
    Chemical Substances LEPR protein, human ; Leptin ; Receptors, Leptin
    Language Polish
    Publishing date 2010-06-17
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 130894-4
    ISSN 0017-0011
    ISSN 0017-0011
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  7. Book: Mikrobiologie

    Drews, Gerhart

    die Entdeckung der unsichtbaren Welt

    2010  

    Author's details Gerhart Drews
    Keywords Mikrobiologie ; Geschichte
    Language German
    Size XIV, 245 S. : Ill., graph.Darst
    Publisher Springer
    Publishing place Heidelberg u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT016313907
    ISBN 978-3-642-10756-6 ; 9783642107573 ; 3-642-10756-7 ; 3642107575
    Database Catalogue ZB MED Medicine, Health

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    2010 A 2988 order for loan Magazin

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  8. Article: MMQ cells: a model for evaluating the role of G proteins in the modulation of prolactin release.

    Forget, H / Painson, J C / Drews, R T / Lagacé, G / Collu, R

    Molecular and cellular endocrinology

    1993  Volume 93, Issue 2, Page(s) 125–133

    Abstract: ... an interesting model since they only secrete PRL. In order to determine whether and which GTP-binding (G ... the levels of various G proteins (alpha o, alpha s, alpha i, alpha q and beta) and their mRNAs, measured ...

    Abstract It is well known that dopamine (DA) inhibits while vasoactive intestinal peptide (VIP) and angiotensin II (ANG II) stimulate prolactin (PRL) release from normal anterior pituitary lactotrophs; however, elucidation of the intracellular mechanisms involved in these effects has been hindered by the cellular heterogeneity of the anterior pituitary. MMQ cells, isolated from the PRL-secreting rat pituitary tumor 7315a is an interesting model since they only secrete PRL. In order to determine whether and which GTP-binding (G) proteins are involved in the modulation of cyclic 3',5'-adenosine monophosphate (cAMP) accumulation and phospholipids turnover and eventually PRL release, we have performed studies with MMQ cells. For this purpose, the levels of various G proteins (alpha o, alpha s, alpha i, alpha q and beta) and their mRNAs, measured by Western and Northern blots respectively, were correlated with intracellular cAMP accumulation in response to DA, VIP or DA plus VIP, and with inositol phosphates (IPx) formation in response to ANG II, DA or DA plus ANG II. This study shows that, when compared to normal pituitary tissue, the levels of alpha o, alpha o2 and alpha i3 were significantly decreased in MMQ cells; those of alpha o1, alpha i (alpha i1 + alpha i2), alpha s42 and alpha q were very low or undetectable while those of alpha s47 and beta were normal. DA was unable to inhibit basal PRL release and cAMP accumulation. VIP increased both cAMP accumulation and PRL release, while cAMP accumulation elicited by VIP could be suppressed by DA. BAY K 8644-induced PRL release also could be suppressed by DA.(ABSTRACT TRUNCATED AT 250 WORDS)
    MeSH term(s) 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester/pharmacology ; Angiotensin II/analogs & derivatives ; Angiotensin II/pharmacology ; Animals ; Cyclic AMP/physiology ; Dopamine/pharmacology ; Drug Interactions ; Exocytosis/drug effects ; Exocytosis/physiology ; GTP-Binding Proteins/antagonists & inhibitors ; GTP-Binding Proteins/biosynthesis ; GTP-Binding Proteins/classification ; GTP-Binding Proteins/physiology ; Gene Expression Regulation, Neoplastic/drug effects ; Inositol Phosphates/metabolism ; Neoplasm Proteins/genetics ; Neoplasm Proteins/physiology ; Phospholipids/metabolism ; Pituitary Neoplasms/metabolism ; Pituitary Neoplasms/pathology ; Prolactin/metabolism ; RNA, Messenger/genetics ; Rats ; Signal Transduction/drug effects ; Thyrotropin-Releasing Hormone/pharmacology ; Tumor Cells, Cultured/drug effects ; Tumor Cells, Cultured/metabolism ; Vasoactive Intestinal Peptide/pharmacology ; Virulence Factors, Bordetella/pharmacology
    Chemical Substances Inositol Phosphates ; Neoplasm Proteins ; Phospholipids ; RNA, Messenger ; Virulence Factors, Bordetella ; Angiotensin II (11128-99-7) ; Vasoactive Intestinal Peptide (37221-79-7) ; angiotensin II, Sar(1)-Ile(5)- (51833-69-3) ; Thyrotropin-Releasing Hormone (5Y5F15120W) ; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester (71145-03-4) ; Prolactin (9002-62-4) ; Cyclic AMP (E0399OZS9N) ; GTP-Binding Proteins (EC 3.6.1.-) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 1993-06
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 187438-x
    ISSN 1872-8057 ; 0303-7207
    ISSN (online) 1872-8057
    ISSN 0303-7207
    DOI 10.1016/0303-7207(93)90115-z
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  9. Article: SSCP polymorphism in exon 8B of the human G protein alpha O2 subunit (GNA01) gene.

    Drews, R T / Lagacé, G / Gravel, R A / Collu, R

    Human molecular genetics

    1993  Volume 2, Issue 8, Page(s) 1333

    MeSH term(s) Base Sequence ; Chromosome Mapping ; Chromosomes, Human, Pair 16 ; DNA Primers ; Exons ; GTP-Binding Proteins/genetics ; Humans ; Macromolecular Substances ; Molecular Sequence Data ; Polymerase Chain Reaction ; Polymorphism, Genetic
    Chemical Substances DNA Primers ; Macromolecular Substances ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 1993-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1108742-0
    ISSN 1460-2083 ; 0964-6906
    ISSN (online) 1460-2083
    ISSN 0964-6906
    DOI 10.1093/hmg/2.8.1333
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  10. Article ; Online: Robotics Research Growth in Latin America: Topical Collection on LARS 2020.

    Drews-Jr, Paulo L J / Gonçalves, Luiz M G

    Journal of intelligent & robotic systems

    2023  Volume 107, Issue 1, Page(s) 15

    Language English
    Publishing date 2023-01-17
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 1479543-7
    ISSN 1573-0409 ; 0921-0296
    ISSN (online) 1573-0409
    ISSN 0921-0296
    DOI 10.1007/s10846-022-01789-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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