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Article: Health Related Quality of Life in Interstitial Lung Disease: Can We Use the Same Concepts Around the World?

Aronson, Kerri I / Suzuki, Atsushi

2021 Volume 8, Page(s) 745908

Abstract: Health-Related Quality of Life (HRQOL) is increasingly viewed as an important patient-centered outcome by leading health organizations, clinicians, and patients alike. This is especially true in the interstitial lung disease community where patients ... ...

Abstract	Health-Related Quality of Life (HRQOL) is increasingly viewed as an important patient-centered outcome by leading health organizations, clinicians, and patients alike. This is especially true in the interstitial lung disease community where patients often struggle with progressive and debilitating disease with few therapeutic options. In order to test the effectiveness of new pharmacologic therapies and non-pharmacologic interventions globally in ILD, this will require expansion of clinical research studies to a multinational level and HRQOL will be an important endpoint to many. In order to successfully expand trials across multiple nations and compare the results of studies between different communities we must recognize that there are differences in the concepts of HRQOL across the world and have strategies to address these differences. In this review, we will describe the different global influences on HRQOL both generally and in the context of ILD, discuss the processes of linguistic translation and cross-cultural adaptation of HRQOL Patient Reported Outcome Measures (PROMs), and highlight the gaps and opportunities for improving HRQOL measurement in ILD across the world.
Language	English
Publishing date	2021-10-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.745908
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Article ; Online: Clinical trials of pharmacological interventions for SARS-CoV-2 published in leading medical journals report adherence but not how it was assessed.

Lee, Charlotte / Otunla, Afolarin / Brennan, Isabelle / Aronson, Jeffrey K / Nunan, David

British journal of clinical pharmacology

2024 Volume 90, Issue 4, Page(s) 1130–1141

Abstract: Aims: Adherence to pharmacological interventions in clinical trials is crucial for accurate identification of beneficial and adverse outcomes. The ways in which adherence to interventions should be reported in trial publications are described in the ... ...

Abstract	Aims: Adherence to pharmacological interventions in clinical trials is crucial for accurate identification of beneficial and adverse outcomes. The ways in which adherence to interventions should be reported in trial publications are described in the Template for Intervention Description and Replication (TIDieR), a 12-item extension of the Consolidated Standards of Reporting Trials reporting guidelines. The objective of this study was to assess compliance with TIDieR Items 11 and 12 of randomized controlled trials (RCTs) of interventions in SARS-CoV-2 infection published in 5 selected journals during 2021. Methods: We assessed pharmacological interventions for SARS-CoV-2 infection reported in RCTs published in 2021 in the Annals of Internal Medicine, The BMJ, JAMA, The Lancet and The New England Journal for Medicine for compliance with TIDieR items addressing intervention adherence (Items 11 and 12). We calculated proportional adherence for pharmacological and comparator interventions where available. Results: We found 75 eligible RCTs. Twenty-eight (37%) reported results of SARS-CoV-2 vaccinations. Compliance with Items 11 and 12 could be assessed in 71 of these 75. Of the 71 RCTs, 37 (52%) reported how adherence was assessed (Item 11), and 70 reported adherence rates (Item 12). Only 1 of the 71 RCTs (1.4%, 0-7.6%) fully complied with TIDieR Items 11 and 12. Conclusion: Half of RCTs of SARS-CoV-2 pharmacological interventions published in leading medical journals in 2021 complied with reporting of how adherence assessments were made and almost none complied with both TIDieR Items 11 and 12. The implications for interpretation, application and replication of findings based on these publications warrant consideration.
MeSH term(s)	Humans ; SARS-CoV-2 ; Guideline Adherence ; COVID-19 ; Periodicals as Topic ; Research Design ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.15992
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Zs.A 1118: Show issues

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Article ; Online: Utilizing Human-Induced Pluripotent Stem Cells to Study Cardiac Electroporation Pulsed-Field Ablation.

Maizels, Leonid / Heller, Eyal / Landesberg, Michal / Glatstein, Shany / Huber, Irit / Arbel, Gil / Gepstein, Amira / Aronson, Doron / Sharabi, Shirley / Beinart, Roy / Segev, Amit / Maor, Elad / Gepstein, Lior

Circulation. Arrhythmia and electrophysiology

2024 Volume 17, Issue 3, Page(s) e012278

Abstract: Background: Electroporation is a promising nonthermal ablation method for cardiac arrhythmia treatment. Although initial clinical studies found electroporation pulsed-field ablation (PFA) both safe and efficacious, there are significant knowledge gaps ... ...

Abstract	Background: Electroporation is a promising nonthermal ablation method for cardiac arrhythmia treatment. Although initial clinical studies found electroporation pulsed-field ablation (PFA) both safe and efficacious, there are significant knowledge gaps concerning the mechanistic nature and electrophysiological consequences of cardiomyocyte electroporation, contributed by the paucity of suitable human in vitro models. Here, we aimed to establish and characterize a functional in vitro model based on human-induced pluripotent stem cells (hiPSCs)-derived cardiac tissue, and to study the fundamentals of cardiac PFA. Methods: hiPSC-derived cardiomyocytes were seeded as circular cell sheets and subjected to different PFA protocols. Detailed optical mapping, cellular, and molecular characterizations were performed to study PFA mechanisms and electrophysiological outcomes. Results: PFA generated electrically silenced lesions within the hiPSC-derived cardiac circular cell sheets, resulting in areas of conduction block. Both reversible and irreversible electroporation components were identified. Significant electroporation reversibility was documented within 5 to 15-minutes post-PFA. Irreversibly electroporated regions persisted at 24-hours post-PFA. Per single pulse, high-frequency PFA was less efficacious than standard (monophasic) PFA, whereas increasing pulse-number augmented lesion size and diminished reversible electroporation. PFA augmentation could also be achieved by increasing extracellular Ca Conclusions: Cardiac electroporation may be studied using hiPSC-derived cardiac tissue, providing novel insights into PFA temporal and electrophysiological characteristics, facilitating electroporation protocol optimization, screening for potential PFA-sensitizers, and investigating the mechanistic nature of PFA antiarrhythmic properties.
MeSH term(s)	Humans ; Induced Pluripotent Stem Cells/metabolism ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/surgery ; Anti-Arrhythmia Agents/therapeutic use ; Myocytes, Cardiac/metabolism ; Electroporation ; Catheter Ablation/methods
Chemical Substances	Anti-Arrhythmia Agents
Language	English
Publishing date	2024-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2426129-4
ISSN	1941-3084 ; 1941-3149
ISSN (online)	1941-3084
ISSN	1941-3149
DOI	10.1161/CIRCEP.123.012278
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Zs.A 6667: Show issues

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Article: Adherence to Guidelines in Heart Failure, Is It Valid for Elderly Patients?

Khoury, Johad / Ghersin, Itai / Braun, Eyal / Elias, Adi / Aronson, Doron / Azzam, Zaher S / Bahouth, Fadel

The Israel Medical Association journal : IMAJ

2022 Volume 24, Issue 11, Page(s) 757–762

Abstract: Background: Current guidelines for the treatment of heart failure with reduced ejection fraction (HFrEF) are based on studies that have excluded or underrepresented older patients.: Objectives: To assess the value of guideline directed medical ... ...

Abstract	Background: Current guidelines for the treatment of heart failure with reduced ejection fraction (HFrEF) are based on studies that have excluded or underrepresented older patients. Objectives: To assess the value of guideline directed medical therapy (GDMT) in HFrEF patients 80 years of age and older. Methods: A single-center retrospective study included patients hospitalized with a first and primary diagnosis of acute decompensated heart failure (ADHF) and ejection fraction (EF) of ≤ 40%. Patients 80 years of age and older were stratified into two groups: GDMT, defined as treatment at hospital discharge with at least two drugs of the following groups: beta-blockers, angiotensin converting enzyme inhibitor (ACEI), angiotensin receptor blocker (ARB), or mineralocorticoid antagonists; and a personalized medicine group, which included patients who were treated with up to one of these drug groups. The primary outcomes were 90-day all-cause mortality, 90-day rehospitalization, and 3-years mortality. Results: The study included 1152 patients with HFrEF. 254 (22%) patients who were at least 80 years old. Of the group, 123 were GDMT at discharge. When GDMT group was compared to the personalized medicine group, there were no statistically significant differences in terms 90-day mortality (17% vs. 13%, P = 0.169), 90-day readmission (51 % vs. 45.6%, P = 0.27), or 3-year mortality (64.5% vs. 63.3%, P = 0.915). Conclusions: Adherence to guidelines in the older adult population may not have the same effect as in younger patients who were studied in the randomized clinical trials. Larger prospective studies are needed to further address this issue.
MeSH term(s)	Humans ; Aged ; Aged, 80 and over ; Heart Failure/diagnosis ; Heart Failure/drug therapy ; Angiotensin Receptor Antagonists/therapeutic use ; Stroke Volume ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Retrospective Studies ; Registries
Chemical Substances	Angiotensin Receptor Antagonists ; Angiotensin-Converting Enzyme Inhibitors
Language	English
Publishing date	2022-11-27
Publishing country	Israel
Document type	Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Zs.A 5470: Show issues

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Article ; Online: Reporting of medication adherence in randomized controlled trials of pharmacological interventions for SARS-CoV-2: a cross-sectional analysis

Lee, Charlotte / Otunla, Afolarin / Brennan, Isabelle / Aronson, Jeffrey K / Nunan, David

medRxiv

Abstract: Background: Adherence to pharmacological interventions in clinical trials is crucial for correct estimation of beneficial and adverse effects, including trials of SARS-CoV-2. The Template for Intervention Description and Replication (TIDieR), a 12-item ... ...

Abstract	Background: Adherence to pharmacological interventions in clinical trials is crucial for correct estimation of beneficial and adverse effects, including trials of SARS-CoV-2. The Template for Intervention Description and Replication (TIDieR), a 12-item extension of the Consolidated Standards of Reporting Trials (CONSORT) reporting guidelines, includes two items (11 and 12) that address intervention adherence reporting in trial publications. Objective: To assess compliance with TIDieR items 11 and 12 of randomised controlled trials (RCTs) of interventions in SARS-CoV-2 infection published in five selected journals during 2021. Methods: We assessed SARS-CoV-2 pharmacological RCTs published in the Annals of Internal Medicine, The BMJ, JAMA, The Lancet, and The New England Journal of Medicine in 2021 for compliance with TIDieR items 11 and 12. Item 11 was assessed in two parts: 11a how intervention adherence was assessed; 11b if any strategies were used to maintain or improve how intervention adherence was maintained or improved. Item 12 assessed the extent to which the intervention was delivered as planned. We calculated raw adherence and proportional (weighted) adherence for pharmacological and comparator interventions where available. Results: We found 75 eligible RCTs, of which 28 (37%) reported results related to SARS-CoV-2 vaccinations. Compliance with items 11a and 12 could be assessed in 71 of these 75. Of those 71 RCTs, 37 (52%, 95% confidence interval 40 to 64%) were compliant with reporting of item 11a. Seven RCTs had a strategy to assess compliance with item 11b, and only three (43%, 9 to 82%) of those complied with item 11b reporting. Of the 71 RCTs, 70 complied with reporting of item 12. Only one of the 71 RCTs (1.4%, 0 to 7.6%) fully complied with TIDieR items 11a, 11b, and 12. Compliance varied across journals. Conclusions: RCTs of SARS-CoV-2 pharmacological interventions published in high-impact medical journals complied variably with reporting of intervention adherence, even though the journals endorse CONSORT. The implications for interpretation, application, and replication of findings based on these publications warrant consideration.
Keywords	covid19
Language	English
Publishing date	2022-10-30
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2022.10.30.22281709
Database	COVID19

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Article ; Online: Diabetes and Prostate Cancer Outcomes in Men with Nonmetastatic Castration-Resistant Prostate Cancer: Results from the SEARCH Cohort.

Sergeyev, Andrei / Gu, Lin / De Hoedt, Amanda M / Amling, Christopher L / Aronson, William J / Cooperberg, Matthew R / Kane, Christopher J / Klaassen, Zachary / Terris, Martha K / Guerrios-Rivera, Lourdes / Freedland, Stephen J / Csizmadi, Ilona

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2023 Volume 32, Issue 9, Page(s) 1208–1216

Abstract: Background: The prognosis of diabetic men with advanced prostate cancer is poorly understood and understudied. Hence, we studied associations between diabetes and progression to metastases, prostate cancer-specific mortality (PCSM) and all-cause ... ...

Abstract	Background: The prognosis of diabetic men with advanced prostate cancer is poorly understood and understudied. Hence, we studied associations between diabetes and progression to metastases, prostate cancer-specific mortality (PCSM) and all-cause mortality (ACM) in men with nonmetastatic castration-resistant prostate cancer (nmCRPC). Methods: Data from men diagnosed with nmCRPC between 2000 and 2017 at 8 Veterans Affairs Health Care Centers were analyzed using Cox regression to determine HRs and 95% confidence intervals (CI) for associations between diabetes and outcomes. Men with diabetes were classified according to: (i) ICD-9/10 codes only, (ii) two HbA1c values > 6.4% (missing ICD-9/10 codes), and (iii) all diabetic men [(i) and (ii) combined]. Results: Of 976 men (median age: 76 years), 304 (31%) had diabetes at nmCRPC diagnosis, of whom 51% had ICD-9/10 codes. During a median follow-up of 6.5 years, 613 men were diagnosed with metastases, and 482 PCSM and 741 ACM events occurred. In multivariable-adjusted models, ICD-9/10 code-identified diabetes was inversely associated with PCSM (HR, 0.67; 95% CI, 0.48-0.92) while diabetes identified by high HbA1c values (no ICD-9/10 codes) was associated with an increase in ACM (HR, 1.41; 95% CI, 1.16-1.72). Duration of diabetes, prior to CRPC diagnosis was inversely associated with PCSM among men identified by ICD-9/10 codes and/or HbA1c values (HR, 0.93; 95% CI, 0.88-0.98). Conclusions: In men with late-stage prostate cancer, ICD-9/10 'code-identified' diabetes is associated with better overall survival than 'undiagnosed' diabetes identified by high HbA1c values only. Impact: Our data suggest that better diabetes detection and management may improve survival in late-stage prostate cancer.
MeSH term(s)	Male ; Humans ; Aged ; Prostatic Neoplasms, Castration-Resistant ; Glycated Hemoglobin ; Prostatic Neoplasms ; Diabetes Mellitus/epidemiology ; Prognosis ; Prostate/pathology ; Prostate-Specific Antigen
Chemical Substances	Glycated Hemoglobin ; Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2023-05-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-22-1324
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Zs.A 3693: Show issues

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Article ; Online: Practice patterns in reporting interstitial lung abnormality at a tertiary academic medical center.

Escalon, Joanna G / Podolanczuk, Anna J / Aronson, Kerri I / Legasto, Alan C / Gruden, James F / Lynch, David A / Rachid, Leena / Rabkova, Yana / Steinberger, Sharon

Clinical imaging

2023 Volume 104, Page(s) 109996

Abstract: Purpose: Interstitial lung abnormality (ILA) is a common finding on chest CTs and is associated with higher all-cause mortality. The 2020 Fleischner Society position paper standardized the terminology and definition of ILA. Despite these published ... ...

Abstract	Purpose: Interstitial lung abnormality (ILA) is a common finding on chest CTs and is associated with higher all-cause mortality. The 2020 Fleischner Society position paper standardized the terminology and definition of ILA. Despite these published guidelines, the extent to which radiologists use this term is unknown. We evaluated practice patterns for identification of ILAs among radiologists at a tertiary academic medical center. Methods: In this retrospective review, we identified 157 radiology reports between January 1, 2010 through December 31, 2021 containing the phrase "interstitial lung abnormality" or "interstitial abnormality". After exclusions, 125 CT scans were reviewed by thoracic-trained radiologists using the sequential reading method. Results: Seventy-seven (62%) patients were found to have ILA (69% subpleural fibrotic, 19% subpleural non-fibrotic, and 6% non-subpleural), nine (7%) were equivocal for ILA and 39 (31%) had no ILA. The term ILA was used exclusively by thoracic-trained radiologists except for two cases. Use of the term ILA has rapidly increased since the position paper publication (none from 2010-2017, one case in 2018, 20 cases in 2019, 41 cases in 2020, and 73 cases in 2021), and cases were typically very mild (1-25% of the lung). Conclusion: While there has been increased use of the term ILA among thoracic-trained radiologists, non-thoracic radiologists have essentially not begun to use the term. Almost one-third of cases labeled ILA on clinical reads were re-classified as not having ILA on research reads.
MeSH term(s)	Humans ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/complications ; Lung/diagnostic imaging ; Lung Neoplasms ; Retrospective Studies ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2023-10-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2023.109996
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Zs.A 1469: Show issues

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Article ; Online: Perspectives of Black Adults Living with Chronic Obstructive Pulmonary Disease on Barriers to Cardiovascular Disease Prevention.

Krishnan, Jamuna K / Murphy, Michaela L / Edgar, Armani S / Aronson, Kerri I / Guri, Albina / Gross, Liam / Younger, Tiffany / Martinez, Fernando J / Safford, Monika M

Annals of the American Thoracic Society

2023 Volume 21, Issue 5, Page(s) 706–715

Abstract: Rationale: ...

Abstract	Rationale:
MeSH term(s)	Humans ; Pulmonary Disease, Chronic Obstructive/ethnology ; Pulmonary Disease, Chronic Obstructive/complications ; Male ; Female ; Aged ; Cardiovascular Diseases/prevention & control ; Cardiovascular Diseases/ethnology ; Middle Aged ; Black or African American ; Health Services Accessibility ; United States/epidemiology ; Qualitative Research ; Interviews as Topic
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2717461-X
ISSN	2325-6621 ; 1943-5665 ; 2325-6621
ISSN (online)	2325-6621 ; 1943-5665
ISSN	2325-6621
DOI	10.1513/AnnalsATS.202304-342OC
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Article: Biallelic EPCAM deletions induce tissue-specific DNA repair deficiency and cancer predisposition.

Forster, V J / Aronson, M / Zhang, C / Chung, J / Sudhaman, S / Galati, M A / Kelly, J / Negm, L / Ercan, A B / Stengs, L / Durno, C / Edwards, M / Komosa, M / Oldfield, L E / Nunes, N M / Pedersen, S / Wellum, J / Siddiqui, I / Bianchi, V /

Weil, B R / Fox, V L / Pugh, T J / Kamihara, J / Tabori, U

NPJ precision oncology

2024 Volume 8, Issue 1, Page(s) 69

Abstract: We report a case of Mismatch Repair Deficiency (MMRD) caused by germline homozygous EPCAM deletion leading to tissue-specific loss of MSH2. Through the use of patient-derived cells and organoid technologies, we performed stepwise in vitro differentiation ...

Abstract	We report a case of Mismatch Repair Deficiency (MMRD) caused by germline homozygous EPCAM deletion leading to tissue-specific loss of MSH2. Through the use of patient-derived cells and organoid technologies, we performed stepwise in vitro differentiation of colonic and brain organoids from reprogrammed EPCAM
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article
ISSN	2397-768X
ISSN	2397-768X
DOI	10.1038/s41698-024-00537-6
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Article ; Online: Zebrafish mbnl mutants model physical and molecular phenotypes of myotonic dystrophy.

Hinman, Melissa N / Richardson, Jared I / Sockol, Rose A / Aronson, Eliza D / Stednitz, Sarah J / Murray, Katrina N / Berglund, J Andrew / Guillemin, Karen

Disease models & mechanisms

2021 Volume 14, Issue 6

Abstract: The muscleblind RNA-binding proteins (MBNL1, MBNL2 and MBNL3) are highly conserved across vertebrates and are important regulators of RNA alternative splicing. Loss of MBNL protein function through sequestration by CUG or CCUG RNA repeats is largely ... ...

Abstract	The muscleblind RNA-binding proteins (MBNL1, MBNL2 and MBNL3) are highly conserved across vertebrates and are important regulators of RNA alternative splicing. Loss of MBNL protein function through sequestration by CUG or CCUG RNA repeats is largely responsible for the phenotypes of the human genetic disorder myotonic dystrophy (DM). We generated the first stable zebrafish (Danio rerio) models of DM-associated MBNL loss of function through mutation of the three zebrafish mbnl genes. In contrast to mouse models, zebrafish double and triple homozygous mbnl mutants were viable to adulthood. Zebrafish mbnl mutants displayed disease-relevant physical phenotypes including decreased body size and impaired movement. They also exhibited widespread alternative splicing changes, including the misregulation of many DM-relevant exons. Physical and molecular phenotypes were more severe in compound mbnl mutants than in single mbnl mutants, suggesting partially redundant functions of Mbnl proteins. The high fecundity and larval optical transparency of this complete series of zebrafish mbnl mutants will make them useful for studying DM-related phenotypes and how individual Mbnl proteins contribute to them, and for testing potential therapeutics. This article has an associated First Person interview with the first author of the paper.
MeSH term(s)	Alternative Splicing ; Animals ; Disease Models, Animal ; Homozygote ; Mutation ; Myotonic Dystrophy/genetics ; Phenotype ; RNA-Binding Proteins/genetics ; Zebrafish
Chemical Substances	RNA-Binding Proteins
Language	English
Publishing date	2021-06-14
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2451104-3
ISSN	1754-8411 ; 1754-8403
ISSN (online)	1754-8411
ISSN	1754-8403
DOI	10.1242/dmm.045773
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