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  1. Article ; Online: Fungi make fun guys.

    Gaffen, Sarah L / Biswas, Partha S

    Cell host & microbe

    2022  Volume 30, Issue 3, Page(s) 277–278

    Abstract: In a recent Cell study, Leonardi et al. show that commensal mucosa-associated gut fungi profoundly impact host immunity, epithelial barrier function, and, unexpectedly, neuroimmune modulation of social behavior. All of these events are controlled by ... ...

    Abstract In a recent Cell study, Leonardi et al. show that commensal mucosa-associated gut fungi profoundly impact host immunity, epithelial barrier function, and, unexpectedly, neuroimmune modulation of social behavior. All of these events are controlled by fungal-induced activation of type 17 cytokines that act on both epithelial cells and neurons.
    MeSH term(s) Cytokines/metabolism ; Epithelial Cells/immunology ; Fungi/immunology ; Symbiosis
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2022.02.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6578: Show issues Location:
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  2. Article ; Online: When IL-17 gets on your nerves.

    Iliev, Iliyan D / Lin, Woan-Yu / Gaffen, Sarah L

    Cell

    2023  Volume 186, Issue 3, Page(s) 466–468

    Abstract: Microbiota-induced IL-17 production mediates CNS processes and animal behavior. However, its role on the peripheral nervous system (PNS) remains largely unknown. Enamorado et al. demonstrate that commensal-specific Th17 cells are recalled following ... ...

    Abstract Microbiota-induced IL-17 production mediates CNS processes and animal behavior. However, its role on the peripheral nervous system (PNS) remains largely unknown. Enamorado et al. demonstrate that commensal-specific Th17 cells are recalled following tissue injury to support local nerve regeneration, a process orchestrated by IL-17 signaling on peripheral neurons.
    MeSH term(s) Animals ; Central Nervous System ; Interleukin-17 ; Peripheral Nervous System ; Nerve Regeneration/physiology ; Signal Transduction ; Peripheral Nerves ; Axons/physiology
    Chemical Substances Interleukin-17
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2022.12.048
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  3. Article ; Online: '(m

    Bechara, Rami / Gaffen, Sarah L

    Trends in immunology

    2021  Volume 42, Issue 12, Page(s) 1073–1076

    Abstract: Covalent RNA modifications that regulate gene expression post transcriptionally, in particular N6-methyladenosine ( ... ...

    Abstract Covalent RNA modifications that regulate gene expression post transcriptionally, in particular N6-methyladenosine (m
    MeSH term(s) Autoimmunity ; Humans ; Inflammation ; RNA, Messenger/metabolism
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2021-10-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2021.10.002
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  4. Article ; Online: Regulation of host-microbe interactions at oral mucosal barriers by type 17 immunity.

    Gaffen, Sarah L / Moutsopoulos, Niki M

    Science immunology

    2020  Volume 5, Issue 43

    Abstract: The oral mucosa is a primary barrier site and a portal for entry of microbes, food, and airborne particles into the gastrointestinal tract. Nonetheless, mucosal immunity at this barrier remains understudied compared with other anatomical barrier sites. ... ...

    Abstract The oral mucosa is a primary barrier site and a portal for entry of microbes, food, and airborne particles into the gastrointestinal tract. Nonetheless, mucosal immunity at this barrier remains understudied compared with other anatomical barrier sites. Here, we review basic aspects of oral mucosal histology, the oral microbiome, and common and clinically significant diseases that present at oral mucosal barriers. We particularly focus on the role of interleukin-17 (IL-17)/T helper 17 (T
    MeSH term(s) Animals ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Mucosal ; Interleukin-17/immunology ; Microbiota ; Mouth Diseases/immunology ; Mouth Diseases/microbiology ; Mouth Mucosa/immunology ; Mouth Mucosa/microbiology ; Th17 Cells/immunology
    Chemical Substances IL17A protein, human ; Interleukin-17
    Language English
    Publishing date 2020-01-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Review
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.aau4594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The metabolism-modulating activity of IL-17 signaling in health and disease.

    Bechara, Rami / McGeachy, Mandy J / Gaffen, Sarah L

    The Journal of experimental medicine

    2021  Volume 218, Issue 5

    Abstract: IL-17 was discovered nearly 30 yr ago, but it has only been recently appreciated that a key function of this cytokine is to orchestrate cellular and organismal metabolism. Indeed, metabolic regulation is integrated into both the physiological and the ... ...

    Abstract IL-17 was discovered nearly 30 yr ago, but it has only been recently appreciated that a key function of this cytokine is to orchestrate cellular and organismal metabolism. Indeed, metabolic regulation is integrated into both the physiological and the pathogenic aspects of IL-17 responses. Thus, understanding the interplay between IL-17 and downstream metabolic processes could ultimately inform therapeutic opportunities for diseases involving IL-17, including some not traditionally linked to this cytokine pathway. Here, we discuss the emerging pathophysiological roles of IL-17 related to cellular and organismal metabolism, including metabolic regulation of IL-17 signal transduction.
    MeSH term(s) Animals ; Cell Proliferation/genetics ; Cell Proliferation/physiology ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Gene Expression Regulation ; Glucose/metabolism ; Glycolysis/genetics ; Glycolysis/physiology ; Humans ; Interleukin-17/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Signal Transduction/physiology
    Chemical Substances Interleukin-17 ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20202191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Interleukin 17 Family Cytokines: Signaling Mechanisms, Biological Activities, and Therapeutic Implications.

    Monin, Leticia / Gaffen, Sarah L

    Cold Spring Harbor perspectives in biology

    2018  Volume 10, Issue 4

    Abstract: The cytokines of the interleukin 17 (IL-17) family play a central role in the control of infections, especially extracellular fungi. Conversely, if unrestrained, these inflammatory cytokines contribute to the pathology of numerous autoimmune and chronic ... ...

    Abstract The cytokines of the interleukin 17 (IL-17) family play a central role in the control of infections, especially extracellular fungi. Conversely, if unrestrained, these inflammatory cytokines contribute to the pathology of numerous autoimmune and chronic inflammatory conditions. Recent advances have led to the approval of IL-17A-blocking biologics for the treatment of moderate to severe plaque psoriasis, but much remains to be understood about the biological functions, regulation, and signaling pathways downstream of these factors. In this review, we outline the current knowledge of signal transduction and known physiological activities of IL-17 family cytokines. We will highlight in particular the current understanding of these cytokines in the context of skin manifestations of disease.
    MeSH term(s) Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Autoimmune Diseases/therapy ; Humans ; Infection/immunology ; Infection/pathology ; Infection/therapy ; Interleukin-17/metabolism ; Interleukin-17/physiology ; Ligands ; Receptors, Interleukin/metabolism ; Receptors, Interleukin/physiology ; Signal Transduction
    Chemical Substances Interleukin-17 ; Ligands ; Receptors, Interleukin
    Language English
    Publishing date 2018-04-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a028522
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Dermatophyte Immune Memory Is Only Skin-Deep.

    Verma, Akash H / Gaffen, Sarah L

    The Journal of investigative dermatology

    2018  Volume 139, Issue 3, Page(s) 517–519

    Abstract: A new report in this issue of Journal of Investigative Dermatology reveals a role for IL-17 and IFN-gamma, signature cytokines of T-helper 17 and T-helper 1 cells, in immunity to Trichophyton benhamiae (Heinen et al., 2018). While there have been many ... ...

    Abstract A new report in this issue of Journal of Investigative Dermatology reveals a role for IL-17 and IFN-gamma, signature cytokines of T-helper 17 and T-helper 1 cells, in immunity to Trichophyton benhamiae (Heinen et al., 2018). While there have been many recent advances in understanding host defenses against common fungi, this work illuminates not only adaptive immunity, but also innate immune responses to dermatophytosis.
    MeSH term(s) Adaptive Immunity ; Arthrodermataceae ; Dermatomycoses ; Humans ; Immunity, Innate ; Immunologic Memory ; Tinea
    Language English
    Publishing date 2018-10-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2018.10.022
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  8. Article ; Online: Fungus Among Us: The Frenemies Within.

    Aggor, Felix E Y / Way, Sing Sing / Gaffen, Sarah L

    Trends in immunology

    2019  Volume 40, Issue 6, Page(s) 469–471

    Abstract: A recent study shows that the commensal fungus Candida albicans is an inducer of differentiation of human ... ...

    Abstract A recent study shows that the commensal fungus Candida albicans is an inducer of differentiation of human CD4
    MeSH term(s) Candida albicans ; Cell Differentiation ; Humans ; Immunity ; Inflammation ; Th17 Cells
    Language English
    Publishing date 2019-04-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2019.04.007
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  9. Article ; Online: Editorial: Fake it 'til you make it: mast cells acquire IL-17 exogenously.

    Huppler, Anna R / Gaffen, Sarah L

    Journal of leukocyte biology

    2016  Volume 100, Issue 3, Page(s) 445–446

    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Editorial
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1189/jlb.3CE0216-071R
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    Zs.A 603: Show issues Location:
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  10. Article ; Online: Candidalysin: discovery and function in Candida albicans infections.

    Naglik, Julian R / Gaffen, Sarah L / Hube, Bernhard

    Current opinion in microbiology

    2019  Volume 52, Page(s) 100–109

    Abstract: Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and ...

    Abstract Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity. Candidalysin is regarded as the first true classical virulence factor of C. albicans but also triggers protective immune responses. This review will discuss how candidalysin was discovered, the mechanisms by which this peptide toxin contributes to C. albicans infections, and how its discovery has advanced our understanding of fungal pathogenesis and disease.
    MeSH term(s) Animals ; Candida albicans/metabolism ; Candidiasis/microbiology ; Candidiasis/physiopathology ; Fungal Proteins/immunology ; Fungal Proteins/metabolism ; Host-Pathogen Interactions ; Humans ; Mycotoxins/immunology ; Mycotoxins/metabolism ; Virulence Factors/immunology ; Virulence Factors/metabolism
    Chemical Substances ECE1 protein, Candida albicans ; Fungal Proteins ; Mycotoxins ; Virulence Factors
    Language English
    Publishing date 2019-07-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2019.06.002
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