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  1. Article ; Online: Nimodipine attenuates dibutyl phthalate-induced learning and memory impairment in kun ming mice: An in vivo study based on bioinformatics analysis.

    Yan, Biao / Ma, Ping / Chen, Shaohui / Cheng, Hongguo / Tang, Min / Sun, Yanling / Yang, Xu / Wu, Yang / Cheng, Menglin

    Environmental toxicology

    2020  Volume 36, Issue 5, Page(s) 821–830

    Abstract: Dibutyl phthalate (DBP), a typical representative of phthalate esters (PAEs), is used as a plasticizer in various industrial applications and has been reported to be responsible for neurobehavioral changes. Despite mounting evidence showing that ... ...

    Abstract Dibutyl phthalate (DBP), a typical representative of phthalate esters (PAEs), is used as a plasticizer in various industrial applications and has been reported to be responsible for neurobehavioral changes. Despite mounting evidence showing that nimodipine (Nim) palys a neuropharmacological and psychopharmacological role in neurons, the attenuating effects of Nim on learning and memory impairment induced by DBP exposure remain unknown. Based on bioinformatics analysis we found that the biological processes affected by both DBP and Nim may involve the calcium signaling pathway, the MAPK signaling pathway and the apoptosis pathway. The results of an in vivo study confirmed that DBP affects the levels of Ca
    MeSH term(s) Animals ; Computational Biology ; Dibutyl Phthalate/toxicity ; Memory Disorders/chemically induced ; Mice ; Nimodipine/toxicity ; Plasticizers
    Chemical Substances Plasticizers ; Dibutyl Phthalate (2286E5R2KE) ; Nimodipine (57WA9QZ5WH)
    Language English
    Publishing date 2020-12-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.23084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2676: Show issues Location:
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  2. Article ; Online: Differentially expressed genes in the ovary of the sixth day of pupal "Ming" lethal egg mutant of silkworm, Bombyx mori.

    Gao, Peng / Chen, An-Li / Zhao, Qiao-Ling / Shen, Xing-Jia / Qiu, Zhi-Yong / Xia, Ding-Guo / Tang, Shun-Ming / Zhang, Guo-Zheng

    Gene

    2013  Volume 527, Issue 1, Page(s) 161–166

    Abstract: The "Ming" lethal egg mutant (l-em) is a vitelline membrane mutant in silkworm, Bombyx mori ...

    Abstract The "Ming" lethal egg mutant (l-em) is a vitelline membrane mutant in silkworm, Bombyx mori. The eggs laid by the l-em mutant lose water, ultimately causing death within an hour. Previous studies have shown that the deletion of BmEP80 is responsible for the l-em mutation in silkworm, B. mori. In the current study, digital gene expression (DGE) was performed to investigate the difference of gene expression in ovaries between wild type and l-em mutant on the sixth day of the pupal stage to obtain a global view of gene expression profiles using the ovaries of three l-em mutants and three wild types. The results showed a total of 3,463,495 and 3,607,936 clean tags in the wild type and the l-em mutant libraries, respectively. Compared with those of wild type, 239 differentially expressed genes were detected in the l-em mutant, wherein 181 genes are up-regulated and 58 genes are down-regulated in the mutant strain. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis results showed that no pathway was significantly enriched and three pathways are tightly related to protein synthesis among the five leading pathways. Moreover, the expression profiles of eight important differentially expressed genes related to oogenesis changed. These results provide a comprehensive gene expression analysis of oogenesis and vitellogenesis in B. mori which facilitates understanding of both the specific molecular mechanism of the 1-em mutant and Lepidopteran oogenesis in general.
    MeSH term(s) Animals ; Bombyx/genetics ; Bombyx/metabolism ; Expressed Sequence Tags ; Female ; Gene Expression Profiling ; Genes, Lethal ; Insect Proteins/genetics ; Insect Proteins/metabolism ; Molecular Sequence Annotation ; Mutation ; Ovary/metabolism ; Ovum/metabolism ; Pupa/genetics ; Pupa/metabolism ; Transcriptome ; Vitelline Membrane/metabolism
    Chemical Substances Insect Proteins
    Language English
    Publishing date 2013-09-15
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2013.05.049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1357: Show issues Location:
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  3. Article: Differentially expressed genes in the ovary of the sixth day of pupal “Ming” lethal egg mutant of silkworm, Bombyx mori

    Gao, Peng / Chen, An-Li / Zhao, Qiao-Ling / Shen, Xing-Jia / Qiu, Zhi-Yong / Xia, Ding-Guo / Tang, Shun-Ming / Zhang, Guo-Zheng

    Gene. 2013 Sept. 15, v. 527, no. 1

    2013  

    Abstract: The “Ming” lethal egg mutant (l-eᵐ) is a vitelline membrane mutant in silkworm, Bombyx mori ...

    Abstract The “Ming” lethal egg mutant (l-eᵐ) is a vitelline membrane mutant in silkworm, Bombyx mori. The eggs laid by the l-eᵐ mutant lose water, ultimately causing death within an hour. Previous studies have shown that the deletion of BmEP80 is responsible for the l-eᵐ mutation in silkworm, B. mori. In the current study, digital gene expression (DGE) was performed to investigate the difference of gene expression in ovaries between wild type and l-eᵐ mutant on the sixth day of the pupal stage to obtain a global view of gene expression profiles using the ovaries of three l-eᵐ mutants and three wild types. The results showed a total of 3,463,495 and 3,607,936 clean tags in the wild type and the l-eᵐ mutant libraries, respectively. Compared with those of wild type, 239 differentially expressed genes were detected in the l-eᵐ mutant, wherein 181 genes are up-regulated and 58 genes are down-regulated in the mutant strain. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis results showed that no pathway was significantly enriched and three pathways are tightly related to protein synthesis among the five leading pathways. Moreover, the expression profiles of eight important differentially expressed genes related to oogenesis changed. These results provide a comprehensive gene expression analysis of oogenesis and vitellogenesis in B. mori which facilitates understanding of both the specific molecular mechanism of the 1-eᵐ mutant and Lepidopteran oogenesis in general.
    Keywords Bombyx mori ; animal ovaries ; death ; eggs ; gene expression ; gene expression regulation ; genes ; mutants ; mutation ; protein synthesis ; silkworms ; vitelline membrane ; vitellogenesis
    Language English
    Dates of publication 2013-0915
    Size p. 161-166.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2013.05.049
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Mutation of a vitelline membrane protein, BmEP80, is responsible for the silkworm "Ming" lethal egg mutant.

    Chen, Anli / Gao, Peng / Zhao, Qiaoling / Tang, Shunming / Shen, Xingjia / Zhang, Guozheng / Qiu, Zhiyong / Xia, Dingguo / Huang, Yongping / Xu, Yunmin / He, Ningjia

    Gene

    2013  Volume 515, Issue 2, Page(s) 313–319

    Abstract: ... on the lateral side. However, the eggs laid by homozygous recessive "Ming" lethal egg mutants (l-e(m)) lose water ...

    Abstract The egg stage is an important stage in the silkworm (Bombyx mori) life cycle. Normal silkworm eggs are usually short, elliptical, and laterally flattened, with a sometimes hollowed surface on the lateral side. However, the eggs laid by homozygous recessive "Ming" lethal egg mutants (l-e(m)) lose water and become concaved around 1h, ultimately exhibiting a triangular shape on the egg surfaces. We performed positional cloning, and narrowed down the region containing the gene responsible for the l-e(m) mutant to 360 kb on chromosome 10 using 2287 F(2) individuals. Using expression analysis and RNA interference, the best l-e(m) candidate gene was shown to be BmEP80. The results of the inverse polymerase chain reaction showed that an ~1.9 kb region from the 3' untranslated region of BmVMP23 to the forepart of BmEP80 was replaced by a >100 kb DNA fragment in the l-e(m) mutant. Several eggs laid by the normal moths injected with BmEP80 small interfering RNAs were evidently depressed and exhibited a triangular shape on the surface. The phenotype exhibited was consistent with the eggs laid by the l-e(m) mutant. Moreover, two-dimensional gel electrophoresis showed that the BmEP80 protein was expressed in the ovary from the 9th day of the pupa stage to eclosion in the wild-type silkworm, but was absent in the l-e(m) mutant. These results indicate that BmEP80 is responsible for the l-e(m) mutation.
    MeSH term(s) 3' Untranslated Regions ; Animals ; Base Sequence ; Bombyx/genetics ; Chromosome Mapping ; DNA Mutational Analysis ; Egg Proteins/genetics ; Egg Proteins/metabolism ; Female ; Gene Expression ; Genes, Lethal ; Genetic Association Studies ; Genetic Linkage ; INDEL Mutation ; Insect Proteins/genetics ; Insect Proteins/metabolism ; Male ; Vitelline Membrane/metabolism
    Chemical Substances 3' Untranslated Regions ; Egg Proteins ; Insect Proteins ; vitelline membrane proteins
    Language English
    Publishing date 2013-02-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2012.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1357: Show issues Location:
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  5. Article ; Online: Response to the letter of Dr. Ming-Hua Zheng and colleagues on "Recombination human hepatocyte growth factor for liver failure".

    Cui, Yao-Li / Meng, Mao-Bin / Tang, Hong / Lei, Xue-Zhong

    Contemporary clinical trials

    2009  Volume 30, Issue 1, Page(s) 102

    MeSH term(s) Hepatocyte Growth Factor/therapeutic use ; Humans ; Liver Failure/drug therapy ; Meta-Analysis as Topic ; Randomized Controlled Trials as Topic ; Recombinant Proteins/therapeutic use
    Chemical Substances Recombinant Proteins ; Hepatocyte Growth Factor (67256-21-7)
    Language English
    Publishing date 2009-01
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2008.09.005
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    Zs.A 1581: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article: Mutation of a vitelline membrane protein, BmEP80, is responsible for the silkworm “Ming” lethal egg mutant

    Chen, Anli / Gao, Peng / Zhao, Qiaoling / Tang, Shunming / Shen, Xingjia / Zhang, Guozheng / Qiu, Zhiyong / Xia, Dingguo / Huang, Yongping / Xu, Yunmin / He, Ningjia

    Gene. 2013 Feb. 25, v. 515, no. 2

    2013  

    Abstract: ... on the lateral side. However, the eggs laid by homozygous recessive “Ming” lethal egg mutants (l-eᵐ) lose water ...

    Abstract The egg stage is an important stage in the silkworm (Bombyx mori) life cycle. Normal silkworm eggs are usually short, elliptical, and laterally flattened, with a sometimes hollowed surface on the lateral side. However, the eggs laid by homozygous recessive “Ming” lethal egg mutants (l-eᵐ) lose water and become concaved around 1h, ultimately exhibiting a triangular shape on the egg surfaces. We performed positional cloning, and narrowed down the region containing the gene responsible for the l-eᵐ mutant to 360kb on chromosome 10 using 2287 F₂ individuals. Using expression analysis and RNA interference, the best l-eᵐ candidate gene was shown to be BmEP80. The results of the inverse polymerase chain reaction showed that an ~1.9kb region from the 3′ untranslated region of BmVMP23 to the forepart of BmEP80 was replaced by a >100kb DNA fragment in the l-eᵐ mutant. Several eggs laid by the normal moths injected with BmEP80 small interfering RNAs were evidently depressed and exhibited a triangular shape on the surface. The phenotype exhibited was consistent with the eggs laid by the l-eᵐ mutant. Moreover, two-dimensional gel electrophoresis showed that the BmEP80 protein was expressed in the ovary from the 9th day of the pupa stage to eclosion in the wild-type silkworm, but was absent in the l-eᵐ mutant. These results indicate that BmEP80 is responsible for the l-eᵐ mutation.
    Keywords Bombyx mori ; DNA ; RNA ; RNA interference ; chromosomes ; eclosion ; eggs ; genes ; homozygosity ; membrane proteins ; molecular cloning ; moths ; mutants ; mutation ; phenotype ; polymerase chain reaction ; pupae ; silkworms ; two-dimensional gel electrophoresis ; vitelline membrane
    Language English
    Dates of publication 2013-0225
    Size p. 313-319.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 391792-7
    ISSN 1879-0038 ; 0378-1119
    ISSN (online) 1879-0038
    ISSN 0378-1119
    DOI 10.1016/j.gene.2012.12.006
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  7. Book: Wan Qing ming yi yong yao jing hua lu

    Guo, Wenyou / Ding, Ganren / Fei, Boxiong / Tang, Zonghai

    (Xin bian shi yong Zhong yi zi xiu jiao cheng)

    1999  

    Title translation Essence of drug applications by famous doctors in late Qing dynasty.
    Author's details Guo Wenyou zhuan
    Series title Xin bian shi yong Zhong yi zi xiu jiao cheng
    MeSH term(s) Materia Medica ; Medicine, Chinese Traditional
    Language Chinese
    Size 649 p.
    Edition Chengdu di 1 ban.
    Publisher Sichuan ke xue ji shu chu ban she
    Publishing place Chengdu
    Document type Book
    ISBN 9787536443105 ; 7536443102
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Book: Tang ming huang

    Li, Tang

    (Li shi xiao cong shu ; 歷史小叢書)

    1977  

    Title variant Tang Minghuang
    Author's details Li tang zhu
    Series title Li shi xiao cong shu
    歷史小叢書
    Keywords China
    Language Chinese
    Size 3, 3, 170 S, 19 cm
    Edition Zai ban
    Publisher Xiang gang hong ye shu ju
    Publishing place Xiang gang
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article ; Online: Embracing the command line: my unexpected career in computational biology.

    Tang, Ming Tommy

    Nature

    2023  

    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-023-03120-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 26: Show issues Location:
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  10. Book: Ming qing shi liao suo yin

    Tang, Chengyuan

    1972  

    Author's details Tang cheng yuan bian zhu
    Language Chinese
    Size 54 p, 21 cm
    Publisher Wei xin shu ju
    Publishing place Tai bei
    Document type Book
    Note Colophon title ; The index covers from Jia bian to Wu bian only
    Database Former special subject collection: coastal and deep sea fishing

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